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Making Sense of the Nonalcoholic Fatty Liver Disease Clinical Practice Guidelines: What Clinicians Need to Know 解读《非酒精性脂肪肝临床实践指南》:临床医生须知
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/dsi23-0014
Kenneth Cusi, Jeff Budd, Eric Johnson, Jay H. Shubrook
{"title":"Making Sense of the Nonalcoholic Fatty Liver Disease Clinical Practice Guidelines: What Clinicians Need to Know","authors":"Kenneth Cusi, Jeff Budd, Eric Johnson, Jay H. Shubrook","doi":"10.2337/dsi23-0014","DOIUrl":"https://doi.org/10.2337/dsi23-0014","url":null,"abstract":"Standards of care summarized in clinical practice guidelines for nonalcoholic fatty liver disease (NAFLD) offer clinicians a streamlined diagnostic and management approach based on the best available evidence. These recommendations have changed a great deal in recent years; today, there is a clear focus on screening for the early identification and risk stratification of patients at high risk of steatohepatitis and clinically significant fibrosis to promote timely referrals to specialty care when needed. This article reviews and provides the rationale for current guidelines for NAFLD screening, diagnosis, treatment, and monitoring and addresses barriers to providing evidence-based NAFLD care and how to overcome them. The current paradigm of care calls for primary care clinicians and specialists to work together, within a multidisciplinary care team familiar with obesity and diabetes care, to provide comprehensive management of these complex patients.","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"509 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action 了解非酒精性脂肪肝的负担:行动起来
Diabetes Spectrum Pub Date : 2024-02-01 DOI: 10.2337/dsi23-0010
Z. Younossi, Linda Henry
{"title":"Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action","authors":"Z. Younossi, Linda Henry","doi":"10.2337/dsi23-0010","DOIUrl":"https://doi.org/10.2337/dsi23-0010","url":null,"abstract":"The prevalence of nonalcoholic fatty liver disease (NAFLD) in the United States is 38%, having increased by 50% within the past 3 decades. The estimated NAFLD prevalence among people with type 2 diabetes is 55–70%. The presence of type 2 diabetes is associated with a higher likelihood of progression of NAFLD to fibrosis development, liver transplant, and death. Cardiovascular disease is the main cause of mortality among people with NAFLD, and the risk of death is significantly higher in people with both NAFLD and type 2 diabetes. NAFLD carries high patient and economic burdens but low awareness among both the general public and health care providers. This article reviews the epidemiology of NAFLD and discusses the need for appropriate risk stratification, referral for specialty care, management of cardiometabolic risk factors, and treatment of the disease. The authors present a call to action to raise awareness of NAFLD and address its increasing burden in a systematic and efficient manner.","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"25 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Project ECHO for Diabetes Improves Primary Care Providers’ Comfort With and Use of Diabetes Medications and Technology 糖尿病 ECHO 项目提高初级保健提供者对糖尿病药物和技术的舒适度和使用率
Diabetes Spectrum Pub Date : 2024-01-26 DOI: 10.2337/ds23-0050
Nicole Ehrhardt, Celeste C. Thomas, Tracy Zou, Ana Gabriela Vasconcelos, Matt Bouchonville
{"title":"Project ECHO for Diabetes Improves Primary Care Providers’ Comfort With and Use of Diabetes Medications and Technology","authors":"Nicole Ehrhardt, Celeste C. Thomas, Tracy Zou, Ana Gabriela Vasconcelos, Matt Bouchonville","doi":"10.2337/ds23-0050","DOIUrl":"https://doi.org/10.2337/ds23-0050","url":null,"abstract":"","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"54 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139594643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role and Perspective of Certified Diabetes Care and Education Specialists in the Development of the 4T Program 认证糖尿病护理和教育专家在制定 4T 计划中的作用和观点
