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The Open Bioactive Compounds Journal最新文献

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Insight into Lectins: Properties, Structure and Proposed Physiological Significance 凝集素的性质、结构和生理意义
The Open Bioactive Compounds Journal Pub Date : 2017-11-14 DOI: 10.2174/1874847301705010057
M. Osman, E. Konozy
{"title":"Insight into Lectins: Properties, Structure and Proposed Physiological Significance","authors":"M. Osman, E. Konozy","doi":"10.2174/1874847301705010057","DOIUrl":"https://doi.org/10.2174/1874847301705010057","url":null,"abstract":"","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123373778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Antidiabetic and antioxidant potential of GancidinW from Streptomyces paradoxus VITALK03 悖论链霉菌VITALK03中甘酸苷w的抗糖尿病和抗氧化作用
The Open Bioactive Compounds Journal Pub Date : 2017-10-31 DOI: 10.2174/1874847301705010031
L. Ravi, A. Ragunathan, K. Krishnan
{"title":"Antidiabetic and antioxidant potential of GancidinW from Streptomyces paradoxus VITALK03","authors":"L. Ravi, A. Ragunathan, K. Krishnan","doi":"10.2174/1874847301705010031","DOIUrl":"https://doi.org/10.2174/1874847301705010031","url":null,"abstract":"Materials and Methods: Antidiabetic potential of GW was evaluated by assay of α-amylase and α-glucosidase inhibitory activity; haemoglobin glycosylation and yeast glucose uptake. The antioxidant potential of GW was assessed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, 2,2′azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization assay and superoxide assay. The inhibition of α-amylase and α-glucosidase by GW was also studied by in Silico molecular docking analysis.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116069989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Marine Sp. VITMK1 Derived Pyrrolo [1, 2-A] Pyrazine-1, 4-Dione, Hexahydro-3-(2-Methylpropyl) and Its Free Radical Scavenging Activity 海洋Sp. VITMK1衍生吡咯[1,2 - a]吡嗪- 1,4 -二酮，六氢-3-(2-甲基丙基)及其自由基清除活性
The Open Bioactive Compounds Journal Pub Date : 2017-09-26 DOI: 10.2174/1874847301705010023
M. Manimaran, K. Kannabiran
{"title":"Marine Sp. VITMK1 Derived Pyrrolo [1, 2-A] Pyrazine-1, 4-Dione, Hexahydro-3-(2-Methylpropyl) and Its Free Radical Scavenging Activity","authors":"M. Manimaran, K. Kannabiran","doi":"10.2174/1874847301705010023","DOIUrl":"https://doi.org/10.2174/1874847301705010023","url":null,"abstract":"","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131555902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Justification of Traditional Uses of Asparagus racemosus (Shatavari) - A Miracle Herb 一种神奇的草药——总状芦笋的传统用途的论证
The Open Bioactive Compounds Journal Pub Date : 2017-09-22 DOI: 10.2174/1874847301704010036
Samira Karim, M. Islam, Z. Tasnim, F. R. Laboni, A. Julie, Z. K. Labu
{"title":"Justification of Traditional Uses of Asparagus racemosus (Shatavari) - A Miracle Herb","authors":"Samira Karim, M. Islam, Z. Tasnim, F. R. Laboni, A. Julie, Z. K. Labu","doi":"10.2174/1874847301704010036","DOIUrl":"https://doi.org/10.2174/1874847301704010036","url":null,"abstract":"Methods: The collected plant was dried and grinded. The coarse powder was shocked in 2000 mL of 90% methanol for several days then filtrated. At 40°C the volume of crude ethanolic extract (CEE) was reduced by a vacuum rotary evaporator followed by concentrated aqueous ethanol extractive was fractionated into petroleum ether (PSF), carbon tetrachloride (CTSF), chloroform soluble fraction (CSF) and aqueous (AQSF) soluble fractions.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133830929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Justification of Traditional Uses of (Shatavari) - A Miracle Herb 一种神奇的草药——传统用法的合理性
The Open Bioactive Compounds Journal Pub Date : 2017-09-22 DOI: 10.2174/1874847301705010009
Samira Karim, M. Islam, Z. Tasnim, F. R. Laboni, A. Julie, Z. K. Labu
