Advancement in Medicinal Plant Research最新文献

{"title":"Why blackseed can be the cure for all illnesses except death","authors":"R. Bhikha","doi":"10.30918/ampr.94.21.019","DOIUrl":"https://doi.org/10.30918/ampr.94.21.019","url":null,"abstract":"The use of plants to prevent and treat illnesses has been known since time immemorial. Blackseed has been used in different civilizations around the world for centuries. The curative properties of blackseed were mentioned in the Bible and further elaborated on by Prophet Mohammed (PBUH) as “Hold on to the use of blackseed, as it has a remedy for every illness except death”. Extensive research conducted over the past century into the phytochemistry of blackseed has identified many active ingredients and confirmed its pharmacological action in the treatment of a vast range of illness conditions across the different systems of the body, including the prevention and treatment of cancer, and optimum functioning of the immune system. Furthermore, the Tibb philosophical principles highlight the ability of the body’s inherent self-healing capacity, known as Physis, and the intricate functioning of the human body, based on the temperamental and humoral theory. This paper emphasizes the importance of Physis, and its role in the maintenance and restoration of health with the regular intake of blackseed, highlighting why blackseed can be a cure for all illnesses except death. Keywords: Blackseed, phytochemistry, pharmacological action, Tibb philosophical principles.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115885478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the effective compounds of Salvia miltiorrhiza through chromatographic fingerprinting coupled with chemometrics","authors":"Y. Tu, Jui-Sheng Lai, Bo-Jein Kuo, Ruo-Han Jian, Tsing-Fen Ho, Miaoli Taiwan Extension Station","doi":"10.30918/AMPR.93.21.014","DOIUrl":"https://doi.org/10.30918/AMPR.93.21.014","url":null,"abstract":"Herbs are rich in the active ingredients of drugs for preventing or treating various disorders. However, conventional bioactivity-guided separation is time and labor-intensive and neglects the additive effect of multiple components. These problems hinder the development of new medicines from natural products. This study established a chemometric analysis method that integrates processes based on the spectrum-effect relationship for the rapid identification of the primary active components of a plant. The high-performance liquid chromatography (HPLC) fingerprints of 171 Salvia miltiorrhiza extracts (SMEs) with varied constituent profiles were analyzed. Chemometric analysis was performed to establish an HPLC fingerprint–bioactivity relationship to explore the components of SMEs that contribute to the antioxidant activity and cytotoxicity effect, respectively. The results indicated that the developed strategy can be used to identify components largely contributing to particular bioactivities and re-evaluate the efficacy of previously neglected components. The present study identified not only the primary active components of S. miltiorrhiza but also the optimal ratios of constituents, validating the method for use in the future investigation and development of herbal medicines. Keywords: Chemometric, herb, antioxidant, cytotoxicity, fingerprint, Salvia miltiorrhiza.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"500 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116204654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and characterization of propitious bioactive compounds from Cassia singueana L.","authors":"Bilkisu A. Adedoyin, O. I. Adeniran, A. Muhammed, S. Dangoggo, L. Nahar, G. Sharples, S. Sarker","doi":"10.30918/ampr.84.20.027","DOIUrl":"https://doi.org/10.30918/ampr.84.20.027","url":null,"abstract":"Cassia singueana L. is widely used in traditional medicine for the treatment of various ailments. The present work was set to investigate the antioxidant and antimicrobial activity of this plant and its secondary metabolites. Three bioactive compounds, lupeol, eugenol and octadecadienoic acid methyl ester, were isolated from the root extract of the plant using bioactivity-guided normal phase column chromatography. The antioxidant effect was studied using the in vitro assays, e.g., 