Revista Espanola de Cirugia Ortopedica y Traumatologia最新文献

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[Translated article] The influence of socioeconomic status and psychological factors on surgical outcomes of the carpometacarpal osteoarthritis of the thumb [文章翻译]社会经济和心理因素对梯形跖骨关节炎手术治疗结果的影响。
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2024.11.022
A.M. Martín-Fuentes , C. Ojeda-Thies , M. Campoy-Serón , C. Ortega-Romero , L.R. Ramos-Pascua , D. Cecilia López
{"title":"[Translated article] The influence of socioeconomic status and psychological factors on surgical outcomes of the carpometacarpal osteoarthritis of the thumb","authors":"A.M. Martín-Fuentes ,&nbsp;C. Ojeda-Thies ,&nbsp;M. Campoy-Serón ,&nbsp;C. Ortega-Romero ,&nbsp;L.R. Ramos-Pascua ,&nbsp;D. Cecilia López","doi":"10.1016/j.recot.2024.11.022","DOIUrl":"10.1016/j.recot.2024.11.022","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate to what extent people with carpometacarpal thumb osteoarthritis that are socioeconomically disadvantaged and have psychological disorders report higher pain levels and worse patient-rated upper-extremity functionality after surgical treatment.</div></div><div><h3>Material and method</h3><div>A single centre, retrospective observational cohort study analysing 100 patients diagnosed with thumb carpometacarpal osteoarthritis between 2013 and 2019. Patients were divided into two groups (50/50), depending on whether they received surgical or conservative treatment. The socio-economic status (ESeC classification) and presence of psychological comorbidities were investigated. Functional outcomes were assessed using the Visual Analogue Scale (VAS), Q-DASH questionnaire and Kapandji score. Current mental disorders were evaluated using STAI, PHQ-9 and PCS screening scales.</div></div><div><h3>Results</h3><div>Measures of functional hand scores (Q-DASH) were higher and had considerably less pain in surgically treated participants, although thumb mobility (Kapandji) was more restricted. They were also associated with higher scores on psychological assessment scales. Sixty-four per cent of the patients came from lower socio-economic classes and suffered from poorer scores on the mental health screening questionnaires. Of the patients manage surgically, 54% were diagnosed of dysthymic disorder and showed significantly worse patient-rated upper-extremity function (Q-DASH questionnaire, median [IR]: 31.8 [20.5–54.6] than patients without psychological disorders (median [IR]: 13.6 [2.3–36.5]). No differences were found for patients with and without dysthymic disorder managed nonoperatively.</div></div><div><h3>Conclusions</h3><div>Patients with higher rates of depression, anxiety and pain catastrophizing behaviour showed significantly worse outcomes after surgery for osteoarthritis of the first carpometacarpal joint. Lower socio-economic class significantly influences levels of depression and anxiety but did not affect functional outcome. Surgical treatment of carpometacarpal thumb osteoarthritis achieved better self-perceived hand function (QDASH, VAS, Kapandji) than conservative treatment.</div></div>","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages T167-T176"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Translated article] The importance of online presence and best practices for the orthopedic surgeon in social media 在线存在和良好社交网络实践对整形外科医生的重要性。
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2024.12.003
M. Vázquez Gómez , M. Galipienso Eri , J. Dellonder Frigolé , A. Hernández Martínez
{"title":"[Translated article] The importance of online presence and best practices for the orthopedic surgeon in social media","authors":"M. Vázquez Gómez ,&nbsp;M. Galipienso Eri ,&nbsp;J. Dellonder Frigolé ,&nbsp;A. Hernández Martínez","doi":"10.1016/j.recot.2024.12.003","DOIUrl":"10.1016/j.recot.2024.12.003","url":null,"abstract":"","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages T222-T223"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Translated article] Efficacy of new active viscosupplements on the behaviour of an experimental model of osteoarthritis 新的活性粘胶补充剂在骨关节炎实验模型行为中的有效性。
