Cesko-Slovenska Pediatrie最新文献_第2页

[The physiology of puberty]. [青春期的生理学]。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

L Lisá

引用次数: 0

[Dangers in external treatment of skin diseases in childhood]. [儿童皮肤病外敷治疗的危害]。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

S Capková, V Kohoutová

引用次数: 0

[Long-term home oxygen therapy]. [长期家庭吸氧治疗]。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

V Vávrová

引用次数: 0

[Improvement in the prognosis for growth in a boy with central precocious puberty and growth hormone deficiency treated concurrently with growth hormone and D-Trp-6-LHRH gonadoliberin analog]. [同时治疗生长激素和D-Trp-6-LHRH促性腺素类似物对中发性性早熟和生长激素缺乏症男孩生长预后的改善]。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

M Snajderová, J Lebl, D Zemková, S Kolousková, M Pechová

引用次数: 0

[The effect of growth hormone therapy on thyroid parameters]. 生长激素治疗对甲状腺参数的影响。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

J Lebl, M Pechová, S Kolousková, M Snajderová

{"title":"[The effect of growth hormone therapy on thyroid parameters].","authors":"J Lebl, M Pechová, S Kolousková, M Snajderová","doi":"","DOIUrl":"","url":null,"abstract":"Clinical observations and experimental studies indicate that administration of growth hormone (GH) affects thyroid parameters either via inhibited TSH secretion or via activation of the peripheral conversion of T4 to T3. For a period of six months after the onset of GH treatment basic thyroid parameters (TSH and total T3 and T4) were followed up in two groups of children: in 10 euthyroid girls with Turner's syndrome (TS) (age 6.2-11.3 years), hitherto not treated with GH and in six children (2 boys) with isolated idiopathic growth hormone deficiency (IGHD) (age 9.5-14.1 years). In the latter group GH treatment, 0.37 to 0.47 IU/kg/week for a period of 0.8 to 4.3 years preceded. This treatment was discontinued for 30 days before the investigation was started. During this treatment the condition was assessed as euthyroid without administration of L-thyroxine. Both groups of children were treated with GH administered by daily injection, girls with TS had a dose of 1 IU/kg/week, children with IGHD 0.42 IU/kg/week. In these girls with TS in the course of six months no change of the investigated parameters was recorded. In children with IGHD after three months' treatment a drop of T4 from (mean +/- SD) of 119 +/- 11 to 84 +/- 21 nmol/l (p = 0.01) occurred and a rise of the T3/T4 (x 100) index from 1.77 +/- 0.24 to 2.73 +/- 0.69 (p = 0.01) and of TSH from 1.1 +/- 0.7 to 2.2 +/- 0.6 mU/l (p = 0.005). The T3 level did not change. Within 6 months of treatment these changes receded completely and the levels returned to baseline values.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":39741,"journal":{"name":"Cesko-Slovenska Pediatrie","volume":"49 1","pages":"34-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19116641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Long-term therapy of true precocious puberty in girls using Decapetyl-Depot, a superactive gonadoliberin agonist in depot microcapsulated form]. [使用Decapetyl-Depot，一种微胶囊形式的超活性性腺激素激动剂，长期治疗女孩真性性早熟]。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