Diabetes Spectrum Pub Date : 2024-01-19 DOI: 10.2337/ds23-0010
Jeannine Leverenz, Brianna Leverenz, Priya Prahalad, Franziska K. Bishop, Piper Sagan, Anjoli Martinez-Singh, Barry Conrad, Annette Chmielewski, Julianne Senaldi, D. Scheinker, David M. Maahs
{"title":"Role and Perspective of Certified Diabetes Care and Education Specialists in the Development of the 4T Program","authors":"Jeannine Leverenz, Brianna Leverenz, Priya Prahalad, Franziska K. Bishop, Piper Sagan, Anjoli Martinez-Singh, Barry Conrad, Annette Chmielewski, Julianne Senaldi, D. Scheinker, David M. Maahs","doi":"10.2337/ds23-0010","DOIUrl":"https://doi.org/10.2337/ds23-0010","url":null,"abstract":"","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"9 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycemic Management in Insulin Naive Patients in the Inpatient Setting 住院环境中胰岛素无效患者的血糖管理
Diabetes Spectrum Pub Date : 2024-01-18 DOI: 10.2337/ds23-0007
M. Goldstein, Shahidul Islam, Sophie Nicolich-Henkin, Lauren Bellavia, Stanislaw Klek
{"title":"Glycemic Management in Insulin Naive Patients in the Inpatient Setting","authors":"M. Goldstein, Shahidul Islam, Sophie Nicolich-Henkin, Lauren Bellavia, Stanislaw Klek","doi":"10.2337/ds23-0007","DOIUrl":"https://doi.org/10.2337/ds23-0007","url":null,"abstract":"\u0000 \u0000 The ideal inpatient insulin regimen efficiently attains the target blood glucose range, effectively treats hyperglycemia, and minimizes the risk of hypoglycemia. The objective of this study was to compare glycemic targets achieved by using correctional monotherapy (CM) and basal-bolus therapy (BBT) in insulin-naive patients in the inpatient setting to determine optimal blood glucose management for these patients.\u0000 \u0000 \u0000 \u0000 This was a retrospective observational cohort study of 792 patients with diabetes not on home insulin therapy who were admitted to an academic hospital over a 5.5-month period. The percentage of hyperglycemic and hypoglycemic values in each group were compared.\u0000 \u0000 \u0000 \u0000 Among the 3,112 measured blood glucose values obtained from 792 patients within the first 24 hours of insulin administration, 28.5% were hyperglycemic in the BBT group compared with 23.5% in the CM group. When adjusted for covariates, there was a 23% decrease in hyperglycemia in the BBT group (incidence rate ratio = 0.77, 95% CI 0.64–0.95, P = 0.006). Increases in A1C and admission blood glucose, as well as decreases in admission creatinine and inpatient steroid use, were independently associated with higher rates of hyperglycemia, adjusted for all other covariates. There was no significant difference between the groups in the rate of hypoglycemia, which was 1.9% in the BBT group and 1.4% in the CM group (P = 0.301).\u0000 \u0000 \u0000 \u0000 Utilizing BBT in insulin-naive patients admitted to the hospital within the first 24 hours of insulin administration results in lower rates of hyperglycemia without higher rates of hypoglycemia when compared with CM.\u0000","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"119 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing Prescribing Patterns of Diabetes Medications at an Adult Medicine Clinic: A Focus on Glucagon-Like Peptide 1 Receptor Agonists and Sodium–Glucose Cotransporter 2 Inhibitors 描述一家成人内科诊所的糖尿病药物处方模式:聚焦胰高血糖素样肽 1 受体激动剂和钠-葡萄糖共转运体 2 抑制剂
Diabetes Spectrum Pub Date : 2024-01-05 DOI: 10.2337/ds22-0095
Ashley N. Shtoyko, Meaghan B. Murphy, Jenna L. Harris, Caitlin Toomey, Elizabeth M. Phillips
{"title":"Characterizing Prescribing Patterns of Diabetes Medications at an Adult Medicine Clinic: A Focus on Glucagon-Like Peptide 1 Receptor Agonists and Sodium–Glucose Cotransporter 2 Inhibitors","authors":"Ashley N. Shtoyko, Meaghan B. Murphy, Jenna L. Harris, Caitlin Toomey, Elizabeth M. Phillips","doi":"10.2337/ds22-0095","DOIUrl":"https://doi.org/10.2337/ds22-0095","url":null,"abstract":"","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"2 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139381158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Community Engagement Methods to Guide Study Protocol Decisions for School-Aged Children With Type 1 Diabetes. 利用社区参与方法指导1型糖尿病学龄儿童的研究方案决策
