Recent Patents on Drug Delivery and Formulation最新文献

{"title":"Scientific Papers and Patents on Substances with Unproven Effects. Part 2.","authors":"Sergei V Jargin","doi":"10.2174/1872211313666190819124752","DOIUrl":"10.2174/1872211313666190819124752","url":null,"abstract":"<p><p>Several examples are discussed in this review, where substances without proven effects were proposed for practical use within the scope of evidence-based medicines. The following is discussed here: generalizations of the hormesis concept and its use in support of homeopathy; phytoestrogens and soy products potentially having feminizing effects; glycosaminoglycans for the treatment of osteoarthritis and possibilities of their replacement by diet modifications; flavonoids recommended for the treatment of chronic venous insufficiency and varicose veins; acetylcysteine as a mucolytic agent and its questionable efficiency especially by an oral intake; stem cells and cell therapies. In conclusion, placebo therapies can be beneficial and ethically justifiable but it is not a sufficient reason to publish biased information. Importantly, placebo must be devoid of adverse effects, otherwise, it is named pseudo-placebo. Therapeutic methods with unproven effects should be tested in high-quality research shielded from the funding bias. Some issues discussed in this review are not entirely clear, and the arguments provided here can initiate a constructive discussion.</p>","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"6 1","pages":"160-173"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43227336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific Papers and Patents on Substances with Unproven Effects.","authors":"Sergei V Jargin","doi":"10.2174/1872211313666190307162041","DOIUrl":"https://doi.org/10.2174/1872211313666190307162041","url":null,"abstract":"<p><p>It is evident from reviewing scientific literature that the quality of argumentation in some areas of medical research has deteriorated during the last decades. Publication of a series of questionable reliability has continued without making references to the published criticism; examples are discussed in this review. Another tendency is that drugs without proven efficiency are advertised, corresponding products patented and marketed as evidence-based medications. Professional publications are required to register drugs and dietary supplements to obtain permissions for the practical use; and such papers appeared, sometimes being of questionable reliability. Several examples are discussed in this review when substances without proven effects were patented and introduced into practice being supported by publications of questionable reliability. Some of the topics are not entirely clear; and the arguments provided here can induce a constructive discussion.</p>","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"13 1","pages":"37-45"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1872211313666190307162041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37036607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery.","authors":"Srividya Gorantla,&nbsp;Tejashree Waghule,&nbsp;Vamshi Krishna Rapalli,&nbsp;Prem Prakash Singh,&nbsp;Sunil Kumar Dubey,&nbsp;Ranendra Narayan Saha,&nbsp;Gautam Singhvi","doi":"10.2174/1872211314666200108094851","DOIUrl":"https://doi.org/10.2174/1872211314666200108094851","url":null,"abstract":"<p><p>Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.</p>","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"13 4","pages":"291-300"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37521532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Editorial Board Member","authors":"R. Gemeinhart","doi":"10.2174/187221131202180806111325","DOIUrl":"https://doi.org/10.2174/187221131202180806111325","url":null,"abstract":"","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221131202180806111325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48429154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Selections.","authors":"","doi":"10.2174/187221131201180530074014","DOIUrl":"https://doi.org/10.2174/187221131201180530074014","url":null,"abstract":"","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"12 1 1","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221131201180530074014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41922458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Editorial Board Member","authors":"Prem N. Gupta","doi":"10.2174/187221131201180529124916","DOIUrl":"https://doi.org/10.2174/187221131201180529124916","url":null,"abstract":"","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221131201180529124916","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44279268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Produits de protection solaire - Formulation et