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ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology最新文献

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Asparagine depletion by the antileukemic agent PEGylated asparaginase induces hepatic stellate cell activation and fibrosis 抗白血病药物聚乙二醇化天冬酰胺酶使天冬酰胺耗竭可诱导肝星状细胞活化和纤维化
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.156500
Yi Zhu, Keito Hoshitsuki, Christian Fernandez
{"title":"Asparagine depletion by the antileukemic agent PEGylated asparaginase induces hepatic stellate cell activation and fibrosis","authors":"Yi Zhu, Keito Hoshitsuki, Christian Fernandez","doi":"10.1124/jpet.122.156500","DOIUrl":"https://doi.org/10.1124/jpet.122.156500","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131728473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Excessive exercise increases metabolites associated with pathophysiologic changes in ultramarathon runners 过度运动增加了与超级马拉松运动员病理生理变化相关的代谢物
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.191160
M. Marszałek, Zofiia Wicik, A. Ciechanowicz, D. Keswani, C. Eyileten-Postuła, S. Wiecha, Lukasz Malek, M. Kucia, M. Postuła
{"title":"Excessive exercise increases metabolites associated with pathophysiologic changes in ultramarathon runners","authors":"M. Marszałek, Zofiia Wicik, A. Ciechanowicz, D. Keswani, C. Eyileten-Postuła, S. Wiecha, Lukasz Malek, M. Kucia, M. Postuła","doi":"10.1124/jpet.122.191160","DOIUrl":"https://doi.org/10.1124/jpet.122.191160","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130911022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of novel genetic mutations in aldehyde dehydrogenase 2 that cause alcohol flushing in humans 导致人类酒精潮红的醛脱氢酶2新基因突变的特征
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.208930
F. Rwere, Rafaela CR Hell, Xuan Yu, E. Gross
{"title":"Characterization of novel genetic mutations in aldehyde dehydrogenase 2 that cause alcohol flushing in humans","authors":"F. Rwere, Rafaela CR Hell, Xuan Yu, E. Gross","doi":"10.1124/jpet.122.208930","DOIUrl":"https://doi.org/10.1124/jpet.122.208930","url":null,"abstract":"ID 20893","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130028047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D Reconstruction Reveals Changes in Mitochondrial Morphology in Mouse Skeletal Muscle Across Aging and Upon Loss of the MICOS Complex 三维重建揭示了小鼠骨骼肌线粒体形态在衰老和MICOS复合物丢失后的变化
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.138430
K. Neikirk, Z. Vue, Lar L. Vang, Edgar Garza-Lopez, Antentor Hinton
{"title":"3D Reconstruction Reveals Changes in Mitochondrial Morphology in Mouse Skeletal Muscle Across Aging and Upon Loss of the MICOS Complex","authors":"K. Neikirk, Z. Vue, Lar L. Vang, Edgar Garza-Lopez, Antentor Hinton","doi":"10.1124/jpet.122.138430","DOIUrl":"https://doi.org/10.1124/jpet.122.138430","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130126134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic Exposure to Organophosphate Pesticides and Elevated Markers of Systemic Inflammation: Possible Neuroinflammatory and Genotoxic Effects 慢性暴露于有机磷农药和全身性炎症标志物升高:可能的神经炎症和基因毒性作用
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.190690
Dina El-Gameel, N. A. Hamdy, Amira F. El-Yazbi, Maha A. Ghanem, Labiba K. El-Khordaugi, S. Abdallah, Y. Mechref, A. El-Yazbi
{"title":"Chronic Exposure to Organophosphate Pesticides and Elevated Markers of Systemic Inflammation: Possible Neuroinflammatory and Genotoxic Effects","authors":"Dina El-Gameel, N. A. Hamdy, Amira F. El-Yazbi, Maha A. Ghanem, Labiba K. El-Khordaugi, S. Abdallah, Y. Mechref, A. El-Yazbi","doi":"10.1124/jpet.122.190690","DOIUrl":"https://doi.org/10.1124/jpet.122.190690","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130757698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of SULT1A1 Genetic Polymorphisms on the Sulfation of Clioquinol and Iodoquinol by Human SULT1A1 Allozymes SULT1A1基因多态性对人SULT1A1等位酶对氯喹诺和碘喹诺磺化作用的影响
