Japan Journal of Clinical & Medical Research最新文献

{"title":"GCs-beta and B-arrestins Regulate Nrf2 via NR4As Productive Pathway Mediated by B-adrenergic for Anti-inflammation and Adopting Myocardial and Immune Functions","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jjcmr/2023(3)151","DOIUrl":"https://doi.org/10.47363/jjcmr/2023(3)151","url":null,"abstract":"The nuclear receptors “NR4As” productive pathway is the so important pathways for activating classic estrogen receptors and are important for regulating the adopted cellular anti-inflammatory growth (mediated by glucocorticoids, Nrf2, Ang2-AT2, and VEGF-A synthesis)which considered as the basic for B-arrestins synthesis which adopt B Adrenergic, and Nrf2 synthesis, that Nrf2 is strong activator to ACE functions for promoting Ang2-AT2 and VEGF-A synthesis for running the adopted anti-inflammatory growth and heme oxygenase. The modulation of oxidative stress will be done by serotonin synthesis (regulated by tryptophan “TGG”) which will promote melatonin synthesis which necessary to activate glucocorticoids productions via NR4A2 pathway followed by B-arrestins and Nrf2 productions for activating Ang2-AT2 and VEGF-A productions. That melatonin synthesis will be associated with GTPase production which promote and activate OPA1 repairs and functions, and responsible for activating glutamine synthesis which stabilize Leu functions through Nrf2 functions. This study concluded that NR4As productive pathway are the important pathway for improving anti-oxidation through improving IL6 productivity to IL17 productions, and is important for glucocorticoids-beta synthesis followed by B-arrestins productions which activate B Adrenergic synthesis that are necessary for activating Nrf2 production that followed by activating ACE for Ang2-AT2 and VEGF-A synthesis for running anti-inflammatory growth, modulating antioxidative stress, activate heme oxygenase, modulating brain function and memories growth , and activating T-cells and B-cell functions. That NR4As exert multilevel regulations of brain function and cardiac functions that protect immune survival from vascular cardiac diseases, and are the primary modulator to pro-inflammation and stimulator for variety of active genes and subunits started by estrogen and GCs-beta productions which followed by activating B-arrestins which activate B Adrenergic synthesis which has the roles of activating Nrf2 productions for adopting antioxidative functions, heme oxygenase, vasoconstriction functions, and anti-inflammatory growth mediated by Ang2-AT2 and VEGF-A synthesis.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"158 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128866376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Soaring Increase of Resistant Microorganisms Demands Immediate Action Solutions are Available","authors":"J. Guggenbichler, Sigmund Guggenbichler","doi":"10.47363/jjcmr/2023(3)146","DOIUrl":"https://doi.org/10.47363/jjcmr/2023(3)146","url":null,"abstract":"Clinical environments provide an ideal reservoir for the growth, proliferation, and transmission of pathogenic organisms. Surfaces in hospitals e.g. hospital furniture, ECG lead wires and other cables, push buttons of infusion pumps, control knobs of ventilation machines, textiles as well as implantable biomaterials like central venous catheters, urologic catheters, endotracheal tubes are contaminated increasingly frequent with multiresistant microorganisms. These microorganisms are distributed by the hands of the nursing personnel throughout the hospital with serious, life threatening consequences. 1.8 million patients suffer from a nosocomial infection per year in Europe; approximately 180,000 deaths are attributed to these infections. The Centers for Disease Control (CDC) estimates that 2 million U.S. patients per year acquire a hospital-related infection. These infections cause 90,000 deaths each year and cost an average of $47,000 per patient to treat. The added cost to hospitals is $4.8 billion anually for extended care treatment. Microorganisms show an increasing rate of resistance against the majority of antibiotics including carbapenems as last available antibiotic. 700,000 deaths have been rеρorted worldwide, 30 000 deaths alone in Europe during the last year due to infections where no effective antimicrobial substance was available. The use of disinfectants is ostensibly intended to remove/kill pathogens on surfaces. However studies have shown that more than one-half the time, surfaces are not adequately cleaned or are re-contaminated within minutes. Much emphasis has been put therefore on hand disinfection. However there are also rеρorts of the emergence of alcohol tolerant/insensitive microorganisms e.g., vancomycin resistant enterococci. This phenomenon has the potential to undermine the effectiveness of alcohol based disinfectant standard precautions. The reason for this dramatic development of resistant microorganisms is still in debate. The indiscriminate use of antibiotics for prevention of a bacterial superinfections e.g. sinusitis, otitis media after a viral infections is frequently incriminated, however this seems to have little impact on the occurrence of multi-resistant hospital pathogens in general. However individual patients are seriously affected by the selection of multi-resistant pathogens. In contrast there is increasing evidence that the widespread use of disinfectants is responsible: disinfectants - analogous to antibiotics - must be incorporated into the metabolism of microorganisms. This is inevitably associated with induction of resistance by transfer of resistance plasmids e.g. induction of efflux pumps. 