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The Open Bioactive Compounds Journal最新文献

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Medicinal and Aromatic Plants as a Source of Bioactive Constituents 药用和芳香植物作为生物活性成分的来源
The Open Bioactive Compounds Journal Pub Date : 2021-06-18 DOI: 10.2174/1874847302109010001
C. Arora, R. Padalia
{"title":"Medicinal and Aromatic Plants as a Source of Bioactive Constituents","authors":"C. Arora, R. Padalia","doi":"10.2174/1874847302109010001","DOIUrl":"https://doi.org/10.2174/1874847302109010001","url":null,"abstract":"","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124629090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic Activity-Guided Isolation from Achillea monocephala, and Biological Activities of its Different Extracts 以细胞毒活性为导向的单头阿基那分离及其不同提取物的生物活性研究
The Open Bioactive Compounds Journal Pub Date : 2020-08-18 DOI: 10.2174/1874847302008010007
T. Taşkın, E. Güler, Şeyda Şentürk, D. Çelik, T. Arabaci, Ü. S. Gürer
{"title":"Cytotoxic Activity-Guided Isolation from Achillea monocephala, and Biological Activities of its Different Extracts","authors":"T. Taşkın, E. Güler, Şeyda Şentürk, D. Çelik, T. Arabaci, Ü. S. Gürer","doi":"10.2174/1874847302008010007","DOIUrl":"https://doi.org/10.2174/1874847302008010007","url":null,"abstract":"The aim of the current research was to evaluate in vitro cytotoxic activities of n-hexan, chloroform, ethyl acetate and methanol extracts and to isolate the active compounds from the extract showing the strongest cytotoxic activity. In addition to this, it was aimed to evaluate the biological activities (cytotoxic, antioxidant, anti-urease, anticholinesterase, antimicrobial) of different extracts and active compounds from Achillea monocephala.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122759204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Drying Potential of Leaves Oil of Zanthoxylum armatum DC from North India 北印度花椒叶油的干燥潜力
The Open Bioactive Compounds Journal Pub Date : 2020-07-20 DOI: 10.2174/1874847302109010009
L. Rana, Ankita Rai, L. Tewari, N. Chopra, N. C. Pandey, G. Tewari
{"title":"Drying Potential of Leaves Oil of Zanthoxylum armatum DC from North India","authors":"L. Rana, Ankita Rai, L. Tewari, N. Chopra, N. C. Pandey, G. Tewari","doi":"10.2174/1874847302109010009","DOIUrl":"https://doi.org/10.2174/1874847302109010009","url":null,"abstract":"\u0000 \u0000 The study on drying and its social acceptance has increased rapidly. Among different drying techniques, shade drying is one of the most feasible methods to keep intact from the decay of the main active components of the plant materials. Shade drying is an ancient drying method that increases durability, major constituents and activity of the plant material.\u0000 \u0000 \u0000 \u0000 Research was conducted to examine the drying potential of aromatic leaves oil of Zanthoxylum armatum DC.\u0000 \u0000 \u0000 \u0000 The fresh plant material was collected from Lohaghat, Champawat district of Uttarakhand and hydrodistilled before and after shade drying to assess the changes in the quality of volatile constituents by GC and GC-MS techniques. A two-tailed paired t-test was executed to assess the difference between drying treatments using MS-Excel.\u0000 \u0000 \u0000 \u0000 The major components in the fresh oil were 2-undecane, linalool, (E)-β-ocimene, α-pinene and β-phellandrene. In the oil from dried material, the three predominant compounds were noted. A significant increase was observed in the percentage of β-phellandrene, undecanal and myrcene after shade drying (p<0.01). Five components absent in the fresh plant material appeared and one disappeared during the drying process.\u0000 \u0000 \u0000 \u0000 Shade drying significantly influenced the essential oil composition of Z. armatum.\u0000","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129860532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Phytochemicals from Citrus Limon Juice as Potential Antibacterial Agents 柑橘柠檬汁中的植物化学物质作为潜在的抗菌剂
The Open Bioactive Compounds Journal Pub Date : 2020-02-14 DOI: 10.2174/1874847302008010001
Nitika Singh, Jyotsna Jaiswal, Priyanka Tiwari, B. Sharma
{"title":"Phytochemicals from Citrus Limon Juice as Potential Antibacterial Agents","authors":"Nitika Singh, Jyotsna Jaiswal, Priyanka Tiwari, B. Sharma","doi":"10.2174/1874847302008010001","DOIUrl":"https://doi.org/10.2174/1874847302008010001","url":null,"abstract":"Citrus limon (lemon) belongs to the Rutaceae family and has great therapeutic applications. The chemical ingredients of C. limon have been used in the formulation of several ethnic herbal medicines. The application of antibiotics has shown the development of drug resistance in antibacterial drugs. Due to the drug-resistant nature of microorganisms, there is an urgent need to develop a novel drug active against wildtype and MDR resistant strains of pathogens.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132961401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Analysis of Raspberry Ketone in Nutraceutical Formulation Using Fourier Transform Infrared Spectrophotometric Method 傅立叶变换红外分光光度法分析营养品配方中的覆盆子酮
The Open Bioactive Compounds Journal Pub Date : 2019-12-05 DOI: 10.2174/1874847301907010008
