Southern African Journal of Gynaecological Oncology最新文献_第4页

Breast cancer among women in sub-Saharan Africa: prevalence and a situational analysis 撒哈拉以南非洲妇女癌症患病率和情况分析

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Southern African Journal of Gynaecological Oncology Pub Date : 2017-10-30 DOI: 10.1080/20742835.2017.1391467

Samuel N Cumber, K. Nchanji, J. Tsoka-Gwegweni

引用次数: 46

p16 and Ki-67 immunohistochemical staining reduces inter- and intra-observer variability in the grading of cervical squamous intraepithelial lesions of South African women p16和Ki-67免疫组织化学染色降低了南非妇女宫颈鳞状上皮内病变分级的观察者之间和观察者内部的变异性

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Southern African Journal of Gynaecological Oncology Pub Date : 2017-09-14 DOI: 10.1080/20742835.2017.1370841

C. Solomon, M. Louw, Mc van Aardt, G. Dreyer

{"title":"p16 and Ki-67 immunohistochemical staining reduces inter- and intra-observer variability in the grading of cervical squamous intraepithelial lesions of South African women","authors":"C. Solomon, M. Louw, Mc van Aardt, G. Dreyer","doi":"10.1080/20742835.2017.1370841","DOIUrl":"https://doi.org/10.1080/20742835.2017.1370841","url":null,"abstract":"Background: Cervical carcinoma was the second leading malignancy in South African women (following breast carcinoma) in 2010. This study aimed to correlate histopathological criteria and immunohistochemical stains in terms of the grading of cervical intraepithelial precursor lesions and evaluate intra- and inter-observer variability with only histology and with additional immunohistochemical stains. Methods: Archival tissue from large-loop excision of the transformation zone (LLETZ) was graded on two separate occasions by an independent observer in terms of lesional severity. The section with the highest grade precursor lesion was selected and submitted for immunohistochemical stains that included p16 and Ki-67. These stains were also evaluated on two separate occasions by an independent observer. Results: This study showed kappa values of 0.47 and 0.46 respectively for the separate histological evaluations of the observer and the original pathology report. The kappa value for the two evaluations of the observer was 0.57. Thus inter- and intra-observer variability is fair with the use of routinely stained histological slides. The two Ki-67 assessments had a kappa value of 0.85 and the p16 had a value of 0.80. Intra-observer agreement was markedly higher when using immunohistochemistry. Conclusion: Although in most cases of precursor lesions of the cervix the grading can be made on routinely stained sections, intra- and inter-observer variability remains high. Immunohistochemical markers reduce this variability and aid in deciding in which group to place ambiguous lesions.","PeriodicalId":41638,"journal":{"name":"Southern African Journal of Gynaecological Oncology","volume":"9 1","pages":"25 - 29"},"PeriodicalIF":0.3,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20742835.2017.1370841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44663325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mitotically active cellular fibroma of the ovary: a rare case and review of literature 卵巢有丝分裂活性细胞纤维瘤：一例罕见病例及文献复习

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Southern African Journal of Gynaecological Oncology Pub Date : 2017-08-16 DOI: 10.1080/20742835.2017.1361644

Rohini V. Kulkarni, R. Bhat, Vibhawari Dhakharia, A. Gangoli, K. Sharma

引用次数: 1

Adherence to guidelines on prophylaxis of chemotherapy-induced nausea and vomiting in the National Cancer Institute, Sudan 苏丹国家癌症研究所预防化疗引起恶心和呕吐指南的遵守情况

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Southern African Journal of Gynaecological Oncology Pub Date : 2017-02-28 DOI: 10.4102/SAJO.V1I0.9

