Uroonkoloji Bulteni-Bulletin of Urooncology最新文献

{"title":"Active Surveillance in Prostate Cancer","authors":"V. Izol, N. Akdoğan","doi":"10.4274/uob.820","DOIUrl":"https://doi.org/10.4274/uob.820","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49274827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Presentation of Germ Cell Neoplasia: Persistant Müllerian Duct Syndrome","authors":"A. Beksac, M. Dönmez, Ç. Aydın, D. Baydar, M. Yazıcı, A. Ergen, B. Akdogan","doi":"10.4274/UOB.825","DOIUrl":"https://doi.org/10.4274/UOB.825","url":null,"abstract":"Persistent Müllerian duct syndrome (PMDS) is defined as the presence of Müllerian remnants in a phenotypically and karyotypically male (1). PMDS is caused either by the lack of anti-Müllerian hormone, receptor insensitivity or a defect in the timing of the release of Müllerian inhibiting factor (MIF). PMDS is regarded as a form of pseudohermaphroditism due to presence of uterus and is shown to be inherited autosomal recessively (2). Although it is predominantly seen in pediatric age group presenting as undescended testis with or without inguinal hernia, it might be presented as an inguinal or intraabdominal mass in adulthood (3). Herein we report 2 cases of PMDS with review of the literature. Case Presentations","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47902449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Length and Tumor Grades of Positive Surgical Margin Have an Impact on Biochemical Recurrence After Prostatectomy","authors":"M. Koparal, C. Acar, Betul Ogut, E. Tokat, Fatih Bicaklioglu, I. Gönül, A. Batur, T. Sözen","doi":"10.4274/UOB.859","DOIUrl":"https://doi.org/10.4274/UOB.859","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48622242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Sex and Age Differences on Pathology Results in Primary Bladder Cancer Patients","authors":"H. Türk, Sıtkı Ün, Batuhan Ergani","doi":"10.4274/uob.857","DOIUrl":"https://doi.org/10.4274/uob.857","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47986569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Human Papilloma Virus and Bladder Cancer","authors":"O. Inci, E. Taştekin, H. Akdere","doi":"10.4274/UOB.556","DOIUrl":"https://doi.org/10.4274/UOB.556","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46984735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the New Developments in Urinary, Serum and Tissue Biomarkers in Prostate Cancer?","authors":"H. Şahin, M. Çetinkaya, H. Deliktaş","doi":"10.4274/uob.620","DOIUrl":"https://doi.org/10.4274/uob.620","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70977338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Adrenal Lymphoma: A Case Report","authors":"I. Kazaz, Ayhan Arslan, Nergiz Erkut, O. Kutlu","doi":"10.4274/uob.876","DOIUrl":"https://doi.org/10.4274/uob.876","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49029673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycobacterium Brumae Extract Fractions with Potential Immunotherapeutic Activity for Bladder Cancer","authors":"Zeliha Ertürk, Esra Büber, H. Özen, Ö. Çelikbıçak, B. Salih, N. Acan","doi":"10.4274/UOB.905","DOIUrl":"https://doi.org/10.4274/UOB.905","url":null,"abstract":"Amaç: Lokal ve sistemik yan etkilerine rağmen, yüksek riskli kasa invaziv olmayan mesane kanserinde (KİOMK) Bacillus Calmette-Guérin (BCG) uygulanması altın standart tedavidir. Biz mesane kanseri tedavisi için canlı suşlar yerine daha az toksik ve daha güçlü terapötik ajanlar geliştirmeyi hedefledik. Gereç ve Yöntem: İmmünostimülan ve sitotoksik aktiviteleri BCG ile benzerlik gösteren patojen olmayan Mycobacterium brumae suşu kullanıldı. Bakteriler ısı muamelesinden sonra sonike edildi. Sulu çözeltiyle ve asetonla ekstre edilerek hazırlanmış örnekler ters faz ve kuvvetli iyon değiştirici kolonlar kullanılarak yüksek performanslı sıvı kromatografisi uygulandı. Örneklerin tümör nekroz faktörü-α (TNF-α) uyarıcı aktiviteleri ve matriks-yardımlı lazer desorpsiyon-iyonlaştırmalı-kütle spektrometri çıktıları incelendi. Bulgular: Sonuç olarak, m/z oranları 1800 ve 3600 dolayındaki iki bileşenin TNF-α uyarıcı aktiviteden sorumlu olabileceği ortaya çıkarıldı. Sonuç: Bu bileşenler