American Journal of Clinical and Experimental Medicine最新文献

{"title":"Comparing Olanzapine with Placebo in Patients with Anorexia Nervosa for Increasing BMI and Weight Gain","authors":"Jalal Jbara, Hedyeh Shaabani, Ekaterine Cherkezishvili, Siavash Hosseinpour Chermahini","doi":"10.11648/j.ajcem.20241201.12","DOIUrl":"https://doi.org/10.11648/j.ajcem.20241201.12","url":null,"abstract":"Anorexia nervosa is an eating disorder characterized by exceptionally low body weight and a feeling of disgust toward food. In addition, it causes complications for the affected person as it affects their immunity, weakens them quickly, makes them sick and malnourished. The commonly known treatment for anorexia nervosa is psychological treatment using methods such as CBT and MANTRA. With the introduction of pharmacological medications, the aim of this review is now to determine whether olanzapine is effective compared to placebo in increasing BMI and weight gain. It was found that olanzapine had a large increase in BMI compared to placebo [F (1, 20) =6.64, p=0.018] and that it significantly reduced depression and anxiety. Further studies found that olanzapine patients gained weight more quickly and reached their BMI goals more quickly than patients taking a placebo. On the other hand, a contradictory result was found, namely that there was no significant difference between olanzapine and placebo in terms of weight recovery and psychological, depressive and anxiety symptoms. It is concluded that reliance on pharmacological therapies should be minimized until new evidence emerges and that psychotherapies such as CBT and MANTRA should be relied upon primarily to increase BMI in patients with anorexia nervosa.\u0000","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"14 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Governance of the Basic Healthcare Security System and Economic Development in China in the Context of COVID-19","authors":"Liang Zhang","doi":"10.11648/j.ajcem.20231106.11","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231106.11","url":null,"abstract":"","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"23 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Three Different Methods for the Treatment of Macrolide-Unresponsive Mycoplasma Pneumoniae Pneumonia in Children","authors":"Linfang Wan","doi":"10.11648/j.ajcem.20231105.12","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231105.12","url":null,"abstract":"","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139282259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Markers in the Diagnosis of Neonatal Necrotizing Enterocolitis","authors":"Yingying Chen, Yan Pan, Qihong Fan","doi":"10.11648/j.ajcem.20231105.11","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231105.11","url":null,"abstract":"","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139282309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism Study of GanDouLing Mitigating Liver Fibrosis in Wilson’s Disease via Regulating the PI3K/AKT/mTOR Pathway to Activate Autophagy","authors":"Shao-Peng Huang, Sen Chen, Huan Wu, An Zhou, Huai-Zhou Jiang, Hai Bian, Yun-Lai Wang, Zheng-Rong Zhang, Yi-Kang Cai, Hui Jiang, Peng Wu","doi":"10.11648/j.ajcem.20231104.12","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231104.12","url":null,"abstract":"","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"160 42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139310446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 3–3'diindolylmethane (DIM) on Acute Radiation Lung Injury in Mice Via the TGF-β1 Pathway","authors":"Qin Ge","doi":"10.11648/j.ajcem.20231104.11","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231104.11","url":null,"abstract":"","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139312262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome Analysis of Conservative Management of Acute Calculus Cholecystitis in Addis Ababa University Teaching Hospitals Addis Ababa, Ethiopia: Retrospective Study","authors":"Belete Shekuro, Paulos Jaleta Wondasho, H. Seife, Nebiyu Seyoum, Sahlu Wondimu","doi":"10.11648/j.ajcem.20231103.13","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231103.13","url":null,"abstract":": Back ground: cholecystectomy for an acutely inflamed gall bladder is accompanied with significant perioperative complications Conservative (non operative management) is considered to be the standard of care mainly in the developed world . Non operative management is still widely practiced in many developing countries including Ethiopia. This study aimed to assess the outcome of such a conservative management in teaching hospitals Addis Ababa, Ethiopia. Method: Hospital based cross-sectional study design was conducted. Data was entered and analyzed by SPSS version 20. Chi-square, binary logistic regression, at 95% CI and P-value <0.05 were used to examine relationship between dependent and independent variables. Results: A total of 134 cases were admitted. In this study the mean age is 41.67, (95% CI 39.5 to 43.9) and M: F ratio is 1:2.2 and Age of the patients ranged between 15-80 years and majority of them were in the age group of 35-44 (32.1%) years. Conservative treatment during index admission was successful in 96.27% of the cases but mean duration of hospital stay 5.54 days, 95% CI (5.03, 6.05) . Duration of illness before (OR = 3.47: 1.26-9.55 ) and Duration of hospital stay (OR = 1.92: 1.28-2.87) were determinant factors for index admission. 