DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)最新文献

A 28-Year-Old Male Patient With Right Heart Failure Due To Pulmonary Hypertension 一例28岁男性肺动脉高压右心衰患者

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-11-01 DOI: 10.14710/dmj.v11i6.35882

Yuri Savitri, Wina Yunida M Siregar, Viola Septina, M. F. Arif, Arini Nashirah, Narisha Amelia Putri

{"title":"A 28-Year-Old Male Patient With Right Heart Failure Due To Pulmonary Hypertension","authors":"Yuri Savitri, Wina Yunida M Siregar, Viola Septina, M. F. Arif, Arini Nashirah, Narisha Amelia Putri","doi":"10.14710/dmj.v11i6.35882","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35882","url":null,"abstract":"Abstract Right Heart Failure (RHF) as a rapidly progressive syndrome with systemic congestion in the setting of impaired RV filling and/or decreased RV outflow output. A 28-year-old male patient, a photographer, lived in North Aceh was admitted to the ED of Cut Meutia Hospital. He was admitted with worsening dyspnea since 2 days before, initiated after a periode of fever. He also complained of fatigue, palpitations in ordinary activities and chest pain occasionally. He had history of presyncope and syncope. He denied any history of hypertension, type 2 diabetes, allergies, and active smoking. He had no congenital or family history of heart disease. Physical examination revealed full of conciousness with slightly abnormal vital sign. He had malar rash, dilated jugular vein. The apex of the heart shifts to the axilla anterior line, S1>S2 with systolic murmur (+). ECG showed complete RBBB with RAD and chest x-ray showed cardiomegaly. The transthoracic echocardiogram revealed severe TR (Tricuspid Regurgitation), dilatation of RARV (Right Atrium Right Ventricle), with severe PH (Pulmonary Hypertension). The patient was diagnosed with RHF (Right Heart Failure) caused by primary PH. The patient was placed on intravenous furosemide, spironolacton, digoxin, and sildenafil. Treatment and lifestyle modification were expected to improve the quality of life.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124832954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric Analysis of Publication on Protein Nanoparticle Using VOSviewer 利用VOSviewer对蛋白质纳米颗粒发表文献计量学分析

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-11-01 DOI: 10.14710/dmj.v11i6.35942

R. Ananda, Asep Bayu Dani Nandiyanto

{"title":"Bibliometric Analysis of Publication on Protein Nanoparticle Using VOSviewer","authors":"R. Ananda, Asep Bayu Dani Nandiyanto","doi":"10.14710/dmj.v11i6.35942","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35942","url":null,"abstract":"Background: A Study to determine the development of research can be done by bibliometric analysis technique. There are many studies that have been carried out on bibliometric analysis. However, research on bibliometric analysis of published data in the field of protein nanoparticles that has been carried out specifically to determine research development has not been carried out. \u0000Objective: This study aims to examine the development of protein nanoparticle research through a bibliometric approach. \u0000Methods: The article data was obtained from the Google Scholar database using the publish or perish reference manager software. The keyword \"Protein Nanoparticles\" is used with a publication time span from 2012 to 2022. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. \u0000Results: The article data obtained and considered relevant were 390 articles. The results of the analysis of the development of protein nanoparticle publications in the last 10 years show quite frequent fluctuations. Research fluctuations occurred in 2012 to 2020. There was a decline in 2020-2022 from 35 in 2020 to 19 in 2022. In 2012 and 2014 research on protein nanoparticles became popular, with 47 studies each. \u0000Conclusion: Based on the results of mapping the collected article data, it can be seen that the keyword protein nanoparticles is still rarely used in research. It can be concluded that the field of protein nanoparticles is still very likely to be researched and associated with other terms, this will have a higher impact on the novelty of the research.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132259473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient With RHD Ec MR Severe, MS Moderate And Trombus In LV, When We Do The Surgeom In Cut Meutia Regional General Hospital 在切梅蒂亚地区总医院行RHD Ec重症、中度、左室畸形患者的手术分析

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-11-01 DOI: 10.14710/dmj.v11i6.35993

Yuri Savitri, Helma Humairah, Jauza Raudhatul Jannah Mendrofa, N. Afni, Della Vega Nisha Ayuna

{"title":"Patient With RHD Ec MR Severe, MS Moderate And Trombus In LV, When We Do The Surgeom In Cut Meutia Regional General Hospital","authors":"Yuri Savitri, Helma Humairah, Jauza Raudhatul Jannah Mendrofa, N. Afni, Della Vega Nisha Ayuna","doi":"10.14710/dmj.v11i6.35993","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35993","url":null,"abstract":"Rheumatic heart disease (RHD) is damage of the heart valves due to acute rheumatic fever (ARF) which results from the body’s autoimmune response to Streptococcus pyogenes (group A Streptococcus bacteria) infection which is a throat infection. Acute rheumatic fever is one of the most important causes of cardiovascular morbidity and mortality in the developing countries. A 25-years-old male patient, domiciled in Alue Dalam, Darul Aman, East Aceh, admitted to emergency department of Cut Mutia hospital, the patient was brought to the hospital by his family at 05.0o pm on January 27th, 2022. Patient referred from Graha Bunda hospital. Patient was admitted to the hospital with complaints shortness of breath. Shortness of breath is felt during activity and worsens at night. Shortness of breath since yesterday. The patient also complained of pounding. The pounding has been felt for five days before arriving at the hospital. The patient also has chest pain, and tired easily. Past medical history such hypertension and diabetes mellitus are denied. Physical examination before treatment was obtained: the patient looked restless, weakness, and akker. Echocardiography examination showed the MR Severe, MS moderate, AR moderate, TR moderate, PH mild, AML calsification, all chamber dilatation, and thrombus LV. The patient was given initial treatment in Cut Mutia General Hospital.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125379359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 52-Years Old Male Patient With Aorta Regurgitation Et Causa Rheumatic Heart Desease In Cut Meutia Regional General Hospital Cut metia地区总医院52岁男性主动脉反流所致风湿性心脏病患者1例