M. Elhassan, Arwa Ali, M. Elmustafa

{"title":"Adherence to guidelines on prophylaxis of chemotherapy-induced nausea and vomiting in the National Cancer Institute, Sudan","authors":"M. Elhassan, Arwa Ali, M. Elmustafa","doi":"10.4102/SAJO.V1I0.9","DOIUrl":"https://doi.org/10.4102/SAJO.V1I0.9","url":null,"abstract":"Objective : To evaluate the adherence to American Society of Clinical Oncology (ASCO) guidelines for antiemetic prophylaxis of chemotherapy-induced nausea and vomiting and assess the outcomes of the prescribed antiemetic drugs. Methods : This prospective, observational study enrolled chemotherapy-naive cancer patients who were admitted to the National Cancer Institute between May and July 2015 for intravenous chemotherapy. Patient’s demographic data, chemotherapy protocols and types of antiemetic drugs were collected by reviewing patients’ files, chemotherapy prescription forms and interviewing the patients. Results : The data revealed that 90% of pre-chemotherapy antiemetic prescriptions did not adhere to antiemetic guidelines. The trends of non-adherence included an overuse of ondansetron (14%), under-prescribing of dexamethasone (16%) and corticosteroid duplication (14%). Regarding antiemetic use for the prevention of delayed emesis, the data showed that 90% of antiemetic prescriptions were non-adherent with ASCO guidelines, with overuse of ondansetron (20%) and metoclopramide (37%) and lack of dexamethasone prescriptions (80%) on days 2 and 3 being the most frequently reported trends. The percentage of patients with complete response (no emesis or rescue therapy) over 5 days post chemotherapy was 36%. Conclusion : The study indicated an extremely low adherence rate to ASCO guidelines for antiemetic prophylaxis of chemotherapy-induced nausea and vomiting. Non-adherence included a trend of both underuse and overuse of indicated antiemetic medications.","PeriodicalId":41638,"journal":{"name":"Southern African Journal of Gynaecological Oncology","volume":"1 1","pages":"5-8"},"PeriodicalIF":0.3,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4102/SAJO.V1I0.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43086167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impact of percutaneous nephrostomy in South African women with advanced cervical cancer and obstructive uropathy 经皮肾造瘘术对南非晚期宫颈癌症和阻塞性尿路病患者的影响

IF 0.3

Southern African Journal of Gynaecological Oncology Pub Date : 2017-01-02 DOI: 10.1080/20742835.2017.1352644

M. V. van Aardt, J. van Aardt, A. Mouton

{"title":"Impact of percutaneous nephrostomy in South African women with advanced cervical cancer and obstructive uropathy","authors":"M. V. van Aardt, J. van Aardt, A. Mouton","doi":"10.1080/20742835.2017.1352644","DOIUrl":"https://doi.org/10.1080/20742835.2017.1352644","url":null,"abstract":"Objectives: South Africa women with cervical carcinoma present at younger ages and the majority with advanced-stage disease. Certain patients may have a favourable outcome after placement of a percutaneous nephrostomy (PCN) for obstructive uropathy in cervical cancer. Methods: A retrospective audit was conducted at the Gynaecological Oncology Unit, University of Pretoria. All patients with primary untreated cervical cancer with renal impairment secondary to obstructive uropathy were included. Urea, creatinine and potassium were recorded for patients receiving PCN before insertion and after treatment. Results: In total, 54 patients were included. The mean age was 49.5 years. The number of patients receiving PCN was 28 (51.9%) and 26 (48.1%) women did not. Altogether, 25% of patients had improvement in renal function after insertion of PCN and in 10.3% renal function worsened. Some 50% of these patients received palliative radiotherapy, 7% started therapeutic chemo-radiation and 7% of patients completed treatment. Response to treatment was unknown for 21% of patients, 7% showed partial response and 10.7% died of their disease. In the control group, 15.4% of patients had severe renal failure; 7.7% of patients never started treatment and 7.7% received palliative radiotherapy; 11.5% died of their disease. Some 26.9% of patients without PCN fell in the renal failure group, of whom 19.2% received palliative radiotherapy. Conclusion: PCN in patients with cervical cancer and obstructive uropathy, even if HIV positive, is safe with minimal complications. An improvement in renal function was shown after insertion. PCN improved the number of patients qualifying for initiation and completion of treatment.","PeriodicalId":41638,"journal":{"name":"Southern African Journal of Gynaecological Oncology","volume":"9 1","pages":"10 - 6"},"PeriodicalIF":0.3,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20742835.2017.1352644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49317745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The severity and optimal management of iron deficiency and anaemia before radiation for cervical cancer at the University of Pretoria Academic Hospitals 比勒陀利亚大学学术医院宫颈癌放射治疗前缺铁和贫血的严重程度和最佳管理

