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[Quantitative Evaluation of Intracardiac Blood Flow by Left Ventricle Dynamic Anatovy Based On Exact Solutions of Non-Stationary Navier-Stocks Equations for Selforganized tornado-Like Flows of Viscous Incompresssible Fluid]. [基于粘性不可压缩流体自组织龙卷风流的非平稳Navier-Stocks方程精确解的左心室动态解剖对心内血流的定量评价]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2016-01-01
E A Talygin, N A Zazybo, S T Zhorzholiany, I M Krestinich, A A Mironov, G I Kiknadze, L A Bokerya, A Y Gorodkov, V N Makarenko, S A Alexandrova
{"title":"[Quantitative Evaluation of Intracardiac Blood Flow by Left Ventricle Dynamic Anatovy Based On Exact Solutions of Non-Stationary Navier-Stocks Equations for Selforganized tornado-Like Flows of Viscous Incompresssible Fluid].","authors":"E A Talygin,&nbsp;N A Zazybo,&nbsp;S T Zhorzholiany,&nbsp;I M Krestinich,&nbsp;A A Mironov,&nbsp;G I Kiknadze,&nbsp;L A Bokerya,&nbsp;A Y Gorodkov,&nbsp;V N Makarenko,&nbsp;S A Alexandrova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>New approach to intracardiac blood flow condition analysis based on geometric parameters of left ventricle flow channel has been suggested. Parameters, that used in this method, follow from exact solutions of nonstationary Navier-Stocks equations for selforganized tornado-like flows of viscous incompressible fluid. The main advantage of this method is considering dynamic anatomy of intracardiac cavity and trabeculae relief of left ventricle streamlined surface, both registered in a common mri-process, as flow condition indicator. Calculated quantity options that characterizes blood flow condition can be use as diagnostic criterias for estimation of violation in blood circulation function which entails heart ejection reduction. Developed approach allows to clarify heart jet organization mechanism and estimate the share of the tornado-like flow self-organization in heart ejection structure.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"47 1","pages":"48-68"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34458341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Glutamate lonotropic Receptors: Structure, Localisation, Function]. [谷氨酸嗜电性受体:结构，定位，功能]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2016-01-01
V N Perfilova, I N Tyurenkov
{"title":"[Glutamate lonotropic Receptors: Structure, Localisation, Function].","authors":"V N Perfilova,&nbsp;I N Tyurenkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data on the structure, location and function of ionotropic glutamate receptors is shown. These include NMDA-, AMPA-, kainate and orphan receptor, activation them ensures the formation of an action potential. The ionotropic receptors are present in the CNS and peripheral organs. There are a large number of them allosteric modulators, agonists and antagonists. NMDA- and AMPA-receptors play a key role in the origin and manifestation of long-term potentiation. When NMDA- and AMPA-receptors are hyperactivity excitotoxicity arises--a pathological process that causes damage and death of neurons. The ionotropic glutamate receptors are involved in the regulation of mental functions, respiratory, sensory, cardiovascular, nociceptive, etc. g. systems.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"47 1","pages":"80-96"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34375243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulation of Ovarian Function: Part of the Gas Transmitters NO, CO and H2S]. [调节卵巢功能:部分气体发射器NO、CO和H2S]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01
V M Chertok, V G Zenkina
{"title":"[Regulation of Ovarian Function: Part of the Gas Transmitters NO, CO and H2S].","authors":"V M Chertok,&nbsp;V G Zenkina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review discusses the management of ovarian function and participation in the process of a new class of cellular regulators--Gasotransmitters (NO, CO and H2S). According to modern concepts in regulatory processes, in addition to hypothalamic-pituitary mechanisms involved a large and diverse group of ovary cells (interstitial, internal theca and atretic bodies, follicular epithelium, teka-luteal and granulosa-luteal cells of the corpus luteum), which not only mediate the gonadotropic stimulation, but satisfy the for the production of a wide range of biologically active substances. These materials are expected to participate in all these processes gaseous mediators. However, our knowledge of topochemistry, mechanisms and the role of these substances in the important organs of the reproductive system-ovary, fragmentary and do not allow to form a holistic understanding of the cellular mechanisms by which Gasotransmitters have a regulating effect on the individual structures of the ovary in normal functioning of the body and disease. Creation of an experimental model for studying the mechanisms of gaseous mediators in different cell types of ovarian, including endothelial and smooth muscle cells of blood vessels, in which the functional significance of these substances may be particularly significant, will provide fundamental knowledge for the development of new approaches to the treatment of diseases of the reproductive system.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 4","pages":"74-89"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34486281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gas Signalling in Mammalian Cells]. [哺乳动物细胞中的气体信号]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01
