Journal of Medical Sciences (Taiwan)最新文献

Syringomyelia secondary to Thoracic Intervertebral Disc Protrusion: A rare condition 继发于胸椎间盘突出症的脊髓空洞:一种罕见的疾病

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_153_22

S. Hui, Anas Tharek, I. Ibrahim, M. Zakaria

引用次数: 0

The current concept of hemostasis in total knee arthroplasty: A narrative review 目前全膝关节置换术中止血的概念:一个叙述性的回顾

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_61_23

Chang-Tse Lee, Zhi-Hong Zheng

引用次数: 0

Effect of betahistine on isolated rats' tracheal smooth muscles 倍他司汀对离体大鼠气管平滑肌的影响

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_224_22

Y. Chou, Hsing-Won Wang

{"title":"Effect of betahistine on isolated rats' tracheal smooth muscles","authors":"Y. Chou, Hsing-Won Wang","doi":"10.4103/jmedsci.jmedsci_224_22","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_224_22","url":null,"abstract":"Background: Betahistine is used as an H3 antagonist. It has been used to treat balance disorders. During the administration of the drug, the trachea may be affected through oral intake. Aim: This study aimed to determine the effects of betahistine on the tracheal smooth muscle of rats in vitro. Methods: On a rat trachea that had been isolated and immersed in Krebs solution in a muscle bath, we evaluated the efficacy of betahistine. We examined how the application of parasympathetic mimetic agents altered tracheal contractility. The betahistine was evaluated using the following criteria: the drug's effects on tracheal smooth muscle contractions triggered by parasympathetic mimetic 10− 6 M methacholine, electrically induced tracheal smooth muscle contractions, and resting tracheal smooth muscle tension were listed below. Results: At preparation concentrations as high as 10− 4 M, betahistine produced a substantial relaxing response. The medication also prevented spike contraction brought by electrical field stimulation. However, betahistine alone had a negligible effect on the basal tension of the trachea at increasing concentrations. Conclusion: According to this study, excessive levels of betahistine might actually oppose cholinergic receptors and prevented the tracheal smooth muscles parasympathetic activity.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"177 - 182"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41545686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal polyps with atypical presentations: A case series 不典型表现的胃肠道息肉：一系列病例

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_218_22

Prosanta Bhattacharjee, Sourav Chakraborty

引用次数: 0

A prospective study of vitamin D deficiency in patients with hemorrhagic stroke 出血性中风患者维生素D缺乏的前瞻性研究

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_109_22

Yi-An Chen, Kuan-Yin Tseng, M. Chung, Peng-Wei Wang, Dueng-Yuan Hueng, Kuan-Nien Chou

{"title":"A prospective study of vitamin D deficiency in patients with hemorrhagic stroke","authors":"Yi-An Chen, Kuan-Yin Tseng, M. Chung, Peng-Wei Wang, Dueng-Yuan Hueng, Kuan-Nien Chou","doi":"10.4103/jmedsci.jmedsci_109_22","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_109_22","url":null,"abstract":"Background: There is accumulating evidence that Vitamin D deficiency contributes to the occurrence of stroke, including ischemic and hemorrhagic strokes. However, the relationship between Vitamin D levels and the risk of hemorrhage stroke was less conclusive. Aim: This prospective study is aimed for relationship between Vitamin D status and specific nonlobar hemorrhagic stroke in a Taiwanese cohort. Methods: A prospective study of 44 adult patients (32 males and 12 females; 27 aged <65 years and 17 ≥65 years) with acute nonlobar spontaneous intracerebral hemorrhage (sICH) was undertaken for 24 months (December 2017–November 2019) in a general reference teaching hospital. The serum 25-hydroxyvitamin D (25(OH) D) level was examined within 1 day of the stroke. The associations between Vitamin D status, age, low-density lipoprotein levels, and hemorrhagic stroke were analyzed using the Chi-squared test for comparisons. Statistical significance was set at P < 0.05. Results: The mean serum concentration of (25(OH) D) was 20.30 ng/ml. There were 14 patients with Vitamin D insufficiency (<30 ng/ml), and 23 with Vitamin D deficiency (<20 ng/ml). There was no age dependence to the Vitamin D deficiency and insufficiency in patients with acute nonlobar sICH. We also found no significant correlation between Vitamin D deficiency and low-density lipoprotein concentration. Conclusion: A particularly high prevalence of Vitamin D deficiency was found in Taiwanese patients with specific hemorrhagic stroke, acute nonlobar sICH, and this was independent of age or serum low-density lipoprotein levels.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"154 - 158"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41405486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Levosimendan as adjuvant therapy for cardiogenic shock patients with temporary ventricular assist device 左西孟旦辅助治疗临时心室辅助装置对心源性休克患者的影响