IF 0.3

Southern African Journal of Gynaecological Oncology Pub Date : 2017-01-02 DOI: 10.1080/20742835.2017.1321219

G. Dreyer, A. Mostert, C. Visser, A. Mouton

{"title":"The severity and optimal management of iron deficiency and anaemia before radiation for cervical cancer at the University of Pretoria Academic Hospitals","authors":"G. Dreyer, A. Mostert, C. Visser, A. Mouton","doi":"10.1080/20742835.2017.1321219","DOIUrl":"https://doi.org/10.1080/20742835.2017.1321219","url":null,"abstract":"Background: In patients with locally advanced cervical cancer who receive radiotherapy, outcomes correlate significantly with haemoglobin level before and during therapy. These patients often have severe anaemia and require repeated transfusions to achieve and maintain optimal haemoglobin levels. Methods: Women with anaemia and cervical cancer needing primary radiation treatment were randomised to two groups: the study group received limited transfusion with intravenous and oral iron therapy; the control group received transfusion and oral iron. Haemoglobin (Hb) levels, transfusion and markers of iron status were recorded initially and during follow up. Results: Forty-three participants were randomised; data for 39 were available for analysis: 19 received limited transfusion with parenteral and then oral iron (Fe group); 20 had allogenic transfusion and oral iron (Tf group). Average Hb levels in the Fe group displayed a steady rise over a 12-week follow-up while levels in the Tf group declined at about 0.5 g/dl per week. At week 12 pre-treatment levels were again reached despite intermittent transfusions. Conclusions: Anaemic patients with late-stage cervical cancer in this setting have severe iron deficiency that necessitates aggressive correction before radiation. While patients with severe or critical anaemia and those who require radiation without delay need immediate transfusion, sufficient iron is critical to help replenish stores and sustain Hb levels. Patients with longer waiting times before radiation or less severe anaemia should have parenteral iron supplementation at the time of diagnosis and transfusion can be delayed until the time of radiation treatment.","PeriodicalId":41638,"journal":{"name":"Southern African Journal of Gynaecological Oncology","volume":"9 1","pages":"11 - 15"},"PeriodicalIF":0.3,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20742835.2017.1321219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43938639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Invasive cervical cancer and human immunodeficiency virus (HIV) infection at Tygerberg Academic Hospital in the period 2003–2007: demographics and characteristics 2003-2007年期间Tygerberg学术医院的侵袭性宫颈癌症和人类免疫缺陷病毒（HIV）感染：人口统计学和特征

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Southern African Journal of Gynaecological Oncology Pub Date : 2017-01-02 DOI: 10.1080/20742835.2017.1333700

