Turkish Journal of Immunology最新文献_第5页

Nasal Immune Responses to Human Metapneumovirus 鼻对人偏肺病毒的免疫反应

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.1173

Imelda C. Leitich, E. Mogaka

引用次数: 1

Role of Cytokines on Fetal Immune Programming 细胞因子在胎儿免疫编程中的作用

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/TJI.2019.1017

Namrata Dubey, M. Nair, Aparna Singh, Jayasuriya Ravichandran, D. Umapathy, K. Ramkumar

{"title":"Role of Cytokines on Fetal Immune Programming","authors":"Namrata Dubey, M. Nair, Aparna Singh, Jayasuriya Ravichandran, D. Umapathy, K. Ramkumar","doi":"10.25002/TJI.2019.1017","DOIUrl":"https://doi.org/10.25002/TJI.2019.1017","url":null,"abstract":"Fetal Immune Programming (FIP) is the reset of the normal fetal development due to the changes in the metabolic environment during critical period in the intrauterine life. Barker’s hypothesis states that, uterus is the first environment which the developing fetal immune system encounters. Several reports revealed that intrauterine growth retardation is the cause for increased risk of several non-communicable diseases to the fetus. FIP is connected with maternal immune milieu and hence has a significant impact on the fetal immune system. T-lymphocytes (T-cells) are important for coordinating the immune response and can be characterized into subsets according to their phenotypic characteristics as type-1, type-2 and regulatory T-cells. Each T-cell subset has an exclusive functional role, including their capacity to produce proand anti-inflammatory cytokines in response to an immune challenge. Type 1 T cells produce, interferon-γ, interleukin-2 and tumour necrosis factor-α, which promote cellular immune responses, whereas type 2 T cells produce IL-4, IL-5, IL-9, IL10 and IL-13 that provide optimal help for humoral immune responses. Although it is known that T cell cytokines produced in response to fetal molecules could have a role in fetal programming and fetal immune outcomes, the molecular mechanisms underlying the regulation of the immune components at various levels are yet to be elucidated. The present review outlines the role of cytokines on fetal immune programming which would aid in understanding alarmingly increasing incidence of diseases associated with immune dysregulation in the fetus.","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":"2 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87955274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse Responses of Neurons and Monocytes to Titanium Dioxide Nanoparticle Exposure 神经元和单核细胞对二氧化钛纳米颗粒暴露的不同反应

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/TJI.2019.1037

A. Engin, E. D. Engin

引用次数: 0

Kronik Granülomatöz Hastalarında ve Bu Hastalığı Genetik Olarak Taşıyan Bireylerde Lenfosit Fonksiyonları

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.1111

İsmail Öğülür, Ezgi Barış, Ayça Kıykım, Dilek Başer, Gamze Akgün, Ahmet Ozen, Safa Bariş, E. Karakoc-Aydiner

引用次数: 0

The Association Between Vitamin D Levels and Infections in Patients with Primary Immunodeficiency 原发性免疫缺陷患者维生素D水平与感染之间的关系

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.1005

P. G. Cetinkaya, D. Ayvaz, Hacer Cüzdanci, I. Tezcan

引用次数: 0

A Review on Computational Tools and Databases for the Development of Vaccines Against Infectious Diseases 传染病疫苗研制的计算工具和数据库综述

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.1182

Q. M. S. Jamal

引用次数: 0

Strategies to Overcome Neuroendocrine Immune Deficits in Aging: Role of Neuroendocrine-Immune Modulators and Bioactive Plant Extracts 克服衰老中神经内分泌免疫缺陷的策略:神经内分泌免疫调节剂和生物活性植物提取物的作用

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.1027

H. P. Priyanka, R. S. Nair

{"title":"Strategies to Overcome Neuroendocrine Immune Deficits in Aging: Role of Neuroendocrine-Immune Modulators and Bioactive Plant Extracts","authors":"H. P. Priyanka, R. S. Nair","doi":"10.25002/tji.2019.1027","DOIUrl":"https://doi.org/10.25002/tji.2019.1027","url":null,"abstract":"The neuroendocrine immune network functions in a delicate balance during health and the ability to maintain this balance through disease affects the outcome of the disease. During aging, there is a general decline in each of these systems that reflects on their synergistic functions and affect homeostasis leading to age-associated diseases including cancer, autoimmunity and degenerative diseases. Immunomodulation by estrogen through cyclic menstrual variations and precipitous decline during reproductive aging, facilitates the development of several female-specific age-associated diseases such as autoimmunity, osteoporosis, cardiovascular diseases and hormone-dependent cancers. Centrally and peripherally, norepinephrine released from sympathetic innervation of lymphoid organs plays a key role in naïve T-cell regulation. Hypothalamic catecholaminergic networks play a crucial role in endocrine regulation and indirectly affect immune functions during health and disease. Immune mediators such as cytokines can cross the blood brain barrier and bind to central neurons eliciting sickness behaviour and facilitate reprogramming of energy reserves to be used to fight the disease. Monoamine oxidase inhibitors like deprenyl and synthetic drugs like donepezil have been shown to exert positive effects on the age-associated decline in the neuroendocrine-immune network by delaying peripheral degeneration and increasing immune functions. Similar beneficial effects have been observed in vitro and in vivo in rats treated with Brahmi (Bacopa monnieri) and Noni (Morinda citrifolia). Comparative analysis of the strategies for reversing age-associated immunosenescence using synthetic drugs and natural remedies have shown significant immunomodulatory effects in middle-aged and old rats through modulation of MAPK and NF-kB signaling cascades.","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":"14 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75802197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of Tumor Necrosis Factor-a and Interleukin-6 in Chronic Suppurative Otitis Media 肿瘤坏死因子-a和白细胞介素-6在慢性化脓性中耳炎中的表达

