Journal of Medical Sciences (Taiwan)最新文献_第8页

Respiratory syncytial virus and Streptococcus pneumoniae Co-infection in an elderly individual within a familial cluster 呼吸道合胞病毒和肺炎链球菌合并感染的一个家庭聚集性老年人

Journal of Medical Sciences (Taiwan) Pub Date : 2023-01-01 DOI: 10.4103/jmedsci.jmedsci_318_21

Ju-Chien Hsueh, Der‐Ming Chu, F. Chang, Yung-Chih Wang

引用次数: 0

Refixation of labrum in pincer type of femoroacetabular impingement 钳夹型股骨髋臼撞击中阴唇再充填术

Journal of Medical Sciences (Taiwan) Pub Date : 2023-01-01 DOI: 10.4103/jmedsci.jmedsci_331_21

Tsang-Shuo Shao, Pei-Hung Shen, R. Pan

引用次数: 1

Psychological Impacts of COVID-19 Pandemic 新冠肺炎大流行的心理影响

Journal of Medical Sciences (Taiwan) Pub Date : 2023-01-01 DOI: 10.4103/jmedsci.jmedsci_269_21

Cian-Cian Lin, C. Yeh

引用次数: 7

Elucidating the role of SLC4A7 in glioma prognosis: A comprehensive approach combining bioinformatics, single-cell analysis, and tissue validation 阐明SLC4A7在胶质瘤预后中的作用:结合生物信息学、单细胞分析和组织验证的综合方法

Journal of Medical Sciences (Taiwan) Pub Date : 2023-01-01 DOI: 10.4103/jmedsci.jmedsci_96_23

Yao-Feng Li, Tung Liu, Nien-Tzu Liu, Yu-Chuan Huang, Wei-Wen Hsu, Yu-Chieh Lin

{"title":"Elucidating the role of SLC4A7 in glioma prognosis: A comprehensive approach combining bioinformatics, single-cell analysis, and tissue validation","authors":"Yao-Feng Li, Tung Liu, Nien-Tzu Liu, Yu-Chuan Huang, Wei-Wen Hsu, Yu-Chieh Lin","doi":"10.4103/jmedsci.jmedsci_96_23","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_96_23","url":null,"abstract":"Background: Gliomas, prevalent and lethal brain tumors, present limited treatment options despite advancements in understanding their molecular features. SLC4A7, an SLC4 family member and potential biomarker, is involved in acid-base regulation, affecting cancer cell growth. Targeting this mechanism may offer new therapeutic strategies. Aim: This study examines SLC4A7's role in gliomas and its potential as a therapeutic target. Methods: Genomic, whole exon sequencing, and single-cell sequencing datasets from glioma patients were processed and analyzed, followed by gene set enrichment analysis (GSEA). Cellular components and immune cell populations were investigated using 12-cell state and CIBERSORT analyses. Tissue microarray and immunohistochemistry were employed, with an automated semi-quantitative system scoring staining. ANOVA determined the significance of immunostaining scores related to clinical parameters. Results: Our data found increased SLC4A7 in tumor components correlated with higher tumor grading and poorer prognosis. Immunohistochemistry confirmed a relationship between SLC4A7 protein expression with tumor grade and the proliferation index. GSEA linked high SLC4A7 to cell proliferation and inflammation signaling. PIK3CAs were identified as a potential upstream in IDH mutant glioma but not in IDH wildtype. A positive correlation between heightened SLC4A7 expression and tumor mutation burden suggested genomic instability's role in SLC4A7 upregulation. Cellular heterogeneity analysis highlighted the importance of inflammatory cells, particularly macrophage M0. Conclusion: This study emphasizes SLC4A7's significance in adult gliomas, associating increased expression with high tumor grade, poor prognosis, enhanced proliferation, and inflammation. Investigating SLC4A7 may provide insights into cancer biology and contribute to developing innovative therapeutic targets for improved brain tumor treatments.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135958449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SEVERE MATERNAL MALNUTRITION: WHETHER THE BABIES ARE AT RISK OF BOTTLE FEEDING? 母亲严重营养不良：婴儿是否有奶瓶喂养的风险？

Journal of Medical Sciences (Taiwan) Pub Date : 2022-12-30 DOI: 10.52764/jms.22.30.4.1

Kaleem UR Rehman Syed, Sabahat Amir, Imad Ali shah, Asad Ullah, H. Bashir, S. Bahar

