Journal of Medical Sciences (Taiwan)最新文献

The current concept of hemostasis in total knee arthroplasty: A narrative review 目前全膝关节置换术中止血的概念:一个叙述性的回顾

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_61_23

Chang-Tse Lee, Zhi-Hong Zheng

引用次数: 0

Effect of betahistine on isolated rats' tracheal smooth muscles 倍他司汀对离体大鼠气管平滑肌的影响

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_224_22

Y. Chou, Hsing-Won Wang

{"title":"Effect of betahistine on isolated rats' tracheal smooth muscles","authors":"Y. Chou, Hsing-Won Wang","doi":"10.4103/jmedsci.jmedsci_224_22","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_224_22","url":null,"abstract":"Background: Betahistine is used as an H3 antagonist. It has been used to treat balance disorders. During the administration of the drug, the trachea may be affected through oral intake. Aim: This study aimed to determine the effects of betahistine on the tracheal smooth muscle of rats in vitro. Methods: On a rat trachea that had been isolated and immersed in Krebs solution in a muscle bath, we evaluated the efficacy of betahistine. We examined how the application of parasympathetic mimetic agents altered tracheal contractility. The betahistine was evaluated using the following criteria: the drug's effects on tracheal smooth muscle contractions triggered by parasympathetic mimetic 10− 6 M methacholine, electrically induced tracheal smooth muscle contractions, and resting tracheal smooth muscle tension were listed below. Results: At preparation concentrations as high as 10− 4 M, betahistine produced a substantial relaxing response. The medication also prevented spike contraction brought by electrical field stimulation. However, betahistine alone had a negligible effect on the basal tension of the trachea at increasing concentrations. Conclusion: According to this study, excessive levels of betahistine might actually oppose cholinergic receptors and prevented the tracheal smooth muscles parasympathetic activity.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"177 - 182"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41545686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal polyps with atypical presentations: A case series 不典型表现的胃肠道息肉：一系列病例

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_218_22

Prosanta Bhattacharjee, Sourav Chakraborty

引用次数: 0

Oral to nasal endotracheal tube exchange in patients difficult to undergo laryngoscopy 喉镜检查困难患者的口腔-鼻腔气管插管更换

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_31_22

Chia-Dan Cheng, C. Cherng

引用次数: 0

Surgical and nonsurgical treatments for proximal femur fractures: A narrative review 股骨近端骨折的手术和非手术治疗：叙述性综述

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_22_23

Wei-Chin Chen, Zhi-Hong Zheng

引用次数: 0

Solitary fibrous tumor in the preperitoneal space mimicking an intra-abdominal tumor 腹膜前间隙孤立的纤维性肿瘤，类似腹内肿瘤

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_192_22

Chun-Ti Hu, M. Ho, C. Hsieh

引用次数: 0

Investigating the prognosis gene profile of triple-negative breast cancer 三阴性乳腺癌预后基因谱的研究

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_160_22

Ya-Ting Chang, L. Kao, G. Liao, Ying-Chuan Chen, Je-Ming Hu, Yu-Tien Chang

{"title":"Investigating the prognosis gene profile of triple-negative breast cancer","authors":"Ya-Ting Chang, L. Kao, G. Liao, Ying-Chuan Chen, Je-Ming Hu, Yu-Tien Chang","doi":"10.4103/jmedsci.jmedsci_160_22","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_160_22","url":null,"abstract":"Background: Current therapeutic strategies have poor effects in triple-negative breast cancer (TNBC) patients due to lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression. Identification of novel genes of TNBC prognosis aids in the development of effective treatment strategies. Aim: We aim at explore key genes related to TNBC recurrence. Methods: RNAseq and clinical characteristics data were derived from The Cancer Genome Atlas Breast Invasive Carcinoma project. Ninety-seven TNBC patients were included. We used DESeq2 and Cox regression to identify significant genes to TNBC recurrence. Pathway enrichment analysis and protein–protein interaction plot were conducted to understand the functions of target genes. Results: We discovered top nine important genes for TNBC recurrence. Lower mRNA expression of potassium voltage-gated channel subfamily Q member 5, H3 clustered histone 10, and ADP-ribosylation factor-like protein 17 and higher mRNA expression of synuclein beta, interleukin 6 (IL-6), casein kappa, RHOC, phosphodiesterase 8B, and laminin subunit alpha 3 (LAMA3) were associated with higher risk of recurrence. IL-6, LAMA3, and Ras homolog family member V (RHOV) genes out of nine candidate genes can make the best prediction of TNBC recurrence (area under receiver operating characteristic curve: 0.95, sensitivity: 0.89 and specificity: 0.97). The top three significant Gene Ontology (GO) pathways are nucleosome, ion gated channel activity, and epidermis development. Significant GO pathways can be categorized into four functions: cell–cell adhesion, cell transportation, cell proliferation, ion channel and transporter, and immune. Conclusion: We discovered that the gene set of IL6, LAMA3, and RHOV can accurately predict TNBC recurrence. These genes warrant further study to confirm their causal association with TNBC prognosis and possible treatment targets.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"159 - 166"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45020461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MULTI-DRUG RESISTANT ESCHERICHIA COLI AND THEIR SENSITIVITY TO ORAL FOSFOMYCIN IN URINARY TRACT INFECTIONS: A SINGLE-CENTER EXPERIENCE 多重耐药大肠杆菌及其对口服磷霉素在尿路感染中的敏感性:单中心经验

