Mammalian genome : official journal of the International Mammalian Genome Society最新文献_第6页

Interferon-stimulated genes: new platforms and computational approaches. 干扰素刺激基因:新的平台和计算方法。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-07-07 DOI: 10.1007/s00335-018-9755-6

Richard Green, Reneé C Ireton, Michael Gale

{"title":"Interferon-stimulated genes: new platforms and computational approaches.","authors":"Richard Green, Reneé C Ireton, Michael Gale","doi":"10.1007/s00335-018-9755-6","DOIUrl":"https://doi.org/10.1007/s00335-018-9755-6","url":null,"abstract":"Interferon-stimulated genes (ISGs) are the effectors of interferon (IFN) actions and play major roles in innate immune defense against microbial infection. During virus infection, ISGs impart antiviral actions to control virus replication and spread but can also contribute to disease pathology if their expression is unchecked. Antiviral ISGs have been identified by a variety of biochemical, genetic, and virologic methods. New computational approaches are expanding and redefining ISGs as responders to a variety of stimuli beyond IFNs, including virus infection, stress, and other events that induce cytokines. These studies reveal that the expression of ISG subsets link to interferon regulatory factors (IRF)s, NF-kB, and other transcription factors that impart gene expression in specific cell types independently of IFNs, including stem cells and other cell types where ISGs are constitutively expressed. Here, we provide a broad overview of ISGs, define virus-induced genes (VSG)s, and discuss the application of computational approaches and bioinformatics platforms to evaluate the functional role of ISGs in epigenetics, immune programming, and vaccine responses.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"593-602"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9755-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36292269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Genetic control of alphavirus pathogenesis. 甲病毒发病机制的遗传控制。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-08-27 DOI: 10.1007/s00335-018-9776-1

Victoria K Baxter, Mark T Heise

{"title":"Genetic control of alphavirus pathogenesis.","authors":"Victoria K Baxter, Mark T Heise","doi":"10.1007/s00335-018-9776-1","DOIUrl":"https://doi.org/10.1007/s00335-018-9776-1","url":null,"abstract":"Alphaviruses, members of the positive-sense, single-stranded RNA virus family Togaviridae, represent a re-emerging public health concern worldwide as mosquito vectors expand into new geographic ranges. Members of the alphavirus genus tend to induce clinical disease characterized by rash, arthralgia, and arthritis (chikungunya virus, Ross River virus, and Semliki Forest virus) or encephalomyelitis (eastern equine encephalitis virus, western equine encephalitis virus, and Venezuelan equine encephalitis virus), though some patients who recover from the initial acute illness may develop long-term sequelae, regardless of the specific infecting virus. Studies examining the natural disease course in humans and experimental infection in cell culture and animal models reveal that host genetics play a major role in influencing susceptibility to infection and severity of clinical disease. Genome-wide genetic screens, including loss of function screens, microarrays, RNA-sequencing, and candidate gene studies, have further elucidated the role host genetics play in the response to virus infection, with the immune response being found in particular to majorly influence the outcome. This review describes the current knowledge of the mechanisms by which host genetic factors influence alphavirus pathogenesis and discusses emerging technologies that are poised to increase our understanding of the complex interplay between viral and host genetics on disease susceptibility and clinical outcome.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"408-424"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9776-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36435366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei. 伯氏疟原虫感染小鼠脑型疟疾的遗传分析。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-06-19 DOI: 10.1007/s00335-018-9752-9

Sabrina Torre, David Langlais, Philippe Gros

{"title":"Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.","authors":"Sabrina Torre, David Langlais, Philippe Gros","doi":"10.1007/s00335-018-9752-9","DOIUrl":"https://doi.org/10.1007/s00335-018-9752-9","url":null,"abstract":"Malaria is a common and sometimes fatal disease caused by infection with Plasmodium parasites. Cerebral malaria (CM) is a most severe complication of infection with Plasmodium falciparum parasites which features a complex immunopathology that includes a prominent neuroinflammation. The experimental mouse model of cerebral malaria (ECM) induced by infection with Plasmodium berghei ANKA has been used abundantly to study the role of single genes, proteins and pathways in the pathogenesis of CM, including a possible contribution to neuroinflammation. In this review, we discuss the Plasmodium berghei ANKA infection model to study human CM, and we provide a summary of all host genetic effects (mapped loci, single genes) whose role in CM pathogenesis has been assessed in this model. Taken together, the reviewed studies document the many aspects of the immune system that are required for pathological inflammation in ECM, but also identify novel avenues for potential therapeutic intervention in CM and in diseases which feature neuroinflammation.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"488-506"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9752-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36240890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research. 利用近交小鼠品系SPRET/EiJ为炎症和感染研究提供新的见解。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-06-09 DOI: 10.1007/s00335-018-9751-x