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.202930
M. Rasool, Ming-Cheh Liu
{"title":"Impact of SULT1A1 Genetic Polymorphisms on the Sulfation of Clioquinol and Iodoquinol by Human SULT1A1 Allozymes","authors":"M. Rasool, Ming-Cheh Liu","doi":"10.1124/jpet.122.202930","DOIUrl":"https://doi.org/10.1124/jpet.122.202930","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"705 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115125275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor Bearing Mice 雷帕霉素全氟碳纳米颗粒对卵巢荷瘤小鼠的安全性评价
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.507130
Adam Mitchell, Q. Zhou, A. Akk, J. Harding, Luke E. Springer, J. Gaut, Ping Fan, I. Spasojević, C. Pham, S. Wickline, Danielle Rauch, K. Fuh, H. Pan
{"title":"Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor Bearing Mice","authors":"Adam Mitchell, Q. Zhou, A. Akk, J. Harding, Luke E. Springer, J. Gaut, Ping Fan, I. Spasojević, C. Pham, S. Wickline, Danielle Rauch, K. Fuh, H. Pan","doi":"10.1124/jpet.122.507130","DOIUrl":"https://doi.org/10.1124/jpet.122.507130","url":null,"abstract":",","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124613675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CYP4F2*3 (V433M) Polymorphism Impacts Benzalkonium Chloride Metabolism in an Alkyl Chain Length-Dependent Manner CYP4F2*3 (V433M)多态性以烷基链长度依赖的方式影响苯扎氯铵代谢
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.538270
Linxi Zhu, Ryan P. Seguin, Nathan Alade, J. Calamia, K. Thummel, Libin Xu
{"title":"CYP4F2*3 (V433M) Polymorphism Impacts Benzalkonium Chloride Metabolism in an Alkyl Chain Length-Dependent Manner","authors":"Linxi Zhu, Ryan P. Seguin, Nathan Alade, J. Calamia, K. Thummel, Libin Xu","doi":"10.1124/jpet.122.538270","DOIUrl":"https://doi.org/10.1124/jpet.122.538270","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122266792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering immunological mechanisms underlying the efficacy of nanoparticle-based vaccines and novel adjuvants against Opioid Use Disorder (OUD) 解读纳米颗粒疫苗和新型佐剂对抗阿片类药物使用障碍(OUD)功效的免疫学机制
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.283050
Fatima FH. Hamid, Scott Schactler, Debra Walter, Hardik Amin, Minh-Ngoc T. Le, D. Burkhart, Chenming Zhang, M. Pravetoni
{"title":"Deciphering immunological mechanisms underlying the efficacy of nanoparticle-based vaccines and novel adjuvants against Opioid Use Disorder (OUD)","authors":"Fatima FH. Hamid, Scott Schactler, Debra Walter, Hardik Amin, Minh-Ngoc T. Le, D. Burkhart, Chenming Zhang, M. Pravetoni","doi":"10.1124/jpet.122.283050","DOIUrl":"https://doi.org/10.1124/jpet.122.283050","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"18 S1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120858297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-alcoholic Fatty Liver Disease (NAFLD) causes Erythropoietin Hyporesponsiveness 非酒精性脂肪性肝病(NAFLD)引起促红细胞生成素反应性低下
ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology Pub Date : 2023-05-18 DOI: 10.1124/jpet.122.188420
Huixi Zou, Xiaoyu Yan
{"title":"Non-alcoholic Fatty Liver Disease (NAFLD) causes Erythropoietin Hyporesponsiveness","authors":"Huixi Zou, Xiaoyu Yan","doi":"10.1124/jpet.122.188420","DOIUrl":"https://doi.org/10.1124/jpet.122.188420","url":null,"abstract":"","PeriodicalId":406058,"journal":{"name":"ASPET 2023 Annual Meeting Abstract - Pharmacogenomics and Translational Pharmacology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133265438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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