{"title":"SEVERE MATERNAL MALNUTRITION: WHETHER THE BABIES ARE AT RISK OF BOTTLE FEEDING?","authors":"Kaleem UR Rehman Syed, Sabahat Amir, Imad Ali shah, Asad Ullah, H. Bashir, S. Bahar","doi":"10.52764/jms.22.30.4.1","DOIUrl":"https://doi.org/10.52764/jms.22.30.4.1","url":null,"abstract":"Objectives: This research paper aims at finding the association between maternal malnutrition with their choice of feeding practices (breast, bottle, or mix) of infants who are under 6 months of age.\u0000Material and Methods: This cross-sectional study was undertaken from 1st March 2019 to 31st August 2019 at the inpatient and outpatient of the pediatric department of Khyber Teaching Hospital Peshawar. The data was collected on a predesigned proforma recording demographic characteristics of the responders and their feeding practices; exclusive breastfeeding or mixed (breast+ bottle) feeding. Additionally, maternal malnutrition was assessed by calculating their BMI. The data were analyzed in SPSS version 23. Chi-squared was used to analyze the data.\u0000Results: A total of 278 mothers of infants 1-6 months were interviewed about their feeding practices and BMI recorded. The association between maternal malnutrition and breast/bottle feeding was insignificant (P>0.05).\u0000Conclusion: There is no association between maternal malnutrition and the choice of bottle feeding of infants.\u0000Keywords: Infants, bottle feeding, breastfeeding, maternal malnourishment, body mass index\u0000 ","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46372160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PLATELET INDICES IN LEUKEMIAS: - A CROSS SECTIONAL STUDY 白血病的血小板指数:一项横断面研究

Journal of Medical Sciences (Taiwan) Pub Date : 2022-12-30 DOI: 10.52764/jms.22.30.4.12

Huma Riaz, M. Idrees, Saima Qayyum, M. Waqas, Zarmina Hussain, M. I. Khan

{"title":"PLATELET INDICES IN LEUKEMIAS: - A CROSS SECTIONAL STUDY","authors":"Huma Riaz, M. Idrees, Saima Qayyum, M. Waqas, Zarmina Hussain, M. I. Khan","doi":"10.52764/jms.22.30.4.12","DOIUrl":"https://doi.org/10.52764/jms.22.30.4.12","url":null,"abstract":"Objective: To evaluate the pattern of changes in the platelet indices in different Leukemias.\u0000Material and method: This descriptive cross-sectional study was conducted in the Pathology Department of Khyber Teaching Hospital from January 2021 to December 2021 (1-year duration). Diagnosed acute and chronic leukemia cases were included while those receiving therapeutic chemotherapy were excluded. The platelet count was analyzed as a part of complete blood counts by the Sysmex Hematology analyzer in the Hematology section of the Pathology department. The changes observed in the platelet counts in different types of leukemia were recorded in a proforma. Mean, standard deviation, frequency and percentages were used to compute variables.\u0000Results: The age range of the 100 included cases of leukemia was 01 - 50 years. The mean age of the study population was 30 ± 10 SD years. Platelet count was low in acute Leukemias and chronic lymphocytic leukemia. Only in chronic myeloid leukemia, raised platelet count was seen (in 62% of cases). Mean platelet volume and platelet distribution width were decreased in all leukemias.\u0000Conclusion: Platelet indices are decreased in Leukemias, with the exception of chronic myeloid leukemia where platelet count is raised.\u0000Keywords: Platelet count, Acute lymphoid leukemia, Acute myelogenous leukemia, Chronic lymphocytic leukemia, Chronic myelogenous leukemia.\u0000 \u0000 \u0000 ","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47344438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FREQUENCY OF HELICOBACTER PYLORI INFECTION AS DETECTED BY STOOL ANTIGEN TEST IN PATIENTS WITH FUNCTIONAL DYSPEPSIA 功能性消化不良患者粪便抗原检测幽门螺杆菌感染的频率

Journal of Medical Sciences (Taiwan) Pub Date : 2022-12-30 DOI: 10.52764/jms.22.30.4.18