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), superoxide anion and metal chelation methods. The compounds were screened for their antimicrobial activity against four bacteria, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumonia and a fungus, Candida albicans using the agar diffusion method. The MIC/MBC of the extracts were determined by the micro-dilution method. Chemical structures of the isolated compounds were determined using FTIR and NMR spectroscopy. Whilst all three compounds showed certain levels of antioxidant activity, the most prominent antimicrobial activity was observed only against S. aureus. In general, results from the work provided some evidence to support the traditional medicinal uses of C. singueana. Keywords: Detection, elucidation, phytochemical, Cassia singueana.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114618441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular identification of some fungi associated with soft dates (Phoenix dactylifera L.) in Saudi Arabia","authors":"Mashael Al-Mutarrafi, N. Elsharawy, Aisha Al-Ayafi, Ahmed Almatrafi, H. Abdelkader","doi":"10.30918/ampr.74.19.038","DOIUrl":"https://doi.org/10.30918/ampr.74.19.038","url":null,"abstract":"The Kingdom of Saudi Arabia is considered one of the major dates producing zones in the world, contributing 13% of the total world production. Most of the dates are delivered to local markets without any treatment thus, may be leading to microbial contamination which may increase the incidence of microbial growth. Some pathogenic fungi associated with soft dates (Phoenix dactylifera Linn.) collected from Almadinah Almunawarah, local markets, was isolated and molecularly identified during summer 2019. Contaminated date samples (Sukkary, Ajwa, Shalabi madinah, Barni and Sogea) were placed on PDA plates and incubated at 26°C for 5 days. Morphological and molecular identification of the resulting fungi were investigated. Molecular identification of fungal isolates was conducted using the internal transcribed spacer (ITS) region of the ribosomal DNA (rDNA). Fungal DNAs were amplified by PCR using ITS1-F (5’TCCGTAGGTGAACCTGCGG-3’) and ITS4 (5’-TCCTCCGCTTATTGATATGC-3’). The purified PCR products were sequenced and the obtained nucleotide sequences were submitted to GenBank on the NCBI. The results showed that the most dominant isolated fungi were Aspergillus niger (100%) associated with “Sogea”, followed by Aspergillus tubingensis (66%) isolated from “Shalabi Almadinah” (40%), Rhizopus stolonifer (36.3%) associated with “Ajwa”, Talaromyces minioluteus (14.2%) isolated from “Sukkary”, respectively. Soft dates are most likely contaminated due to the artificial rise in moisture content and the related inappropriate storage conditions. In conclusion, the study has declared that Aspergillus spp. considered the most fungal contamination of date fruits. Fungal contamination may have an effect on the public health by their mycotoxins which may lead to severe poisoning, diarrhea, emesis, and death. Most date fruits sold and marketed are neither covered nor protected in any way from environmental contamination. If these dates are consumed without thoroughly washing that may induce imminent mycotic infection. The study recommended that prevention of dates fruit mold spoilage should be avoided by application of hazard analysis, critical control point programs and adherence to hygienic good manufacturing practices.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"213 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115948356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portulaca oleracea L. extracts enhance GLUT4 translocation to the surface of muscle cells in insulin dependent and independent fashion","authors":"Sleman Kadan, Y. Sasson, H. Zaid","doi":"10.30918/ampr.74.19.035","DOIUrl":"https://doi.org/10.30918/ampr.74.19.035","url":null,"abstract":"Portulaca oleracea L. is a grassy plant with a fleshy stem, succulent leaves, yellow or white small flowers and small black seeds. P. oleracea used as a medicinal plant in many countries, as a diuretic, febrifuge, vermifuge, antiseptic, anti-spasmodic, anti-bacterial, anti-inflammatory and anti-oxidant. It is in use also as anti-diabetic medicinal herb. The aim of this study was to evaluate the effect of the aerial parts of