19% of patients encountered complication while waiting for cholecystectomy. Comorbidity ( AOR = 4.06: 1.49 - 11.07; value = 0.006 ). GB stone impacted at the neck ( AOR = 3.39: (1.259-9.13); value = 0.016) were associated factors identified. In this study out of 131 cases treated and discharged improved and appointed for interval-cholecystectomy only 71.7% of them had interval -cholecystectomy in two-year period. The rest 13 (9.7%) patients did not show up follow up after admission booked (registered under waiting list for bed). 3 patients died with complications directly or indirectly related to conservative management cholecystitis. Conclusion and Recommendations : this study revealed patients arrival to hospital is delayed and also stayed prolonged time in the hospital. significant number of patients also developed complications while waiting for interval cholecystectomy and also significant Number of patients did not get cholecystectomy service. Nationwide introduction of emergency laparoscopic cholecystectomy and Patient referral system, admission, discharge and follow up system needs revision.","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"704 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122987452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Simple Pulmonary Apex Pleural Hypertrophy and Adhered (sPAPHA) in Chest CT Examination of Young People (18-40 Years)","authors":"Xinhua He, Cao Hetao","doi":"10.11648/j.ajcem.20231103.12","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231103.12","url":null,"abstract":"","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological Research of Incisor Root Resorption After Camouflaged Orthodontic Treatment of Adult Skeletal Class III Malocclusion","authors":"Lin-na Wang, H. Yan, Yu-ze Zhang, Wei-wei Chang, Zi-yang Liu, Li-ru Zhao, Shi-xuan An, Wen-sheng Ma","doi":"10.11648/j.ajcem.20231103.11","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231103.11","url":null,"abstract":": Objective : CBCT and Mimics software were performed to investigate the incisor root resorption after camouflaged orthodontic treatment of adult skeletal class III malocclusion. Methods : Thirty permanent dentition adult patients with skeletal class III malocclusion were included in orthodontic department. CBCT data of each patient at pretreatment and posttreatment were acquired and three-dimensional (3D) digital models were reconstructed. Image registration was performed of each incisor 3D model before and after camouflaged treatment. Observation, classification and statistics of 3D model overlap were performed, as well as the morphological changes of root resorption were described. Results: (1) Either the upper or lower incisors, slope form resorption had the most percentage (49.17%, 46.67%; 51.67%, 49.16%), followed by cone-shaped form resorption, and flat form resorption had the less percentage. In the upper incisors, the root resorption was mainly in the lingual-labial direction (46.67%, 41.67%), while in the lower incisors, it was in the labial-lingual direction. (2) The result of Kappa consistency test is good (K=0.471, 0.441). Conclusions : The root of the upper and lower incisors showed various morphological changes after camouflaged treatment of adult skeletal class III malocclusion. The absorption was mainly manifested as slope form and cone-shaped form, and flat form resorption can be seen. 3D model registration can be used as a reliable auxiliary method for the morphological study of root absorption.","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"470 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123034049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Serum VEGF and FAS in Prognosis of Gastric Cancer","authors":"Hou Jianzhang, Zhan Shuli, Yu Jianlei, L. Hongyan, Hou Zhenjiang","doi":"10.11648/j.ajcem.20231102.13","DOIUrl":"https://doi.org/10.11648/j.ajcem.20231102.13","url":null,"abstract":"","PeriodicalId":404444,"journal":{"name":"American Journal of Clinical and Experimental Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116877864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}