Natural Resources for Human Health最新文献_第5页

In silico Investigation of inhibitory characteristics of phytoconstituents from Moringa oleifera against SARS-CoV-2 viral proteins 辣木植物成分对SARS-CoV-2病毒蛋白抑制特性的实验研究

Natural Resources for Human Health Pub Date : 2022-09-21 DOI: 10.53365/nrfhh/153401

A. Shrivastava, D. Chaudhary, L. Shrestha, Anjan Palikhey, Chandrajeet Kumar Yadav, Deepak Basyal, B. Joshi, Mohammad Ujair Shekh

{"title":"In silico Investigation of inhibitory characteristics of phytoconstituents from Moringa oleifera against SARS-CoV-2 viral proteins","authors":"A. Shrivastava, D. Chaudhary, L. Shrestha, Anjan Palikhey, Chandrajeet Kumar Yadav, Deepak Basyal, B. Joshi, Mohammad Ujair Shekh","doi":"10.53365/nrfhh/153401","DOIUrl":"https://doi.org/10.53365/nrfhh/153401","url":null,"abstract":"The global pandemic situation caused by rare viral pneumonia occurs in late December 2019 in Wuhan, China, which we now recognize as COVID-19. The molecular docking was used to identify potential phytoconstituents of Moringa oleifera and reference drug hydroxychloroquine on SARS-CoV-2 main protein by using AutoDock 4.2.6 and Auto dock Vina. All the physicochemical and bioactive parameters (ADME, toxicity study, receptor interaction, PASS analysis, drug-likeness) were determined using different online validated software. The binding energy of all SAR-CoV-2 proteins with selected phytoconstituents of Moringa oleifera were found to be beta carotene, vitamin E; myricetin, quercetin showed the highest binding affinity with all interacting proteins comparable with other drugs and reference drug hydroxychloroquine as an order: beta carotene > myricetin > quercetin > vitamin E> hydroxychloroquine>quinic acid. The MD simulation analysis of viral protein (6MOJ) with beta carotene, vitamin E and myricetin demonstrated strong stability at 300 K. All three complexes exhibit persistent RMSDs value (0.25 – 1.5 Å) of protein side-chain Cα atoms during the 3 ns MD simulation time scale. The minor changes of all three ligands with 2 different viral proteins increasing the compactness of ligands with protein in radius of gyration suggested the strong structural activity of ligands and the least fluctuation during the MD simulation (31.2, 30.0 and 31.2), respectively. In the present study revealed that all the active constituents of Moringa oleifera show good binding affinity, but beta carotene and myricetin have an excellent affinity with SARS-CoV-2 proteins respectively.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131148685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Benzo[c]phenanthridine alkaloids and glycosylated flavonoids from the roots of Zanthoxylum gilletii (Rutaceae) 花椒科花椒根中苯并[c]苯胺生物碱和糖基化黄酮类化合物的研究

Natural Resources for Human Health Pub Date : 2022-09-21 DOI: 10.53365/nrfhh/154598

Liliane Clotilde Dzouemo, Emmanuel Ngeufa Happi, Mouthe Gervais Happi, Willifred Dongmo Tekapi Tsopgni, J. Wansi

引用次数: 1

FT-IR coupled secondary metabolites profiling and biological activities of Neolamarckia cadamba leaves 傅里叶变换红外(FT-IR)耦合的新木杨叶片次生代谢产物分析及生物活性研究

Natural Resources for Human Health Pub Date : 2022-09-15 DOI: 10.53365/nrfhh/148092

J. George, Pratik P. Dhavan, B. Jadhav, G. Meshram, V. Patil

引用次数: 1

The upshots of COVID-19 quarantine over diet, social interaction and education COVID-19隔离对饮食、社交和教育的影响

Natural Resources for Human Health Pub Date : 2022-09-14 DOI: 10.53365/nrfhh/147311

