Journal of Basic and Clinical Health Sciences最新文献_第3页

Effects of Curcumin Treatment on Cell Energy Status, Levels of Mitochondrial Enzymes, and Gene Expression of Glucose-related Mechanism in Panc-1 and BxPC-3 Cell Lines 姜黄素处理对Panc-1和BxPC-3细胞系细胞能量状态、线粒体酶水平和葡萄糖相关机制基因表达的影响

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-07-19 DOI: 10.30621/jbachs.1180856

E. Korucu, E. Menevse, Dudu Erkoç Kaya, F. Gokturk, H. Arıkoğlu

{"title":"Effects of Curcumin Treatment on Cell Energy Status, Levels of Mitochondrial Enzymes, and Gene Expression of Glucose-related Mechanism in Panc-1 and BxPC-3 Cell Lines","authors":"E. Korucu, E. Menevse, Dudu Erkoç Kaya, F. Gokturk, H. Arıkoğlu","doi":"10.30621/jbachs.1180856","DOIUrl":"https://doi.org/10.30621/jbachs.1180856","url":null,"abstract":"Background and Purpose:. Curcumin is an active component of turmeric, has antitumor, immunomodulatory, anti-inflammatory effects. It was aimed to investigate the effects of the administration of curcumin on the energy metabolism, the abnormal redox defense mechanism profile, the malignant transformation indicator of Panc-1 and BxPC-3 pancreatic cancer cells. \u0000Methods: BxPC-3 and Panc-1 cells were incubated, were replaced with containing various concentrations of curcumin (10-125 μM) for 24 h. Cell lysate Adenosine triphosphate (ATP), Adenosine diphosphate (ADP), Adenosine monophosphate (AMP), Manganese superoxidase (MnSOD), and cytochrome p450 reductase (CPR) concentrations were analyzed with HPLC and ELISA methods. Genes expression of Lactate dehydrogenase (LDH), mitochondrially encoded ATP synthase membrane subunit 6 (MTATP6), Glucose transporter 1 (GLUT1), and cytochrome p450 were analyzed. \u0000Results and Conclusion: IC50 values for 24 hours were found as 47,26 μM in BxPC-3 and 45,84 μM in Panc-1 cells. Treatment with curcumin inhibits oxidative stress by increasing MnSOD enzyme levels. ATP levels did not change in BxPC-3 cells, but it showed an increase in Panc-1 supplemented with curcumin. The effects of curcumin on GLUT-1 are significantly important at a dose of curcumin of 45 μM concentration and affect glucose consumption in both cells. Curcumin showed anti-proliferative, and antioxidant effects.","PeriodicalId":40972,"journal":{"name":"Journal of Basic and Clinical Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47196968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Health Status of Juvenile Inmates in A Detention Center in Turkey 土耳其某拘留中心少年犯的口腔健康状况

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-07-19 DOI: 10.30621/jbachs.1230992

Sevgi Zorlu, Didem Öner Özdaş, C. Koyuncuoğlu, Nurcan TEZCİ ÖZGÜR, Utku Gaye DİKME GÜVELİ, B. Karaduman

{"title":"Oral Health Status of Juvenile Inmates in A Detention Center in Turkey","authors":"Sevgi Zorlu, Didem Öner Özdaş, C. Koyuncuoğlu, Nurcan TEZCİ ÖZGÜR, Utku Gaye DİKME GÜVELİ, B. Karaduman","doi":"10.30621/jbachs.1230992","DOIUrl":"https://doi.org/10.30621/jbachs.1230992","url":null,"abstract":"Purpose: There are very few studies about the oral health status of juvenile inmates. This study aimed to determine past dental attendance, medicament usage, and smoking habits, besides oro-dental status, including caries prevalence and periodontal health status of juvenile inmates in detention centers. Material and Methods: This cross-sectional study was conducted on 232 juvenile male inmates (mean-age:16.65±0.91) in a detention center in Istanbul-Turkey. After taking general demographic information, the subjects were clinically examined according to WHO criteria. In addition, the Plaque Index (PI) and Gingival Index (GI) were recorded at Ramfjord teeth to evaluate periodontal status. All data were statistically analyzed using the IBM Statistical Package for Social Sciences (SPSS) 22.0 programme, Pearson correlation coefficient, Spearman's rho correlation coefficient, chi-square test, Fisher's exact test, Kruskal-Wallis test, and One-way ANOVA test. Results: Average length of stay was 6.54±8.38 months. 44.4% of inmates have never visited a dentist. The mean DMFT, PI, and GI scores of the subjects were 6.78±4.07, 1.18±0.55, and 1.13±0.47, respectively. In addition, 80.2% of inmates smoked before being taken to the detention center. Conclusion: This study indicated that the oral health of detained inmates was poor. Prison health services should not be isolated but integrated into national and regional health systems.","PeriodicalId":40972,"journal":{"name":"Journal of Basic and Clinical Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41717596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can frontal QRS-T angle predict mortality in patients with severe Crimean-Congo Hemorrhagic Fever? 额QRS-T角能预测严重克里米亚-刚果出血热患者的死亡率吗？

