Senior Care Pharmacist最新文献

{"title":"Antibiotic Route of Administration: Is Oral the New IV in Older Adults?","authors":"Alice N Hemenway, Heather Zimmerman, Elias B Chahine","doi":"10.4140/TCP.n.2025.457","DOIUrl":"10.4140/TCP.n.2025.457","url":null,"abstract":"<p><p><b>Background</b> Oral therapy is widely used to treat many infections. However, there is less consensus regarding the use of oral antibiotics for serious infections. <b>Objective</b> This review aims to evaluate randomized controlled trials (RCTs) comparing intravenous and oral antibiotic treatments for osteomyelitis, endocarditis, and bacteremia, with a particular emphasis on data pertaining to older adults. <b>Data Source</b> A list of RCTs comparing intravenous and oral antibiotics for these types of infections was compiled through a search of PubMed and EMBASE. <b>Data Synthesis</b> A total of 19 RCTs were identified, including nine for osteomyelitis, three for endocarditis, six for bacteremia, and one addressing both osteomyelitis and bacteremia. All trials reported no significant difference between intravenous and oral antibiotic treatments. The inclusion of older adults varied across infection types. For osteomyelitis, only three of the ten RCTs had a mean patient age of 60 years or older. For endocarditis, two of the three RCTs had a mean patient age of 60 years or older. Lastly, for bacteremia, four of the seven RCTs had a mean patient age of 60 years or older. <b>Discussion</b> All retrieved RCTs support the use of fully or partially oral antibiotic regimens for osteomyelitis, endocarditis, and bacteremia. Although data support the use of oral antibiotics in older adults for all three infection types, the number of trials that included older adults varied. <b>Conclusions</b> Several RCTs support the use of fully or partially oral antibiotic regimens for osteomyelitis, endocarditis, and bacteremia. Oral agents may be reasonable options for older adults, depending on an individual's benefit-to-risk assessment.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 11","pages":"457-471"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Medication Reconciliation in a Patient with Parkinson's Disease.","authors":"Sarah Steely Wright, Charlie Wright","doi":"10.4140/TCP.n.2025.443","DOIUrl":"10.4140/TCP.n.2025.443","url":null,"abstract":"<p><p>In this case, a 67-year-old male experienced a progression of his Parkinson's disease symptoms following an inpatient hospitalization for pneumonia. He presents to the neurology clinic for follow-up, where the neurology ambulatory care pharmacist was consulted to assist with his case. The pharmacist identified a medication reconciliation discrepancy that resulted in an unintentional change in the dosing frequency of his carbidopa/levodopa. This, combined with the initiation of metoclopramide, a dopamine-receptor antagonist, led to a worsening of his Parkinson's symptoms. His carbidopa/levodopa dose was titrated back to the previous regimen, metoclopramide was discontinued, and his symptoms significantly improved. This case highlights the importance of best practices in medication reconciliation for patients with Parkinson's disease, the impact of drug-disease interactions, and emphasizes the critical role of ambulatory care pharmacists in geriatric patient care.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 11","pages":"443-449"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Patients to Actively Manage Their Health.","authors":"Demetra Antimisiaris, Patricia W Slattum","doi":"10.4140/TCP.n.2025.431","DOIUrl":"10.4140/TCP.n.2025.431","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 11","pages":"431-432"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equipping Patients to Think Like Pharmacists: The Solution to Drug-Related Morbidity and Mortality May Be Right Under Our Noses.","authors":"Brian J Isetts","doi":"10.4140/TCP.n.2025.433","DOIUrl":"10.4140/TCP.n.2025.433","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 11","pages":"433-434"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Policy to One's Plate: Washington's New Obsession with \"Food Is Medicine\".","authors":"Leigh Davitian","doi":"10.4140/TCP.n.2025.481","DOIUrl":"10.4140/TCP.n.2025.481","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 11","pages":"481-484"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Acceptability of the Minnesota Effective Medication Self-Management Toolkit Four-Step Approach in Low-Income Community-Dwelling Older Adults.","authors":"Emily P Peron, Krista L Donohoe, Amaya Cary, Evelyn Dao, Ryne Johnston, Rahil Syed, Jheanelle Atkinson, Angela Gates, Mikaylah Johnson, Erika Nixon-Lambert, Sabrina Reilly, Ismat Sifa, Elvin T Price, Ericka L Crouse, Lana Sargent, Kristin M Zimmerman, Patricia W Slattum","doi":"10.4140/TCP.n.2025.472","DOIUrl":"10.4140/TCP.n.2025.472","url":null,"abstract":"<p><p><b>Objective</b> To assess the acceptability and perceived utility of the Minnesota Effective Medication Self-Management Toolkit (MEMSMT) four-step approach among participants in the Virginia Commonwealth University (VCU) Mobile Health and Wellness Program (MHWP). <b>Methods</b> Student pharmacist-led focus groups explored medication-related challenges faced by older adults and the perceived utility of the MEMSMT. Participants were recruited from four affordable senior apartment communities served by MHWP. Demographic characteristics of participants were collected and summarized using descriptive statistics. After an explanation of the four-step approach, participants shared their experiences with medication self-management. They then completed the Medication Self-Management Self-Efficacy Checklist and were asked, \"Do you believe that the Minnesota Effective Medication Self-Management Toolkit's four-step approach can help individuals successfully manage their medications?\" Comments regarding medication issues were documented and categorized according to the four aspects of self-medication management evaluated by the MEMSMT: indication, effectiveness, safety, and convenience of use. This study was approved as exempt research by Virginia Commonwealth University's Institutional Review Board (IRB), protocol HM20029554, titled \"Effective Medication Self-Management at Low-Income Senior Housing.