KİOMK tedavisi için yeni ajanlar geliştirme potansiyeline sahiptir. Anahtar Kelimeler: Mycobacterium brumae, kasa invaziv olmayan mesane kanseri, yüksek performanslı sıvı kromatografisi, matriks-yardımlı lazer desorpsiyon-iyonlaştırmalı kütle spektrometri, tümör nekroz faktörü-α Objective: Immunotherapy with intravesical Bacillus Calmette-Guérin (BCG) application is a gold standard treatment for high risk non-muscle invasive bladder cancer (NMIBC), despite its local and systemic side effects. We aimed to develop less toxic and more powerful therapeutic agents for the treatment of bladder cancer than live strain. Materials and Methods: Non-pathogenic Mycobacterium brumae strains resembling BCG in immunostimulating and cytotoxic activities were used. The bacteria were sonicated after heat treatment. Samples prepared by aqueous solution and acetone were subjected to high performance liquid chromatography on reverse phase and strong ion exchange columns. Tumour necrosis factor-α (TNF-α) stimulating activities and the matrixassisted laser desorption/ionization-mass spectroscopy findings of the samples were analysed. Results: As a result, it was revealed that two components, m/z ratios around 1800 and another around m/z 3600 could be responsible for TNF-α stimulating activity. Conclusion: These components have a potential to develop of new agents for NMIBC treatment.","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47606928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficiency of Docetaxel Chemotherapy on Castration Resistant Prostate Cancer: Singe Center Experience","authors":"Evren Süer, N. Hamidi, M. Gökçe, S. Baltacı","doi":"10.4274/UOB.821","DOIUrl":"https://doi.org/10.4274/UOB.821","url":null,"abstract":"77 ©Telif Hakkı 2017 Üroonkoloji Derneği / Üroonkoloji Bülteni Galenos Yayınevi tarafından basılmıştır Ya z›fl ma Ad re si/Ad dress for Cor res pon den ce: Dr. Nurullah Hamidi, Atatürk Eğitim ve Araştırma Hastanesi, Üroloji Kliniği, Ankara, Türkiye Tel.: +90 312 508 22 58 E-mail: dr.nhamidi86@gmail.com ORCID-ID: orcid.org/0000-0002-6825-1813 Ge liş Ta ri hi/Re cei ved: 06.02.2017 Ka bul Ta ri hi/Ac cep ted: 31.05.2017 Objective: Prostate cancer (PCa) is the second most commonly seen cancer type worldwide. Mortality due to PCa is mostly linked to the development of castration resistant PCa (CRPC). In these patients, the main treatment option is docetaxel based chemotherapy (DBC). In this study, we aimed to present our retrospective series. Materials and Methods: We retrospectively evaluated the patients who received DBC in our clinic between January 2004 and December 2015. Totally 162 patients who are histopathologically diagnosed with PCa, clinically and radiographically demonstrated metastasis and fit to European Association of Urology CRPC criteria were included to the study. DBC was given for one day for a 3-week period, with a dose of 75 mg/m2. Prostate specific antigen (PSA) response is evaluated for ≥50% decrease in the PSA level measured at the first day of the chemotherapy. Additionally, overall survival is evaluated. Results: The majority of the patients had high stage and high Gleason score PCa. Of them totally 76% were a primary metastatic. Two-year overall survival was 18.5%, median overall survival was 15.2 months in the study population. PSA response was demonstrated in 59.2% of the patients. In multivariate analysis, the CRPC development time was found to be an independent prognostic factor both for overall survival and PSA response. Conclusion: DBC is still the main treatment option for CRPC patients for long term and successful outcomes.","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70978856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Imaging in Testicular Cancer Diagnosis, Staging and Follow-up","authors":"N. Voyvoda, Bekir Voyvoda, Özden Çamurdan","doi":"10.4274/UOB.694","DOIUrl":"https://doi.org/10.4274/UOB.694","url":null,"abstract":"","PeriodicalId":40816,"journal":{"name":"Uroonkoloji Bulteni-Bulletin of Urooncology","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2017-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48751041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}