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2024.12.009
R.E. Pérez Expósito , M.A. Ortega Núñez , M.J. Buján Varela , R.M. Vega Rodríguez , A.I. Ortíz Chércoles , B.J. De La Torre Escuredo
{"title":"[Translated article] Efficacy of new active viscosupplements on the behaviour of an experimental model of osteoarthritis","authors":"R.E. Pérez Expósito ,&nbsp;M.A. Ortega Núñez ,&nbsp;M.J. Buján Varela ,&nbsp;R.M. Vega Rodríguez ,&nbsp;A.I. Ortíz Chércoles ,&nbsp;B.J. De La Torre Escuredo","doi":"10.1016/j.recot.2024.12.009","DOIUrl":"10.1016/j.recot.2024.12.009","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate with an animal model of osteoarthritis (New Zealand rabbits) the effectiveness of treatment with active viscosupplements (hyaluronic acid loaded with nanoparticles (NPs) that encapsulate anti-inflammatory compounds or drugs.</div></div><div><h3>Material and methods</h3><div>Experimental study composed of 5 groups of rabbits in which section of the anterior cruciate ligament and resection of the internal meniscus were performed to trigger degenerative changes and use it as a model of osteoarthritis. The groups were divided into osteoarthrosis without treatment (I), treatment with commercial hyaluronic acid (HA) (II), treatment with HA with empty nanoparticles (III), treatment with HA with nanoparticles encapsulating dexamethasone (IV) and treatment with HA with nanoparticles that encapsulate curcumin (V). In groups II–V, the infiltration of the corresponding compound was carried out spaced one week apart.</div><div>Macroscopic histological analysis was performed using a scale based on the Outerbridge classification for osteoarthritis.</div></div><div><h3>Results</h3><div>We observed that this osteoarthritis model is reproducible and degenerative changes similar to those found in humans are observed.</div><div>The groups that were infiltrated with hyaluronic acid with curcumin-loaded nanoparticles (V), followed by the dexamethasone group (IV) presented macroscopically less fibrillation, exposure of subchondral bone and sclerosis (better score on the scale) than the control groups (I) (osteoarthritis without treatment), group (II) treated with commercial hyaluronic acid and hyaluronic acid with nanoparticles without drug (III).</div></div><div><h3>Conclusions</h3><div>The use of active viscosupplements could have an additional effect to conventional hyaluronic acid treatment due to its antioxidant and anti-inflammatory effect. The most promising group was hyaluronic acid with nanoparticles that encapsulate curcumin and the second group was the one that encapsulates dexamethasone.</div></div>","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages T150-T157"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ensayo clínico aleatorizado sobre la utilidad de la impresión 3 D en las fracturas intraarticulares de radio distal 3D打印在桡骨远端关节内骨折中的随机临床试验。
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2023.05.011
P.Á. Sebastián Giraldo , M. Elvira Soler , A. Fernández Kang , F. Martínez Martínez , A. García López
{"title":"Ensayo clínico aleatorizado sobre la utilidad de la impresión 3 D en las fracturas intraarticulares de radio distal","authors":"P.Á. Sebastián Giraldo ,&nbsp;M. Elvira Soler ,&nbsp;A. Fernández Kang ,&nbsp;F. Martínez Martínez ,&nbsp;A. García López","doi":"10.1016/j.recot.2023.05.011","DOIUrl":"10.1016/j.recot.2023.05.011","url":null,"abstract":"<div><h3>Objectives</h3><div>We evaluated the utility of 3<!--> <!-->D printing technology for preoperative planning in the treatment of intra-articular fractures of the distal radius in relation to the improvement of surgical technique, radiological and clinical results.</div></div><div><h3>Material and methods</h3><div>A total of 30 patients with 2<!--> <!