efficacité","authors":"C. Couteau, Laurence Coiffard","doi":"10.51257/a-v1-j2312","DOIUrl":"https://doi.org/10.51257/a-v1-j2312","url":null,"abstract":"Les produits de protection solaire (PPS), dont l’utilisation fait partie de la strategie globale de prevention des cancers cutanes, sont des cosmetiques, en Europe. Ils sont apparus sur le marche dans les annees 1930 et, depuis lors, leur composition n’a cesse d’evoluer. Apres avoir donne un certain nombre de definitions et fait les rappels reglementaires necessaires, cet article detaille le role des produits de protection solaire, role a mettre en perspective avec leur composition et particulierement avec le choix des filtres par le formulateur. Sont enfin decrites les methodes mises en œuvre afin d’evaluer leur efficacite.","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89898576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawn: Novel Ternary Polymeric Blends for Controlled Release Matrices Containing Weakly Basic Model Drug.","authors":"Wasfy M Obeidat, Shadi F Gharaibeh, Abdolelah A Jaradat","doi":"10.2174/1872211312666180123120021","DOIUrl":"10.2174/1872211312666180123120021","url":null,"abstract":"<p><p>Ahead of Print article withdrawn by publisher.</p>","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35758993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effets des cosmétiques sur la peau et leur objectivation","authors":"T. Lihoreau, C. Viennet, A. Elkhyat, Adeline Jeudy, Ferial Fanian, S. Mac-Mary, J. Sainthillier, C. Courderot-Masuyer, S. Robin, Y. Lboutounne, Gwenaël Rolin, P. Humbert","doi":"10.51257/a-v1-j3004","DOIUrl":"https://doi.org/10.51257/a-v1-j3004","url":null,"abstract":"Les cosmetiques sont appliques sur la peau saine, et revendiquent des actions de nettoyage, parfumage ou protection (definition du code de la sante publique). Sous l’impulsion de dermatologues, scientifiques et industriels, la recherche en cosmetologie s’est developpee et permet desormais d’objectiver leur efficacite de maniere scientifique et a l’aide de methodes toujours plus pointues, en laboratoire ou directement sur l’homme au cours d’essais cliniques. Cet article traite des principales techniques et des contraintes a prendre en compte dans le cadre de la science de la mesure de la peau : la « biometrologie cutanee ».","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84674527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis.","authors":"Deepak Sharma,&nbsp;Amit Sharma,&nbsp;Rajeev Garg","doi":"10.2174/1872211313666190128151038","DOIUrl":"https://doi.org/10.2174/1872211313666190128151038","url":null,"abstract":"<p><strong>Background: </strong>During the recent two decades, the development of mucoadhesive drug delivery system has been gained tremendous importance to cure many recurrent diseases of the oral cavity. The drug delivery through the buccal route is quite challenging due to limited absorption area, movements of the target region and regular flow of saliva lead to the sub-therapeutic drug level in the buccal region.</p><p><strong>Objective: </strong>The aim is to develop unidirectional release mucoadhesive buccal film for the mucosal delivery of Benzydamine Hydrochloride (WO2016126217Al, EP0812193B1) and evaluate the effects of a different grade of HPMC polymer (US5980942A) with the presumption to prolong the residence time and therapeutic effectiveness at the target site.</p><p><strong>Methods: </strong>Mucoadhesive buccal films were prepared by solvent casting evaporation method by employing different grades of HPMC as mucoadhesive and rate controlling polymer. Total twenty-four formulations were developed using ethyl cellulose as a backing layer. The prepared films were subjected to various physicochemical parameters.</p><p><strong>Results: </strong>The physicochemical parameters were found to be varied according to the type and concentration of polymer used. On the basis of in vitro drug release, desired ex-vivo mucoadhesive time, mucoadhesive force the formulations F4, F9, F14 and F19 were subjected to ex vivo drug permeation study. The F14 film containing 1% w/v of HPMC K50M was considered optimized final formulation due to higher ex vivo drug permeation. Drug-excipient compatibility was confirmed by FTIR and DSC. XRD of final formulation revealed the amorphous nature of drug. SEM indicated the perfect binding between backing and adhesive layer.</p><p><strong>Conclusion: </strong>The developed mucoadhesive buccal film having adequate physicochemical properties was capable to provide prolonged residence time and sustained delivery as compared to existing conventional therapies.</p>","PeriodicalId":40024,"journal":{"name":"Recent Patents on Drug Delivery and Formulation","volume":"12 4","pages":"277-294"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36908588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}