Journal of Medical Sciences (Taiwan) Pub Date : 2023-05-23 DOI: 10.52764/jms.23.31.2.1

Iqbal Haider, Sana Ullah, K. Bibi, Hammad Naeem, Hamza M Ali, Wazir Mohammad Khan

{"title":"MULTI-DRUG RESISTANT ESCHERICHIA COLI AND THEIR SENSITIVITY TO ORAL FOSFOMYCIN IN URINARY TRACT INFECTIONS: A SINGLE-CENTER EXPERIENCE","authors":"Iqbal Haider, Sana Ullah, K. Bibi, Hammad Naeem, Hamza M Ali, Wazir Mohammad Khan","doi":"10.52764/jms.23.31.2.1","DOIUrl":"https://doi.org/10.52764/jms.23.31.2.1","url":null,"abstract":"Objectives: To determine the frequency of Escherichia coli (E. Coli) with multi-drug resistance and sensitivity to oral Fosfomycin in urinary tract infections in a public sector hospital of Peshawar Pakistan.\u0000Material and Methods: A descriptive cross-sectional study with a convenient consecutive sampling technique at the Department of Medicine Khyber Teaching Hospital Peshawar. A total of 179 patients were recruited in the current study. Detailed history and examination were carried out followed by routine baseline investigations. Under rigorous aseptic settings, two clean midstream urine samples from patients exhibiting symptoms of a urinary tract infection were collected. These samples were then promptly transferred to the hospital laboratory for routine evaluation and E.Coli inoculation on culture media. Once E.Coli was detected, it was tested for antibiotic sensitivity and resistance against the antibiotics mentioned. The multi-drug resistant (MDR) strains were isolated and their sensitivity was checked against oral fosfomycin. All the variables of data were recorded in SPSS version 20. Descriptive and inferential statistics will be utilized to elaborate study findings. \u0000Results: The mean age in this study was 37 years with a standard deviation was ±11.27.Seventy-three (41%) patients were males and 106 (59%) patients were females. One hundred and eleven (62%) patients had multidrug-resistant E.Coli among which oral Fosfomycin was sensitive in 108(97%) patients and was resistant in 3(3%) patients presenting with urinary tract infection.\u0000Conclusion: The multidrug-resistant E. coli strains are common in our setup. However, oral fosfomycin has documented sensitivity against these MDR strains of E. coli in the majority of UTI cases. \u0000Keywords: Multidrug-resistant Escherichia coli, Drug Sensitivity, Fosfomycin, urinary tract infection","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47271625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PERCEPTION OF FOURTH-YEAR MEDICAL STUDENTS REGARDING THEIR EDUCATIONAL ENVIRONMENT IN THE PEDIATRIC UNIT OF KHYBER TEACHING HOSPITAL 四年级医学生对开伯尔教学医院儿科教育环境的看法

Journal of Medical Sciences (Taiwan) Pub Date : 2023-05-23 DOI: 10.52764/jms.23.31.2.3