\" <b>Results</b> Five focus groups included 40 participants who took an average of 7.5 ± 5.2 medications daily. Most participants were Black (85%), female (70%), and had low health literacy (44%). The average age of participants was 72.2 years (SD ± 7.1). Examples of medication challenges were categorized as related to indication, effectiveness, safety, or convenience. Based on responses to the Medication Self-Management Self-Efficacy Checklist, participants expressed high confidence in their medication self-management skills. A vast majority of participants (94%) reported that using the MEMSMT four-step approach can help individuals successfully self-manage their medications. <b>Conclusion</b> Participants perceive the four-step process in the MEMSMT as a useful approach to improving medication self-management among residents of low-income senior apartment communities in the Richmond metropolitan area. Further evaluation of the Medication Self-Management Self-Efficacy Checklist is warranted.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 11","pages":"472-480"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacists and Falls Prevention: It's That Time of the Year!","authors":"Demetra Antimisiaris, Patricia W Slattum","doi":"10.4140/TCP.n.2025.377","DOIUrl":"10.4140/TCP.n.2025.377","url":null,"abstract":"","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 10","pages":"377-378"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Respiratory Syncytial Virus Vaccines in the Older Adult.","authors":"Brian Torres, Julie M King, Robert M Richardson","doi":"10.4140/TCP.n.2025.402","DOIUrl":"10.4140/TCP.n.2025.402","url":null,"abstract":"<p><p><b>Background</b> Respiratory syncytial virus (RSV) can cause severe illness, particularly in older adults, leading to thousands of hospitalizations and deaths annually among individuals aged 65 and older. In May 2023, the U.S. Food and Drug Administration (FDA) approved two vaccines, Arexvy® (RSVPreF3) and Abrysvo® (RSVpreF), for the prevention of RSV-related lower respiratory tract disease (LRTD) in adults aged 60 years and older. In May 2024, the FDA approved a third RSV vaccine, mRESVIA® (mRNA-1345). In June 2024, the Centers for Disease Control and Prevention (CDC) updated its guidance to recommend a single dose of an RSV vaccine for all adults aged 75 years and older, as well as those aged 60 to 74 years old with risk factors for severe disease. Clinical trials have demonstrated that all three vaccines are safe and effective in reducing RSV-related morbidity and mortality. <b>Objective</b> To review the literature describing the safety, efficacy, tolerability, and clinical application of RSV vaccines in older adults. <b>Data Sources</b> Primary literature identified through PubMed, the U.S. clinical trial registry, and CDC resources from 2021 to 2025, with an emphasis on randomized clinical trials and key studies supporting FDA approval. <b>Data Synthesis</b> Arexvy® (RSVPreF3), Abrysvo® (RSVpreF), and mRESVIA® (mRNA-1345) have demonstrated efficacy in reducing the risk of RSV-associated LRTD and severe RSV-associated LRTD in adults aged 60 years and older. Reported adverse effects include injection-site pain, myalgia, fatigue, and headaches. Economic analyses suggest that all three vaccines are potentially cost-effective. <b>Conclusion</b> RSV poses a significant risk of morbidity and mortality, especially in older adults. Arexvy® (RSVPreF3), Abrysvo® (RSVpreF), and mRESVIA® (mRNA-1345) have been shown to effectively prevent LRTD caused by RSV in individuals aged 60 and older. Pharmacists play a vital role in supporting CDC recommendations, educating patients and optimizing preventive health strategies.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 10","pages":"402-411"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric Pharmacotherapy Case Series: Evaluating Fall Risk in Older Adults with Hyponatremia.","authors":"Tatyana Gurvich, Chris Paxos, Nahirony Sánchez","doi":"10.4140/TCP.n.2025.390","DOIUrl":"10.4140/TCP.n.2025.390","url":null,"abstract":"<p><p>Mild psychotropic-induced hyponatremia is well in older adults. Although it is generally asymptomatic and does not require treatment, hyponatremia can increase the risk of falls, especially when combined with chronic conditions typical of frail patients. This clinical presentation adds a layer of complexity when managing pharmacotherapy and reducing fall risk in older adults. Viewing patients through the lens of the 4M framework provided by the John A. Hartford Foundation enables pharmacists to deliver holistic, patient-centered care, by addressing each of the four pillars (What Matters, Medication, Mentation, and Mobility) and adjusting care goals as patients progress through their lifespan. We present a case of an older adult with multiple comorbidities who recently experienced a fall, illustrating an approach to deprescribing and simplifying the medication regimen without compromising quality of care, while simultaneously improving quality of life.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 10","pages":"390-401"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on the Management of Hyperuricemia and Gout in Older Adults.","authors":"Madison W Carter, Youssef M Roman","doi":"10.4140/TCP.n.2025.379","DOIUrl":"10.4140/TCP.n.2025.379","url":null,"abstract":"<p><p>Various comorbidities and extensive medication regimens often complicate the management of gout in older adults. Even in the general population, managing gout can be challenging, as clinicians must develop strategies for acute gout treatment, assess the need for chronic management, and optimize prophylaxis for gout flares. Several factors influence the choice of pharmacologic therapy, including the patient's medical history, current medications, social and family history, ethnicity, age, and care preferences. This article reviews gout management with a focus on older adults through a case study approach, highlighting the importance of shared decision-making. The integration of pharmacists into direct patient care introduces a novel model of pharmacist-led gout management, which can improve adherence to urate-lowering therapy and optimize medication selection. Despite the rising prevalence of gout, it remains one of the most poorly managed diseases. This review aims to emphasize key principles for effective and safe gout management, taking into account the comorbidities and medications commonly encountered in the older adult population.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"40 10","pages":"379-389"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}