Steven Timmermans, Jolien Souffriau, Jolien Vandewalle, Lise Van Wyngene, Kelly Van Looveren, Tineke Vanderhaeghen, Claude Libert

引用次数: 1

The impact of host genetic background in the Pseudomonas aeruginosa respiratory infections. 宿主遗传背景对铜绿假单胞菌呼吸道感染的影响。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-06-12 DOI: 10.1007/s00335-018-9753-8

Nicola Ivan Loré, Cristina Cigana, Barbara Sipione, Alessandra Bragonzi

{"title":"The impact of host genetic background in the Pseudomonas aeruginosa respiratory infections.","authors":"Nicola Ivan Loré, Cristina Cigana, Barbara Sipione, Alessandra Bragonzi","doi":"10.1007/s00335-018-9753-8","DOIUrl":"https://doi.org/10.1007/s00335-018-9753-8","url":null,"abstract":"Understanding the significance of human genetic diversity in modulating host susceptibility to opportunistic infections is an emerging challenge in the field of respiratory illnesses. While it is recognized that diverse bacterial strains account for differential disease manifestations, emerging data indicate that host genetic diversity is an important determinant factor that influences the severity of opportunistic infections. With particular regard to respiratory illnesses mediated by the gram-negative bacterium Pseudomonas aeruginosa, diverse genetic background is also emerging as a key contributor. Human-genome-wide association studies are a common approach for determining the inter-individual genetic variation associated with variability of the pulmonary infections. Historically, diverse murine inbred mouse strains and ex-vivo cellular models were considered complementary to human studies for establishing the contribution of genetic background to P. aeruginosa respiratory infections. More recently, the development of a new mouse model of infection, mirroring human airway diseases, combined with innovative murine resource populations, modelling human genetic variation, provides additional insights into the mechanisms of genetic susceptibility. In this review, we cover the recent state of the art of human and animal studies and we discuss future potential challenges in the field of P. aeruginosa respiratory infections.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"550-557"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9753-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36260404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Of mice and men: the host response to influenza virus infection. 小鼠和人:宿主对流感病毒感染的反应。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-06-15 DOI: 10.1007/s00335-018-9750-y

Heike Kollmus, Carolin Pilzner, Sarah R Leist, Mark Heise, Robert Geffers, Klaus Schughart

{"title":"Of mice and men: the host response to influenza virus infection.","authors":"Heike Kollmus, Carolin Pilzner, Sarah R Leist, Mark Heise, Robert Geffers, Klaus Schughart","doi":"10.1007/s00335-018-9750-y","DOIUrl":"https://doi.org/10.1007/s00335-018-9750-y","url":null,"abstract":"Influenza virus (IV) infections represent a very serious public health problem. At present, no established biomarkers exist to support diagnosis for respiratory viral infections and more importantly for severe IV disease. Studies in animal models are extremely important to understand the biological, genetic, and environmental factors that contribute to severe IV disease and to validate biomarker candidates from human studies. However, mouse human cross-species comparisons are often compromised by the fact that animal studies concentrate on the infected lungs, whereas in humans almost all studies use peripheral blood from patients. In addition, human studies do not consider genetic background as variable although human populations are genetically very diverse. Therefore, in this study, we performed a cross-species gene expression study of the peripheral blood from human patients and from the highly genetically diverse Collaborative Cross (CC) mouse population after IV infection. Our results demonstrate that changes of gene expression in individual genes are highly similar in mice and humans. The top-regulated genes in humans were also differentially regulated in mice. We conclude that the mouse is a highly valuable in vivo model system to validate and to discover gene candidates which can be used as biomarkers in humans. Furthermore, mouse studies allow confirmation of findings in humans in a well-controlled experimental system adding enormous value to the understanding of expression and function of human candidate genes.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"446-470"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9750-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36261846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Insights into the pathogenesis of herpes simplex encephalitis from mouse models. 小鼠模型对单纯疱疹脑炎发病机制的研究。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-08-23 DOI: 10.1007/s00335-018-9772-5

