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Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II. 直接分析 RNA 聚合酶 II Rpb1 C 端域上的磷酸化位点
IF 16
Journal of Medical and Dental Sciences Pub Date : 2016-01-21 DOI: 10.1016/j.molcel.2015.12.021
Hyunsuk Suh, Scott B Ficarro, Un-Beom Kang, Yujin Chun, Jarrod A Marto, Stephen Buratowski
{"title":"Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II.","authors":"Hyunsuk Suh, Scott B Ficarro, Un-Beom Kang, Yujin Chun, Jarrod A Marto, Stephen Buratowski","doi":"10.1016/j.molcel.2015.12.021","DOIUrl":"10.1016/j.molcel.2015.12.021","url":null,"abstract":"<p><p>Dynamic interactions between RNA polymerase II and various mRNA-processing and chromatin-modifying enzymes are mediated by the changing phosphorylation pattern on the C-terminal domain (CTD) of polymerase subunit Rpb1 during different stages of transcription. Phosphorylations within the repetitive heptamer sequence (YSPTSPS) of CTD have primarily been defined using antibodies, but these do not distinguish different repeats or allow comparative quantitation. Using a CTD modified for mass spectrometry (msCTD), we show that Ser5-P and Ser2-P occur throughout the length of CTD and are far more abundant than other phosphorylation sites. msCTD extracted from cells mutated in several CTD kinases or phosphatases showed the expected changes in phosphorylation. Furthermore, msCTD associated with capping enzyme was enriched for Ser5-P while that bound to the transcription termination factor Rtt103 had higher levels of Ser2-P. These results suggest a relatively sparse and simple \"CTD code.\" </p>","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"49 4 1","pages":"297-304"},"PeriodicalIF":16.0,"publicationDate":"2016-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86068011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic cytological evaluation and immunocytochemistry of minichromosome maintenance protein 2 and p53 significantly improve cytological diagnosis of pancreaticobiliary adenocarcinoma. 小染色体维持蛋白2和p53的系统细胞学评估和免疫细胞化学可显著提高胰腺胆管腺癌的细胞学诊断。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/jmds.630103
Naoya Abe, Kozue Matsuo, Toshio Kumasaka, Koichi Naka, Syoichi Hashimoto, Tamiko Takemura, Mutsunori Fujiwara, Yukiko Ito, Ryo Nakata, Takuya Hashimoto, Masatoshi Makuuchi, Yurie Soejima, Motoji Sawabe
{"title":"Systematic cytological evaluation and immunocytochemistry of minichromosome maintenance protein 2 and p53 significantly improve cytological diagnosis of pancreaticobiliary adenocarcinoma.","authors":"Naoya Abe,&nbsp;Kozue Matsuo,&nbsp;Toshio Kumasaka,&nbsp;Koichi Naka,&nbsp;Syoichi Hashimoto,&nbsp;Tamiko Takemura,&nbsp;Mutsunori Fujiwara,&nbsp;Yukiko Ito,&nbsp;Ryo Nakata,&nbsp;Takuya Hashimoto,&nbsp;Masatoshi Makuuchi,&nbsp;Yurie Soejima,&nbsp;Motoji Sawabe","doi":"10.11480/jmds.630103","DOIUrl":"https://doi.org/10.11480/jmds.630103","url":null,"abstract":"<p><p>Endoscopic retrograde cholangiopancreatography (ERCP) brushing cytology often cannot distinguish adenocarcinoma from reactive epithelial changes. We attempted to improve the diagnostic sensitivity of ERCP using the following methods: systematic cytological evaluation, immunocytochemical examination of minichromosome maintenance proteins (MCM) 2 and p53, and a combination of these methods. ERCP specimens from 53 patients (13 benign and 40 malignant cases) were studied. First, we reclassified the cases into three categories according to the systematic cytological evaluation: negative, suspicious, and positive. Secondly, immunocytochemistry was performed for MCM 2 and p53. The cut-off values were set at 25% labeling index (LI) for MCM 2 and 10% LI for p53, respectively. We evaluated the sensitivity, specificity, and diagnostic accuracy. The sensitivity of the systematic cytological evaluation alone did not improve significantly, compared with the original screening examination (77% vs. 68%). The sensitivity of immunocytochemistry for MCM 2 and p53 was 90% (P < 0.05) and 68%, respectively. Applying only the suspicious or positive categories, the sensitivity improved significantly to 93% for the combination of systematic cytological evaluation and immunocytochemistry for MCM 2 and p53 (P < 0.01). In conclusion, the combination of morphology and immunocytochemistry for MCM 2 and p53 may help to overcome the diagnostic cytological difficulties of pancreaticobiliary adenocarcinoma. </p>","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 1","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/jmds.630103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34484252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Evaluation of simulation learning materials use to fill the gap in Japanese dental English education. 评价模拟学习材料的使用,填补了日本牙科英语教育的空白。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/jmds.630101