Ghulam Abbas, S. Iqbal, Jamaluddin

{"title":"FREQUENCY OF HELICOBACTER PYLORI INFECTION AS DETECTED BY STOOL ANTIGEN TEST IN PATIENTS WITH FUNCTIONAL DYSPEPSIA","authors":"Ghulam Abbas, S. Iqbal, Jamaluddin","doi":"10.52764/jms.22.30.4.18","DOIUrl":"https://doi.org/10.52764/jms.22.30.4.18","url":null,"abstract":"OBJECTIVES\u0000To determine H. Pylori frequency in patients presenting with functional dyspepsia using H. Pylori antigen test in the stool sample.\u0000 \u0000MATERIALS AND METHODS\u0000One hundred and sixty-five adult patients presenting with symptoms suggestive of functional dyspepsia to the medical outpatients’ Department of Khyber Teaching Hospital Peshawar, were tested for Helicobacter Pylori by detecting stool Helicobacter Pylori antigen. Patients with chronic debilitating illnesses or peptic ulcer disease were excluded from the study. The frequency of the positive test was calculated. The independent-sample t-test and Chi-square test were used to compare the results for different variables. A P-value of 0.05 was considered significant.\u0000 \u0000RESULTS\u0000Out of 165 patients, 54% were males and 46% were females. The mean age of the patients was 32±7 years, ranging from 18 to 52 years. The stool antigen test for H. Pylori was positive in 58% of patients. Proton pump inhibitor drugs significantly affect the positive results. Alanine aminotransferase levels were significantly different between the stool antigen-positive and stool antigen-negative patients.\u0000 \u0000CONCLUSION\u0000Helicobacter Pylori infection is quite common in patients with functional dyspepsia. These patients with positive antigen tests should be treated with H. Pylori eradication therapy.\u0000 \u0000KEYWORDS\u0000Helicobacter Pylori, Dyspepsia, Stool antigen test\u0000 ","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47889128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PATTERN OF INJURIES IN ROAD TRAFFIC ACCIDENTS AT PESHAWAR: AN AUTOPSY BASED STUDY 白沙瓦道路交通事故伤害模式:基于尸体解剖的研究

Journal of Medical Sciences (Taiwan) Pub Date : 2022-12-30 DOI: 10.52764/jms.22.30.4.11

Faizan Nadeem, Muhammad Wasif, Noor ul baqi, Iftikhar Ahmad

{"title":"PATTERN OF INJURIES IN ROAD TRAFFIC ACCIDENTS AT PESHAWAR: AN AUTOPSY BASED STUDY","authors":"Faizan Nadeem, Muhammad Wasif, Noor ul baqi, Iftikhar Ahmad","doi":"10.52764/jms.22.30.4.11","DOIUrl":"https://doi.org/10.52764/jms.22.30.4.11","url":null,"abstract":"Objective\u0000To assess the pattern of injuries in autopsy examination of road traffic accident cases at Peshawar.\u0000Materials and Methods\u0000A community-based descriptive cross-sectional study included a total of 94 candidates presented for autopsy at the forensic medicine department, Khyber medical college from 01st July 2020 to 30th June 2021.\u0000Results\u0000The age of the subjects ranged from 2-80 years with a mean age of 36.9 ± 20.7 years. 96.8 % of subjects were having multiple injuries whereas, 3.2% were having a single injury. Overall, 94 cases had a total number of 303 injuries, out of which 90.76% were small-sized, 7.92% were medium-sized and 1.32% were large-sized including all kinds of injuries. The most common presenting injury was laceration (87.2%), preceded by abrasion (59.6%), then contusion (51.1%), fracture (23.4%), and hematoma (2.1%). The most common region involved in RTA was head & neck with 86.17%. Maximal deaths occurred within 3-6 hours following an RTA. The most common cause of death was an injury to the brain and its associated vessels. There is no significant correlation noted between the patterns of injury and the cause of death of subjects (p<0.05).\u0000Conclusion\u0000Our study shows the pattern of injuries and causes of death via RTA, as there is no study conducted in this region. It will be useful to Law Enforcement agencies in implementing rules and regulations in preventing RTA and public awareness.\u0000Keywords: Road Traffic accidents, Autopsy findings","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41637593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLINICO-PATHOLOGICAL PROFILE OF PATIENTS OF DENGUE FEVER IN DISTRICT PESHAWAR 白沙瓦地区登革热患者临床病理分析

Journal of Medical Sciences (Taiwan) Pub Date : 2022-12-30 DOI: 10.52764/jms.22.30.4.14