Mathieu Mancini, Silvia M Vidal

{"title":"Insights into the pathogenesis of herpes simplex encephalitis from mouse models.","authors":"Mathieu Mancini, Silvia M Vidal","doi":"10.1007/s00335-018-9772-5","DOIUrl":"https://doi.org/10.1007/s00335-018-9772-5","url":null,"abstract":"A majority of the world population is infected with herpes simplex viruses (HSV; human herpesvirus types 1 and 2). These viruses, perhaps best known for their manifestation in the genital or oral mucosa, can also cause herpes simplex encephalitis, a severe and often fatal disease of the central nervous system. Antiviral therapies for HSV are only partially effective since the virus can establish latent infections in neurons, and severe pathological sequelae in the brain are common. A better understanding of disease pathogenesis is required to develop new strategies against herpes simplex encephalitis, including the precise viral and host genetic determinants that promote virus invasion into the central nervous system and its associated immunopathology. Here we review the current understanding of herpes simplex encephalitis from the host genome perspective, which has been illuminated by groundbreaking work on rare herpes simplex encephalitis patients together with mechanistic insight from single-gene mouse models of disease. A complex picture has emerged, whereby innate type I interferon-mediated antiviral signaling is a central pathway to control viral replication, and the regulation of immunopathology and the balance between apoptosis and autophagy are critical to disease severity in the central nervous system. The lessons learned from mouse studies inform us on fundamental defense mechanisms at the interface of host-pathogen interactions within the central nervous system, as well as possible rationales for intervention against infections from severe neuropathogenic viruses.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"425-445"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9772-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36447167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Human genetics of mycobacterial disease. 分枝杆菌疾病的人类遗传学。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-08-16 DOI: 10.1007/s00335-018-9765-4

Monica Dallmann-Sauer, Wilian Correa-Macedo, Erwin Schurr

{"title":"Human genetics of mycobacterial disease.","authors":"Monica Dallmann-Sauer, Wilian Correa-Macedo, Erwin Schurr","doi":"10.1007/s00335-018-9765-4","DOIUrl":"https://doi.org/10.1007/s00335-018-9765-4","url":null,"abstract":"Mycobacterial diseases are caused by members of the genus Mycobacterium, acid-fast bacteria characterized by the presence of mycolic acids within their cell walls. Claiming almost 2 million lives every year, tuberculosis (TB) is the most common mycobacterial disease and is caused by infection with M. tuberculosis and, in rare cases, by M. bovis or M. africanum. The second and third most common mycobacterial diseases are leprosy and buruli ulcer (BU), respectively. Both diseases affect the skin and can lead to permanent sequelae and deformities. Leprosy is caused by the uncultivable M. leprae while the etiological agent of BU is the environmental bacterium M. ulcerans. After exposure to these mycobacterial species, a majority of individuals will not progress to clinical disease and, among those who do, inter-individual variability in disease manifestation and outcome can be observed. Susceptibility to mycobacterial diseases carries a human genetic component and intense efforts have been applied over the past decades to decipher the exact nature of the genetic factors controlling disease susceptibility. While for BU this search was mostly conducted on the basis of candidate genes association studies, genome-wide approaches have been widely applied for TB and leprosy. In this review, we summarize some of the findings achieved by genome-wide linkage, association and transcriptome analyses in TB disease and leprosy and the recent genetic findings for BU susceptibility.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"523-538"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9765-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36406093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Identification of genes associated with susceptibility to Mycobacterium avium ssp. paratuberculosis (Map) tissue infection in Holstein cattle using gene set enrichment analysis-SNP. 禽分枝杆菌ssp易感基因的鉴定。利用基因集富集分析- snp分析荷斯坦牛的副结核(Map)组织感染。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2017-11-28 DOI: 10.1007/s00335-017-9725-4

