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A: Pathogenic mechanisms最新文献

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A28 Targeted overexpression of HTT alters the cholesterol- and neuroendocrine transcriptome in the hypothalamus A28靶向过表达HTT改变下丘脑的胆固醇和神经内分泌转录组
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.28
Elna Dickson, Amoolya Sai Dwijesha, Natalie Andersson, Sofia Lundh, M. Björkqvist, Å. Petersén, R. Soylu-Kucharz
{"title":"A28 Targeted overexpression of HTT alters the cholesterol- and neuroendocrine transcriptome in the hypothalamus","authors":"Elna Dickson, Amoolya Sai Dwijesha, Natalie Andersson, Sofia Lundh, M. Björkqvist, Å. Petersén, R. Soylu-Kucharz","doi":"10.1136/jnnp-2022-ehdn.28","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.28","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"2022 27","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114085740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A25 Fiber type analysis in huntington disease skeletal muscle A25亨廷顿病骨骼肌纤维类型分析
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.25
A. Abdelmoez, M. Orth, A. Neueder
{"title":"A25 Fiber type analysis in huntington disease skeletal muscle","authors":"A. Abdelmoez, M. Orth, A. Neueder","doi":"10.1136/jnnp-2022-ehdn.25","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.25","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122227378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A05 Early transcriptional modifications of the developing brain in huntington disease 亨廷顿病中发育中的大脑的早期转录修饰
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.5
Radhia Kacher, Julie Six, Marie Coutelier, Rania Hilab, J. Guégan, A. Durr, S. Humbert
{"title":"A05 Early transcriptional modifications of the developing brain in huntington disease","authors":"Radhia Kacher, Julie Six, Marie Coutelier, Rania Hilab, J. Guégan, A. Durr, S. Humbert","doi":"10.1136/jnnp-2022-ehdn.5","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.5","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131851280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A18 Indirect pathway linage-specific alterations from early development in Huntington’s disease A18亨廷顿病早期发展的间接途径谱系特异性改变
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.18
Cristina Vila, Francisco J. Londoño, A. Esteve-Codina, Francisco J Molina-Ruiz, J. Canals
{"title":"A18 Indirect pathway linage-specific alterations from early development in Huntington’s disease","authors":"Cristina Vila, Francisco J. Londoño, A. Esteve-Codina, Francisco J Molina-Ruiz, J. Canals","doi":"10.1136/jnnp-2022-ehdn.18","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.18","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130758564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A37 Elucidating the mechanism of Huntingtin involvement in il-6 secretion in mast cells stimulated through toll-like receptor 4 A37阐明亨廷顿蛋白参与toll样受体4刺激肥大细胞il-6分泌的机制
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.37
M. J. Pérez-Rodríguez, F. Pérez-Severiano, G. Reyes-Cruz, C. González Espinosa
{"title":"A37 Elucidating the mechanism of Huntingtin involvement in il-6 secretion in mast cells stimulated through toll-like receptor 4","authors":"M. J. Pérez-Rodríguez, F. Pérez-Severiano, G. Reyes-Cruz, C. González Espinosa","doi":"10.1136/jnnp-2022-ehdn.37","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.37","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134632084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A17 Glial-specific transcriptomic changes in HD HD中胶质细胞特异性转录组变化
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.17
Sunniva M. K. Bøstrand, L. Seeker, Nina-Lydia Kazakou, Nadine Bestard-Cuche, S. Jäkel, N. Henderson, W. V. Roon-Mom, Josef Priller, A. Williams
{"title":"A17 Glial-specific transcriptomic changes in HD","authors":"Sunniva M. K. Bøstrand, L. Seeker, Nina-Lydia Kazakou, Nadine Bestard-Cuche, S. Jäkel, N. Henderson, W. V. Roon-Mom, Josef Priller, A. Williams","doi":"10.1136/jnnp-2022-ehdn.17","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.17","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122210927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A21 Astrocytes at the hub of neuronal dysfunction in Huntington´s disease: dissecting the role of arms/kidins220 on astrocytes’ secretome A21星形胶质细胞在亨廷顿病神经元功能障碍的中枢:剖析arms/kidins220在星形胶质细胞分泌组中的作用
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.21
Marc Espina, L. López-Molina, Anika Pupak, Nadia Di Franco, V. Brito, J. Arévalo, S. Ginés
{"title":"A21 Astrocytes at the hub of neuronal dysfunction in Huntington´s disease: dissecting the role of arms/kidins220 on astrocytes’ secretome","authors":"Marc Espina, L. López-Molina, Anika Pupak, Nadia Di Franco, V. Brito, J. Arévalo, S. Ginés","doi":"10.1136/jnnp-2022-ehdn.21","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.21","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"165 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115696454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A35 Calpains contribute to the molecular pathogenesis of spinocerebellar ataxia type 17 calpain参与脊髓小脑共济失调17型的分子发病机制
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.35
J. Weber, Stefanie Cari Anger, Priscila Pereira Sena, Rana Dilara Incebacak Eltemur, Chrisovalantou Huridou, F. Fath, Caspar Gross, Nicolas Casadei, O. Riess, H. Nguyen
{"title":"A35 Calpains contribute to the molecular pathogenesis of spinocerebellar ataxia type 17","authors":"J. Weber, Stefanie Cari Anger, Priscila Pereira Sena, Rana Dilara Incebacak Eltemur, Chrisovalantou Huridou, F. Fath, Caspar Gross, Nicolas Casadei, O. Riess, H. Nguyen","doi":"10.1136/jnnp-2022-ehdn.35","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.35","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129996064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A09 Ran-translation products are selectively taken up by a microglia cell line and induce an inflammatory response via the NLRP3 inflammasome pathway A09 ran -翻译产物被小胶质细胞系选择性摄取，并通过NLRP3炎症小体途径诱导炎症反应
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.9
Raul Nicolás Jamin, C. Dansokho, M. Heneka, P. Weydt
{"title":"A09 Ran-translation products are selectively taken up by a microglia cell line and induce an inflammatory response via the NLRP3 inflammasome pathway","authors":"Raul Nicolás Jamin, C. Dansokho, M. Heneka, P. Weydt","doi":"10.1136/jnnp-2022-ehdn.9","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.9","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127301310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A10 Structural and mechanistic studies of a supramolecular switch behind the polyglutamine expansion threshold in Huntington‘s disease 亨廷顿病中聚谷氨酰胺扩张阈值背后的超分子开关的结构和机制研究
A: Pathogenic mechanisms Pub Date : 2022-09-01 DOI: 10.1136/jnnp-2022-ehdn.10
Irina Matlahov, J. Boatz, Patrick C. A. Wel
{"title":"A10 Structural and mechanistic studies of a supramolecular switch behind the polyglutamine expansion threshold in Huntington‘s disease","authors":"Irina Matlahov, J. Boatz, Patrick C. A. Wel","doi":"10.1136/jnnp-2022-ehdn.10","DOIUrl":"https://doi.org/10.1136/jnnp-2022-ehdn.10","url":null,"abstract":"","PeriodicalId":403341,"journal":{"name":"A: Pathogenic mechanisms","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116906108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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