10 167 рublications (PUBMed Jan. 2023) are available in the international literature which document the resistance of microorganisms against disinfectants; 649 рublications describe the cross resistance with antibiotics, at the same time there are 11 237 publications on the toxicity of disinfectants.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130752371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncompliance with Medication Treatment: A Case Report of a Patient with Coronary Heart Disease","authors":"P. Theofilou","doi":"10.47363/jjcmr/2023(3)144","DOIUrl":"https://doi.org/10.47363/jjcmr/2023(3)144","url":null,"abstract":"Medication compliance is a determining factor treatment effectiveness, as non-adherence reduces the optimum clinical benefit. Patients can experience significant positive changes such as improving their quality of life, increasing life expectancy, reducing of disease complications and risk of disability, reduction of clin progression of the disease, increase in the patient’s trust towards the doctor, increase the effectiveness of the drug and treatment.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129586547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on Sleep and Role of Yoga as a Non – Pharmacological Intervention","authors":"Shalini Rai, V. Rai, Varnika Singh","doi":"10.47363/jjcmr/2023(3)147","DOIUrl":"https://doi.org/10.47363/jjcmr/2023(3)147","url":null,"abstract":"COVID-19 pandemic vastly affected the mental health of people causing psychological distress with problems as emotional disturbance, stress, mood alterations, anger, depression, irritability, confusion, emotional exhaustion, emotional isolation, insecurity, social stigma, post-traumatic stress symptoms, insomnia reported in almost all sectors and strata of the society globally. The impact of ongoing mutations in the nature of the SARS COVID -2 virus, changing presentations of the disease, ongoing disease and deaths, quarantine, isolation, post COVID complications, lock-down, socio economic crisis all have impacted the mental health of people negatively having a major brunt on the sleep. Sleep is a vital biophysiological phenomenon playing a crucial role in systemic physiology, including metabolism, immunity, endocrinal, brain and cardiovascular functions. Disruption of sleep is related with both short-term as well as long term consequences, ranging from increased stress responsivity, mood disorders, impaired cognition and performance, somatic problems like headache, abdominal pain to hypertension, dyslipidemia, CVD, metabolic syndrome, type 2 diabetes mellitus, and increased risk of cancers and death. Studies have reported mental health and sleep to be affected by COVID-19 in general population as well as in health care workers. Mental health and sleep are deeply interrelated with one affecting the other and also the general health, healing and quality of life of the individual. Still, sleep remains to be an underrecognized component of health as concerned to its management. This paper presents the impact of COVID – 19 on sleep form the studies documented and how yoga can be an effective non-pharmacological intervention for prevention and managing the sleep disturbances.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133925201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mini Review on The Relationship Between Coffee And Tea Consumption And Iron Absorption in The Gut – Iron Deficiency Anemia","authors":"Cagri Baris Gunec","doi":"10.47363/jjcmr/2023(3)145","DOIUrl":"https://doi.org/10.47363/jjcmr/2023(3)145","url":null,"abstract":"This mini-review study was conducted to illustrate the relationship (s) between coffee and tea consumption and iron absorption in the gut – iron deficiency anemia. Due to their polyphenol type and content, black tea and coffee consumption was found to significantly increase the risk of iron deficiency anemia, whereas green tea consumption had no effect on how well iron was absorbed by the duodenum part of the small intestine. For critically ill patients, it is advised to wait at least an hour between meals and the consumption of tea or coffee in order to stop the advancement of iron deficiency anemia caused by polyphenols. It is also recommended to consume enhancers (ascorbic acid, meat, fish, and poultry, as prevalent in most industrialized nations) with black tea and coffee to counter the adverse effects of their polyphenols.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126839640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Prediction of COVID-19 Transmission in Internal Air-Conditioned Environments","authors":"Ioannis Rentoumis","doi":"10.47363/jjcmr/2022(2)143","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)143","url":null,"abstract":"COVID-19 has had destructive consequences for health, economy and has altered every aspect of everyday human activity. The outbreak was first identified in December 2019 in Wuhan, China. The declaration of the disease as a “Public Health Emergency of International Concern” for the World Health Organization took place on January 30, 2020. Furthermore, 105,5 million cases have been reported until 06 February 2021. Public distancing in internal environments has been applied as a safety measure to prevent transmission. A controversial topic is the safe distance from person to person. The social distancing regulation, for internal public places, has been arbitrarily defined ignoring the potential aerodynamics effects of inlets, such as air-conditioning units, windows and doors. The velocity of the intake airflow has the potential to transfer a droplet from the nose or the mouth of a patient in greater than the indicated distance. The present study focuses on a model of a supermarket that includes a ventilation system and open