H. Aboul‐Enein, Oana Mihaela Antochi, G. Nechifor, A. Bunaciu
{"title":"Analysis of Raspberry Ketone in Nutraceutical Formulation Using Fourier Transform Infrared Spectrophotometric Method","authors":"H. Aboul‐Enein, Oana Mihaela Antochi, G. Nechifor, A. Bunaciu","doi":"10.2174/1874847301907010008","DOIUrl":"https://doi.org/10.2174/1874847301907010008","url":null,"abstract":"A Fourier Transform Infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of Raspberry Ketone (RK) and Caffeine (CAF) in a nutraceutical formulation.Conventional KBr-spectra and KBr+0.5 mg Microcrystalline Cellulose (MCC)-spectra were used as the basis for a better determination of active substances in the nutraceutical formulation. A calibration model was developed using caffeine and raspberry ketone standards of varying concentrations in the mid-infrared region (4000-400 cm-1). The Beer-Lambert law was used in data processing.The results indicate that FT-IR spectrometry is applicable to the analytical quantification of RK and CAF in the nutraceutical formulation.The method proposed is simple, precise and not time-consuming compared to the chromatographic methods that are cited in the literature. Quantification is performed in about 10-15 minutes, including sample preparation and spectral acquisition.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"234 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133707467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Harpin Proteins Improve Bioactive Compounds Content in Crimson Seedless Table Grape Harpin蛋白提高赤红无核食用葡萄生物活性物质含量
The Open Bioactive Compounds Journal Pub Date : 2019-05-31 DOI: 10.2174/1874847301907010001
P. Crupi, G. Debiase, G. Masi, F. Mangione, L. Tarricone
{"title":"Harpin Proteins Improve Bioactive Compounds Content in Crimson Seedless Table Grape","authors":"P. Crupi, G. Debiase, G. Masi, F. Mangione, L. Tarricone","doi":"10.2174/1874847301907010001","DOIUrl":"https://doi.org/10.2174/1874847301907010001","url":null,"abstract":"\u0000 \u0000 Frequently, in warm climates such as Mediterranean areas, a red-pink table grape ‘Crimson Seedless’ does not reach a good berry skin color; and an acceptable anthocyanin bioactive compounds content, responsible for the red color of berries. Harpin proteins are biotechnologically developed bio-activators that, if applied on plants during the growing period, trigger the expression of hundreds of genes among which those associated with the biosynthesis of bioactive compounds (such as anthocyanins).\u0000 \u0000 \u0000 \u0000 This research aimed at using harpin proteins to test their suitability in improving the grape skin color.\u0000 \u0000 \u0000 \u0000 Beta-harpin protein 1% p.a. (400 g/Ha) was applied to ‘Crimson Seedless’ vines three times at the beginning of veraison. Six samplings were carried out for both the treated and control grapes until commercial harvest. In the skin extracts, total and individual anthocyanins content was determined by UV-Vis and RP-HPLC-DAD analyses, respectively.\u0000 \u0000 \u0000 \u0000 The collected results confirmed that the application of harpin proteins effectively stimulated the anthocyanin biosynthesis leading to make peonidin-3O-glucoside, cyanidin-3O-glucoside, and malvidin-3O-glucoside values from 2 to almost 10 folds higher in treated grapes than in control grapes (P < 0.05).\u0000 \u0000 \u0000 \u0000 \u0000 Actually, harpin proteins improved the color of the berry skin, leading to a significantly higher concentration of anthocyanins in treated than in control grapes.\u0000","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129395921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation, Characterization and Antimicrobial Activity of Schiff Base of (E) - N - (4-(Thiophen-2-ylmethyleneamino) Phenylsulfonyl) Acetamide Metal Complexes (E) - N -(4-(噻吩-2-基亚氨基)苯磺酰基)乙酰胺金属配合物席夫碱的制备、表征及抑菌活性
The Open Bioactive Compounds Journal Pub Date : 2018-02-21 DOI: 10.2174/1874847301806010001
A. S. Abu-Khadra, A. Afify, Amr Mohamed, R. Farag, H. Aboul‐Enein
{"title":"Preparation, Characterization and Antimicrobial Activity of Schiff Base of (E) - N - (4-(Thiophen-2-ylmethyleneamino) Phenylsulfonyl) Acetamide Metal Complexes","authors":"A. S. Abu-Khadra, A. Afify, Amr Mohamed, R. Farag, H. Aboul‐Enein","doi":"10.2174/1874847301806010001","DOIUrl":"https://doi.org/10.2174/1874847301806010001","url":null,"abstract":"Department of Basic Science, Faculty of Engineering Science, Sinai University, North Sinai, Egypt Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129Torino, Italy Department of Chemistry, Faculty of Science, Taibah University, 41411-Al-Madinah, Saudi Arabia The Higher Institute of Optics Technology (HIOT), Heliopolis, 17361-Cairo, Egypt Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo12622, Egypt","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124077655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
High Value-Added Biomolecules from Beach Waste of Marine Origin-Screening for Potential Candidates among Seagrass of the Cymodoceaceae Family 从海洋来源的海滩废弃物中提取高附加值生物分子——菊科海草潜在候选分子的筛选
The Open Bioactive Compounds Journal Pub Date : 2017-12-29 DOI: 10.2174/1874847301705010083