Naoko Seki, Janelle Moross, Masayo Sunaga, Koki Hobo, Tomoe Miyoshi, Hiroshi Nitta, Atsuhiro Kinoshita, Ikuko Morio
{"title":"Evaluation of simulation learning materials use to fill the gap in Japanese dental English education.","authors":"Naoko Seki,&nbsp;Janelle Moross,&nbsp;Masayo Sunaga,&nbsp;Koki Hobo,&nbsp;Tomoe Miyoshi,&nbsp;Hiroshi Nitta,&nbsp;Atsuhiro Kinoshita,&nbsp;Ikuko Morio","doi":"10.11480/jmds.630101","DOIUrl":"https://doi.org/10.11480/jmds.630101","url":null,"abstract":"<p><p>Even though English is most frequently the common language when the patient's native language differs from that of a dentist, the opportunities for Japanese undergraduate dental students to learn dental English are now quite limited. The purposes of our study were to investigate: the effectiveness and feasibility of the computer-assisted simulation materials as one solution strategy for dental English education in Japan, and the needs and demands for dental English from the learners' side. Interactive simulation materials for medical interviews in English and clinical cases which were translated to English, were delivered via Learning Management System (LMS) to nineteen trainee residents of dentistry (residents). Evaluation for the materials, learners' knowledge and interests in the contents, and ease of operation were obtained by post-questionnaire (response rates were 100% and 95%, respectively). Both questionnaire-surveys received positive feedback toward the materials, yet 47% answered that they lacked the level of knowledge about contents of the medical interview in English. Results were sufficient to suggest that the residents would like to have the opportunity to study or practice medical interview in English, or English related to dentistry, and that the simulation materials could be one of the solution strategies for opportunity provision. </p>","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/jmds.630101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34484250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Drug delivery and transmission of lidocaine using iontophoresis in combination with direct and alternating currents. 离子电泳联用直流电和交流电给药和传递利多卡因。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/jmds.630402
Takutoshi Inoue, T. Sugiyama, T. Ikoma, H. Shimazu, R. Wakita, H. Fukayama
{"title":"Drug delivery and transmission of lidocaine using iontophoresis in combination with direct and alternating currents.","authors":"Takutoshi Inoue, T. Sugiyama, T. Ikoma, H. Shimazu, R. Wakita, H. Fukayama","doi":"10.11480/jmds.630402","DOIUrl":"https://doi.org/10.11480/jmds.630402","url":null,"abstract":"The present study investigates how effectively lidocaine ions are transported across a cellophane membrane through the application of either a direct current (DC) or alternating current (AC). The cellophane membrane was set on a parallelplate- type acrylic cell with platinum electrodes at both ends, filled with a donor cell of a 1 % aqueous solution of lidocaine and a receptor cell with distilled water. Lidocaine concentrations were measured for 60 min while the following voltages were applied, with changes every 10 min: 3 V DC and 7.5 V sine wave AC; frequency at 1 kHz. As a result, lidocaine concentrations in the receptor cell increased in a time-dependent manner. Significant increases in lidocaine concentrations were observed in groups where the voltage combination consisted of DC 30 min/AC 30 min, DC 50 min/AC 10 min, DC 60 min and AC 10 min/DC 50 min, compared with the passive diffusion group or in groups where voltage application was performed for 20, 30 , 40, 50 and 60 min. Significant increases were also observed in groups where the voltage combination consisted of A C 6 0 min, D C 10 min/AC 5 0 min, AC 3 0 min/ DC 30 min and AC 50 min/DC 10 min, compared with the passive diffusion group or in groups where voltage application was performed for 40, 50 and 60 min. These results suggest that lidocaine was delivered more rapidly with DC than with AC, and that its ions are transported faster when voltage is switched from DC to AC than from AC to DC, which is presumably due to the contribution of electrorepulsion by DC voltage application and the vibration energy infiltration mechanism owning to AC. Iontophoresis in combination with DC and AC was found to enable highly efficient drug delivery that shares the benefits of both forms of current application.