NowotworyPub Date : 2023-09-05DOI: 10.5603/njo.a2023.0033
Angelina P. Kaleta-Pilarska, Kamil Barański
{"title":"Mental adjustment to cancer in patients with colorectal cancer","authors":"Angelina P. Kaleta-Pilarska, Kamil Barański","doi":"10.5603/njo.a2023.0033","DOIUrl":"https://doi.org/10.5603/njo.a2023.0033","url":null,"abstract":"Introduction. Exploration of the psychological aspects of cancer may play a key role in the disease’s progression. Active mental strategies have been associated with a better prognosis. Due to these associations, the aim of this study is to assess the prevalence and elucidate determinants influencing mental adjustment in patients with colorectal cancer. Material and methods. A cross-sectional study identifying 200 patients with colorectal cancer. The mental state of patients was measured with an adaptation the of mini-MAC questionnaire. Results. Constructive determinants influencing the occurrence of mental adaptation to colorectal cancer are the presence of the disease in the family, fitness status and smoking status. Education level is an important destructive determinant influencing the occurrence of mental adaptation to colorectal disease. Conclusions. Among the patients with colorectal cancer, the destructive and constructive style of mental adaptation occurs with a similar frequency (26.5% and 22.5%).","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135363978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2023-09-05DOI: 10.5603/njo.96116
Elwira Gliwska, Anna M. Badowska Kozakiewicz
{"title":"Alcohol availability, consumption, and knowledge of alcohol-related cancer risk among citizens of Warsaw","authors":"Elwira Gliwska, Anna M. Badowska Kozakiewicz","doi":"10.5603/njo.96116","DOIUrl":"https://doi.org/10.5603/njo.96116","url":null,"abstract":"Introduction. The high availability of alcohol products and low awareness of their harmful effects appear to influence individual health conditions and cancer risk. Material and methods. We used publicly available data on alcohol retailers in Warsaw to assess the availability of alcohol products for each district of the city and the AUDIT C questionnaire to assess drinking behavior. Results. Alcohol outlets were located within 500 meters of residence for most of the study group. We found risky alcohol consumption in about 15% of respondents. Knowledge about the harmfulness of excessive alcohol consumption had a statistically significant effect on the number of drinks consumed (p < 0.05). Conclusions. The study confirmed the high availability and affordability of alcoholic products and the high percentage of risky alcohol behaviors among Warsaw’s citizens. In addition, low awareness of the harmful effects of alcohol was associated with higher consumption, which emphasizes the need to improve educational strategies.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135363983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2023-09-05DOI: 10.5603/njo.a2023.0031
Magdalena Tarkowska, Iwona Głowacka-Mrotek, Damian Peterson, Michał Jankowski, Beata Pilarska, Łukasz Leksowski, Dorota Ratuszek-Sadowska, Anna Lewandowska, Piotr Jarzemski
{"title":"Quality of life at 3 to 5 years after surgical treatment of renal cell carcinoma – a pilot cross-sectional study","authors":"Magdalena Tarkowska, Iwona Głowacka-Mrotek, Damian Peterson, Michał Jankowski, Beata Pilarska, Łukasz Leksowski, Dorota Ratuszek-Sadowska, Anna Lewandowska, Piotr Jarzemski","doi":"10.5603/njo.a2023.0031","DOIUrl":"https://doi.org/10.5603/njo.a2023.0031","url":null,"abstract":"Introduction. Predicted distant health-related quality of life is one of the key elements in the long-term assessment of the effectiveness of therapy, and a factor to be taken into account when deciding upon the choice of therapeutic options in modern cancer surgery. To assess the quality of life of patients having undergone surgical treatment for renal cell carcinoma. Material and methods. This cross-sectional study was carried out in a group of 44 (17 radical nephrectomy [RN], 27 nephron-sparing surgery [NSS]) patients having received surgical treatment for renal cell carcinoma at the Department of Urology of the University Hospital no. 2 in Bydgoszcz. The control group consisted of 24 subjects within a matching age range. The standardized WHOQOL-BREF questionnaire was used as the study tool. Results. No statistically significant differences (p > 0.05) were observed with regard to the subjectively assessed quality of life depending on the type of surgery performed, i.e. RN vs. NSS. A positive correlation was observed between the higher scores within the social (p = 0.0453) and environmental (p = 0.0156) domains and the laparoscopic approach. Lower scores within the somatic (p = 0.0023), environmental (p = 0.0189) and emotional (p = 0.0356) scale domains were observed in female patients. A statistically significant inverse relationship was observed between the cancer stage and the self-assessed overall health scores (p = 0.0025). Conclusions. Minimally invasive surgical techniques open up the potential for the achievement of better quality of life of patients after surgery. Clinical and demographic variables influence the long-term health-related quality of life scores.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135363982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2023-06-27DOI: 10.5603/njo.96212
