2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED)最新文献

Access to cytoplasm of living single cells by nanofluidic technology* 利用纳米流体技术获取活单细胞细胞质*

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641638

K. Mawatari, Lin Ling, T. Kitamori

引用次数: 0

Thermoresponsive Nanohybrids for Tumor Imaging 热响应纳米杂化物用于肿瘤成像

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641671

Harini Hapuarachchi, M. Premaratne

引用次数: 1

Controlled release of vancomycin from bone plate via layer-by-layer coating 万古霉素从骨板逐层包衣的控制释放

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641661

N. Nasongkla, Komgrit Eawsakul

引用次数: 2

Enhanced Superradiant Cancer Hyperthermia using a Ring Shaped Assembly of Quantum Dots 利用环形量子点组装增强超辐射癌症热疗

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641670

S. Mallawaarachchi, M. Premaratne

引用次数: 0

Determine the Binding Epitope of the Low Affinity Interaction between Dengue Virus and CLEC5A by a Multivalent-Interaction-Reinforcing Sensor Surface 利用多价相互作用增强传感器表面确定登革热病毒与cle5a低亲和力相互作用的结合表位

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641682

Yen-Ting Tung, Ruei-Ning Jhang, Yi-Ling Lin, Gou-Jen Wang

{"title":"Determine the Binding Epitope of the Low Affinity Interaction between Dengue Virus and CLEC5A by a Multivalent-Interaction-Reinforcing Sensor Surface","authors":"Yen-Ting Tung, Ruei-Ning Jhang, Yi-Ling Lin, Gou-Jen Wang","doi":"10.1109/NANOMED.2018.8641682","DOIUrl":"https://doi.org/10.1109/NANOMED.2018.8641682","url":null,"abstract":"The binding affinity between dengue virus E-protein and its receptor CLEC5A is week, hence it is hardly detected through traditional methods (i.e. ELISA), let alone examining the binding epitope between them. A much sensitive method must be developed for providing fast and accurate detection to achieve this goal. Unlike the common modification, which focused on increasing surface area of the working surface for raising the sensitive of the sensor, surface modification with the purpose of increasing multivalent interaction between virus and sensor surface was used in this study for improving the sensor’s sensitive. Different scale of nano-hemisphere was fabricated in order to study the influence of surface structure to dengue virus binding through multivalent interaction. Japanese encephalitis virus, which has the size similar to the dengue virus, was used to investigate the binding epitope between viral E-protein and CLEC5A through the multivalent-interaction-enhanced sensor chip. We found that the glycosylation on amino acid D67 is critical to the interaction between virus and CLEC5A, however, the glycosylation on amino acid N154 will hinder the interaction between virus and CLEC5A through amino acid D67 and reduce the binding affinity between virus and CLEC5A. This study not only point out the important of multivalent interaction between analyte and sensor surface, but also the first study about determining the binding epitope between dengue virus and CLEC5A through a biosensor. The nano-hemisphere sensor surface developed in this study will be commonly used in detecting the interaction between animal virus and its receptor in the future.","PeriodicalId":398305,"journal":{"name":"2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125954048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanometer Scale Coating Using Atomic Layer Deposition Technique To Enhance Performance of Bio-Medical Devices 利用原子层沉积技术制备纳米涂层以提高生物医学器件的性能

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641639

A. Jugessur, A. Textor, C. Grierson

{"title":"Nanometer Scale Coating Using Atomic Layer Deposition Technique To Enhance Performance of Bio-Medical Devices","authors":"A. Jugessur, A. Textor, C. Grierson","doi":"10.1109/NANOMED.2018.8641639","DOIUrl":"https://doi.org/10.1109/NANOMED.2018.8641639","url":null,"abstract":"Nanofabrication is the meeting ground of engineering, biology, physics, medicine and chemistry. Most of these disciplines converge at the nanoscale, towards the same building blocks, principles, tools of investigation and fabrication. By the same token, micro- and nano-fabrication techniques are applicable in a wide range of non-traditional research areas and advance manufacturing, in particular, applications in the biomedical areas have been growing rapidly. In this work, a semiconductor microfabrication technique such as atomic layer deposition (ALD) has been applied to bio-medical stent devices as the preferred nano-scale coating method that demonstrated an enhanced in the device performance that is directly related to conformal and uniform atomic level coating. In this work, bio-medical stent devices are coated with sub-30 nm thickness of Aluminum Oxide using a plasma-enhanced ALD method. This work also describes the characterization of layer thickness using various techniques such as Ellipsometry, Scanning electron microscopy and Focused ion beam scanning electron microscopy and the results demonstrate the conformality and uniformity of the coating layer. The work also demonstrates the impact of the ALD coating on the successful adherence and coatings of other subsequent organic layer coatings on the stent device that ultimately improves the performance of the ALD coated stent devices in terms of its anti-clotting properties.","PeriodicalId":398305,"journal":{"name":"2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED)","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124638046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Novel Centrifugal Device for Mass-Production of Healthy Mitochondria 一种大规模生产健康线粒体的新型离心装置

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641562

Sung-Tzu Chen, Jui-Chih Chang, Chin‐San Liu, Gou-Jen Wang

{"title":"A Novel Centrifugal Device for Mass-Production of Healthy Mitochondria","authors":"Sung-Tzu Chen, Jui-Chih Chang, Chin‐San Liu, Gou-Jen Wang","doi":"10.1109/NANOMED.2018.8641562","DOIUrl":"https://doi.org/10.1109/NANOMED.2018.8641562","url":null,"abstract":"In this research, we propose a novel centrifugal device for mass-production of healthy mitochondria. The device is mainly consists of two main parts. One is a microfluidic device, which is fabricated by simple photolithographic process and PDMS casting, for efficient disruption of the cell membrane. One is a container that is manufactured by 3D printing for the storage of cell suspension. After assembly, a centrifuge used in a general laboratory is then applied, a large amount of suspended cells can be pushed through the microfluidic device to destroy the cell membrane by centrifugal force. The high-purity and chemical free mitochondria are then extracted via differential centrifugation. The membrane protein structure (complex I–V and Tom 20) of the extracted mitochondria was examined by Western blot. The purity of the extracted mitochondria via flow cytometry and TEM. Experimental results revealed that complex I–V expression of the extracted mitochondria with the proposed device was close to that of the mitochondria extracted using a conventional kit. Furthermore, the results of Tom20 expression demonstrated that our device could extract similar amounts of mitochondria to the conventional kit. The mitochondrial membrane potential proved that mitochondria retained normal activity after extraction by the proposed device. These results confirmed that the proposed microfluidic device could obtain healthy mitochondria, with no structural damage and altered activities in 30 min.","PeriodicalId":398305,"journal":{"name":"2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116781914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large Area Precision Cell Traction Force Measurements Using Gold Disk Mounted Micro-Pillars 使用金盘安装微柱的大面积精密电池牵引力测量

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641656

Xing Haw Marvin Tan, Angelyn V. Ngyuen, A. Rowat, P. Chiou

引用次数: 3

Measurement of Impedance Changes Associated with Developmental Phases in Artemia Cysts 与青蒿囊肿发育阶段相关的阻抗变化测量

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/NANOMED.2018.8641547

M. A. Rahman, K. Matthews, Maurice Garcia, A. Ohta

引用次数: 0

NANOMED 2018 Author Index NANOMED 2018作者索引

2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) Pub Date : 2018-12-01 DOI: 10.1109/nanomed.2018.8641611

引用次数: 0