doors. For the transmission of COVID-19 in an air-conditioned internal space, two different designs were implemented and studied. Internal shelving, furnishing and human models are also being considered. The numerical results obtained are compared with those obtained by two well-known empirical models related to the effective velocity of incoming air and the virus concentration. It is concluded that the computational results obtained in the present study are in acceptable agreement with those obtained by simple empirical models, especially when the standard k-ε model of turbulence is used. Thus, for the cases of coughing and sneezing patients, where we studied the largest particles that sediment onto the floor, the 6-foot (≈1,82 m) rule applies well. However, pathogen-laced particles, coming for example from asymptomatic patients, travel through the air indoors when people breathe and talk. Therefore, there is not much benefit to the 6-foot rule because the air a person is breathing tends to rise and comes down elsewhere, so the person is more exposed to the average background than to a person at a distance. Future research should concentrate rather on the amount of time spent inside rather than distances. As the COVID-19 pandemic is progressing, the present study is flexible and can be applied generally in crowded places. Furthermore, the general outcome is that individuals should maintain the distance of 1,65 meters and it should be applied as guidelines to help reduce the infection risk.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130282358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DCs- IL2 Necessary for Glucocorticoids Which Necessary for Interferons Synthesis and Serotonin Synthesis then Promote Ang2- At2 and VEGF-A for Anti-Inflammatory Growth","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jjcmr/2022(2)142","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)142","url":null,"abstract":"Dendritic cells (DCs) play an important role in improving and adapting immune responses, and development of chronic inflammation through producing Interleukin-2 which stimulate beta oxidation processes by OPA1 synthase for promoting both IFN-beta and GC-beta production followed by alpha oxidations for TLR4 and SIRPα1 production and for nucleocytosolic acetyl-CoA alpha production which considered as signature of a “growth specifically for anti-inflammatory growth. Glucocorticoids and glutamine are the basic tools for increasing immune efficiency (regulated by OPA1 enzymes) and the main for regulating the adopted Interferons, that the deficiency in glucocorticoids synthesis and glutamine will suppress immune activities and will lead to deficiency in Interferons productions followed by decreasing in macrophages and T-cells functions. The formation of Glucocorticoid-gamma and IFN-gamma started by the effects of Cox2 on inflammatory sources followed by cytokine kinases production for IL2 synthesis upon synthetase functions followed by synthase for glucocorticoid-beta and IFN-beta productions which followed by phospholipase effect for producing PD-L1 synthesis which promote the progression of ovarian cancer.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124996808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curious Case of Acute Abdomen","authors":"S. Chatterjee","doi":"10.47363/jjcmr/2022(2)140","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)140","url":null,"abstract":"A 35 year old male bank employee by profession presented with c/o pain in abdomen with abdominal distension and fullness since last 4 weeks. Intensity of pain had increased over the past 15 days. He had a history of fever intermittently for the past 3 months for which he had been taking medication initially .Off recent fever started subsiding even without medication. He complained of anorexia and weight loss over these 3 months.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133683738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review and Proposals Regarding Organ Donation Education","authors":"F. Cantarovich","doi":"10.47363/jjcmr/2022(2)139","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)139","url":null,"abstract":"The global persistence of organ shortage justifies a study of the current state of this social emergency and a rational discussion of the possible alternatives for a necessary solution.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"176 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124327965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyrimidine TAT TAC Kinases Promote B-Arrestins and Rac1 for Adopting Myocardial Constrictions and Gpcrs Ratio by Ang2-AT2 Synthesis and Anti-Inflammatory Growth","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jjcmr/2022(2)141","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)141","url":null,"abstract":"The orphan nuclear pathway (regulated by pyrimidine TAT and TAC kinases and OPA1 enzymes) has the roles of producing the Beta-subunit (fatty Acyl-COAbeta) upon the effects of synthase which regulate B-arrestins synthesis for adopting ACE for Ang2-AT2 synthesis from Ang1-AT1 (that adopt GPCRs ratio) . The inhibition in synthase and in pyrimidines kinases will reflect Inhibition in Acyl-COA-beta synthesis followed by cholesterol and long fatty chains accumulations with high affinity to bind with k and Na salts that can precipitated and cause lipotoxicity. B-arrestins play a well established role in the dampening of G-protein coupled receptors (GPCRs) accumulation, that prevent their increasing through its adopting to ACE for activating Ang2-AT2 synthesis from Ang1-AT1.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126352408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}