Renata Langfort, Maciej Krzakowski, Dariusz M. Kowalski, Rafał Krenke, Tadeusz Orłowski, Witold Rzyman, Bartosz Wasąg
{"title":"Expert opinion on adjuvant treatment with osimertinib in patients with non-small cell lung carcinoma after radical tumor resection","authors":"Renata Langfort, Maciej Krzakowski, Dariusz M. Kowalski, Rafał Krenke, Tadeusz Orłowski, Witold Rzyman, Bartosz Wasąg","doi":"10.5603/njo.96212","DOIUrl":"https://doi.org/10.5603/njo.96212","url":null,"abstract":"1Department of Pathology, National Research Institute of Tuberculosis and Lung Diseases, Warsaw, Poland 2Department of Lung Cancer and Thoracic Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland 3Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland 4Department of Surgery, National Research Institute of Tuberculosis and Lung Diseases, Warsaw, Poland 5Department of Thoracic Surgery, Medical University of Gdańsk, Poland 6Chair and Department of Biology and Medical Genetics, Medical University of Gdańsk, Poland 7Laboratory of Clinical Genetics, University Clinical Centre, Gdańsk, Poland","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135503896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2022-01-01DOI: 10.5603/NJO.a2022.0013
K. Slosarek, T. Rutkowski, Adam Gądek, Łukasz Sroka, Ł. Dolla, R. Rutkowski, J. Jaroszewicz
{"title":"Dose estimation in patients treated with radiotherapy for SARS-COVID disease based on EPID measurement","authors":"K. Slosarek, T. Rutkowski, Adam Gądek, Łukasz Sroka, Ł. Dolla, R. Rutkowski, J. Jaroszewicz","doi":"10.5603/NJO.a2022.0013","DOIUrl":"https://doi.org/10.5603/NJO.a2022.0013","url":null,"abstract":"Introduction. COVID radiotherapy requires performance of all radiotherapy (RT) procedures during one site visit due to the infectious nature of the disease. The aim of the study was to develop methods of estimating the delivered dose based on electronic portal image device (EPID) signal during treatment. Material and methods. Electronic portal image device signal was measured as a function of the phantom dose. The dose in 14 COVID patients was estimated for two X6MV beams. Results. The method allows to estimate dose in phantom with uncertainty of 12%. In this case, a systematic error was reported. Therefore, coefficients for clinical data were calculated and used to determine the dose in patients. The mean difference between the dose calculated and the dose measured for the 14 patients was 1%, but the uncertainty of this method was estimated as ±6% Conclusions. The proposed method may be useful in clinical practice as in vivo method. However, due to high uncertainty, it should be dedicated to the detection of “big” errors.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"457 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76063914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2021-06-09DOI: 10.5603/NJO.2021.0033
P. Koczkodaj, M. Cedzyńska, P. Rutkowski, Amelia Janiak, I. Przepiórka, A. Ciuba, M. Mańczuk, K. Przewoźniak, J. Didkowska
{"title":"Smoking cessation help for cancer patients – a pilot project “Quitting Supports Treatment”","authors":"P. Koczkodaj, M. Cedzyńska, P. Rutkowski, Amelia Janiak, I. Przepiórka, A. Ciuba, M. Mańczuk, K. Przewoźniak, J. Didkowska","doi":"10.5603/NJO.2021.0033","DOIUrl":"https://doi.org/10.5603/NJO.2021.0033","url":null,"abstract":"Available data suggest that up to 50% of cancer patients, who were smoking before diagnosis, continue to smoke during treatment, unaware of the damage caused due to continued tobacco use and the undervalued benefits of quitting smoking after a cancer diagnosis. Structured initiatives aimed at helping cancer patients give up smoking was undertaken at the M. Sklodowska-Curie National Research Institute of Oncology in Warsaw (Poland) within the pilot project “Quitting Supports Treatment (QST)”. QST was launched in September 2019 and was a joint initiative of two departments: 1. The Cancer Epidemiology and Primary Prevention Department and 2. The Soft Tissue/Bone Sarcoma and Melanoma Department. Moreover, QST works with the significant support of Department of Nurses and Midwives Professional Development. The preliminary results suggest the need for several organizational improvements in order to increase QST participation rates. Revision of previous experiences could bring valuable conclusions with regards to the effectiveness of QST, but also for other similar projects.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"100 1","pages":"176-178"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78606223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2021-06-09DOI: 10.5603/NJO.2021.0032
J. Gil, I. Łaczmańska, M. Sąsiadek, M. Ziętek
