[GPR119受体激动剂:特点、生理作用及在2型糖尿病和代谢综合征治疗中的应用前景]。

Q4 Biochemistry, Genetics and Molecular Biology

Uspekhi Fiziologicheskikh Nauk Pub Date : 2015-10-01

I N Tyurenkov, D V Kurkin, D A Bakulin, E M Lomkina, E V Volotova

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引用次数: 0

摘要

近十年来，GPR119受体引起了世界范围内众多研究团体的高度关注。该受体在肠内分泌L-和k -肠细胞和胰腺β细胞中表达。2005年首次发现GPR119的内源性配体:脂肪酸代谢物、一些磷脂和脂肪酸酰胺衍生物。GPR119受体参与葡萄糖代谢调节:葡萄糖依赖型胰岛素分泌、葡萄糖依赖型肠促胰岛素分泌、食欲控制、胃排空以及β细胞增殖。因此，GPR119是一些脂肪酸衍生物的“传感器”，GPR119是治疗2型糖尿病的一个有前景的新药理靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[GPR119 Receptor Agonists: Characteristics, Physiological Role, Prospects of Use in the Treatment of Diabetes Mellitus Type 2 and Metabolic Syndrome].

Last decade GPR119 receptor attracted great attention of many researchers groups worldwide. This receptor is expressed in enteroendocrine L- and K-intestinal cells and pancreas beta cells. First endogenous ligands for GPR119 was found in 2005: fatty acid metabolites, some phospholipids and fatty acid amides derivatives. GPR119 receptor is involved in the glucose metabolism regulation: glucose-dependent insulin secretion, glucose-independent incretin secretion, appetite control, gastric emptying, as well as beta cell proliferation. Thus, GPR119 is a "sensor" of some fatty acid derivatives and-GPR119 is a promising new pharmacological target for the treatment of type 2 diabetes.

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来源期刊

Uspekhi Fiziologicheskikh Nauk Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal publishes reviews on various aspects of physiology and also original articles concerned with fundamental problems, based both on the data available in literature and on the experimental results obtained by the contributor.