Proceedings of the 9th World Congress on New Technologies最新文献_第5页

Formulation, Optimization, and Invitro Characterization of Lipid-Based Nanoparticles for Effective Delivery to The Liver 有效递送至肝脏的脂基纳米颗粒的配方、优化和体外表征

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icnfa23.107

Dina M. Gaber, Nabila Borae, M. Gayed

{"title":"Formulation, Optimization, and Invitro Characterization of Lipid-Based Nanoparticles for Effective Delivery to The Liver","authors":"Dina M. Gaber, Nabila Borae, M. Gayed","doi":"10.11159/icnfa23.107","DOIUrl":"https://doi.org/10.11159/icnfa23.107","url":null,"abstract":"- Chronic liver disorders are the major causes of illness and mortality worldwide. Patients with chronic liver diseases have a greater chance of developing cirrhosis, hepatocellular carcinoma, progressive liver fibrosis, and subsequently liver failure. Currently there are no effective treatments available for patients with the various kinds of liver diseases. The use of nanotechnology is considered a rapidly growing field of interest for the safe and targeted delivery of insufficiently water-insoluble hepatoprotective drugs. Therefore, the nanoparticle combination improves bioavailability and plasma stability of drugs with poor aqueous solubility. Thus, this study aims at developing chemically and physically stable Fenretinide loaded solid lipid nanoparticles (FEN-SLNs) for successful delivery to the liver. The nanoencapsulation of FEN in Gelucire-based, surfactant-free SLNs was developed. SLNs were characterized in terms of physicochemical properties, surface morphology, drug loading, release behavior as well as in vivo biodistribution study. The results showed that adopting hot homogenization method for preparation of FEN loaded solid lipid nanoparticles using Gelucire 50/13 and Precirol provided chemically and physically stable FEN-SLNs. Further, the optimized FEN-SLNs has particle size 298.3 ± 2.54 and PDI 0.3 with negative zeta potential -15.2 ± 3.61 mV, and Entrapment efficiency exceeding 92%. Furthermore, in vitro release experiment ensured sustained release of FEN over > 24 h with no signs of degradation. In addition, TEM photomicrographs showed spherical particles. Noteworthy, the in vivo biodistribution results showed that fluorescently labeled SLNs retained in the liver for 8h with diminished migration to the other organs unlike the free dye. In conclusion the study highlights the effective encapsulation of FEN and effective delivery to the liver.","PeriodicalId":398088,"journal":{"name":"Proceedings of the 9th World Congress on New Technologies","volume":"172 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131109968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Non-Target Screening Of Organic Micropollutants In Durgam Cheruvu Lake, India 印度Durgam Cheruvu湖有机微污染物的非靶筛选

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icepr23.147

Sai Krishna Duddupudi, Sreekar Varma Penmetsa, Madhu Kumar Kumara, Nikhil Sai Raghav Vasili, D. Bhattacharyya, Keerthi Katam

{"title":"Non-Target Screening Of Organic Micropollutants In Durgam Cheruvu Lake, India","authors":"Sai Krishna Duddupudi, Sreekar Varma Penmetsa, Madhu Kumar Kumara, Nikhil Sai Raghav Vasili, D. Bhattacharyya, Keerthi Katam","doi":"10.11159/icepr23.147","DOIUrl":"https://doi.org/10.11159/icepr23.147","url":null,"abstract":"– The main objective of this study is to evaluate the water quality of Durgam Cheruvu Lake, Hyderabad, India by comprehensively analysing organic micropollutants. Samples were collected from three different sites in the lake and nontargeted screening was performed using liquid chromatography-quadrupole time-of-flight (LC-QTOF). A total of 183 compounds were detected in all samples. This includes pharmaceuticals, herbicides, fungicides, pesticides, hormones, steroids, UV filters, plasticizers, cyanotoxins, and metabolites. In all samples, pharmaceuticals accounted for approximately 50%, herbicides 8%, and metabolites 9%. The high abundance va lues were observed for 17 α β – Dihydroequilin, Avobenzone, Sibutramine, Butachlor, Napropamide, and Estriol at all the sampling locations. Estriol and 17αβ – Dihydroequilin are classified as the largest endocrine disruptors among many micropollutants. Eutrophication-related cyanotoxins including Microcystin-LR and Anatoxin-A have been identified in the lake. Additionally, the urine metabolites of Clarithromycin, Flunitrazepam, and other transformed metabolites of cocaine-d3 and Amitriptyline were discovered. Overall, veterinary medications, narcotic pharmaceuticals, pain killers, anti-psychotic, anti-depressant, and anti-obesity drugs were found to be the most prevalent components in the lake samples, indicating the discharge of domestic and industrial wastewater into the lake.","PeriodicalId":398088,"journal":{"name":"Proceedings of the 9th World Congress on New Technologies","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124200555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coupling Leaching-Bioremediation for Petroleum-Contaminated Soil 石油污染土壤的耦合浸出-生物修复