J N Kiser, M Neupane, S N White, H L Neibergs

{"title":"Identification of genes associated with susceptibility to Mycobacterium avium ssp. paratuberculosis (Map) tissue infection in Holstein cattle using gene set enrichment analysis-SNP.","authors":"J N Kiser, M Neupane, S N White, H L Neibergs","doi":"10.1007/s00335-017-9725-4","DOIUrl":"https://doi.org/10.1007/s00335-017-9725-4","url":null,"abstract":"Multiple genome-wide association analyses have investigated susceptibility to bovine paratuberculosis, but few loci have been identified across independent cattle populations. A SNP-based gene set enrichment analysis (GSEA-SNP) allows expanded identification of genes with moderate effects on a trait through the enrichment of gene sets instead of identifying only few loci with large effects. Therefore, the objective of this study was to identify genes that were moderately associated with Mycobacterium avium ssp. paratuberculosis (Map) tissue infection using GSEA-SNP in Holstein cattle from the Pacific Northwest (PNW; n = 205) and from the PNW and Northeast (PNW+NE; n = 245) which were previously genotyped with the Illumina BovineSNP50 BeadChip. The GSEA-SNP utilized 4389 gene sets from five databases. For each annotated gene in the UMD3.1 assembly (n = 19,723), the most significant SNP within each gene and its surrounding region (10 kb up- and downstream) was selected as a proxy for that gene. Any gene set with a normalized enrichment score > 2.5 was considered enriched. Thirteen gene sets (8 PNW GSEA-SNP; 5 PNW+NE) were enriched in these analyses and all have functions that relate to nuclear factor kappa beta. Nuclear factor kappa beta is critical to gut immune responses, implicated in host immune responses to other mycobacterial diseases, and has established roles in inflammation as well as cancer. Gene sets and genes moderately associated with Map infection could be used in genomic selection to allow producers to select for less susceptible cattle, lower the prevalence of the disease, and reduce economic losses.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"539-549"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-017-9725-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35598585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice. 小鼠突发性和预突发性人类冠状病毒发病机制的建模。

IF 2.5

Mammalian genome : official journal of the International Mammalian Genome Society Pub Date : 2018-08-01 Epub Date: 2018-07-24 DOI: 10.1007/s00335-018-9760-9

Adam S Cockrell, Sarah R Leist, Madeline G Douglas, Ralph S Baric

{"title":"Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice.","authors":"Adam S Cockrell, Sarah R Leist, Madeline G Douglas, Ralph S Baric","doi":"10.1007/s00335-018-9760-9","DOIUrl":"https://doi.org/10.1007/s00335-018-9760-9","url":null,"abstract":"The emergence of highly pathogenic human coronaviruses (hCoVs) in the last two decades has illuminated their potential to cause high morbidity and mortality in human populations and disrupt global economies. Global pandemic concerns stem from their high mortality rates, capacity for human-to-human spread by respiratory transmission, and complete lack of approved therapeutic countermeasures. Limiting disease may require the development of virus-directed and host-directed therapeutic strategies due to the acute etiology of hCoV infections. Therefore, understanding how hCoV-host interactions cause pathogenic outcomes relies upon mammalian models that closely recapitulate the pathogenesis of hCoVs in humans. Pragmatism has largely been the driving force underpinning mice as highly effective mammalian models for elucidating hCoV-host interactions that govern pathogenesis. Notably, tractable mouse genetics combined with hCoV reverse genetic systems has afforded the concomitant manipulation of virus and host genetics to evaluate virus-host interaction networks in disease. In addition to assessing etiologies of known hCoVs, mouse models have clinically predictive value as tools to appraise potential disease phenotypes associated with pre-emergent CoVs. Knowledge of CoV pathogenic potential before it crosses the species barrier into the human population provides a highly desirable preclinical platform for addressing global pathogen preparedness, an overarching directive of the World Health Organization. Although we recognize that results obtained in robust mouse models require evaluation in non-human primates, we focus this review on the current state of hCoV mouse models, their use as tractable complex genetic organisms for untangling complex hCoV-host interactions, and as pathogenesis models for preclinical evaluation of novel therapeutic interventions.","PeriodicalId":412165,"journal":{"name":"Mammalian genome : official journal of the International Mammalian Genome Society","volume":" ","pages":"367-383"},"PeriodicalIF":2.5,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00335-018-9760-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36339980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18