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 4 1","pages":"71-77"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/jmds.630402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64012023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Identification of frequency, severity and risk factors of complications after open gastrectomy: Retrospective analysis of prospectively collected database using the Clavien-Dindo classification. 开放式胃切除术后并发症发生频率、严重程度及危险因素的识别:采用Clavien-Dindo分类对前瞻性收集的数据库进行回顾性分析。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/JMDS.630303
M. Nakagawa, K. Kojima, M. Inokuchi, Keiji Kato, H. Sugita, Sho Otsuki, K. Sugihara
{"title":"Identification of frequency, severity and risk factors of complications after open gastrectomy: Retrospective analysis of prospectively collected database using the Clavien-Dindo classification.","authors":"M. Nakagawa, K. Kojima, M. Inokuchi, Keiji Kato, H. Sugita, Sho Otsuki, K. Sugihara","doi":"10.11480/JMDS.630303","DOIUrl":"https://doi.org/10.11480/JMDS.630303","url":null,"abstract":"Introduction The purpose of this study was to identify the frequency, severity, and risk factors of complications after open gastrectomy using the Clavien- Dindo classification because institution-specific criteria were mostly used in the previous articles. Materials and Methods All complication data were obtained from our prospectively collected database of open gastrectomy from January 1999 to December 2012 (n=539). Complications were classified into either major surgical complications such as pancreatic fistula, abdominal abscess, and anastomotic leakage, or others. Frequency and severity were graded retrospectively according to the Clavien- Dindo classification for subsequent analysis of risk factors. Results There were 222 events occurred in 156 patients (28.9%). Complications of grade IIIa or greater were 8.3% for major surgical complications and 10.6% for all complications. The mortality rate was 1.1%. Blood loss was the only independent risk factor for major surgical complications of grade IIIa or greater (odds ratio 1.923, 95% Confidence Interval 0.320-0.786, p=0.003). Total gastrectomy was the only independent risk factor for all complications of grade IIIa or greater (Odds ratio 2.075, 95% Confidence Interval 0.260-0.896, p=0.021). Disscussion The present study provided the objective overview regarding complications after open gastrectomy. Blood loss and total gastrectomy were revealed as the significant risk factors for complications.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 2-3 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/JMDS.630303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64011948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Hypoxia enhances proliferation through increase of colony formation rate with chondrogenic potential in primary synovial mesenchymal stem cells. 缺氧通过增加原代滑膜间充质干细胞具有成软骨潜能的集落形成率来促进增殖。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/jmds.630401
T. Ohara, T. Muneta, Y. Nakagawa, Yu Matsukura, S. Ichinose, H. Koga, K. Tsuji, I. Sekiya
{"title":"Hypoxia enhances proliferation through increase of colony formation rate with chondrogenic potential in primary synovial mesenchymal stem cells.","authors":"T. Ohara, T. Muneta, Y. Nakagawa, Yu Matsukura, S. Ichinose, H. Koga, K. Tsuji, I. Sekiya","doi":"10.11480/jmds.630401","DOIUrl":"https://doi.org/10.11480/jmds.630401","url":null,"abstract":"Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus regeneration. Use of primary MSCs is the preferable because these cells are safer than cells passaged several times in terms of probability of chromosome abnormalities. The effect of hypoxia on the proliferation of MSCs is controversial and remains unknown in primary synovial MSCs. Primary synovial MSCs were cultured at normoxia or hypoxia, and colony number, cell number, surface epitopes, mitochondria activity, TEM finding, and chondrogenic potential were analyzed. To investigate the effect of hypoxia on attachment of synovial MSCs, cells were cultured at hypoxia for the first 3 days, then cultured at normoxia. To investigate the effect of hypoxia on proliferation, cells were also cultured at hypoxia for the last 11 days. Hypoxia increased colony number and cell number per dish in primary synovial MSCs. Hypoxia did not affect cell number per colony, surface epitopes, mitochondria activity, TEM finding or chondrogenic potential. Hypoxia for the first 3 days did not alter colony number per dish or cell number per dish, while hypoxia for the last 11 days increased. Hypoxia enhanced proliferation through increase of colony formation rate with chondrogenic potential in primary synovial MSCs.