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icepr23.114

B. Qin, Fanbin Meng, Liming Ren, Jianlin Jiang, H. Gong

引用次数: 0

Effects Of Chlorine And Fluorine On The Vibrational Properties Of Nanoporous Germanium: A Theoretical Approach 氯和氟对纳米多孔锗振动性能影响的理论研究

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icnfa23.124

R. Bermeo-Campos, F. Salazar, A. Trejo, Á. Miranda, M. Cruz‐Irisson

{"title":"Effects Of Chlorine And Fluorine On The Vibrational Properties Of Nanoporous Germanium: A Theoretical Approach","authors":"R. Bermeo-Campos, F. Salazar, A. Trejo, Á. Miranda, M. Cruz‐Irisson","doi":"10.11159/icnfa23.124","DOIUrl":"https://doi.org/10.11159/icnfa23.124","url":null,"abstract":"Extended Abstract Since the discovery of photoluminescence in nanoporous silicon in 1990, nanoporous semiconductors have attracted much attention due to their different properties and potential applications. Compared to porous silicon, nanoporous Germanium (pGe) has been less studied, due to its difficult synthesis that involves a bipolar electrochemical etching in hydrochloric acid, compared to the rather simple synthesis of porous Silico. However, pGe has been used in optoelectronics as photodetector, battery electrode for energy storage and backside reflector for photovoltaics. However, the theoretical characterization of this material is still scarce, this kind of investigation could be of the outmost importance in order to accelerate the development of applications using this nanostructured material, especially the determination of their vibrational properties which could indicate the stability of this material and its thermodynamic properties which are crucial for electronic and thermoelectric applications, also vibrational spectroscopies such as Raman and Infrared are intrinsically linked to the vibrational properties, by modelling these spectrums experimental investigations have a valuable resource for comparison since these are two of the most used non-destructive characterization techniques. In this work we study the vibrational properties of pGe using the first principles density functional perturbation theory and the supercell scheme [1,2 ]. The nanoporous structures are modelled by removing","PeriodicalId":398088,"journal":{"name":"Proceedings of the 9th World Congress on New Technologies","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133227375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomedicine as a Promising Approach to Overcome Current Challenges in Cancer Radiotherapy 纳米医学是克服当前癌症放疗挑战的一种有前途的方法

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icnfa23.002

D. Chithrani

{"title":"Nanomedicine as a Promising Approach to Overcome Current Challenges in Cancer Radiotherapy","authors":"D. Chithrani","doi":"10.11159/icnfa23.002","DOIUrl":"https://doi.org/10.11159/icnfa23.002","url":null,"abstract":"By 2040, the number of new cancer cases per year is expected to rise to 29.5 million and the number of cancer-related deaths to 16.4 million. Approximately 50 percent of all cancer patients can benefit from radiotherapy (RT). Although an increasing number of patients survive at least five years past their cancer diagnosis, cancer continues to be the leading cause of death worldwide. RT is an essential element of curative treatment of many cancers including breast, prostate, cervix, head and neck, lung, and brain. For prostate cancer, radiotherapy dose-escalation is known to improve disease control, but can also increase late normal tissue toxicity. Despite advancements in treatment planning & delivery we are now approaching the limit of RT dose that can be safely delivered to patients, creating a clear need for novel methods to enhance radiotherapy effects to further improve the survival, while reducing side effects. Enhancing targeted delivery of radiotherapy (RT) has tremendous potential to maximize the effect of dose given to the tumor and reduce the dose given to normal tissue. One of the current strategies to preferentially increase tumor radiation dose effect is to add a radiosensitizer to RT, which has improved survival for those with cancers. Dr. Chithrani uses gold nanoparticles in combination with other radiation sensitizing agents to optimize current radiotherapy. In this talk, she will discuss the promising outcomes of such novel strategies to overcome current challenges imposed by the tumour and its microenvironment.","PeriodicalId":398088,"journal":{"name":"Proceedings of the 9th World Congress on New Technologies","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133232873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atmospheric correction of Sentinel-2 images for accurate identification of vegetation distribution Sentinel-2遥感影像的大气校正，用于准确识别植被分布

