Issue 2 2022最新文献

Metabolic cardiocytoprotectors (trimetazidine and trimethylhydrazine) in geriatrics.Short review 代谢性心肌细胞保护剂(曲美他嗪和三甲肼)在老年病学中的应用。短的审查

Issue 2 2022 Pub Date : 2022-06-07 DOI: 10.47855/jal9020-2022-2-5

L. Kuprash, O. Kuprash, Svetlana Gudarenko

引用次数: 0

Structural damage of myelin in experimental Parkinsonism and prospects for their drug correction in the clinic of Parkinson's disease 实验性帕金森病髓磷脂结构损伤及其在帕金森病临床药物矫正的前景

Issue 2 2022 Pub Date : 2022-05-09 DOI: 10.47855/jal9020-2022-2-3

K. Rozova, Tatiana Gasyuk, N. Karasevich, I. Karaban

{"title":"Structural damage of myelin in experimental Parkinsonism and prospects for their drug correction in the clinic of Parkinson's disease","authors":"K. Rozova, Tatiana Gasyuk, N. Karasevich, I. Karaban","doi":"10.47855/jal9020-2022-2-3","DOIUrl":"https://doi.org/10.47855/jal9020-2022-2-3","url":null,"abstract":"Changes in myelin ultrastructure under experimental Parkinsonism in the tissues of the medulla oblongata and striatum were performed under experimental Parkinsonism induced by rotenone administration in 30 adult rats of the Wistar line. Clinico-electromyographic studies were performed on patients with Parkinson's disease with a stage of disease 2.0 -3.0 (Hoehn a. Yahr). \u0000Efficacy of Cerebrolysin has been shown to correct myelin abnormalities to elucidate the effect on the muscle reflex response to irritation of sensitive nerve fibres of the mixed nerve with subsequent monosynaptic activation of motor neurons and spinal cord neurons. One of the mechanisms associated with myelin damage in Parkinsonism is the development of mitochondrial dysfunction, in any case, its ultrastructural component. The use of Cerebrolysin leads to a significant elimination of mitochondrial dysfunction and myelin damage. It can be assumed that the positive effect of the drug lies in the antioxidant effect, which, in turn, effect the transmembrane conductivity, which should be considered one of the neuroprotective effects of the drug.\u0000\u0000Keywords: experimental Parkinsonism; Parkinson's disease; myelin; medulla oblongata; sriatum; mitochondrial dysfunction; transmembrane conductivity; cerebrolysin.","PeriodicalId":395284,"journal":{"name":"Issue 2 2022","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133643996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating the functional age of the cardiorespiratory system 估计心肺系统的功能年龄

Issue 2 2022 Pub Date : 2022-05-04 DOI: 10.47855/jal9020-2022-2-2

A. Pisaruk, V. Shatilo, I. Antoniuk-Shcheglova, V.Р. Chyzhova, L. Mekhova, S. Naskalova, N. Koshel, S. Ivanov

引用次数: 1

Posttraumatic stress disorder: online poll of people who experienced war stress in Ukraine in 2022 创伤后应激障碍:对2022年乌克兰经历战争压力的人进行的在线调查

Issue 2 2022 Pub Date : 2022-05-03 DOI: 10.47855/jal9020-2022-2-4

A. Pisaruk, V. Shatilo, V.Р. Chyzhova, N. Koshel, L. Pisaruk, S. Ivanov

{"title":"Posttraumatic stress disorder: online poll of people who experienced war stress in Ukraine in 2022","authors":"A. Pisaruk, V. Shatilo, V.Р. Chyzhova, N. Koshel, L. Pisaruk, S. Ivanov","doi":"10.47855/jal9020-2022-2-4","DOIUrl":"https://doi.org/10.47855/jal9020-2022-2-4","url":null,"abstract":"Abstract. The gold standard for diagnosing PTSD is structured clinical interviews, the PCL-5 scale. To use of this English-language translator in Ukraine, we have made a translation to the Ukrainian language. For the collection of data, we use the online method which was divided by the Google company (Google Forms). Our task was to measure the frequency of PTSD development in different groups of people who survived the military stress in Ukraine from February -to April of 2022. The interview was taken with 212 persons years of aged 18 to 82 years, which live in Kyiv and before the city. The experiment was carried out from April 14 to May 17, 2022. The incidence of PTSD in people who were in the war zone was 43.1%, and in refugees - 27.5%. At the same time, in people who were outside the combat zone, the incidence of PTSD was significantly lower - 18.6%. Thus, the verification of the PCL-5 scale on the Ukrainian population of people affected by the war showed that this scale adequately assesses the severity of war stress and can be used for diagnostic PTSD.\u0000Keywords: war stress, posttraumatic stress disorder, Ukraine-2022","PeriodicalId":395284,"journal":{"name":"Issue 2 2022","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133869278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Quercetin effect on endogenous factors of cardiovascular risk and ageing biomarkers in elderly people 槲皮素对老年人心血管危险内源性因素和衰老生物标志物的影响

Issue 2 2022 Pub Date : 2022-05-02 DOI: 10.47855/10.47855/jal9020-2022-2-1

V. Shatilo, I. Antonyuk-Shcheglova, S. Naskalova, O. Bondarenko, Oksana Hrib, Dmitry Krasnienkov, A. Pisaruk

引用次数: 1