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_209_22

Ying-Hsiang Wang, P. Hsu, Y. Tsai, Chih-Yuan Lin, Hong-Yan Ke, Chien-Sung Tsai

{"title":"Levosimendan as adjuvant therapy for cardiogenic shock patients with temporary ventricular assist device","authors":"Ying-Hsiang Wang, P. Hsu, Y. Tsai, Chih-Yuan Lin, Hong-Yan Ke, Chien-Sung Tsai","doi":"10.4103/jmedsci.jmedsci_209_22","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_209_22","url":null,"abstract":"Background: Temporary ventricular-assisted device (VAD) provides timely organ perfusion in patients with cardiogenic shock and serves as a bridge to heart transplant. Intravenous levosimendan could provide pharmacologic inotropic support. Aim: We aimed to investigate the adjuvant efficacy of levosimendan in patients with temporary VAD, especially for VAD weaning. Methods: We retrospectively reviewed the medical records of patients receiving temporary VAD for cardiogenic shock between January 2017 and May 2019 in a medical center in Taiwan. Patients were divided into the levosimendan (n = 9, administered levosimendan immediately after VAD), and control groups (n = 20, no levosimendan administered). The biochemistry of systemic perfusion was compared at 1 and 3 days after VAD. After 2 months, the cardiac function of the patients with successful VAD weaning was evaluated by echocardiography. At 6 months follow-up, survival outcome and Kaplan–Meier survival curves were presented. Results: In total, 29 patients receiving temporary VAD for cardiogenic shock were enrolled, including 9 patients treated with levosimendan infusion. In the levosimendan group, both mean arterial pressure and lactate level decreased significantly (P = 0.037 and 0.023, respectively), and the ratio of arterial oxygen partial pressure to fractional inspired oxygen improved significantly (P = 0.048). No difference in inotropes tapering, consciousness, systemic perfusion biochemistry, and cardiac enzymes. Echocardiography showed significantly improved systolic function and pulmonary artery pressure 2 months later (P = 0.043 and 0.046, respectively) in patients with successful weaning. The levosimendan group had a better weaning rate (P = 0.013) and lower mortality rate (P = 0.571) at 6-month follow-up. Conclusion: The levosimendan group showed a better weaning rate and lower mortality rate.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"167 - 176"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44480184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral to nasal endotracheal tube exchange in patients difficult to undergo laryngoscopy 喉镜检查困难患者的口腔-鼻腔气管插管更换

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_31_22

Chia-Dan Cheng, C. Cherng

引用次数: 0

Surgical and nonsurgical treatments for proximal femur fractures: A narrative review 股骨近端骨折的手术和非手术治疗：叙述性综述

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_22_23

Wei-Chin Chen, Zhi-Hong Zheng

引用次数: 0

Solitary fibrous tumor in the preperitoneal space mimicking an intra-abdominal tumor 腹膜前间隙孤立的纤维性肿瘤，类似腹内肿瘤

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_192_22

Chun-Ti Hu, M. Ho, C. Hsieh

引用次数: 0

Investigating the prognosis gene profile of triple-negative breast cancer 三阴性乳腺癌预后基因谱的研究

Journal of Medical Sciences (Taiwan) Pub Date : 2023-07-01 DOI: 10.4103/jmedsci.jmedsci_160_22

Ya-Ting Chang, L. Kao, G. Liao, Ying-Chuan Chen, Je-Ming Hu, Yu-Tien Chang

{"title":"Investigating the prognosis gene profile of triple-negative breast cancer","authors":"Ya-Ting Chang, L. Kao, G. Liao, Ying-Chuan Chen, Je-Ming Hu, Yu-Tien Chang","doi":"10.4103/jmedsci.jmedsci_160_22","DOIUrl":"https://doi.org/10.4103/jmedsci.jmedsci_160_22","url":null,"abstract":"Background: Current therapeutic strategies have poor effects in triple-negative breast cancer (TNBC) patients due to lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 expression. Identification of novel genes of TNBC prognosis aids in the development of effective treatment strategies. Aim: We aim at explore key genes related to TNBC recurrence. Methods: RNAseq and clinical characteristics data were derived from The Cancer Genome Atlas Breast Invasive Carcinoma project. Ninety-seven TNBC patients were included. We used DESeq2 and Cox regression to identify significant genes to TNBC recurrence. Pathway enrichment analysis and protein–protein interaction plot were conducted to understand the functions of target genes. Results: We discovered top nine important genes for TNBC recurrence. Lower mRNA expression of potassium voltage-gated channel subfamily Q member 5, H3 clustered histone 10, and ADP-ribosylation factor-like protein 17 and higher mRNA expression of synuclein beta, interleukin 6 (IL-6), casein kappa, RHOC, phosphodiesterase 8B, and laminin subunit alpha 3 (LAMA3) were associated with higher risk of recurrence. IL-6, LAMA3, and Ras homolog family member V (RHOV) genes out of nine candidate genes can make the best prediction of TNBC recurrence (area under receiver operating characteristic curve: 0.95, sensitivity: 0.89 and specificity: 0.97). The top three significant Gene Ontology (GO) pathways are nucleosome, ion gated channel activity, and epidermis development. Significant GO pathways can be categorized into four functions: cell–cell adhesion, cell transportation, cell proliferation, ion channel and transporter, and immune. Conclusion: We discovered that the gene set of IL6, LAMA3, and RHOV can accurately predict TNBC recurrence. These genes warrant further study to confirm their causal association with TNBC prognosis and possible treatment targets.","PeriodicalId":39900,"journal":{"name":"Journal of Medical Sciences (Taiwan)","volume":"43 1","pages":"159 - 166"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45020461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0