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 4 1","pages":"61-70"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/jmds.630401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64012010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Relationship between regional population and healthcare delivery in Japan. 日本地区人口与卫生保健服务的关系
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/jmds.630102
Takeo Niga, Maiko Mori, Kazuo Kawahara
{"title":"Relationship between regional population and healthcare delivery in Japan.","authors":"Takeo Niga,&nbsp;Maiko Mori,&nbsp;Kazuo Kawahara","doi":"10.11480/jmds.630102","DOIUrl":"https://doi.org/10.11480/jmds.630102","url":null,"abstract":"<p><p>In order to address regional inequality in healthcare delivery in Japan, healthcare districts were established in 1985. However, regional healthcare delivery has now become a national issue because of population migration and the aging population. In this study, the state of healthcare delivery at the district level is examined by analyzing population, the number of physicians, and the number of hospital beds. The results indicate a continuing disparity in healthcare delivery among districts. We find that the rate of change in population has a strong positive correlation with that in the number of physicians and a weak positive correlation with that in the number of hospital beds. In addition, principal component analysis is performed on three variables: the rate of change in population, the number of physicians per capita, and the number of hospital beds per capita. This analysis suggests that the two principal components contribute 90.1% of the information. The first principal component is thought to show the effect of the regulations on hospital beds. The second principal component is thought to show the capacity to recruit physicians. This study indicates that an adjustment to the regulations on hospital beds as well as physician allocation by public funds may be key to resolving the impending issue of regionally disproportionate healthcare delivery. </p>","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/jmds.630102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34484251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Study on Evaluation of Alanine Aminotransferase (ALT) as Surrogate Marker in Hepatitis Virus Test. 丙氨酸转氨酶(ALT)作为替代标志物在肝炎病毒检测中的价值研究。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/JMDS.630302
Daisuke Ikeda, M. Sugawa, K. Kawahara
{"title":"Study on Evaluation of Alanine Aminotransferase (ALT) as Surrogate Marker in Hepatitis Virus Test.","authors":"Daisuke Ikeda, M. Sugawa, K. Kawahara","doi":"10.11480/JMDS.630302","DOIUrl":"https://doi.org/10.11480/JMDS.630302","url":null,"abstract":"Nucleic acid amplification test (NAT), which was introduced by the Japanese Red Cross Society in October 1999, began to be performed for screening of blood transfusion formulations in Japan in August 2014. In this study, the precision of immunological screenings of hepatitis B (HBsAg, HBcAb, and HBsAb), hepatitis C (HCVAb), and human immunodeficiency (HIVAb) virus antigens in donated blood were evaluated. In addition, the sensitivity of the alanine aminotransferase (ALT) test for detection of the hepatitis B and C viruses was re-evaluated. Immunological screenings showed high precision of detecting the viral antigens. In contrast, the ALT test showed much lower precision of detecting the presence of the hepatitis B and C viruses. Results of the NAT and immunological screenings revealed that ALT levels in donors were more strongly correlated with their levels of gammaglutamyltranspeptidase (γGTP) and body mass index (BMI), than with the results of NAT and immunological screening. Our study indicates that elevated level(s) of ALT, were more likely to be associated with lifestyles factors such as high intake of alcohol or obesity than with infection. Therefore, ALT may be excluded as surrogate markers of HBV, HCV, and HIV in donated blood.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 2-3 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/JMDS.630302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64011940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Usefulness of the transfer function index for diagnosing peripheral arterial disease in patients with arterial calcification. 传递函数指数对动脉钙化患者外周动脉疾病的诊断价值。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/jmds.630104
