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Modern Mineral Oil Hydrocarbon Analysis 现代矿物油碳氢化合物分析
LCGC Europe Pub Date : 2023-04-01 DOI: 10.56530/lcgc.eu.do5379f3
G. Purcaro
{"title":"Modern Mineral Oil Hydrocarbon Analysis","authors":"G. Purcaro","doi":"10.56530/lcgc.eu.do5379f3","DOIUrl":"https://doi.org/10.56530/lcgc.eu.do5379f3","url":null,"abstract":"LCGC Europe spoke to Giorgia Purcaro from the University of Liège in Belgium, about her work investigating\u0000mineral oil hydrocarbons (MOH) using comprehensive two-dimensional gas chromatography (GC×GC) and\u0000the practical advantages that a novel liquid chromatography–two-dimensional gas chromatography–time-of-flight-mass spectrometry/flame ionization detection (LC–GC×GC–TOF-MS/FID) method offers the analyst.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122620182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purification and Isolation of Cannabinoids: Current Challenges and Perspectives 大麻素的纯化和分离:当前的挑战和前景
LCGC Europe Pub Date : 2023-04-01 DOI: 10.56530/lcgc.eu.jp5571c5
Simona Felletti, Greta Compagnin, Y. Krauke, Svea Stephan, G. Greco, A. Buratti, T. Chenet, C. De Luca, Martina Catani, A. Cavazzini
{"title":"Purification and Isolation of Cannabinoids: Current Challenges and Perspectives","authors":"Simona Felletti, Greta Compagnin, Y. Krauke, Svea Stephan, G. Greco, A. Buratti, T. Chenet, C. De Luca, Martina Catani, A. Cavazzini","doi":"10.56530/lcgc.eu.jp5571c5","DOIUrl":"https://doi.org/10.56530/lcgc.eu.jp5571c5","url":null,"abstract":"The recent legalization of cannabis in many countries and its increased use in scientific and medical research as a result of its therapeutic properties have focused attention on the need for large quantities of highly purified cannabinoids. This is particularly important for the production of (new) analytical-grade standards, used as reference materials, and for the execution of clinical trials to test the biological activity of the single compounds that could potentially be used as new drugs or active pharmaceutical ingredients (APIs). To date, various purification strategies, usually based on several steps, have been proposed with different outcomes. However, all these methods have both advantages and disadvantages. This review will report on the challenges and future perspectives in the purification and isolation of major and minor cannabinoids from cannabis extracts.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125225086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Sorptive Sample Preparation Techniques for Separation Science 用于分离科学的新型吸附制样技术
LCGC Europe Pub Date : 2023-03-01 DOI: 10.56530/lcgc.eu.zq5279u1
V. Samanidou, A. Kabir
{"title":"Novel Sorptive Sample Preparation Techniques for Separation Science","authors":"V. Samanidou, A. Kabir","doi":"10.56530/lcgc.eu.zq5279u1","DOIUrl":"https://doi.org/10.56530/lcgc.eu.zq5279u1","url":null,"abstract":"The primary analytical challenge is to selectively extract the target analytes using a suitable sample preparation technique and introduce them into the downstream analytical instrument. The critical step in the chemical analysis is sample preparation. Sorptive sample preparation techniques are among the new generation of microextraction approaches, and are compliant with green analytical chemistry principles. A recent intercontinental collaboration between two academic research laboratories—the Aristotle University of Thessaloniki, Greece, and the Florida International University, USA—has yielded a significant number of analytical/bioanalytical methods using fabric phase sorptive extraction (FPSE), magnet integrated fabric phase sorptive extraction (MI-FPSE), and capsule phase microextraction (CPME) for the isolation of various analytes from different complex sample matrices. A brief description of these techniques with regards to principle, synthesis, applications, and advantages and disadvantages along with paradigms is presented.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117340876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromatography and COVID-19 色谱法和COVID-19
LCGC Europe Pub Date : 2023-03-01 DOI: 10.56530/lcgc.eu.ec7268d7
S. Fekete
{"title":"Chromatography and COVID-19","authors":"S. Fekete","doi":"10.56530/lcgc.eu.ec7268d7","DOIUrl":"https://doi.org/10.56530/lcgc.eu.ec7268d7","url":null,"abstract":"","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122856172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Separation Techniques in the Analysis of mRNA Therapeutic Drug Substances and Drug Products 分离技术在治疗原料药和制剂mRNA分析中的作用
LCGC Europe Pub Date : 2023-02-01 DOI: 10.56530/lcgc.eu.hk6689y3
Christina Vanhinsbergh
{"title":"The Role of Separation Techniques in the Analysis of mRNA Therapeutic Drug Substances and Drug Products","authors":"Christina Vanhinsbergh","doi":"10.56530/lcgc.eu.hk6689y3","DOIUrl":"https://doi.org/10.56530/lcgc.eu.hk6689y3","url":null,"abstract":"Messenger ribonucleic acids (mRNA) therapeutics are becoming more widespread pharmaceutical tools to treat a wide range of diseases or infections, as highlighted by regulatory approval of two vaccines for SARS‑CoV-2. Alongside their use as vaccines, they also play a role in protein replacement therapy to ensure therapeutic protein is synthesized within the patient. Structural elements, such as the 5’ cap, UTR regions, reading frame, and poly A tail are considered as critical quality attributes (CQAs) that are subject to a range of analytical techniques. However, chromatography and other separation methods are commonly used for characterization and quantification of the drug substance and drug product. This article reviews a range of techniques available for separative analysis of mRNA therapeutics, their associated impurities, and delivery vehicles.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126191652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning and Nontargeted Liquid Chromatography–Mass Spectrometry to Assess Ecotoxicity 机器学习和非靶向液相色谱-质谱法评估生态毒性