A. Munir, Sabahat Amir, Farooq Ahmad, Usman Mehboob, Aqeel Muhammed

{"title":"PERCEPTION OF FOURTH-YEAR MEDICAL STUDENTS REGARDING THEIR EDUCATIONAL ENVIRONMENT IN THE PEDIATRIC UNIT OF KHYBER TEACHING HOSPITAL","authors":"A. Munir, Sabahat Amir, Farooq Ahmad, Usman Mehboob, Aqeel Muhammed","doi":"10.52764/jms.23.31.2.3","DOIUrl":"https://doi.org/10.52764/jms.23.31.2.3","url":null,"abstract":"Objectives: The study aimed to assess the students’ perception of the educational environment in the pediatric unit of Khyber teaching hospital using Dundee Ready Educational Environment Measures (DREEM).\u0000Material and Methods: This cross-sectional, questionnaire-based study was conducted at the Department of Child Health Khyber Teaching Hospital Peshawar, Pakistan, from May to November 2019. The sample size included 220 students fourth-year students. The study instrument was the DREEM questionnaire, which has 50 items that assess five domains. There are 50 items with 5 subscales and the maximum score is 200. Descriptive statistics were used to calculate the mean and standard deviation of the DREEM and the five domains\u0000Results: Of the 220 Students, 100 completed the questionnaire, resulting in a response rate of 45%. The total DREEM score was 113.14/200 (56.57%). The results showed that student’s perception of their learning environment was 27.31/48 (56.89%), the perception of teachers was 25.45/44 (57.84%), self-perception of their academics was 18.97/32 (59.28%), their perception of the atmosphere was 27.7/48 (57.7%), and social self-perception was 13.7/28 (48.96%).\u0000Conclusion: The study found that the atmosphere in the pediatric ward of Khyber Teaching Hospital was perceived positively by the students. However, the total DREEM score and points in the subdomains did not fall in the excellent category and remained one step below the highest rank. Therefore, there is room for improvement in the educational climate at the pediatric ward of Khyber Teaching Hospital.\u0000Keywords: Dundee Ready Educational Environment Measures (DREEM), educational environment measures.\u0000 ","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46385903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FREQUENCY OF THE AGENESIS OF PALMARIS LONGUS AND FLEXOR DIGITORUM SUPERFICIALIS TENDONS AMONG INDIVIDUALS 个体掌长肌和指浅屈肌肌腱发育不全的频率

Journal of Medical Sciences (Taiwan) Pub Date : 2023-05-23 DOI: 10.52764/jms.23.31.2.9

N. Rafique, Anum Rafique, Hafsa Bint Bilal, Izzah Nawaz, Mohab O. M. Ali

{"title":"FREQUENCY OF THE AGENESIS OF PALMARIS LONGUS AND FLEXOR DIGITORUM SUPERFICIALIS TENDONS AMONG INDIVIDUALS","authors":"N. Rafique, Anum Rafique, Hafsa Bint Bilal, Izzah Nawaz, Mohab O. M. Ali","doi":"10.52764/jms.23.31.2.9","DOIUrl":"https://doi.org/10.52764/jms.23.31.2.9","url":null,"abstract":"Objective: To find out the frequency of hereditary absence of palmaris longus and flexor digitorum superficialis tendons among individuals visiting physiotherapy clinics of 2 hospitals in Pakistan.\u0000Methods: This cross-sectional study was conducted in Government hospitals in twin cities (Islamabad and Rawalpindi), Pakistan from September 2018 to March 2019. For examination, a standardized clinical Schaeffer's test and three additional tests were used for the assessment of palmaris longus (PL), and a standardized simple, and the modified test was used for flexor digitorum superficialis (FDS). Data were analyzed by using SPSS 23.\u0000Results: Out of 619 individuals, 51.7% were men and 48.3% women were examined. The mean age of males was 33.4 years ± 14.5 and of females 35.9 years ± 13.4. Palmaris longus muscle was absent in 49.3% of participants with bilateral absence being more common. Unilateral absence of the PL muscle was found to be more in the left hand. Its absence in the left hand was found more common in females than in males (11.7% females, 9.1% males). This research showed agenesis of PL is gender dependent. (p< 0.05), and no association was found among the standard FDS and PL tendon test, that is r (617) =0.046, p= 0.249.\u0000Conclusion(s): The absence of palmaris longus muscle is more frequently found in women and in the left hand. Agenesis of FDS is rare in individuals and has no association with agenesis of palmaris longus.\u0000Keywords: Association, agenesis, humans, muscle, population.\u0000 ","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48384742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0