{"title":"Justification of Traditional Uses of (Shatavari) - A Miracle Herb","authors":"Samira Karim, M. Islam, Z. Tasnim, F. R. Laboni, A. Julie, Z. K. Labu","doi":"10.2174/1874847301705010009","DOIUrl":"https://doi.org/10.2174/1874847301705010009","url":null,"abstract":"","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123637103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition and Biological Activity of the Essential Oil and Solvent Extracts of 植物精油及溶剂提取物的化学成分及生物活性
The Open Bioactive Compounds Journal Pub Date : 2017-09-22 DOI: 10.2174/1874847301004010043
A. Jassbi, M. Zare, F. H. Jamebozorgi
{"title":"Chemical Composition and Biological Activity of the Essential Oil and Solvent Extracts of","authors":"A. Jassbi, M. Zare, F. H. Jamebozorgi","doi":"10.2174/1874847301004010043","DOIUrl":"https://doi.org/10.2174/1874847301004010043","url":null,"abstract":"Forty five components were identified in the oil, among them, germacrene D (18.1±0.1%), bicyclogermacrene (1.4±0.0%), and spathunelnol (2.7±0.0%) were the major sesquiterpenoids, n-tetradecanol (4.9±0.0%) was the most abundant fatty alcohol and diisobuthyl phthalate (43.9±0.2%) was the most abundant constituent. The extracts of aerial parts of Sc. nodosa were prepared using different solvents; dichloromethane (DCM), methanol (MeOH) and MeOH: H2O (80:20). Antibacterial activity of the oil and each solvent extract was tested against three Gram-positive and three Gram-negative bacteria by nutrient broth micro dilution method. Among the tested microorganisms, Staphylococcus epidermidis (IC50 1.25-5mg/ml), Bacillus subtilis (IC50 1.25mg/ml) and Escherichia coli (IC50 1.25mg/ml) were the most susceptible to the applied oils and the extracts. The antioxidant potential and total phenol contents of the extracts were assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and FolinCiocalteu reagent, respectively. Methanol and 80% methanol extracts of the plant showed relatively weak DPPH radical scavenging activity and low amounts of total phenol contents.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129450904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition and Biological Activity of the Essential Oil and Solvent Extracts of Scaligeria Nodosa 黄芩挥发油及溶剂提取物的化学成分及生物活性研究
The Open Bioactive Compounds Journal Pub Date : 2017-09-22 DOI: 10.2174/1874847301005010016
A. Jassbi, M. Zare, F. H. Jamebozorgi
{"title":"Chemical Composition and Biological Activity of the Essential Oil and Solvent Extracts of Scaligeria Nodosa","authors":"A. Jassbi, M. Zare, F. H. Jamebozorgi","doi":"10.2174/1874847301005010016","DOIUrl":"https://doi.org/10.2174/1874847301005010016","url":null,"abstract":"","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121579193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Cytotoxic Activity of Two Cembranoid Diterpenes from Nicotiana Sylvestris Against Three Human Cancer Cell Lines 烟叶中两种类黄酮二萜对三种人类癌细胞的细胞毒活性研究
The Open Bioactive Compounds Journal Pub Date : 2017-09-21 DOI: 10.2174/1874847301705010001
A. Jassbi, M. Vafapour, A. Shokrollahi, O. Firuzi, M. Zare, Jima N. Chandran, B. Schneider, I. Baldwin
{"title":"Cytotoxic Activity of Two Cembranoid Diterpenes from Nicotiana Sylvestris Against Three Human Cancer Cell Lines","authors":"A. Jassbi, M. Vafapour, A. Shokrollahi, O. Firuzi, M. Zare, Jima N. Chandran, B. Schneider, I. Baldwin","doi":"10.2174/1874847301705010001","DOIUrl":"https://doi.org/10.2174/1874847301705010001","url":null,"abstract":"RESEARCH ARTICLE Cytotoxic Activity of Two Cembranoid Diterpenes from Nicotiana Sylvestris Against Three Human Cancer Cell Lines Amir Reza Jassbi, Marzieh Vafapour, Ardeshir Shokrollahi, Omidreza Firuzi, Mehdi Zare, Jima N. Chandran, Bernd Schneider and Ian T. Baldwin Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Department of Phytochemistry, Yasouj university, Yasouj 75914-353, Iran Research group Biosynthesis/NMR, Max Planck Institute for Chemical Ecology, Jena, Germany Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, D-07745 Jena, Germany","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128691640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Isolation and Identification of γ- Sitosterol by GC-MS from the Leaves of Girardinia heterophylla (Decne) 气相色谱-质谱联用法分离鉴定杂叶树叶中γ-谷甾醇