Diabetes Spectrum Pub Date : 2024-01-01 Epub Date: 2023-09-08 DOI: 10.2337/ds23-0018
Fayo Abadula, Lori C Jordan, Lauren LeStourgeon, Sarah S Jaser
{"title":"Using Community Engagement Methods to Guide Study Protocol Decisions for School-Aged Children With Type 1 Diabetes.","authors":"Fayo Abadula, Lori C Jordan, Lauren LeStourgeon, Sarah S Jaser","doi":"10.2337/ds23-0018","DOIUrl":"10.2337/ds23-0018","url":null,"abstract":"<p><strong>Introduction: </strong>Many challenges exist in developing multisite protocols for newly diagnosed children with type 1 diabetes. Our research team engaged community members to increase the likelihood of study success during a planning grant for a longitudinal study aimed at understanding risk and protective factors for neurocognitive function in school-aged children newly diagnosed with type 1 diabetes.</p><p><strong>Methods: </strong>Two methods were used to obtain caregiver input into study protocol decisions. The first was a survey given to caregivers of children with diabetes (<i>n</i> = 21) about which aspects of the study protocol would make families more or less likely to participate. The second was a Community Engagement (CE) Studio to obtain recommendations from a diverse group of caregivers of children with diabetes (<i>n</i> = 7) on key aspects of recruitment and enrollment.</p><p><strong>Results: </strong>Results from both the survey and the CE Studio indicated that caregivers were interested and willing to participate in a longitudinal study of this nature. Both methods resulted in similar preferences for the type and amount of compensation, convenient study visits, flexible scheduling options, and receipt of neurocognitive test results. Recommendations from the CE Studio included additional strategies to minimize participant burden and enhance communication around study participation.</p><p><strong>Conclusion: </strong>Both the feasibility survey and the CE Studio were useful mechanisms to obtain caregiver input during the study's planning and design phase. Uniquely, the CE Studio approach offers researchers the ability to gain valuable community member input with minimal staff effort.</p>","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":" ","pages":"95-99"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10877206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47217144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liraglutide and Robust A1C Reductions Among People With Type 2 Diabetes Requiring Appetite Control: A Review of Two Cases 利拉鲁肽和需要控制食欲的 2 型糖尿病患者的 A1C 显著降低:两个病例的回顾
Diabetes Spectrum Pub Date : 2023-12-14 DOI: 10.2337/ds23-0052
Mason A. Pitts, Ryanne H. Griggs, Macey R. Hall, McKinley S. Tankersley, Jeremy L. Johnson
{"title":"Liraglutide and Robust A1C Reductions Among People With Type 2 Diabetes Requiring Appetite Control: A Review of Two Cases","authors":"Mason A. Pitts, Ryanne H. Griggs, Macey R. Hall, McKinley S. Tankersley, Jeremy L. Johnson","doi":"10.2337/ds23-0052","DOIUrl":"https://doi.org/10.2337/ds23-0052","url":null,"abstract":"","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"8 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138972748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pragmatic Rethinking of Glucose Monitoring for the Incarcerated 务实地反思对被监禁者的血糖监测
Diabetes Spectrum Pub Date : 2023-12-05 DOI: 10.2337/ds23-0036
Rebecca E. Luethy, Renee C. Lipinski, Jennifer L. West