P. oleracea 50% ethanol/50% water and methanol based extracts on the glucose transporter-4 (GLUT4) translocation to the plasma membrane of muscle cells. Anti-diabetic activity of the extracts was examined by measuring the relative amount of GLUT4 translocation to the plasma membrane in the presence and absence of insulin. L6 muscle cells, stably expressing myc-tagged GLUT4, repeatedly shown to display insulin regulated GLUT4 traffic, were used as a model in this project. L6 myoblasts were pre-treated with increasing concentrations of P. oleracea extracts for 20 h, followed by 3 h serum-deprivation and insulin stimulation for 20 min and then GLUT4myc levels at the plasma membrane was determined. Toxicity of the extracts was determined by MTT assay and LDH leakage assay. Results obtained show no cytotoxic effects in cells treated for 24 h with 50% ethanol and methanol P. oleracea extract up to 1 mg/ml and 0.5 mg/ml extract respectively as measured with MTT and LDH-leakage assays. GLUT4 translocation to the plasma membrane was elevated by 2.6 and 4 folds (-/+ insulin) after treatment for 20 h with 1 mg/ml P. oleracea 50% ethanol extract and 1.7 and 3 folds (-/+ insulin) when treated with 0.5 mg/ml methanol extract. These results indicate that P. oleracea anti-diabetic proporties are mediated in part by increasing GLUT4 distribution in the muscle plasma membrane.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132032093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of β-carbolines in Thai Picrasma javanica Bl.; the source of potential antimalarial agents","authors":"C. Saiin, Juggreewut Junwised, N. Nuengchamnong, K. Ingkaninan","doi":"10.30918/AMPR.72.19.025","DOIUrl":"https://doi.org/10.30918/AMPR.72.19.025","url":null,"abstract":"The bark of Picrasma javanica Bl. (Family Simaroubaceae) has been widely used in the traditional medicines for the treatment of malaria in Myanmar, Indonesia and Thailand. In previous studies, thirteen βcarbolines were isolated from P. javanica growing in Indonesia and New Guinea. The present study aimed to identify the chemical components of Thai P. javanica by using thin layer chromatography (TLC) and high resolution mass spectrometry (MS). It demonstrated that there were at least six β-carbolines in stem bark of Thai P. javanica; composed of 1-ethyl-β-carboline, 1-ethyl-4-methoxy-β-carboline (crenatine), 4-methoxy-1vinyl-β-carboline (dehydrocrenatine), 5or 6or 8-dehydrocrenatine, 5or 8-hydroxycrenatine, picrasidine G and picrasidine T. Three of them i.e. crenatine, dehydrocrenatine and 6-dehydrocrenatine had the antimalarial activities. Thus, Thai P. javanica shall be reserved as medicinal plant for malaria disease treatment.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129170761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of organic acids and total acidity in alfalfa (Medicago sativa L.) collected from different locations in the Republic of North Macedonia","authors":"Valentina Butleska Gjoroska, Marija Krstik, L. Cvetanovska, L. K. Gudeva, Arhimedova Str. No Skopje Ss. Cyril Mathematics","doi":"10.30918/ampr.73.19.024","DOIUrl":"https://doi.org/10.30918/ampr.73.19.024","url":null,"abstract":"The role of alfalfa (Medicago sativa L.) in the development of agricultural production and intensification of forage production is due to the high potential of biomass on the one hand anti-oxidative and nutritional value on the other hand. Modern techniques have been used for analysing of organics acids. Organic acids are formed during cell respiration as products of total dissemination of carbohydrates and generally serve as starting substances for the biosynthesis of different compounds such as fatty acids and fats, amino acids, vitamins, coenzymes, pigments and other substances. Organic acids are key metabolites in plants, and their amounts depend on the intensity of cell respiration. The accumulation of some organic acids in plants is closely related to the intensity of enzymatic reactions as well as to various environmental factors. On the cellular level, the metabolism of organic acids is of high importance for several biochemical pathways, such as the cycle of tricarboxylic acids and the glyoxalate cycle. Organic acids that are synthesised in these cycles are used by plants as precursors in the biosynthesis of other organic compounds. Significant differences are found in the production of organics acids between the locations in Ovche Pole region on the one hand and Skopje and Tetovo regions on the other hand. We investigated various organic acids (citric, acetic, wine, malic and lactic acid) and the total acidity in alfalfa (Medicago sativa L.) from three different regions of the Republic of North Macedonia, in 19 different locations and three harvests.