The Open Bioactive Compounds Journal Pub Date : 2013-12-13 DOI: 10.2174/1874847301004010025
N. Tripathi, Sunita Kumar, R. Singh, C. Singh, P. Singh, V. Varshney
{"title":"Isolation and Identification of γ- Sitosterol by GC-MS from the Leaves of Girardinia heterophylla (Decne)","authors":"N. Tripathi, Sunita Kumar, R. Singh, C. Singh, P. Singh, V. Varshney","doi":"10.2174/1874847301004010025","DOIUrl":"https://doi.org/10.2174/1874847301004010025","url":null,"abstract":"Girardinia heterophylla, known as Himalayan Nettle commonly grows in temperate and subtropical Himalayas. Plant leaves were collected in winter season and analyzed using appropriate chemical methods and the biochemical con- stituents were ascertained. An unknown compound was isolated from leaves of the plant. After being collected, analyzed by GC-MS and compared with NIST standard chart library, it was declared to be � -sitosterol, an epimer of � -sitosterol. � - sitosterol has been reported for the first time in Girardinia heterophylla and has potential to be used as an antidiabetic ow- ing to its remarkable medicinal properties.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115586030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Effects of Glycyrrhetic Acid (GE) on Some Gluconeogenic Enzymes, Lipoprotein Lipase and Peroxisome Proliferator-Activated Receptors Alpha and Gamma 甘草次酸(GE)对某些糖异生酶、脂蛋白脂肪酶和过氧化物酶体增殖物激活受体α和γ的影响
The Open Bioactive Compounds Journal Pub Date : 2013-10-29 DOI: 10.2174/1874847301004010014
Hui Ping Yaw, S. Ton, K. A. Kadir, Tee Yee Tan, Y. W. Teo, Michael Yohanes
{"title":"Effects of Glycyrrhetic Acid (GE) on Some Gluconeogenic Enzymes, Lipoprotein Lipase and Peroxisome Proliferator-Activated Receptors Alpha and Gamma","authors":"Hui Ping Yaw, S. Ton, K. A. Kadir, Tee Yee Tan, Y. W. Teo, Michael Yohanes","doi":"10.2174/1874847301004010014","DOIUrl":"https://doi.org/10.2174/1874847301004010014","url":null,"abstract":"The aim of this study was to examine the role of glycyrrhetic acid (GE) as a potential compound in the amelio- ration of metabolic syndrome. Rats given intraperitoneal injection of GE were sacrificed after 24 hours. Blood was col- lected for the determination of glucose, insulin and lipid profiles; while tissues were used for 11� -HSD1, gluconeogenic enzymes activities, PPAR-� /-� and LPL expression by RT-PCR. Intraperitoneal injection of 50mg/kg GE to normal rats significantly lowered blood glucose while insulin level and HOMA-IR showed no significant changes. H6PDH activities increased in the liver, kidney, subcutaneous and visceral adipose tissues and quadriceps femoris but decreased in the ab- dominal muscle. PEPCK activities were significantly reduced in the kidney and decreased in the liver but showed an in- crease in the subcutaneous and visceral adipose tissues. G6Pase activities were found to be reduced in both the liver and kidney. 11� -HSD1 activities increased in the liver but decreased in all other tissues. There were improvements in lipid profiles in GE-treated rats. Up-regulation of LPL activity was seen in all tissues except quadriceps femoris. PPAR-� ex- pression was up-regulated in the liver, heart and abdominal muscle while down-regulated in the kidney and quadriceps femoris but were undetectable in the subcutaneous and visceral adipose tissues. PPAR-� expression was up-regulated in all tissues except the kidney. GE prevented hyperglycaemia and improved lipid profiles possibly through 11� -HSD1 inhi- bition instead of via PPAR agonism.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130689530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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