{"title":"Personalised medical management of patients with melanoma (part 1)","authors":"J. Gil, I. Łaczmańska, M. Sąsiadek, M. Ziętek","doi":"10.5603/NJO.2021.0032","DOIUrl":"https://doi.org/10.5603/NJO.2021.0032","url":null,"abstract":"In recent years, a dynamic increase has been observed in occurrence of melanomas, especially in young and middle-aged patients. This is the reason why curing these patients has become a priority also in the economic context. Melanomas belong to a group of neoplasms of very high genetic heterogeneity. The most common genetic alterations concern two signalling pathways: mitogen-activated pathway (MAPK) and phosphoinositide 3-kinase (PI3K) pathway. Identification of the characteristic molecular changes in the neoplastic tissue allows optimisation and individualisation of the therapy. Thus, it contributes to an increase in successful cancer treatment, reduction of treatment side effects and to improvement of the patients’ quality of life. Currently, the standard management of skin melanoma patients involves – along with surgical treatment and classical chemo/radiotherapy which is now less frequently used – also introduction of targeted therapy focused on molecular changes within the tumour tissue as well as immunotherapy which relies on activating the immune system.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"19 1","pages":"169-175"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83677919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2021-06-09DOI: 10.5603/NJO.2021.0028
Adam Dmitruk, T. Olesiński, P. Hevelke, Łukasz Zyskowski, A. Rutkowski
{"title":"Long-term results of randomized studies on the use of a gentamicin-collagen sponge in rectal cancer – depending on the length of time between the completion of radiotherapy and the surgery","authors":"Adam Dmitruk, T. Olesiński, P. Hevelke, Łukasz Zyskowski, A. Rutkowski","doi":"10.5603/NJO.2021.0028","DOIUrl":"https://doi.org/10.5603/NJO.2021.0028","url":null,"abstract":"Introduction. Two randomized studies on the use of a gentamicin-collagen sponge (GRM01/1997 and GRM02/2007) in rectal cancer surgery showed a statistically significant decrease in the rate of distant metastases in the experimental group and a similar rate of local recurrences. The objective of the presented study was a retrospective evaluation of the effect of the GRM use on the observed rate of generalized recurrences, disease-free survival (DFS), overall survival (OS) and cancer-specific survival (CSS) – depending on the length of the interval between radiotherapy and surgery. Materials and methods. The study comprised 239 patients, included previously into randomized studies, in whom the 5 x 5 Gy radiotherapy was used. In 204 people, the surgery was made within 7 days of the completion of radiotherapy (group A). The remaining group of 35 patients were operated on after 4–8 weeks (group B). The follow-up period was 5 years. The statistical analysis was made with the Kaplan-Meier test. The value of α = 0.05 was degfined as the threshold of statistical significance. Results. In both groups, there were no statistical differences between the patients operated on with the use of GRM and those operated on without the use of GRM. The analysis took into consideration the most significant parameters, which could affect the oncological results, (ypTNM, lympho-vascular invasion (LVI), blood vessel invasion (BVI). In group A, the use of GRM was connected with a lower rate of metachronic distant metastases (p = 0.002; RR 0.41; 95% CI [0.24–0.72]), the prolongation of DFS (p = 0.008; HR 2.16; 95% CI [1.20–3.83]) and of CSS (p = 0.010; HR 2.37; 95% CI [1.20–4. 67]). No such relationships were observed in group B. Conclusions. The use of GRM decreases the risk of distant metastases and has an influence on the prolongation of recurrence free survival, but only when surgery is carried out within 7 days of the completion of irradiation.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"72 1","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72936297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NowotworyPub Date : 2021-06-09DOI: 10.5603/NJO.A2021.0019
A. Celejewska, B. Maciejewski, J. Wydmański, K. Składowski
{"title":"The efficacy of IORT (intraoperative radiotherapy) for early advanced breast cancer depending on the time delay of external beam irradiation (EXRT) post conservative breast surgery (CBS)","authors":"A. Celejewska, B. Maciejewski, J. Wydmański, K. Składowski","doi":"10.5603/NJO.A2021.0019","DOIUrl":"https://doi.org/10.5603/NJO.A2021.0019","url":null,"abstract":"Introduction. The following study focuses on the efficacy of the IORT (14.4 izoGy2.0) as part of conservative surgery with adjuvant EXRT (50 Gy in 25 fractions) for low risk 109 early breast cancer patients and 106 intermediate or nonlinear high risk patients with adjuvant chemoradiation or chemotherapy followed by the EXRT. Material and methods. The accumulation of the rates of local recurrences (LR) and distant metastases (DM) are characterized by nonlinear but two-phase curves. Results. During the first 5 years, 67% of all LR, and only 43% of all DM occurred, and between the 8th and 10th years the LR curve steeply increases by 25% and the DM by 48%. Conclusion. This suggest that a 5-year follow-up is too short and should be extended to 10 years. Among the analyzed prognostic factors, the time interval (TI) between IORT and adjuvant EXRT has occurred the major prognostic risk factor. If the TI is extended over 60 days (delayed EXRT), the LR and the DM risk undergoes a3–10 fold increase. Concurrent CH-EXRT significantly lowers local and distant failures, compared with delayed EXRT after completing CHT. Therefore, delayed EXRT completely ruins the expected efficacy of the IORT.","PeriodicalId":39938,"journal":{"name":"Nowotwory","volume":"1 1","pages":"133-138"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73463832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}