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-07-12 DOI: 10.30621/jbachs.1298337

Anıl Şahin, Oğuz Gündoğdu, Onur Avcı

引用次数: 0

Changes in Respiratory Muscle Pressure of Healthy Individuals with Different Levels of Immersion in Water: Observational Study 不同浸水程度健康人呼吸肌压力变化的观察研究

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-07-10 DOI: 10.30621/jbachs.1273896

B. Gürpınar, S. Özyürek, A. Elvan, S. Tükel

引用次数: 0

Analysis of Cancers in A University Hospital Employees between 2006 and 2022 2006 - 2022年A大学医院员工癌症分析

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-07-07 DOI: 10.30621/jbachs.1284320

Serkan Çeli̇kgün, Tulay Koc, R. Ucku

{"title":"Analysis of Cancers in A University Hospital Employees between 2006 and 2022","authors":"Serkan Çeli̇kgün, Tulay Koc, R. Ucku","doi":"10.30621/jbachs.1284320","DOIUrl":"https://doi.org/10.30621/jbachs.1284320","url":null,"abstract":"Objective: Healthcare workers are exposed to a variety of hazardous chemicals and agents that may have long-term effects on their health. One of the health problems caused by these chemicals and agents is cancer. The aim of this descriptive study is to evaluate the cancers seen in those working in a university hospital between 01.01.2006 and 30.06.2022. \u0000Material – Methods: All healthcare professionals diagnosed with cancer between 01.01.2006-30.06.2022 were included in this descriptive study. The age, sex, occupation, working unit, and cancer type of the patients were evaluated. Data were analyzed with the statistical program SPSS-22 (SPSS Inc., Chicago, IL, USA). Data were presented using descriptive statistics (means and standard deviations for continuous variables; numbers and percentages for categorical variables). \u0000Results: Between 01.01.2006 and 30.06.2022, 186 people working at Sivas Cumhuriyet University were diagnosed with cancer. Forty-seven point eight percent (n = 89) of them are male; the mean age of those diagnosed with cancer is 46.0 ± 8.9 (min 22, max 62). The most common cancers are thyroid (21.5%), breast (16.7%), head and neck (9.7%), hematopoietic system (9.1%), and gastric-colon (8.6%) cancers. When evaluated according to occupational groups, 22.6% of them are office workers, 19.9% are academicians, 15.6% are workers, 14.0% are nurses, 10.2% are health technicians, and 8.2% are research assistants. \u0000Conclusion: In this institution, which has 2721 personnel, approximately 16 employees are diagnosed with cancer each year. Detailed records of patients diagnosed with cancer, especially healthcare professionals, should be kept. More studies are needed in detail on behaviors related to occupational exposures and cancer risk. It may be beneficial reducing the burden of work-related cancers also for the well-being of healthcare workers.","PeriodicalId":40972,"journal":{"name":"Journal of Basic and Clinical Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43993855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ensuring Specificity as a Strategy for Increasing Alarm Safety 确保专一性是提高报警安全性的策略

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-06-20 DOI: 10.30621/jbachs.1251111

Gülnur Gül, Ş. Seren İntepeler

引用次数: 0

The Effects of Respiratory Muscle Functions on Trunk Muscle Endurance in Healthy Young Adults 健康青年呼吸肌肉功能对躯干肌肉耐力的影响

Journal of Basic and Clinical Health Sciences Pub Date : 2023-05-31 DOI: 10.30621/jbachs.1160363

Özge OCAKER AKTAN, Rıdvan AKTAN, Hazal YAKUT, Sevgi ÖZALEVLİ, Bilge KARA

{"title":"The Effects of Respiratory Muscle Functions on Trunk Muscle Endurance in Healthy Young Adults","authors":"Özge OCAKER AKTAN, Rıdvan AKTAN, Hazal YAKUT, Sevgi ÖZALEVLİ, Bilge KARA","doi":"10.30621/jbachs.1160363","DOIUrl":"https://doi.org/10.30621/jbachs.1160363","url":null,"abstract":"Purpose: Respiratory muscles play a dual role in breathing and trunk stability during activities. The relationship between respiratory muscle functions and trunk stability has not yet been clarified. The aim of the study was to examine the effects of respiratory muscle functions on trunk muscle endurance in healthy young adults.  Methods: McGill's trunk muscle endurance tests, which consist of trunk flexion endurance test (FE), Sorensen test (ST) and Side Bridge test (SB), were used to evaluate the participants' trunk muscle endurance. Respiratory muscle strength was evaluated by measuring intraoral maximal inspiratory and expiratory pressures using an intraoral pressure meter device. The respiratory muscle endurance test was performed with the incremental threshold load protocol using a threshold IMT device.  Results: A total of 51 healthy young adults, with a mean age of 21.8 ± 3.2 years, were evaluated. The results of the linear regression models were significantly explained 46% of the variance in the SB and 38% in the FE, (for SB Adj R2=0.46, F=21.40, p< 0.001 and for FE Adj R2=0.38, F=15.65, p< 0.001). Respiratory muscle endurance contributed 30% to the endurance of the trunk flexor muscles, while respiratory muscle strength contributed only 8%. Similarly, respiratory muscle endurance contributed 38% to the endurance of the trunk lateral flexor muscles, while respiratory muscle strength contributed only 8%.  Conclusion: Although respiratory muscle strength and respiratory muscle endurance were independent contributors to trunk muscle endurance, respiratory muscle endurance more affected trunk muscle endurance than respiratory muscle strength in healthy young adults.","PeriodicalId":40972,"journal":{"name":"Journal of Basic and Clinical Health Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135195338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association between Fertility Status and Women’s Sexual Esteem: A Methodological and Analytical Study 生育状况与女性性自尊的关系:一项方法与分析研究