-->B and C fractures of the AO classification were operated on by a single surgeon with a volar plate, randomly divided into two groups, 15 of them with conventional planning (Rx and CT) and 15 adding a 3<!--> <!-->D model of the fracture and the previous simulation of the intervention. Simulation time, surgical time in minutes, radioscopy time in minutes, loss of material expressed in lost screws were recorded. Clinical evaluation based PRWE questionnaire and full radiographic analysis was done for all patients with a mean follow-up of 6 months by an independent, blinded observed.</div></div><div><h3>Results</h3><div>No statistically significant differences were observed in the PRWE questionnaire (<em>p</em> <!-->=<!--> <!-->0.22), nor were we observed differences in the radiological values, except in relation to the articular step (<em>p</em> <!-->=<!--> <!-->0.028), which represents statistical significance, but in both groups the median was of 0.0 (0.0–0.0). We also did not see statistically significant differences in surgical times (<em>p</em> <!-->=<!--> <!-->0.745), radioscopy (<em>p</em> <!-->=<!--> <!-->0.819) or in the loss of synthesis material (<em>p</em> <!-->=<!--> <!-->0.779).</div></div><div><h3>Conclusions</h3><div>3<!--> <!-->D printing has not improved the parameters studied in relation to routinely operated patients.</div></div>","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages 199-205"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10052946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful prophylactic measures for the eradication of Staphylococcus aureus infections in elective hip primary and revision arthroplasty 在择期髋关节初次和翻修关节置换术中根除金黄色葡萄球菌感染的成功预防措施。
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2024.08.001
J.C. Perdomo-Lizarraga , A. Combalia , J.A. Fernández-Valencia , A. Alías , J. Aponcio , L. Morata , A. Soriano , E. Muñoz-Mahamud
{"title":"Successful prophylactic measures for the eradication of Staphylococcus aureus infections in elective hip primary and revision arthroplasty","authors":"J.C. Perdomo-Lizarraga ,&nbsp;A. Combalia ,&nbsp;J.A. Fernández-Valencia ,&nbsp;A. Alías ,&nbsp;J. Aponcio ,&nbsp;L. Morata ,&nbsp;A. Soriano ,&nbsp;E. Muñoz-Mahamud","doi":"10.1016/j.recot.2024.08.001","DOIUrl":"10.1016/j.recot.2024.08.001","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Staphylococcus aureus</em> stands as the predominant etiological agent in postoperative acute prosthetic joint infections (PJI), contributing to 35–50% of reported cases. This study aimed to evaluate the efficacy of dual prophylaxis incorporating cefuroxime and teicoplanin, in combination with nasal decolonization utilizing 70% alcohol, and oral and body lavage with chlorhexidine.</div></div><div><h3>Material and methods</h3><div>We conducted a retrospective review of electronic health records regarding primary and revision arthroplasties conducted at our institution from 2020 to 2021. Relevant variables linked to prosthetic joint infections (PJI) were documented until the latest follow-up.</div></div><div><h3>Results</h3><div>A total of 539 operations (447 primary arthroplasties and 92 revision arthroplasties) were performed on 519 patients. There were 11 cases of postoperative acute PJI, resulting in infection rates of 1.6% for primary arthroplasties and 4.3% for revision surgeries. Infections were more prevalent in male patients, individuals with an ASA classification<!--> <!-->&gt;<!--> <!-->II, and those undergoing longer operations (&gt;90<!--> <!-->min). <em>S. aureus</em> was not isolated in any of the cases.</div></div><div><h3>Conclusion</h3><div>The prophylactic measures implemented in our institution have exhibited a high efficacy in preventing postoperative acute PJI caused by <em>S. aureus</em>.</div></div>","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages 177-182"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artículo traducido] Enclavado de fracturas intertrocantéricas en población geriátrica: ¿lo sabemos todo?