Yusuf Hussain, Kahkashan Moheet, S. Luqman, A. Meena

{"title":"The upshots of COVID-19 quarantine over diet, social interaction and education","authors":"Yusuf Hussain, Kahkashan Moheet, S. Luqman, A. Meena","doi":"10.53365/nrfhh/147311","DOIUrl":"https://doi.org/10.53365/nrfhh/147311","url":null,"abstract":"This study aimed to determine the impact of COVID-19 lockdown on lifestyle changes, including eating habits, daily routine, behaviour, education and research amid the volunteers of the Council of Scientific and Industrial Research-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India. A well-organised questionnaire with demographic and anthropometric information, dietary information, education and research information, and daily routine habits before, during and after the lockdown was prepared in January-March 2021 for impact analysis. The questionnaire was distributed amongst 600 volunteers. Each section within the questionnaire was explained well for an appropriate response. The questionnaire was collected after 15 days. 150 volunteers responded to the questionnaire, ages ranging from 15-60 years, including 64 males and 86 females. More than 60% sensed a change in hunger and satiety sensations, and 50% gained weight. The Body Mass Index (BMI) of 88 volunteers was reduced with a compromised daily routine and social behaviour. Moreover, 50% of volunteers did not prefer the online education system. The experimental research activities were disrupted, and it took ~72 days to resume. This study concludes that during the lockdown, the lifestyle, eating habits, daily routine, behaviour, and education were compromised but not significantly and therefore, it reverted after the lockdown.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130017661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating phytochemical profiling, in vitro studies and network pharmacology to reveal the antidiabetic action mechanism of Punica granatum fruit peel 综合植物化学分析、体外研究和网络药理学研究，揭示石榴果皮的抗糖尿病作用机制

Natural Resources for Human Health Pub Date : 2022-09-14 DOI: 10.53365/nrfhh/153385

M. Ibrahim, R. Tiwari, Mohammad Fahim, Sadique Nirban

{"title":"Integrating phytochemical profiling, in vitro studies and network pharmacology to reveal the antidiabetic action mechanism of Punica granatum fruit peel","authors":"M. Ibrahim, R. Tiwari, Mohammad Fahim, Sadique Nirban","doi":"10.53365/nrfhh/153385","DOIUrl":"https://doi.org/10.53365/nrfhh/153385","url":null,"abstract":"Despite considerable studies, diabetes continues to affect millions of people worldwide with an increasing rate of morbidity and mortality. Therefore, we aimed to explore the in vitro antidiabetic and antioxidant effects of Punica granatum and also reveal its drug-likeness, toxicity and action mechanism by utilizing SwissADME (absorption, distribution, metabolism and excretion), ProTox-II and network pharmacology, respectively. The results showed that P. granatum has a significant dose-dependent inhibition potential against α-amylase (IC50=131.90 ± 0.44) and α-glucosidase (IC50=149.74 ± 0.58) activity, as well as a significant inhibition in DPPH-free radical scavenging (IC50=108.57 ± 0.52) activity. ADME/Toxicity prediction of the compounds satisfies Lipinski’s rule of five with zero violations and did not find any toxicity. Moreover, network pharmacology revealed that polyphenolic compounds of P. granatum may combat diabetes by acting on key targets such as IRS1, TNF-α, IL6, MAPK3, DPP4, LEPR, GSK3B, PPARA and PIK3CG were strongly involved in glucose metabolism, oxo-inflammatory responses and insulin-related pathways. Based on the finding, we can conclude that P. granatum might be promising therapeutics for the management of diabetes and related disorders.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128780197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Butia capitata (sour coconut) prevents the appearance of Aberrant Crypt Foci in the colon of rats 酸椰子可防止大鼠结肠出现异常隐窝灶

Natural Resources for Human Health Pub Date : 2022-09-14 DOI: 10.53365/nrfhh/150399

A. Gomides, L. Santos, Maria Cristina Barbosa, L. M. Cardoso, M. Pelúzio, Tiago Silva, T. Valente, P. Reis, Maria Anete Santana Valente

{"title":"Butia capitata (sour coconut) prevents the appearance of Aberrant Crypt Foci in the colon of rats","authors":"A. Gomides, L. Santos, Maria Cristina Barbosa, L. M. Cardoso, M. Pelúzio, Tiago Silva, T. Valente, P. Reis, Maria Anete Santana Valente","doi":"10.53365/nrfhh/150399","DOIUrl":"https://doi.org/10.53365/nrfhh/150399","url":null,"abstract":"Colorectal cancer is a life-threatening disease. This study evaluates whether sour coconut (Butia capitata) prevents the appearance of aberrant crypt foci (ACF) in the colon of rats, induced with 1,2-dimethylhydrazine (DMH). The test subjects were divided into four treatment groups: I - Control; II - aqueous extract of sour coconut pulp; III - DMH and IV - Aqueous extract of sour coconut pulp + DMH. The colons of the subjects were submitted to ACF count, analysis of gene expression and histopathological. The count of ACF differed in the proximal portion of the colon between animals treated III and IV, with a lower count in Treatment IV (p <0.05). The interleukin-1 (IL-1) gene (p <0.05) was less expressed in Treatment IV. In the histopalogic analysis of the colons in Treatment IV, less dilation was observed at the base of the crypts and the lumen was moderately dilated. The sour coconut acted in preventing the appearance of ACF, probably due to its high composition in bioactive compounds, such as phenolic compounds, polyunsaturated fatty acids and vitamin E. The anti-inflammatory capacity reduces the expression of the IL-1 gene and preserves the histo-architecture of the colon.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132576924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variations in the Piperine content in three varieties of Pepper and mapping its anti-inflammatory potential by molecular docking 三个辣椒品种胡椒碱含量的变化及其抗炎潜能的分子对接