S V Gusakova, I V Kovalev, L V Smagliy, Y G Birulina, A V Nosarevi, I V Petrova, M A Medvedevi, S N Orlov, V P Reutov
{"title":"[Gas Signalling in Mammalian Cells].","authors":"S V Gusakova,&nbsp;I V Kovalev,&nbsp;L V Smagliy,&nbsp;Y G Birulina,&nbsp;A V Nosarevi,&nbsp;I V Petrova,&nbsp;M A Medvedevi,&nbsp;S N Orlov,&nbsp;V P Reutov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>At the end of the last century after the discovery of signaling functions of nitric oxide (NO, II), a new class of biologically active substances was admitted. It includes so-called gas transmitters acting as intercellular and intracellular regulators of different physiological functions. Currently, this class includes such gases as NO, carbon monoxide (CO) and hydrogen sulfide (H2S). It was found that these gases regulate not only functions of the. gastrointestinal tract and the cardiovascular system, where it has been determined initially, but also affect the function of the central and peripheral nervous.systems. Apparently, they constitute a single complex of gas transmitters, which easily penetrates through the membrane and regulates numerous enzymatic and non enzymatic cells reactions. This review presents the mechanisms of gas transmitters' influence on the electrical and contractile properties of smooth muscle cells (SMC) as a possible new ways to interact with the \"classical\" intracellular signaling cascades (Ca2+, cyclic nucleotides) and effectors systems. On account of their interactions the role of cyclic nucleotides and calcium ions in the implementation of the signal gas molecules functions is analyzed. We summarize the literature data and the results of our own research on the role of SMC membrane ion-transporting systems in myogenic effects of NO, CO and H2S and describe possible reasons of gas transmitters multidirectional influence on the excitation-contraction coupling in SMC.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 4","pages":"53-73"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34486274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulation of Membrane-Dependent Reactions of Blood Coagulation]. [凝血膜依赖性反应的调控]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01
N A Podoplelova, Y N Kotova, E N Lipets, F I Ataullakhanov, M A Panteleev
{"title":"[Regulation of Membrane-Dependent Reactions of Blood Coagulation].","authors":"N A Podoplelova,&nbsp;Y N Kotova,&nbsp;E N Lipets,&nbsp;F I Ataullakhanov,&nbsp;M A Panteleev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>All major coagulation reactions do not occurs in blood plasma itself, these processes are actually two-dimensional reactions localized to thephospholipid membranes. Almost all blood cells, lipoproteins, and microparticles provide assembly of protein complexes. A central role among them are played by platelets and platelet-derived microparticles. On their membranes occurs the most important coagulation reactions such as activation of prothrombin by prothrombin complex, activation of factor X by complexes intrinsic and extrinsic tenase. This reactions are important for processes activation of the contact path coagulation, activation factor XI by thrombin, appearance of enzymatic activity of factor VIIa etc. This review is focused on the membrane-dependent reactions, here are discussed mechanisms and regulation these reactions and the possible prospects of the study.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 4","pages":"3-14"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34551348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Role of Cytokines MIC-1/GDF15 in Development of the Old Age Disease]. [细胞因子MIC-1/GDF15在老年疾病发生中的作用]
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01
V Kh Khavinson, B I Kuznik, N S Linkova, N V Kolchina
{"title":"[The Role of Cytokines MIC-1/GDF15 in Development of the Old Age Disease].","authors":"V Kh Khavinson,&nbsp;B I Kuznik,&nbsp;N S Linkova,&nbsp;N V Kolchina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review provides information about the structure and basic functions of the cytokine MIC-1/GDF15. MIC-1/GDF15 is normally contained not only in blood, but also expressed on cells of reproductive and nervous system. Its concentration increases in various diseases of the central nervous system, cardiovascular system, thromboembolism, malignant tumors and other pathological conditions, the most common in the elderly. It was demonstrated that the correlation between the level of MIC-1/GDF15 and the severity of the pathological process, disease prognosis, including fatalities, therefore it was named \"predictor of death\". In gene promoter MIC-1/GDF15 was detected geroprotective binding sites for peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly. Probably, these peptides regulate the synthesis of MIC-1/GDF15, whereby its geroprotective effect may be accounted.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 4","pages":"38-52"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34551354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological Role of Oligomerny Matriksny of Protein of the Cartilage in Exchange Processes Connecting Tissue]. 软骨蛋白寡聚基质在连接组织的交换过程中的生物学作用。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01
