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A: Pathogenic mechanisms最新文献

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A08 The impact of JAK/STAT signaling on microglia in Huntington´s disease JAK/STAT信号对亨廷顿病小胶质细胞的影响
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.8
A. Blusch, Annika Mattukat, J. König, V. Bader, K. Winklhofer, O. Fatoba, C. Saft, G. Ellrichmann
{"title":"A08 The impact of JAK/STAT signaling on microglia in Huntington´s disease","authors":"A. Blusch, Annika Mattukat, J. König, V. Bader, K. Winklhofer, O. Fatoba, C. Saft, G. Ellrichmann","doi":"10.1136/jnnp-2022-ehdn.8","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.8","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133293582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A16 Mutant Huntingtin aggregates in human HD are focused to emotion-related cortices 人类HD中突变的亨廷顿蛋白聚集集中在情绪相关皮层
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.16
Paul G Scheunemann, S. V. von Hein, V. Bader, Constanze R Parwez, K. Winklhofer, E. Förster, C. Saft, E. Petrasch‐Parwez
{"title":"A16 Mutant Huntingtin aggregates in human HD are focused to emotion-related cortices","authors":"Paul G Scheunemann, S. V. von Hein, V. Bader, Constanze R Parwez, K. Winklhofer, E. Förster, C. Saft, E. Petrasch‐Parwez","doi":"10.1136/jnnp-2022-ehdn.16","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.16","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"171 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116127963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A11 The temporal and spatial appearance of HTT aggregation in the brains of zQ175 mice A11 zQ175小鼠脑内HTT聚集的时空分布
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.11
Edward J. Smith, K. Sathasivam, C. Landles, Georgina F Osborne, Casandra Gomez-Paredes, G. Bates
{"title":"A11 The temporal and spatial appearance of HTT aggregation in the brains of zQ175 mice","authors":"Edward J. Smith, K. Sathasivam, C. Landles, Georgina F Osborne, Casandra Gomez-Paredes, G. Bates","doi":"10.1136/jnnp-2022-ehdn.11","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.11","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131754404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A02 Altered epigenetic and transcriptional regulation during striatum-dependent memory in HD mice A02 HD小鼠纹状体依赖性记忆过程中表观遗传和转录调控的改变
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.2
R. Alcalá-Vida, C. Lotz, J. Séguin, C. Decraene, B. Brulé, A. Awada, A. Bombardier, B. Cosquer, A. Pereira de Vasconcelos, E. Brouillet, J. Cassel, A. Boutillier, K. Merienne
{"title":"A02 Altered epigenetic and transcriptional regulation during striatum-dependent memory in HD mice","authors":"R. Alcalá-Vida, C. Lotz, J. Séguin, C. Decraene, B. Brulé, A. Awada, A. Bombardier, B. Cosquer, A. Pereira de Vasconcelos, E. Brouillet, J. Cassel, A. Boutillier, K. Merienne","doi":"10.1136/jnnp-2022-ehdn.2","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.2","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"29 15","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120887286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A12 Loss of proteostasis in huntington disease – lessons from cockayne syndrome 亨廷顿病中蛋白质平衡的丧失——来自柯凯因综合征的教训
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.12
Maximilian Wagner, F. Khalid, Gaojie Zhu, K. Lindenberg, G. Landwehrmeyer, M. Mulaw, S. Iben
{"title":"A12 Loss of proteostasis in huntington disease – lessons from cockayne syndrome","authors":"Maximilian Wagner, F. Khalid, Gaojie Zhu, K. Lindenberg, G. Landwehrmeyer, M. Mulaw, S. Iben","doi":"10.1136/jnnp-2022-ehdn.12","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.12","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130670968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A13 Proteomic characterization of human induced pluripotent and neural stem cell lines from hd patients and healthy controls 来自hd患者和健康对照的人诱导多能干细胞和神经干细胞的A13蛋白质组学特征
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.13
Katerina Vodickova Kepkova, Jiřina Tylečková, J. Červenka, Katerina Budkova, Ievgeniia Poliakh, P. Vodička
{"title":"A13 Proteomic characterization of human induced pluripotent and neural stem cell lines from hd patients and healthy controls","authors":"Katerina Vodickova Kepkova, Jiřina Tylečková, J. Červenka, Katerina Budkova, Ievgeniia Poliakh, P. Vodička","doi":"10.1136/jnnp-2022-ehdn.13","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.13","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124394524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A40 Human induced pluripotent stem cell as a model system for Huntington’s disease 人类诱导多能干细胞作为亨廷顿病的模型系统
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.40
Katerina Budkova, Tereza Novakova, P. Vodička, Katerina Vodickova Kepkova
{"title":"A40 Human induced pluripotent stem cell as a model system for Huntington’s disease","authors":"Katerina Budkova, Tereza Novakova, P. Vodička, Katerina Vodickova Kepkova","doi":"10.1136/jnnp-2022-ehdn.40","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.40","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114934473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A22 Medium-sized spiny neurons diversity in Huntington’s disease pathology A22中等大小的棘神经元多样性与亨廷顿氏病的病理关系
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.22
G. Bergonzoni, Denise Ferrarini, Aurora Savino, T. Gillis, Nicola Casiraghi, Sarah Geurs, Michele Tebaldi, Valeria Poli, A. Romanel, T. Voet, V. Wheeler, E. Dassi, M. Biagioli
{"title":"A22 Medium-sized spiny neurons diversity in Huntington’s disease pathology","authors":"G. Bergonzoni, Denise Ferrarini, Aurora Savino, T. Gillis, Nicola Casiraghi, Sarah Geurs, Michele Tebaldi, Valeria Poli, A. Romanel, T. Voet, V. Wheeler, E. Dassi, M. Biagioli","doi":"10.1136/jnnp-2022-ehdn.22","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.22","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114948581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A29 Deciphering how fat metabolism and ampk impact autophagy in Huntington’s disease 破译脂肪代谢和ampk如何影响亨廷顿病的自噬
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.29
A.V. Carranza, M. Collado-Pérez, R. Vázquez-Manrique
{"title":"A29 Deciphering how fat metabolism and ampk impact autophagy in Huntington’s disease","authors":"A.V. Carranza, M. Collado-Pérez, R. Vázquez-Manrique","doi":"10.1136/jnnp-2022-ehdn.29","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.29","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129992989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A27 Lipid metabolism modulates polyglutamine-induced toxicity phenotypes though proteostasis in C. elegans 脂质代谢通过蛋白酶抑制调节秀丽隐杆线虫多谷氨酰胺诱导的毒性表型
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.27
J. Tortajada-Pérez, C. Trujillo-Del Río, M. Collado-Pérez, A. P. Gómez-Escribano, J. Millán, R. Vázquez-Manrique
{"title":"A27 Lipid metabolism modulates polyglutamine-induced toxicity phenotypes though proteostasis in C. elegans","authors":"J. Tortajada-Pérez, C. Trujillo-Del Río, M. Collado-Pérez, A. P. Gómez-Escribano, J. Millán, R. Vázquez-Manrique","doi":"10.1136/jnnp-2022-ehdn.27","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.27","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131445491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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