Natural Resources for Human Health Pub Date : 2022-08-27 DOI: 10.53365/nrfhh/150494

Nuradh Joseph, S. Durairaj, Oviya Gowthaman, Vinoth, Kumar Ganesan

{"title":"Variations in the Piperine content in three varieties of Pepper and mapping its anti-inflammatory potential by molecular docking","authors":"Nuradh Joseph, S. Durairaj, Oviya Gowthaman, Vinoth, Kumar Ganesan","doi":"10.53365/nrfhh/150494","DOIUrl":"https://doi.org/10.53365/nrfhh/150494","url":null,"abstract":"Pepper known as the king of spices is one of the most widely used spice in the world, and it has its fair share of medicinal properties as well. It has been used in traditional medicine for many centuries owing to its medicinal properties apart from its flavour and pungent taste. Piperine is the most important bioactive compound present in different Piper species. Differences among the three Piper species common in South India viz. Piper nigrum, Piper longum, and Piper cubeba were evaluated by estimating the various phytochemicals such as alkaloids, flavonoids, and phenols in them. Further, the quantity of piperine in these three Piper species were determined using HPLC analysis. The piperine content in Piper nigrum, Piper longum, and Piper cubeba were found to be 235.05 μg/mL, 268.50 μg/mL, and 8.56 μg/mL respectively. Since inflammation is the major pathology involved in most of the disease conditions and since pepper is traditionally used in managing respiratory inflammation, we ventured to identify its anti-inflammatory potential. Herein, the anti-inflammatory properties of piperine were checked by in silico docking analysis of piperine with inflammatory proteins. The interaction of piperine with NF-κB, COX-2, COX-1, and TNF-α, as evidenced by the binding scores reveals that piperine interacts with them and modulates inflammation. Further in-vitro and in-vivo studies are warranted to scientifically validate the traditional claims.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117334076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidandruff property of Psidium guajava leaf extracts 番石榴叶提取物的去屑性研究

Natural Resources for Human Health Pub Date : 2022-08-27 DOI: 10.53365/nrfhh/150396

Cheetra Bhajan, Joyce Soulange Govinden, Vijayanti Ranghoo Sanmukhiya

{"title":"Antidandruff property of Psidium guajava leaf extracts","authors":"Cheetra Bhajan, Joyce Soulange Govinden, Vijayanti Ranghoo Sanmukhiya","doi":"10.53365/nrfhh/150396","DOIUrl":"https://doi.org/10.53365/nrfhh/150396","url":null,"abstract":"Psidium guajava leaf paste and decoction have long been used in Mauritius for their efficacy in dandruff management. The study aimed to test P. guajava leaf extracts against fungi collected from dandruff patients' scalps, as previous research has shown a strong link between dandruff and dermatophytes. Fungi were isolated and cultured on Sabouraud dextrose agar (SDA), which contained 2% olive oil, 1% Tween 80, and chloramphenicol. The isolates were identified using physiological, macroscopic, microscopic, biochemical, and molecular techniques. Hydrodistillation and Soxhlet extraction of Mauritian P. guajava leaves were used to obtain essential oil and different solvent fractions, which were then screened for the presence of phytochemicals. The microdilution assay was used to test the antifungal activity of harvested extracts against isolates. Neurospora intermedia, Trichoderma atroviride, and Trichosporon asahii were identified as fungi. The solvents chloroform, methanol, and hexane produced higher extract yields (16.2%, 15.2% and 14.7%). The phytochemicals were most abundant in the chloroform-methanol (4:1 v/v) fraction. The methanol fraction had the highest total phenolic content (TPC), total flavonoid content (TFC), and total tannin content (TTC), with concentrations of 298.27 19.66 g GAE/g, 132.1 6.15 g QUE/g, and 118.53 1.60 g GAE/g, respectively. Isolates were most sensitive to chloroform-methanol (4:1 v/v) and methanol fractions, with a MIC of 1.56 mg/mL. From the study, it can be deduced that P. guajava leaf extracts are effective antifungal agents and potential ingredients for natural antidandruff hair products, which are in high demand in the cosmetic industry.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"2010 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127341746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of Rollinia dolabripetala leaves 花楸叶的植物化学筛选及其潜在的抗氧化、抗菌和抗黑色素瘤活性