M. Idrees, Zarmina Hussain, Saima Qayyum, Huma Riaz, M. Waqas, M. I. Khan

{"title":"CLINICO-PATHOLOGICAL PROFILE OF PATIENTS OF DENGUE FEVER IN DISTRICT PESHAWAR","authors":"M. Idrees, Zarmina Hussain, Saima Qayyum, Huma Riaz, M. Waqas, M. I. Khan","doi":"10.52764/jms.22.30.4.14","DOIUrl":"https://doi.org/10.52764/jms.22.30.4.14","url":null,"abstract":"Objectives: This study was conducted with the aim to highlight the clinic-pathological profile of patients with dengue fever in Peshawar.\u0000Materials and methods: It was a cross-sectional study conducted at Khyber Teaching Hospital, Peshawar from September 2021 to January 2022. All cases with positive Dengue serology as done by ICT kit were included in the study. Cases with significant symptoms of Dengue but negative serology were excluded from the study. Clinical data and results of liver function tests were recorded. Mean and standard deviation was used for quantitative data while frequency and percentages were used for qualitative data.\u0000Results: About 100 diagnosed cases of dengue fever were included. Seventy-four (74%) cases had dengue fever, while 24 (24%) cases had dengue hemorrhagic fever. About 2 (2%) cases had dengue shock syndrome. Serum Alanine transaminase level was abnormal in most of the cases.\u0000Conclusion: The study reveals that the majority of the cases of dengue fever have mild to moderate disease. Severe disease was seen in a very small proportion of patients.\u0000Keywords: Dengue hemorrhagic Fever, Liver Function Tests, Platelets count.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43439507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECTIVENESS OF LIRAGLUTIDE IN REDUCING BODY WEIGHT AND IMPROVING GLYCEMIC CONTROL IN PATIENTS WITH T2DM 利拉鲁肽对T2DM患者减轻体重和改善血糖控制的有效性

Journal of Medical Sciences (Taiwan) Pub Date : 2022-12-30 DOI: 10.52764/jms.22.30.4.15

Sifat Ullah, Arshad Hussain, Shaista Kanwal, Arif Jamal, Muhammad Saleh Faisal

{"title":"EFFECTIVENESS OF LIRAGLUTIDE IN REDUCING BODY WEIGHT AND IMPROVING GLYCEMIC CONTROL IN PATIENTS WITH T2DM","authors":"Sifat Ullah, Arshad Hussain, Shaista Kanwal, Arif Jamal, Muhammad Saleh Faisal","doi":"10.52764/jms.22.30.4.15","DOIUrl":"https://doi.org/10.52764/jms.22.30.4.15","url":null,"abstract":"Objective: This study aimed to determine the effects of Liraglutide on glycosylated hemoglobin (HbA1c) and body weight in patients with type 2 diabetes.\u0000Material and Methods: A prospective observational study was conducted in a private tertiary healthcare setting. A total of 58 adult patients with T2DM using oral anti-diabetic agents with or without insulin were enrolled in the study from November 2020 to April 2022. Liraglutide was administered at a dose of 0.6 mg/day which was raised to 1.2 mg/day after 1 week and later to 1.8 mg/day depending upon patient preferences and tolerability. Patients were assessed for changes in their body weight, fasting blood glucose (FBG) level, random blood glucose (RBG) level, and HbA1c at the 1st and 2nd follow-up visits of the 8th and 16th week, respectively.\u0000Results: At the 16th week, the mean weight was 100.78±17.56 vs 102.74±17.26 and 104.11±17.95 at the 8th week and baseline visit, revealing a significant difference across three-time points [F(1.4, 36.45)=8.57, p=0.003]. A post hoc pairwise analysis showed that weight significantly decreased from baseline and 16th-week follow-up visits (p=0.011). Similarly, a significant decrease was observed in mean HbA1c across three-time points [F (2, 39.40) =8.81, p=0.001]. Mean HbA1c at 16th week was 6.61±1.13% vs 8.09±1.43% at baseline (P = 0.001). No significant reduction in FBG, RBG, blood pressure, and serum lipid profile were observed. Moreover, no major side effects occurred in any patient.\u0000Conclusion: Liraglutide is an effective and well-tolerable drug in improving glycemic control, causing significant weight loss in the study population when used as a monotherapy or in combination therapy.\u0000 \u0000KEYWORDS: Liraglutide, Glucagon-like peptide-1 agonist, Type 2 diabetes mellitus, Glycemic control, Weight loss","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49551381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0