M. Grignon-Dubois, B. Rezzonico
{"title":"High Value-Added Biomolecules from Beach Waste of Marine Origin-Screening for Potential Candidates among Seagrass of the Cymodoceaceae Family","authors":"M. Grignon-Dubois, B. Rezzonico","doi":"10.2174/1874847301705010083","DOIUrl":"https://doi.org/10.2174/1874847301705010083","url":null,"abstract":"Method: Six species of seagrass belonging to the genera Syringodium, Cymodocea and Halodule were collected from their native habitat. The L-chiro-inositol content of the crude aqueous extracts prepared from different batches of Cymodocea nodosa flotsam was measured by quantitative H-NMR spectroscopy. High concentrations were found with values ranging from 22.2 to 35.0 mg.g plant dw. The presence of L-chiro-inositol in the tropical species C. rotundata, C. serrulata, Syringodium isoetifolium, and Halodule pinifolia was also characterized by qualitative NMR. The chicoric acid content of crude aqueous methanolic extracts prepared from C. rotundata, C. serrulata, S. isoetifolium, and Halodule pinifolia was determined by quantitative HPLC-DAD. The values found ranged from 0.39 to 6.15 mg.g dry weight. Chicoric acid was unambiguously identified as the major phenolic in S. isoetifolium, and Halodule pinifolia, while it was found in mixture with flavonol derivatives in C. rotundata and C. serrulata. Flavonol derivatives are also of interest for their bioactivity.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127812040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Review on Computational Approaches for Identification of New Targets and Compounds for Fighting Against Filariasis 抗丝虫病新靶点和化合物鉴定的计算方法综述
The Open Bioactive Compounds Journal Pub Date : 2017-12-29 DOI: 10.2174/1874847301705010072
M. Mishra, P. Srivastava
{"title":"Review on Computational Approaches for Identification of New Targets and Compounds for Fighting Against Filariasis","authors":"M. Mishra, P. Srivastava","doi":"10.2174/1874847301705010072","DOIUrl":"https://doi.org/10.2174/1874847301705010072","url":null,"abstract":"Received: October 19, 2017 Revised: November 21, 2017 Accepted: December 21, 2017 Abstract: Background: Lymphatic filariasis is a tropical disease and currently more than 1.4 billion people in 73 countries are at risk but still it is neglected in higher researches. Lymphatic filariasis is wide spread throughout the tropical and subtropical areas of Asia, Africa, the Western Pacific and some parts of the Americas. Though it is a big issue for developing countries but still no proper prophylactic or therapeutic measures are taken out as to protect against filarial infection or to modulate disease.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"520 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123055682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Ameliorative Potential of Natural Antioxidants Against Paraquat-Induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster: A Comparative Study 天然抗氧化剂对百草枯诱导的氧化应激和运动障碍的改善潜力:一项比较研究
The Open Bioactive Compounds Journal Pub Date : 2017-11-14 DOI: 10.2174/1874847301705010043
S. Niveditha, T. Shivanandappa, S. Ramesh
{"title":"Ameliorative Potential of Natural Antioxidants Against Paraquat-Induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster: A Comparative Study","authors":"S. Niveditha, T. Shivanandappa, S. Ramesh","doi":"10.2174/1874847301705010043","DOIUrl":"https://doi.org/10.2174/1874847301705010043","url":null,"abstract":"Background: \u0000Natural antioxidants show neuroprotective potential to protect against neurodegenerative disorders in experimental animals. There is a need to characterize newer promising neuroprotective natural molecules. \u0000 \u0000Objective: \u0000In the present study, we have compared the neuroprotective activity of 4hydroxyisophthalic acid (DHA-I), a novel natural antioxidant from the roots of Decalepis hamiltonii, with the other natural neuroprotective antioxidants, ellagic acid, quercetin and nicotinamide, against paraquat (PQ) neurotoxicity in D. melanogaster. \u0000 \u0000Results: \u0000Flies exposed to multiple (sub-lethal) dose of PQ showed movement disorder characteristic of Parkinson’s disease (PD). The four natural antioxidants showed ameliorative effects against PQ neurotoxicity in the sub-acute model as seen in survivability, locomotor activity as well as oxidative stress markers including reactive oxygen species (ROS), lipid peroxidation and the endogenous antioxidant defenses. \u0000 \u0000Conclusion: \u0000Our study shows that the antioxidant compounds exhibit varying degrees of protection against PQ-induced oxidative stress and neurotoxicity with DHA-I, quercetin, and nicotinamide being the most effective and ellagic acid, the least potent in Drosophila. Our results show that mitochondrial Mn-SOD is a critical target for PQ neurotoxicity and the neuroprotection by the antioxidants involves the attenuation of mitochondrial ROS production and oxidative damage.","PeriodicalId":403551,"journal":{"name":"The Open Bioactive Compounds Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114278318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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