Natural Resources for Human Health Pub Date : 2022-08-27 DOI: 10.53365/nrfhh/152981

Mateus Campos, T. Oliveira, Abelardo Júnior, Marcelo Filardi, Cristiano Souza, M. Costa, Liovando Costa

{"title":"Phytochemical screening and potential antioxidant, antibacterial and anti-melanoma activities of Rollinia dolabripetala leaves","authors":"Mateus Campos, T. Oliveira, Abelardo Júnior, Marcelo Filardi, Cristiano Souza, M. Costa, Liovando Costa","doi":"10.53365/nrfhh/152981","DOIUrl":"https://doi.org/10.53365/nrfhh/152981","url":null,"abstract":"Plants are an important source of natural compounds used for medicine. The Annonaceae family exhibits a cytotoxic effect on different tumor strains and on several bacterial strains. This unprecedented study investigates the antioxidant, anti-melanoma, anti-staphylococcal and anti-streptococcal potential of hydroalcoholic extracts of Rollinia dolabripetala leaves and of 1.7 -dihydroxyxanthone and xanthone phytocompounds. The determination of the antioxidant capacity was performed by the DPPH and lipid peroxidation methods. Isolated phytochemicals xanthone and 1.7-dihydroxyxanthone were also included in cytotoxicity and antimicrobial tests. Assays for antitumor leaf potential were performed on melanoma carcinogenic cells and assays for antibacterial potential were performed on Gram-positive Staphylococcus aureus 29213 (SA13), S. aureus 4075 (SA75) and Streptococcus bovis-01 (SB01) strains. The phytochemical prospection revealed the presence of flavonols, tannins and xanthones. Halo inhibition (mm) of Gram-positive SA13 was 7.00 ± 0.38. There was no inhibitory effect on SA75 and SB01 strains. The antitumor activity, expressed in the minimum lethal concentration (GI50) was in μg/mL: R. dolabripetala: 47.04, 1.7-dihydroxyxanthone: 0.98, Xanthone: 3.38, and 5-Fluorouracil: 0.24. When comparing treatments with 5-Fluorouracil, the best correlation between dosage and the inhibition rate occurs with 1.7-dihydroxy-xanthone followed by R. dolabripetala treatment. In conclusion, R. dolabripetala exhibits antioxidant, anti-staphylococcal and anti-melanoma bioactivities with 1.7-dihydroxy-xanthone exhibiting the best correlation between dosage and inhibition rate. Phytochemicals such as, flavonols, tannins and xanthone reinforce the biological results obtained. The seasonal factor in the collection of plant samples may explain the discrepancies in the phytochemical data of R. dolabripetala compared to other species of the genus.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"325 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123401083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Edible biofilms and coatings; its characterization and advanced industrial applications 食用生物膜和涂层;它的特性和先进的工业应用

Natural Resources for Human Health Pub Date : 2022-08-27 DOI: 10.53365/nrfhh/149622

Manam Walait, Huda Rehman Mir, Kinza Anees

{"title":"Edible biofilms and coatings; its characterization and advanced industrial applications","authors":"Manam Walait, Huda Rehman Mir, Kinza Anees","doi":"10.53365/nrfhh/149622","DOIUrl":"https://doi.org/10.53365/nrfhh/149622","url":null,"abstract":"Edible films and coatings are layers of edible biopolymers (proteins, lipids and polysaccharides) that can be used as an alternate for plastic packaging materials, because plastic packaging is causing environmental pollution and it can deteriorate human health when come in contact with the food product. Along with their environment friendly nature they can carry anti-oxidants, anti-microbials, anti-browning agents, neutraceuticals, pharmaceuticals, colorants, flavors and desired additives to the food product which can prolong their shelf life and increase the aesthetic properties of the food product. Edible films are generated separately by solvent casting and extrusion while edible coating is applied on the food product by spraying or dipping. The conjugation of these edible biopolymers with the nanotechnology (nanoencapsulation, nanofibers and nanoliposomes) can initiate a controlled and targeted release of the additives added in the film or coating. In this review article several novel biopolymers for edible films and coatings have been discussed along with their applications in fruits and vegetable, meat and poultry and dairy industry.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129375699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0