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2025.01.003
P. Checa-Betegón , Á. Ramos-Fernández , G. Ciller-González , M. Vallejo-Carrasco , J. García-Coiradas , J. Valle-Cruz
{"title":"[Artículo traducido] Enclavado de fracturas intertrocantéricas en población geriátrica: ¿lo sabemos todo?","authors":"P. Checa-Betegón ,&nbsp;Á. Ramos-Fernández ,&nbsp;G. Ciller-González ,&nbsp;M. Vallejo-Carrasco ,&nbsp;J. García-Coiradas ,&nbsp;J. Valle-Cruz","doi":"10.1016/j.recot.2025.01.003","DOIUrl":"10.1016/j.recot.2025.01.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Pertrochanteric fractures constitute an important part of the daily activity of the orthopedic surgeon. The aim of this study was to carry out an analysis of pre-, intra- and post-operative radiographic parameters and to analyze the results of stable and unstable intertrochanteric fractures treated with short nails with dynamic distal locking.</div></div><div><h3>Materials and methods</h3><div>Retrospective study in our center, between the years 2017-2021 of patients over 65<!--> <!-->years of age with pertrochanteric fracture. We included 272 patients treated with Gamma3 Nail (Stryker®) with dynamic distal locking. As variables, we recorded: age, medical comorbidities, fracture pattern according to AO/OTA, osteopenia according to Singh's classification, pre-operative (such as diaphyseal extension), intra-operative (such as tip-to-the-apex or medial cortical support) and post-operative radiographic parameters (such as time to consolidation or loss of reduction), pre- and post-operative Barthel, quality of life and complications and reinterventions, such as non-union or cut-out.</div></div><div><h3>Results</h3><div>The mean age was 83.28<!--> <!-->years (65-102). Two hundred four cases were women (75%). The average follow-up was 18.2<!--> <!-->months (12-24). The distribution according to AO/OTA classification was 85.7% 31.A1; 12.5% 31.A2; 1.9% 31.A3. Radiographic consolidation was obtained in 97.4% of cases. Tip to apex distance was less than 25<!--> <!-->mm in 95.6% of cases. Medial cortical support was positive or neutral in 88.6% of cases. Sixty cases (22.1%) of screw back-out were recorded. Eight reinterventions (2.9%) were performed, corresponding to three cut-outs (1.1%), three non-unions (1.1%), one avascular necrosis (0.4%) and one secondary hip osteoarthritis (0.4%).</div></div><div><h3>Conclusions</h3><div>Short nail with dynamic distal locking offers good clinical, radiological and functional results in all types of AO/OTA patterns, without increasing the complication rate, as long as there is an appropriate tip-to-the-apex distance and good medial cortical support.</div></div>","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages T190-T198"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Translated article] Digital orthopaedic surgery: Benefits and challenges of extended reality and spatial computing
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2025.01.004
R. Pérez-Mañanes , J.A. Calvo-Haro
{"title":"[Translated article] Digital orthopaedic surgery: Benefits and challenges of extended reality and spatial computing","authors":"R. Pérez-Mañanes ,&nbsp;J.A. Calvo-Haro","doi":"10.1016/j.recot.2025.01.004","DOIUrl":"10.1016/j.recot.2025.01.004","url":null,"abstract":"","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages T107-T109"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Translated article] Rivaroxaban versus enoxaparin for thromboprophylaxis in orthopedic surgery: A meta-analysis
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2025.01.005
O. Abad Vélaz, I. Carbonel Bueno
{"title":"[Translated article] Rivaroxaban versus enoxaparin for thromboprophylaxis in orthopedic surgery: A meta-analysis","authors":"O. Abad Vélaz,&nbsp;I. Carbonel Bueno","doi":"10.1016/j.recot.2025.01.005","DOIUrl":"10.1016/j.recot.2025.01.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Venous thromboembolism is highly associated with orthopedic surgery, so thromboprophylaxis is an important consideration for orthopedic surgeons. The new oral anticoagulants have clear advantages for clinical practice.</div></div><div><h3>Objectives</h3><div>To analyze the efficacy and safety of rivaroxaban versus enoxaparin for thromboprophylaxis in different orthopedic surgeries.</div></div><div><h3>Material and methods</h3><div>Systematic electronic search of clinical trials was carried out. Data extraction of efficacy outcomes (deep venous thrombosis, pulmonary embolism and death) and safety outcomes (major bleeding and clinically relevant bleeding) was realized.