Yu S Belova
{"title":"[Biological Role of Oligomerny Matriksny of Protein of the Cartilage in Exchange Processes Connecting Tissue].","authors":"Yu S Belova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the review the literary data on studying of biological role of a oligomerny matriksny of protein of the cartilage in exchange processes connecting tissue at people and animals are provided, and also results of own researches on definition of a oligomerny matriksny of protein of the cartilage as a modern marker of a metabolism of an articulate cartilage at children from undifferentiated displaziy conjunctive tissue are briefly described.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 4","pages":"90-6"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34487724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Neurovisalization Studies of the Self]. [自我的神经可视化研究]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01
M Ye Melnikov, M B Shtark
{"title":"[Neurovisalization Studies of the Self].","authors":"M Ye Melnikov,&nbsp;M B Shtark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Paper reviews contemporary standards and results of neurovisualization studies of the human Self. It's been shown, that the medial prefrontal cortex plays the main role in supporting this mental function. The cingulate, the inferior parietal lobule and the precuneus has less influence on this process. Emotional aspects of the Self are also likely to be associated with involvement of the amygdala, and embodiment is related to the insular cortex. In schizophrenia patients, activity of identified network decreases while in case of depression, anxiety or autism it increases.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 4","pages":"15-27"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34551349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[GPR119 Receptor Agonists: Characteristics, Physiological Role, Prospects of Use in the Treatment of Diabetes Mellitus Type 2 and Metabolic Syndrome]. [GPR119受体激动剂:特点、生理作用及在2型糖尿病和代谢综合征治疗中的应用前景]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01
I N Tyurenkov, D V Kurkin, D A Bakulin, E M Lomkina, E V Volotova
{"title":"[GPR119 Receptor Agonists: Characteristics, Physiological Role, Prospects of Use in the Treatment of Diabetes Mellitus Type 2 and Metabolic Syndrome].","authors":"I N Tyurenkov,&nbsp;D V Kurkin,&nbsp;D A Bakulin,&nbsp;E M Lomkina,&nbsp;E V Volotova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Last decade GPR119 receptor attracted great attention of many researchers groups worldwide. This receptor is expressed in enteroendocrine L- and K-intestinal cells and pancreas beta cells. First endogenous ligands for GPR119 was found in 2005: fatty acid metabolites, some phospholipids and fatty acid amides derivatives. GPR119 receptor is involved in the glucose metabolism regulation: glucose-dependent insulin secretion, glucose-independent incretin secretion, appetite control, gastric emptying, as well as beta cell proliferation. Thus, GPR119 is a \"sensor\" of some fatty acid derivatives and-GPR119 is a promising new pharmacological target for the treatment of type 2 diabetes.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 4","pages":"28-37"},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34551352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Connectomics: Neurophysiology, Achievements and Perspectives]. [连接组学:神经生理学，成就和观点]。
Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-07-01
N N Lebedeva, L A Mayorova, E D Karimova, E A Kazimirova
{"title":"[The Connectomics: Neurophysiology, Achievements and Perspectives].","authors":"N N Lebedeva,&nbsp;L A Mayorova,&nbsp;E D Karimova,&nbsp;E A Kazimirova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The review is devoted to researches in the relatively new field of neuroscience--connectomics. The theoretical and applied aspects of connectom studying are observed. The concept of connectom is defined as well as its attributes such as connectivity. The review describes the basic modern methods of the connectom investigation, existing data on the connectom structure in normal and pathological conditions, as well as prospects for the development of a new field of knowledge--connectomics.</p>","PeriodicalId":39939,"journal":{"name":"Uspekhi Fiziologicheskikh Nauk","volume":"46 3","pages":"17-45"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34122342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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