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icepr23.116

Seoyeon Kim, Y. Lee

{"title":"Atmospheric correction of Sentinel-2 images for accurate identification of vegetation distribution","authors":"Seoyeon Kim, Y. Lee","doi":"10.11159/icepr23.116","DOIUrl":"https://doi.org/10.11159/icepr23.116","url":null,"abstract":"Extended Abstract As global warming becomes serious with the increase of greenhouse gases, interest in the impact of climate change on the global environment and human life is increasing. In addition, local abnormal climate phenomena frequently appear according to climate change, and changes in the ecosystem are starting to be detected. Indicators that reflect climate change are diverse, such as agriculture, plant and animal distribution, biological seasons and ecology, and health. Here, the impact on agricultural production in particular seems to be very important [1]. Satellite products such as NDVI (Normalized Difference Vegetation Index), LAI (Leaf Area Index), FPAR (Fraction of Photosynthetically Active Radiation), and PET (Potential EvapoTranspiration) that reflect the growth and vitality of vegetation exist. Through this, changes in agricultural land or forests can be identified. At this time, strict atmospheric correction for high-resolution satellite data is essential in order to use accurate product. The radiation measured at a satellite sensor can have errors due to atmospheric effects such as scattering and absorption while transmitting from the land surface to the sensor. Absorption of sunlight by the atmosphere attenuates the radiation measured using the sensor. Since atmospheric effects in remote sensing cause uncertainty in surface observation, accurate atmospheric correction is an essential preprocessing step for the analysis of surface characterization and environmental monitoring [2]. Among atmospheric correction methods, the physical model-based method has the advantage of calculating the atmospheric contribution numerically using the precise Radiative Transfer Model (RTM) and using it for atmospheric","PeriodicalId":398088,"journal":{"name":"Proceedings of the 9th World Congress on New Technologies","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123794107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence Of Kluyveromyces Lactis Arranged In Suspension And Immobilized On Obtaining Lactic Acid By Cheese Whey Fermentation 悬浮和固定化排列的乳酸克鲁维菌对奶酪乳清发酵制乳酸的影响

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icbb23.108

María Vargas, Carlos Gordillo-Andia,, Danny Tupayachy-Quispe, Jonathan Almirón, F. Roudet

引用次数: 0

The investigation of UV-C LED arrangement on the sterilization of Escherichia coli in flow reactors UV-C LED布置对流动反应器中大肠杆菌杀菌效果的研究

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icepr23.121

Chien-Ping Wang, Jun Liao

{"title":"The investigation of UV-C LED arrangement on the sterilization of Escherichia coli in flow reactors","authors":"Chien-Ping Wang, Jun Liao","doi":"10.11159/icepr23.121","DOIUrl":"https://doi.org/10.11159/icepr23.121","url":null,"abstract":"Extended Abstract In this study, a planar UV reactor with distinct UV-C LED arrangements was proposed to treat potable water. The particle tracing method combined with computational fluid dynamics were used to simulate water velocity field, microbial trajectory and exposure time. The ray tracing method was used to determine the irradiance distribution in water. The simulated variables were integrated to determine the distribution of fluence in water. UV light has been widely used in water sterilization processes because it is safe and simple and does not produce any unwanted by-products [1]. UV-C LEDs have been used instead of mercury lamps in water disinfection processes because of their numerous advantages, such as their long lifespan, mercury-free design, tunable wavelength, and high design flexibility [2,3]. The arrangement of UV-C LEDs substantially affects the light distribution and UV fluence to which microbes are subjected. However, if the distribution of light is not optimized, the performance of reactors employing UV LEDs may be lower than that of reactors employing traditional mercury lamps [4] . According to studies on the application of UV-C LEDs in water disinfection in flow reactors, positively correlating the flow field with the irradiation distribution can aid in the design of highly efficient UV reactors. In this study, the effects of LED arrangement on the efficacy of a planar UV LED reactor for E. coli disinfection under various flow rates were investigated. In this experiment, E. coli IFO 3301 was used to validate the water disinfection performance of the reactor. The bacteria were cultured on NZCYM broth supplemented with deionized water and grown in an incubator. To determine the reactor’s sterilization performance, plate counting was","PeriodicalId":398088,"journal":{"name":"Proceedings of the 9th World Congress on New Technologies","volume":"325 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133954099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerating Renewable Energy by Artificial Intelligence 用人工智能加速可再生能源

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icert23.001

F. Márquez

引用次数: 0

Encapsulation of Sertraline in Biodegradable Polymeric Nanoparticles 舍曲林在可生物降解聚合物纳米颗粒中的包封

Proceedings of the 9th World Congress on New Technologies Pub Date : 2023-08-01 DOI: 10.11159/icepr23.132

Bushra Alquadeib

引用次数: 0