</div></div><div><h3>Results</h3><div>Six randomized and controlled clinical trials were included in this meta-analysis. Compared with enoxaparin the risk of venous thromboembolism was lower with rivaroxaban both in different orthopedic surgeries (RR: 0.51; 95% CI: 0.36–0.73; <em>p</em> <!-->=<!--> <!-->.0002). This result was even better and more homogeneous in the analysis of symptomatic deep venous thrombosis outcome (RR: 0.43; 95% CI: 0.28–0.65; <em>p</em> <!-->&lt;<!--> <!-->.0001; <em>I</em><sup>2</sup> <!-->=<!--> <!-->0%; <em>p</em> <!-->=<!--> <!-->.49). The risk of bleeding was not significantly higher with rivaroxaban (RR: 1.20; 95% CI: 0.97–1.49; <em>p</em> <!-->=<!--> <!-->.09).</div></div><div><h3>Conclusions</h3><div>Rivaroxaban should be considerate such as a more effective alternative for thromboprophylaxis in orthopedic surgery.</div></div>","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages T210-T220"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La importancia de la presencia online y buenas prácticas en redes sociales para el Cirujano Ortopédico 整形外科医生在社交媒体上在线展示和最佳实践的重要性。
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2023.09.010
M. Vázquez Gómez , M. Galipienso Eri , J. Dellonder Frigolé , A. Hernández Martínez
{"title":"La importancia de la presencia online y buenas prácticas en redes sociales para el Cirujano Ortopédico","authors":"M. Vázquez Gómez ,&nbsp;M. Galipienso Eri ,&nbsp;J. Dellonder Frigolé ,&nbsp;A. Hernández Martínez","doi":"10.1016/j.recot.2023.09.010","DOIUrl":"10.1016/j.recot.2023.09.010","url":null,"abstract":"","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages 222-223"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eficacia de nuevos viscosuplementos activos en el comportamiento de un modelo experimental de osteoartritis (新型活性粘液补充剂对骨关节炎实验模型行为的功效)。
Revista Espanola de Cirugia Ortopedica y Traumatologia Pub Date : 2025-03-01 DOI: 10.1016/j.recot.2024.04.006
R.E. Pérez Expósito , M.A. Ortega Núñez , M.J. Buján Varela , R.M. Vega Rodríguez , A.I. Ortíz Chércoles , B.J. De La Torre Escuredo
{"title":"Eficacia de nuevos viscosuplementos activos en el comportamiento de un modelo experimental de osteoartritis","authors":"R.E. Pérez Expósito ,&nbsp;M.A. Ortega Núñez ,&nbsp;M.J. Buján Varela ,&nbsp;R.M. Vega Rodríguez ,&nbsp;A.I. Ortíz Chércoles ,&nbsp;B.J. De La Torre Escuredo","doi":"10.1016/j.recot.2024.04.006","DOIUrl":"10.1016/j.recot.2024.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate with an animal model of osteoarthritis (New Zealand rabbits) the effectiveness of treatment with active viscosupplements (hyaluronic acid loaded with nanoparticles (NPs) that encapsulate anti-inflammatory compounds or drugs.</div></div><div><h3>Material and methods</h3><div>Experimental study composed of 5 groups of rabbits in which section of the anterior cruciate ligament and resection of the internal meniscus were performed to trigger degenerative changes and use it as a model of osteoarthritis. The groups were divided into osteoarthrosis without treatment (I), treatment with commercial hyaluronic acid (HA) (II), treatment with HA with empty nanoparticles (III), treatment with HA with nanoparticles encapsulating dexamethasone (IV) and treatment with HA with nanoparticles that encapsulate curcumin (V). In groups II to V, the infiltration of the corresponding compound was carried out spaced one week apart.</div><div>Macroscopic histological analysis was performed using a scale based on the Outerbridge classification for osteoarthritis.</div></div><div><h3>Results</h3><div>We observed that this osteoarthritis model is reproducible and degenerative changes similar to those found in humans are observed.</div><div>The groups that were infiltrated with hyaluronic acid with curcumin-loaded nanoparticles (V), followed by the dexamethasone group (IV) presented macroscopically less fibrillation, exposure of subchondral bone and sclerosis (better score on the scale) than the control groups (I) (osteoarthritis without treatment), group (II) treated with commercial hyaluronic acid and hyaluronic acid with nanoparticles without drug (III).</div></div><div><h3>Conclusions</h3><div>The use of active viscosupplements could have an additional effect to conventional hyaluronic acid treatment due to its antioxidant and anti-inflammatory effect. The most promising group was hyaluronic acid with nanoparticles that encapsulate curcumin and the second group was the one that encapsulates dexamethasone.</div></div>","PeriodicalId":39664,"journal":{"name":"Revista Espanola de Cirugia Ortopedica y Traumatologia","volume":"69 2","pages":"Pages 150-157"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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