Abulimiti Zainuer, Yoshinori Inoue, Toshifumi Kudo, Takahiro Toyofuku, Kimihiro Igari, Tatsuyuki Kawano
{"title":"Usefulness of the transfer function index for diagnosing peripheral arterial disease in patients with arterial calcification.","authors":"Abulimiti Zainuer,&nbsp;Yoshinori Inoue,&nbsp;Toshifumi Kudo,&nbsp;Takahiro Toyofuku,&nbsp;Kimihiro Igari,&nbsp;Tatsuyuki Kawano","doi":"10.11480/jmds.630104","DOIUrl":"https://doi.org/10.11480/jmds.630104","url":null,"abstract":"<p><strong>Unlabelled: </strong>The aim of this study was to investigate which parameters among the ankle brachial index (ABI), toe brachial pressure index (TBI) and transfer function index (TFI) are useful to accurately diagnose PAD in patients with / without arterial calcification, who have undergone some type of diagnostic imaging.</p><p><strong>Patients and methods: </strong>A total of 102 patients with 192 limbs (mean age: 72.0 ± 8.4 years) underwent plain radiography, ABI, TBI and TFI. A receiver operating characteristics (ROC) analysis was performed to assess possible threshold values that predict PAD in these patients.</p><p><strong>Results: </strong>T he a rea u nder t he c urve ( AUC) o f t he ABI, TBI and TFI were 83.0%, 87.9%, 93.1% in the all limbs group, respectively. In the non-calcified lesion group, the AUC of the ABI, TBI and TFI were 94.4%, 87.9%, 93.1%, respectively. In the calcified lesion group, the AUC of the ABI, TBI and TFI were 71.4%, 87.9% and 92.9%, respectively.</p><p><strong>Conclusions: </strong>A cut-off value of TFI ≦ 1.025 exhibits a higher AUC for detecting the presence of PAD than the ABI and TBI. Therefore, the TFI is considered to be useful to estimate the presence of PAD in all types of patients, especially those with arterial calcification.</p>","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/jmds.630104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34484253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of Depression in Patients Diagnosed with Myocardial Infarction after Undergoing Percutaneous Coronary Intervention: A literature review. 经皮冠状动脉介入治疗后诊断为心肌梗死患者抑郁的预测因素:文献综述。
Journal of Medical and Dental Sciences Pub Date : 2016-01-01 DOI: 10.11480/JMDS.630301
Mana Doi-Kanno, Hiroki Fukahori
{"title":"Predictors of Depression in Patients Diagnosed with Myocardial Infarction after Undergoing Percutaneous Coronary Intervention: A literature review.","authors":"Mana Doi-Kanno, Hiroki Fukahori","doi":"10.11480/JMDS.630301","DOIUrl":"https://doi.org/10.11480/JMDS.630301","url":null,"abstract":"AIM This study identified the factors associated with depression in patients diagnosed with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI). METHODS We searched the literature using PubMed and CINAHL from their inception in 1946 to December 2014. The search terms were \"myocardial infarction,\" \"depression,\" and \"percutaneous coronary intervention.\" Studies which investigated factors associated with depression in patients diagnosed with MI who underwent typical medical procedures were searched. RESULTS Eleven studies met our inclusion criteria. None of these limited their samples to patients with MI who underwent PCI. Twenty-one factors were identified as possible risk factors for depression in patients who were diagnosed with MI and underwent PCI: gender; negative illness beliefs; neuroticism; autonomy; baseline depression scores; previous diagnosis of depression, anxiety, or stress; smoking; marital status; Type D personality; procedure; length of hospital stay; fat intake; functional disability; time engaged in physical activity; social support; and a history of angina, MI, coronary artery bypass graft surgery, PCI, diabetes mellitus, and stroke. CONCLUSIONS This review suggests that these 21 factors should be considered in future studies as possible independent variables or covariates of depression among MI patients who have undergone PCI.","PeriodicalId":39643,"journal":{"name":"Journal of Medical and Dental Sciences","volume":"63 2-3 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11480/JMDS.630301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64011929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
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