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Avances en Biomedicina最新文献

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Inhalation Administration of Leytragin to C57BL/6Y Mice in an ARDS Model Increases the Expression Level of SIRT1 Gene 急性呼吸窘迫综合征(ARDS)模型C57BL/6Y小鼠吸入leytrigin可提高SIRT1基因的表达水平
Avances en Biomedicina Pub Date : 2023-10-05 DOI: 10.33647/2074-5982-19-3-36-41
N. S. Ogneva, L. A. Taboyakova, O. V. Alimkina, N. V. Petrova
{"title":"Inhalation Administration of Leytragin to C57BL/6Y Mice in an ARDS Model Increases the Expression Level of SIRT1 Gene","authors":"N. S. Ogneva, L. A. Taboyakova, O. V. Alimkina, N. V. Petrova","doi":"10.33647/2074-5982-19-3-36-41","DOIUrl":"https://doi.org/10.33647/2074-5982-19-3-36-41","url":null,"abstract":"This paper describes a technique for inhalation administration of Leutragin into the lungs of C57BL/6Y mice in a model of acute respiratory distress syndrome (ARDS). Inhalations were carried out using an OMRON COMP AIR NE-C24 Kids compression inhaler with a nozzle for simultaneous administration to several mice, developed at the Scientific Center of Biomedical Technologies of FMBA of Russia. Modeling of ARDS was carried out by sequential administration of α-galactosylceramide, inhaled at a dose of 1 μg/mouse, and, following 24 hours, a combination of E. coli lipopolysaccharide (LPS) at a dose of 300 μg/mouse. Thirty minutes after the administration of LPS, inhalation administration of the Leytragin drug was carried out to mice in the experimental group and normal saline in the control group. After inhalation, a biomaterial (lung tissue) was collected to evaluate the expression of the SIRT1 gene by RT- PCR as a marker of successful penetration of the drug into the lung tissue.","PeriodicalId":40514,"journal":{"name":"Avances en Biomedicina","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions 证实新生物活性物质用于纠正生理过程和功能的实验模型
Avances en Biomedicina Pub Date : 2023-10-05 DOI: 10.33647/2074-5982-19-3-66-70
K. T. Erimbetov, R. A. Zemlyanoy, A. V. Fedorova, O. V. Obvintseva
{"title":"Experimental Model to Substantiate the Application of New Biologically Active Substances for Correcting Physiological Processes and Functions","authors":"K. T. Erimbetov, R. A. Zemlyanoy, A. V. Fedorova, O. V. Obvintseva","doi":"10.33647/2074-5982-19-3-66-70","DOIUrl":"https://doi.org/10.33647/2074-5982-19-3-66-70","url":null,"abstract":"In this research, we aim to develop and investigate nanostructured clathrate complexes of 20-hydroxyecdysterone, a rhodanine derivative of 3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-4-one, with various clathrate formers, such as arabinogalactan and β-cyclodextrin. For the first time, an experimental model is proposed to justify their use for the correction of physiological processes and functions, both in normal and pathologic conditions in the animal body. The results obtained substantiate the possibility of regulating metabolic processes by activating signaling pathways associated with cell proliferation.","PeriodicalId":40514,"journal":{"name":"Avances en Biomedicina","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Hydrogen Water on the Adrenal Glands of <i>Chincilla Lanigera</i> 氢水对兰香菇肾上腺的影响&lt;/i&gt;
Avances en Biomedicina Pub Date : 2023-10-05 DOI: 10.33647/2074-5982-19-3-71-76
D. V. Petrov, A. A. Ivanov, E. V. Panina, N. V. Petrova, A. E. Sorochan
{"title":"Influence of Hydrogen Water on the Adrenal Glands of &lt;i&gt;Chincilla Lanigera&lt;/i&gt;","authors":"D. V. Petrov, A. A. Ivanov, E. V. Panina, N. V. Petrova, A. E. Sorochan","doi":"10.33647/2074-5982-19-3-71-76","DOIUrl":"https://doi.org/10.33647/2074-5982-19-3-71-76","url":null,"abstract":"The introduction of hydrogen water into the diet of cage-bred Chincilla lanigera (long-tailed chinchilla) was found to affect the morphometric parameters of their adrenal glands. Thus, the adrenal glands of the experimental group were more compact, with their absolute and relative mass being less than that in intact animals. The thickness of the adrenal cortex in the experimental group significantly decreased due to all layers, including the fascicular layer, producing glucocorticoids. The prolonged use of the hydrogen antioxidant reduced the impact of stress in cage-bred animals and had a positive effect on their life indicators.","PeriodicalId":40514,"journal":{"name":"Avances en Biomedicina","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats 纳米乙酰胆碱和胰岛素对猫海马影响的药物-脑电分析
Avances en Biomedicina Pub Date : 2023-10-05 DOI: 10.33647/2074-5982-19-3-58-65
Yu. V. Fokin, S. Yu. Kharitonov, L. A. Taboyakova, N. N. Karkischenko
{"title":"Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats","authors":"Yu. V. Fokin, S. Yu. Kharitonov, L. A. Taboyakova, N. N. Karkischenko","doi":"10.33647/2074-5982-19-3-58-65","DOIUrl":"https://doi.org/10.33647/2074-5982-19-3-58-65","url":null,"abstract":"The central mechanisms of acetylcholine and insulin in nanoparticles via transpalatinal administration to cats were studied using a neuroimaging algorithm, including a software-supported pharmaco-EEG analysis of graphic functions of normalized electrograms. The studied substances were found to exhibit a predominantly depressing action, which begins in the first hours after administration. Liposomal forms of acetylcholine and insulin penetrate the blood-brain barrier and modulate the intracentral relations of the brain, reflected in high-frequency rhythms (mainly γ-rhythms) of the hippocampal region of the brain and associated with the activity of intercalary neurons and pyramidal cells. The substances under study appear to be promising for the prevention and treatment of neuropathies caused, e.g., by geriatric dysfunctions of the cholinergic and insulin signaling systems, as well as for improving memory consolidation and cognitive functions.","PeriodicalId":40514,"journal":{"name":"Avances en Biomedicina","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135483474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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