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-05-30 DOI: 10.30621/jbachs.1176426

Ayşe Deliktaş Demirci, Kamile Kabukçuoğlu, Linn BEATE STRAND, G. Haugan

{"title":"The Association between Fertility Status and Women’s Sexual Esteem: A Methodological and Analytical Study","authors":"Ayşe Deliktaş Demirci, Kamile Kabukçuoğlu, Linn BEATE STRAND, G. Haugan","doi":"10.30621/jbachs.1176426","DOIUrl":"https://doi.org/10.30621/jbachs.1176426","url":null,"abstract":"Purpose: The present study aims (1) to test the psychometrical properties of the Turkish Sexual Esteem subscale of Multidimensional Sexuality Questionnaire in men and women and (2) to examine the association of fertility and sexual esteem in Turkish women. \u0000 \u0000Material and Methods: The full sample was utilized for the psychometric validation, that is reliability and construct validity of the Turkish Sexual Esteem subscale, consisting of 335 men and women. A subsample consisting of 214 fertile and infertile Turkish women, was used for the association study. Data were collected by an online questionnaire. We performed descriptive statistics on both samples; confirmatory factor analysis was applied to test psychometric properties of the Sexual Esteem Subscale, while the associations in fertile and infertile women were evaluated by means of linear regression analysis. \u0000 \u0000Results: The reliability was supported by significant factor loadings and several goodness-of-fit indices. When comparing sexual esteem in infertile women with fertile women, we found that infertile women had higher sexual esteem than fertile women. \u0000 \u0000Conclusion: The Turkish version of the Sexual Esteem subscale is valid and reliable in the Turkish population. The association between fertility and sexual esteem needs to be further investigated in larger samples and in different settings.","PeriodicalId":40972,"journal":{"name":"Journal of Basic and Clinical Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42584650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Restraint Knowledge, Attitudes and Practices of Intensive Care Nurses in Turkey: The Effectiveness of an In-Service Training Program 土耳其重症监护护士的身体约束知识、态度和实践：在职培训计划的有效性

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-05-26 DOI: 10.30621/jbachs.1085844

Selda Karaveli Çakır, E. Yilmaz, Işıl Işık Andsoy

{"title":"Physical Restraint Knowledge, Attitudes and Practices of Intensive Care Nurses in Turkey: The Effectiveness of an In-Service Training Program","authors":"Selda Karaveli Çakır, E. Yilmaz, Işıl Işık Andsoy","doi":"10.30621/jbachs.1085844","DOIUrl":"https://doi.org/10.30621/jbachs.1085844","url":null,"abstract":"Background: Intensive care nurses use physical restraints (PRs) to prevent critically ill patients from disrupting invasive medical equipment, but they may not recognize the negative or positive consequences. \u0000Purpose: The study was conducted with a quasi-experimental, single-group pretest-posttest design to evaluate the impact of PRs training on the knowledge, attitudes, and practices of intensive care nurses. \u0000Materials and Methods: The sample of the study consisted of 81 nurses. The data were obtained using a \" The Individual Data\" and the \"Levels of Knowledge, Attitudes and Practices of Staff Regarding Physical Restraints Questionnaire.\" Descriptive statistics analyzed sample characteristics and Friedman's multiple comparison test performed to compare the effectiveness of training. \u0000Results: It was determined that all nurses applied physical restraint, and the rate of application of these on agitated and restless patients was 100%. Sixty-nine-point nine percent of the nurses decided on the physical restraint together with physicians, and 70.4% of them wanted to receive training about physical restraint. The nurses' attitude, and practice scores about the use of physical restraint in the post-intervention period and retest after 1 and 3 months increased significantly compared to the pre-intervention period (p=.000). \u0000Conclusion: This study showed that the physical restraint training given to the nurses was effective. The findings recommended to carry out in-service training to increase the knowledge levels of nurses about physical restraint and its application, repeat this training periodically and evaluate its effectiveness.","PeriodicalId":40972,"journal":{"name":"Journal of Basic and Clinical Health Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42354590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Functional Health Patterns-based Perceived Health Scale (FHP-PH) and Investigation of Its Psychometric Properties 基于功能健康模式的感知健康量表（FHP-PH）的编制及其心理测量特性的调查

IF 0.2

Journal of Basic and Clinical Health Sciences Pub Date : 2023-05-25 DOI: 10.30621/jbachs.1117695

Y. Kanbay, M. Akgün, Sevil Çınar Özbay, B. Üstün

引用次数: 0