W G Sippell, C J Partsch, R Hümmelink, F Lorenzen

{"title":"[Long-term therapy of true precocious puberty in girls using Decapetyl-Depot, a superactive gonadoliberin agonist in depot microcapsulated form].","authors":"W G Sippell, C J Partsch, R Hümmelink, F Lorenzen","doi":"","DOIUrl":"","url":null,"abstract":"Within the framework of an international prospective multicentre study 93 girls with gonadotropin-dependent precocious puberty were treated with Decapeptyl-Depot LHRH agonist (75 micrograms/kg, once a month by the i.m. route). This treatment led to prompt, immediate and long-term suppression of the pituitary-ovarian axis with subsequent regression of premature onset of secondary sex signs, to the arrest of premature menstruation, to normalization of the pathologically accelerated growth and inhibition of the accelerated bone maturation. This improved the mean expected growth during the first four years of treatment from 159 to 165 cm (p < or = 0.01). Concurrently in the majority complete normalization of the severely impaired mental condition of the affected girls due to the premature onset of puberty occurred (mean onset of puberty -4.5 years). Selective suppression of the pubertally increased gonadotropin secretion was even after prolonged treatment fully reversible after termination of treatment with a subsequent onset of normal puberty and cyclic ovarian activity. Undesirable side-effects and antibodies against Decapeptyl were not detected, the local tolerance of the injected microcapsules was satisfactory. GnRH agonists in depot form are becoming, due to their superior suppressive action incl. that on bone maturation, the drug of choice in long-term treatment of central precocious puberty as they are the first which mitigate or can prevent, if treatment is started in time, a final small stature which frequently is the greatest handicap for a life-time (frequently associated with adverse bodily disproportions).","PeriodicalId":39741,"journal":{"name":"Cesko-Slovenska Pediatrie","volume":"49 1","pages":"13-8"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19116723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comments on the article by Prof. J. Dunovský: The European Council and policy issues relating to children in the future and in the Czech Republic. [对J. Dunovský教授的文章的评论:欧洲理事会和与未来和捷克共和国儿童有关的政策问题。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

J Dittrichová

引用次数: 0

[Measles are still dangerous worldwide]. 麻疹在世界范围内仍然很危险。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

L Vincent

引用次数: 0

[Emotional satisfaction as a part of health and pediatrics]. [情感满足是健康和儿科的一部分]。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

E Horanská

引用次数: 0

[Long-term therapy of central precocious puberty in girls with the gonadoliberin analog D-Trp-6-LHRH after prior therapy with cyproterone acetate]. [既往接受醋酸环丙孕酮治疗后，长期应用促性腺素类似物D-Trp-6-LHRH治疗女孩中枢性性早熟]。

Cesko-Slovenska Pediatrie Pub Date : 1994-01-01

M Snajderová, D Zemková, J Lebl, M Pechová, M Zounarová, S Kolousková

{"title":"[Long-term therapy of central precocious puberty in girls with the gonadoliberin analog D-Trp-6-LHRH after prior therapy with cyproterone acetate].","authors":"M Snajderová, D Zemková, J Lebl, M Pechová, M Zounarová, S Kolousková","doi":"","DOIUrl":"","url":null,"abstract":"A group of five girls with central precocious puberty (CPP) (four girls with idiopathic CPP and one girl with organically conditioned CPP) were treated for a mean period of 17 months (12-20 months) with an agonist of gonadoliberine (aGnRH) D-Trp-6-LHRH(Triptorelin), 60-100 micrograms/kg by the i.m. route, every four weeks. The calendar age (CA) of the girls was at the onset of aGnRH treatment 7.3 +/- 0.7 years, the bone age (BA) 9.6 +/- 1.0 years. Previously Cyproterone acetate treatment administered for an average period of 26 months (4-56 months) was gradually discontinued in the course of 12 weeks. After 12 months aGnRH treatment the growth rate slowed down from 8.1 #/- 2.1 to 6.2 +/- 1.7 cm/year (NS). The bone age increment per calendar year declined at the end of the first year of treatment from 1.7 +/- 0.8 to 0.94 +/- 0.4 (NS). Prediction of the adult height did not change in the course of one year (before aGnRH therapy 158.6 +/- 5.3 after one year's treatment 159.0 +/- 5.3 cm). In all girls premature maturing was arrested already during the original Cyproterone acetate treatment. With the exception of a single patient during aGnRH therapy progression was not recorded. In this girl with the idiopathic form of CPP the authors observed during regular Triptorelin administration, starting from the fourth month, clinical and biochemical manifestations of secondary therapeutic failure after termination of hitherto administered Cyproterone acetate treatment-\"escape from treatment\". Clinical and hormonal indicators improved after addition of Cyproterone acetate. This patient lacks typical symptoms suggesting McCune-Albright's syndrome.","PeriodicalId":39741,"journal":{"name":"Cesko-Slovenska Pediatrie","volume":"49 1","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19116639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0