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.782

Y. Edward, Jacky Munilson, Rossy Rosalinda, Hirowati Ali, D. Irfandy, Delva Swanda

引用次数: 2

Increased Level of Interleukin-17 in Children and Adolescents with Type 1 Diabetes Mellitus and its Association with Vitamin D Deficiency 儿童和青少年1型糖尿病患者白细胞介素-17水平升高及其与维生素D缺乏的关系

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.943

H. Tjahjono, L. Farida

{"title":"Increased Level of Interleukin-17 in Children and Adolescents with Type 1 Diabetes Mellitus and its Association with Vitamin D Deficiency","authors":"H. Tjahjono, L. Farida","doi":"10.25002/tji.2019.943","DOIUrl":"https://doi.org/10.25002/tji.2019.943","url":null,"abstract":"Introduction: The up-regulation of interleukin-17 (IL-17) has been reported to be the pathogenesis of type 1 diabetes mellitus (T1D). On the other hand, vitamin D deficiency is fairly prevalent in T1D. This study aims to investigate IL-17 and vitamin D status and its correlation in children and adolescents with T1D. Material and Methods: A cross sectional study was carried out between January to March 2017. A total of 20 patients aged 12.25±3.74 years old with T1D and 20 healthy control group were involved. Their parents signed an informed consent. Demographic data were obtained using structured questionnaires. Physical, and laboratory examination were also performed. Blood samples were collected and serum vitamin D and IL-17 levels were measured by indirect ELISA were. Results: The serum level of vitamin D serum and IL-17 level between both groups were significantly different (p<0.001). A positive correlation between vitamin D and IL-17 levels (p<0.05; r=+0.566) was found. Conclusion: T1D is a T cell-mediated autoimmune disorder which targets and destroys insulin-producing pancreatic beta-cells. Children and adolescents with T1D show an increased level of IL-17 immunity and vitamin D deficiency. IL-17 immunity control and vitamin D supplementation could be potential targets for further development of T1D therapeutic strategies.","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":"25 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87300369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison of Peripheral Blood Th17 Cells and Associated Cytokines in Fingolimod-Receiving and Untreated Multiple Sclerosis Patients 接受芬戈莫与未接受芬戈莫治疗的多发性硬化症患者外周血Th17细胞及相关细胞因子的比较

IF 1.2

Turkish Journal of Immunology Pub Date : 2019-01-01 DOI: 10.25002/tji.2019.1007

A. Eken, M. Yetkin, F. Okuş, Ş. Erdem, M. Çakır, Yeşim Haliloğlu, Z. B. Azizoglu, H. Altuntaş, Meral Mirza, H. Canatan

{"title":"Comparison of Peripheral Blood Th17 Cells and Associated Cytokines in Fingolimod-Receiving and Untreated Multiple Sclerosis Patients","authors":"A. Eken, M. Yetkin, F. Okuş, Ş. Erdem, M. Çakır, Yeşim Haliloğlu, Z. B. Azizoglu, H. Altuntaş, Meral Mirza, H. Canatan","doi":"10.25002/tji.2019.1007","DOIUrl":"https://doi.org/10.25002/tji.2019.1007","url":null,"abstract":"Introduction: Th17 cells are critical mediators of pathology in several autoimmune diseases including multiple sclerosis (MS). The aim of this study was to quantify Th17 cells and-associated cytokines in the peripheral blood of relapsing remitting multiple sclerosis patients (RRMS). We also aimed to compare those levels in fingolimod-treated, and untreated patients. Material and Methods: Fifteen fingolimod administered RRMS, 9 untreated-RRMS patients and 6 healthy controls were evaluated. Their peripheral blood mononuclear cells (PBMCs) were isolated and sera separated. IL-17A+, IL-22+ and GM-CSF+ T-cells were quantified via intracellular cytokine staining after stimulation using flouresecein activated cell sorter. Serum cytokine levels from all groups were measured via enzyme-linked immunosorbent assay (ELISA). Results: Fingolimod-treated RRMS patients had reduced number of IL-17A+ (p=0.02), IL-22+ (p=0.05), and GMCSF+ (p=0.003) T cells in their peripheral blood compared to those of untreated RRMS patients. This is consistent with sequestration of lymphocytes in the secondary lymphoid organs after fingolimod use. However, the levels of same cytokines in the serum were statistically not different. Conclusions: Fingolimod treatment reduced circulating IL-17A+, IL-22+ or GM-CSF+ T cells in RRMS patients.","PeriodicalId":41088,"journal":{"name":"Turkish Journal of Immunology","volume":"12 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84800684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1