{"title":"A Pragmatic Rethinking of Glucose Monitoring for the Incarcerated","authors":"Rebecca E. Luethy, Renee C. Lipinski, Jennifer L. West","doi":"10.2337/ds23-0036","DOIUrl":"https://doi.org/10.2337/ds23-0036","url":null,"abstract":"\u0000 \u0000 Using continuous glucose monitoring (CGM) improves diabetes-related outcomes in the community, yet the fingerstick blood glucose monitoring (BGM) method is the norm in prisons. The purpose of this study was to investigate the safety and patient perceptions of CGM in the carcerate environment, quantify changes in A1C after initiating CGM, and investigate rates of emergency department (ED) visits for diabetes-related complications comparing CGM users to patients using BGM.\u0000 \u0000 \u0000 \u0000 This pragmatic longitudinal analysis was conducted in two parts. A pilot program was carried out at a single women’s prison. A CGM program was initiated at men’s facilities within a single U.S. state, where A1C change and ED visit rates were investigated.\u0000 \u0000 \u0000 \u0000 Interested patients at an appropriate security level were invited to use CGM. Pre- and post-CGM surveys of glucose monitoring perceptions were administered during the pilot program. Security and perceptions were analyzed descriptively. A1C change was assessed using a t test. Fisher exact test, Barnard exact test, and post-hoc power analysis were applied to ED visits.\u0000 \u0000 \u0000 \u0000 Security was not disrupted. Patient perceptions of glucose monitoring improved with CGM use (n = 6). A1C declined by 0.60% with a medium effect size (Cohen’s d −0.45, n = 42). Power to detect a difference in ED visits was low; however, no CGM patients had an ED visit (n = 758).\u0000 \u0000 \u0000 \u0000 It is safe and efficacious to replace BGM with CGM in prisons when patients are engaged in their care and are at a security level allowing CGM devices in their cells.\u0000","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"24 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138601110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nondisclosure of Type 1 Diabetes in Adolescence: A Single-Center Experience 青春期未披露 1 型糖尿病:单中心经验
Diabetes Spectrum Pub Date : 2023-12-05 DOI: 10.2337/ds23-0006
Judith Nir, A. Liberman, M. Yackobovitch-Gavan, Drora Fraser, Moshe Phillip, Tal Oron
{"title":"Nondisclosure of Type 1 Diabetes in Adolescence: A Single-Center Experience","authors":"Judith Nir, A. Liberman, M. Yackobovitch-Gavan, Drora Fraser, Moshe Phillip, Tal Oron","doi":"10.2337/ds23-0006","DOIUrl":"https://doi.org/10.2337/ds23-0006","url":null,"abstract":"\u0000 \u0000 The aim of this study was to assess the extent of nondisclosure of type 1 diabetes in adolescents and investigate its association with several psychosocial parameters and clinical outcomes.\u0000 \u0000 \u0000 \u0000 This was a cross-sectional study based on data collected from 69 adolescents with type 1 diabetes who were 12–18 years of age and followed at our diabetes clinic. The degree of disclosure, demographics, diabetes management, and psychosocial issues were assessed via questionnaires. Clinical parameters were derived from medical records. Associations between nondisclosure status and clinical and psychosocial study variables were assessed.\u0000 \u0000 \u0000 \u0000 Fifty-three participants (77%) reported some extent of nondisclosure. Nondisclosure was associated with low self-esteem, reduced friend support, and increased diabetes-related worries. Nondisclosure was also found to be associated with diminished self-care behaviors related to insulin administration and with elevated A1C.\u0000 \u0000 \u0000 \u0000 Our results demonstrate that nondisclosure of type 1 diabetes in adolescents may be more common than initially recognized and is likely associated with unfavorable psychological outcomes and reduced self-care and diabetes management. Our results emphasize the importance of social interactions and disclosure in adolescents and may serve as a potential stepping stone to address other social barriers hindering diabetes management.\u0000","PeriodicalId":39737,"journal":{"name":"Diabetes Spectrum","volume":"33 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138600508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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