A. Diarra, H. Botha

{"title":"Invasive cervical cancer and human immunodeficiency virus (HIV) infection at Tygerberg Academic Hospital in the period 2003–2007: demographics and characteristics","authors":"A. Diarra, H. Botha","doi":"10.1080/20742835.2017.1333700","DOIUrl":"https://doi.org/10.1080/20742835.2017.1333700","url":null,"abstract":"Abstract Background: Despite the prevalence of HIV infection in women with pre-invasive and invasive cervical diseases managed at the Gynaecologic Oncology unit of Tygerberg Hospital, there is a lack of local data on the effect HIV/AIDS has on invasive cervical cancer cases managed at this large tertiary institution. Cervical cancer is the most common gynaecological malignancy at Tygerberg Hospital.Objectives: To establish the following in the local cervical cancer population: (1) HIV prevalence; (2) demographics and clinical characteristics (i.e. stage, histology) in HIV seronegative and seropositive women.Methods: A retrospective, descriptive study. Study population: all cases of HIV/AIDS-affected women diagnosed with invasive cervical cancer and managed at the combined gynaecological oncology clinic in Tygerberg Hospital (TBH) compared with HIV/AIDS-unaffected women with cervical cancer 2003–2007; with a follow-up period ending 31 December 2009.Results: In the period 2003–2007, 913 cases of invasive cervical cancer were seen at Tygerberg Academic Hospital (TBH). A total of 838 subjects were HIV seronegative and 75 were HIV seropositive. HIV seropositive subjects were 10 years younger compared with those who were HIV seronegative. The majority of patients in both cohorts never had cervical cytology documented prior to invasive cancer diagnosis. Most women presented with FIGO stages III–IV disease.Conclusion: HIV-affected women present 10 years younger with cervical cancer compared with their HIV-unaffected counterparts. Effective screening is still lacking in this population. The majority of women present with advanced cervical cancer.","PeriodicalId":41638,"journal":{"name":"Southern African Journal of Gynaecological Oncology","volume":"9 1","pages":"1 - 5"},"PeriodicalIF":0.3,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20742835.2017.1333700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46904153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Vaginal leiomyoma presenting as a lateral vaginal wall mass 阴道平滑肌瘤表现为阴道外侧壁肿块

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Southern African Journal of Gynaecological Oncology Pub Date : 2017-01-02 DOI: 10.1080/20742835.2017.1314630

E. I. Wethmar, Arnold D Mouton, G. Dreyer

引用次数: 7

Immunohistochemistry markers in diagnosing high-grade serous carcinoma of ovary with breast metastasis: a rare case report 免疫组织化学标记诊断卵巢高级别浆液性癌伴乳腺转移1例报告

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Southern African Journal of Gynaecological Oncology Pub Date : 2016-11-14 DOI: 10.1080/20742835.2016.1239355

T. Elumalai, A. Mukherji, D. Gochhait

引用次数: 0

Experiences of women receiving high dose rate brachytherapy for cervical cancer at an academic hospital 妇女在某学术医院接受宫颈癌高剂量率近距离治疗的经验

IF 0.3

Southern African Journal of Gynaecological Oncology Pub Date : 2016-11-14 DOI: 10.1080/20742835.2016.1257174

AD Dzaka, J. Maree

{"title":"Experiences of women receiving high dose rate brachytherapy for cervical cancer at an academic hospital","authors":"AD Dzaka, J. Maree","doi":"10.1080/20742835.2016.1257174","DOIUrl":"https://doi.org/10.1080/20742835.2016.1257174","url":null,"abstract":"The objective of this study was to present a descriptive summary of the experiences of women treated with high dose rate brachytherapy for cervical cancer. A qualitative descriptive design was used and 16 women treated at an academic hospital in Gauteng were purposively selected. Qualitative interviews were conducted and thematic analysis was used to analyse the data, from which two themes arose: the treatment experience and experiencing emotional distress. Being treated with brachytherapy was a negative experience causing fear, pain and humiliation. The participants feared the procedure, before receiving the first treatment and even after having had one. Pain was a major problem, as the preventative medication participants received did not protect them from experiencing pain. Having to open and hang their legs was a humiliating experience aggravated by the presence of observers and the rotation of doctors. Their belief in God comforted them and gave them courage to endure the treatment, whilst caring staff comforted and supported them. In addition to individualised patient education, nurses should assess the level of pain women experience before, during and after receiving brachytherapy and advocate for the revision of pain management protocols.","PeriodicalId":41638,"journal":{"name":"Southern African Journal of Gynaecological Oncology","volume":"8 1","pages":"42 - 45"},"PeriodicalIF":0.3,"publicationDate":"2016-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20742835.2016.1257174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60047148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12