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130024238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of volatile compounds and antioxidant activity of the essential oil of oregano (Origanum vulgare L.)","authors":"Jose Tapiero, G. Salamanca, C. Marín","doi":"10.30918/AMPR.72.19.022","DOIUrl":"https://doi.org/10.30918/AMPR.72.19.022","url":null,"abstract":"","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125732879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungitoxic effects of some plant extracts on seedborne fungi pathogens of Bambara groundnut in Awka South of Anambra State, Nigeria","authors":"C. C. Iwuagwu, Raphael Chinoyelum Kpadobi, A. C. Nwogbaga, M. T. Salaudeen, D. E. Iheaturu, F. C. Onejeme","doi":"10.30918/AMPR.72.19.014","DOIUrl":"https://doi.org/10.30918/AMPR.72.19.014","url":null,"abstract":"The research was carried out to test the effect of turmeric and garlic extracts on seed borne fungi pathogens of Bambara groundnut (Vigna subterranean) in Awka South of Anambra State Nigeria. Seed health test of Bambara groundnut seeds sampled from Awka main market was achieved by blotter paper method. The potentials of the isolated organisms to cause diseases was tested in a pathogenicity test using Koch’s procedures. Antifungal effect of methanol and ethyl acetate extracts of tumeric (Curcuma longa) and garlic (Allium sativum) was investigated in an in-vitro experiment against the isolated seed borne pathogens of Bambara groundnut and synthetic fungicide (Mancozeb) as a standard control. The result of pathogenicity test revealed that Aspergillus niger, isolated from Bambara groundnut seeds was pathogenic. The result also showed that all the two plant extracts and synthetic fungicide were effective in inhibiting radial growth of Aspergillus niger which was the only fungi pathogen isolated. Curcuma longa performed closely rated to Mancozeb in the in-vitro experiment, having (75.00, 75.00 and 75.00%) and (72.56, 60.82 and 50.94%) respectively in the three days in culture. The higher the concentration the higher the inhibition values as 30 g/ml consistently gave the highest inhibition values. Also Soxhlet extraction method did better than cold maceration in days 2, 3 in culture. The research have shown that fungitoxic compounds from Curcuma longa could be explored as an eco-friendly alternative to synthetic fungicide (Mancozeb) in the control of Aspergillus niger on Bambara groundnut seeds.","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130421936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of four different solid-phase microextraction fibers for analysis of Plectranthus amboinicus (Lour.) Spreng. leaf volatiles","authors":"G. Pinheiro, Maria Isabel Galbiatti, M. Carneiro, A. Sawaya","doi":"10.30918/AMPR.72.19.020","DOIUrl":"https://doi.org/10.30918/AMPR.72.19.020","url":null,"abstract":"Plectranthus amboinicus (Lour.) Spreng. also known as Indian borage or Mexican mint, is a perennial, succulent and strongly aromatic herb used in folk medicine for the treatment of respiratory diseases and digestive problems (Lukhoba et al., 2006). Characterized by its oregano-like odor and flavor, the species probably originated in Africa or India and it has since become widely distributed around the world for ornamental, medicinal and culinary purposes (Codd, 1975; Lorenzi and Matos, 2008; Arumugam et al., 2016). The therapeutic properties of P. amboinicus extracts are related to various biological activities, such as antimicrobial, antioxidant and antiinflammatory (da Costa et al., 2010; Swamy et al., 2017; Chiu et al., 2012). These properties are speculated to be ABSTRACT","PeriodicalId":413004,"journal":{"name":"Advancement in Medicinal Plant Research","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116273633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}