LCGC Europe Pub Date : 2023-01-01 DOI: 10.56530/lcgc.eu.wg5784a9
A. Kruse, Pilleriin Peets
{"title":"Machine Learning and Nontargeted Liquid Chromatography–Mass Spectrometry to Assess Ecotoxicity","authors":"A. Kruse, Pilleriin Peets","doi":"10.56530/lcgc.eu.wg5784a9","DOIUrl":"https://doi.org/10.56530/lcgc.eu.wg5784a9","url":null,"abstract":"Anneli Kruve and Pilleriin Peets from Stockholm University in Sweden, discuss their latest research in machine learning and nontargeted liquid chromatography–mass spectrometry (LC–MS) to assess ecotoxicity.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126553357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Online Solid-Phase Extraction–Gas Chromatography–Flame Ionization Detection System for Monitoring Contaminants at Parts-Per-Trillion Concentrations in Process Waters 在线固相萃取-气相色谱-火焰电离检测系统监测污染物在万亿分之一的浓度在工艺用水
LCGC Europe Pub Date : 2023-01-01 DOI: 10.56530/lcgc.eu.eb6169h7
Charlotte Lejaegere, J. Vercammen, L. Verheyden, J. Martens
{"title":"Online Solid-Phase Extraction–Gas Chromatography–Flame Ionization Detection System for Monitoring Contaminants at Parts-Per-Trillion Concentrations in Process Waters","authors":"Charlotte Lejaegere, J. Vercammen, L. Verheyden, J. Martens","doi":"10.56530/lcgc.eu.eb6169h7","DOIUrl":"https://doi.org/10.56530/lcgc.eu.eb6169h7","url":null,"abstract":"Online monitoring of odour and taste components that occur at parts-per-trillion (ppt) levels in industrial process waters requires specialized analytical hardware that is generally not compatible with the harsh environmental conditions in these typical industrial settings. An alternative instrumental method is proposed that uses dynamic extraction in combination with gas chromatography (GC) equipped with a simple flame ionization detector (FID) to achieve these extremely low detection limits. The extraction process was fully automated by means of online solid-phase extraction (SPE). The combination of online SPE and GC–FID was used to monitor the quality of process water contaminated with 2-methylisoborneol and geosmin, which are two notorious odour and taste components, in volumes up to 1 L.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130074320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Method Development for Reversed-Phase Separations of Peptides: A Rational Screening Strategy for Column and Mobile Phase Combinations with Complementary Selectivity 多肽反相分离方法的发展:具有互补选择性的色谱和流动相组合的合理筛选策略
LCGC Europe Pub Date : 2022-12-01 DOI: 10.56530/lcgc.eu.qp3971p2
Jennifer K. Field, James Bruce, Stephen Buckenmaier, Ming Yui Cheung, M. Euerby, K. Haselmann, J. Lau, D. Stoll, Marie Sylvester, H. Thøgersen, P. Petersson
{"title":"Method Development for Reversed-Phase Separations of Peptides: A Rational Screening Strategy for Column and Mobile Phase Combinations with Complementary Selectivity","authors":"Jennifer K. Field, James Bruce, Stephen Buckenmaier, Ming Yui Cheung, M. Euerby, K. Haselmann, J. Lau, D. Stoll, Marie Sylvester, H. Thøgersen, P. Petersson","doi":"10.56530/lcgc.eu.qp3971p2","DOIUrl":"https://doi.org/10.56530/lcgc.eu.qp3971p2","url":null,"abstract":"This review article summarizes the results obtained from the combined efforts of a joint academic and industrial initiative to solve the real-life challenge of determining low levels of peptide-related impurities (typically 0.05–1% of the drug substance) in the presence of the related biologically active peptide at a high concentration. A rational screening strategy for pharmaceutically important peptides has been developed that uses combinations of reversed‑phase ultrahigh-pressure liquid chromatography (UHPLC) columns and mobile phases that exhibit complementary reversed-phase chromatographic selectivity using either UV- or mass spectrometry (MS)-compatible conditions. Numerous stationary and mobile phases were categorized using the chemometric tool of principal component analysis (PCA), employing a novel characterization protocol utilizing specifically designed peptide probes. This was successfully applied to the development of a strategy for the detection of impurities (especially isomers) in peptide drug substances using two-dimensional liquid chromatography coupled with MS detection (2D-LC–MS).","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122752427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidimensional Gas Chromatography Moves Forward 多维气相色谱法向前发展
LCGC Europe Pub Date : 2022-12-01 DOI: 10.56530/lcgc.eu.bj8777l1
C. Cordero, Carlo Birch
{"title":"Multidimensional Gas Chromatography Moves Forward","authors":"C. Cordero, Carlo Birch","doi":"10.56530/lcgc.eu.bj8777l1","DOIUrl":"https://doi.org/10.56530/lcgc.eu.bj8777l1","url":null,"abstract":"In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121663926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Mature is Gas Chromatography? An Industry Perspective 气相色谱法有多成熟?行业视角
LCGC Europe Pub Date : 2022-12-01 DOI: 10.56530/lcgc.eu.rn6867l8
F. David, Pat Sandra
{"title":"How Mature is Gas Chromatography? An Industry Perspective","authors":"F. David, Pat Sandra","doi":"10.56530/lcgc.eu.rn6867l8","DOIUrl":"https://doi.org/10.56530/lcgc.eu.rn6867l8","url":null,"abstract":"In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, leading figures from the separation science community explore contemporary trends in separation science and identify possible future developments.","PeriodicalId":402085,"journal":{"name":"LCGC Europe","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130741161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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