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-11-01 DOI: 10.14710/dmj.v11i6.35990

Yuri Savitri, Jauza Raudhatul Jannah Mendrofa

{"title":"A 52-Years Old Male Patient With Aorta Regurgitation Et Causa Rheumatic Heart Desease In Cut Meutia Regional General Hospital","authors":"Yuri Savitri, Jauza Raudhatul Jannah Mendrofa","doi":"10.14710/dmj.v11i6.35990","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35990","url":null,"abstract":"Rheumatic heart disease (rheumatic heart disease) is an acquired heart disease which is a heart valve disorder that persists due to previous acute rheumatic fever, mainly affecting the mitral valve (75%), the aorta (25%), rarely affecting the tricuspid valve, and never affecting the valves lungs. A 52-year-old male patient, domiciled in Mutiara (Alue Awe) Lhokseumawe City, Indonesia. Come for outpatient treatment at Polyclinic of Cut Meutia Hospital. Patients are who routinely go to the polyclinic every month to take medicine. The patient complains of left chest pain, shortness of breath, heart palpitations, cough, tired easily during activities, especially during strenuous activities. History of Diabetes Mellitus is denied, history of hypertension (+). The patient admitted that he was diagnosed with rheumatic heart disease at the age of 19 years. The patient has been undergoing treatment for 33 years by routinely complete checks related to his heart every year and regularly taking medication at the polyclinic every month. The patient admitted at junior high school age he often experienced attacks of fever that went up and down accompanied by pain in the throat. Physical examination found: Compos Mentis (E4V5M6), BP:140/40 mmHg, HR : 92x/i, RR: 23x/i, T; 37.1°C, SpO2 : 95%. Chest examination showed vesicular breath sounds, Rhonki (-), Wheezing (-), Diastolic murmur (+).Echocardiography showed an EF of 70%. AR Severe, MR Moderate. AML Prolapse, Calcification (+), LV Dilatation, LVH Eccentric","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132599752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bibliometric Analysis of Nanocrystalline Cellulose Research as Medical Implant Using VOSviewer 利用VOSviewer对医用植入物纳米纤维素研究的文献计量学分析

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-11-01 DOI: 10.14710/dmj.v11i6.35896

Deaniar Hafilah, A. Nandiyanto

{"title":"A Bibliometric Analysis of Nanocrystalline Cellulose Research as Medical Implant Using VOSviewer","authors":"Deaniar Hafilah, A. Nandiyanto","doi":"10.14710/dmj.v11i6.35896","DOIUrl":"https://doi.org/10.14710/dmj.v11i6.35896","url":null,"abstract":"Background: Nanocrystalline cellulose has potential for biomedical applications due to its abundant material availability, biodegradability, biocompatibility, and low weight. Research on nanocrystalline cellulose as medical implants has rarely been studied in the past 10 years, although this material has tremendous potential such as bone implants and cardiovascular implants. \u0000Objective: This study aims to analyze the development of research on nanocrystalline cellulose as medical implants using a bibliometric approach with computational analysis using VOSviewer. \u0000Methods: The article data was obtained using the Publish or Perish software by retrieving the database from Google Scholar. The keyword “nanocrystalline cellulose, medical implants, biomedical\" is used with the publication time span from 2012 to 2020. Data processing uses Microsoft Excel. Computational mapping using VOSviewer. \u0000Results: Research on the application of nanocrystalline cellulose has been carried out several times, this can be proven from computational mapping analysis using VOSviewer which shows the term \"nanocrystalline cellulose\" is in the same cluster as the term \"medical implant\". However, research on the application of nanocrystalline cellulose as medical implants is still rarely carried out, this is evidenced by the small frequency indicated by the two terms. \u0000Conclusion: Based on the results of mapping the collected article data, research on the application of nanocrystalline cellulose as medical implants is an interesting topic. However, this topic is still rarely studied. Therefore, this review can be a starting point for selecting the topic of research on the application of nanocrystalline cellulose materials as medical implants as a consideration for determining the research theme to be taken.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"65 2 Spec No 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126770230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A REVIEW OF THE MONKEYPOX OUTBREAK IN INDONESIA IN 2022 对2022年印度尼西亚猴痘疫情的回顾

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-09-30 DOI: 10.14710/dmj.v11i5.35895

Meiriani Sari, N. Hairunisa

{"title":"A REVIEW OF THE MONKEYPOX OUTBREAK IN INDONESIA IN 2022","authors":"Meiriani Sari, N. Hairunisa","doi":"10.14710/dmj.v11i5.35895","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35895","url":null,"abstract":"Monkeypox disease (monkey smallpox) is a disease that has never been found in Indonesia since it was first discovered in humans in the Congo in 1970. So if there is one positive confirmed event, then the disease is an Extraordinary Event (KLB). This disease has become a global concern because since May 13, 2022, WHO has received reports of Monkeypox cases from non-endemic countries. It has expanded to 4 WHO regions: Europe, America, Eastern Mediterranean, and Western Pacific. Until now, further investigations and studies are still being carried out to understand more about the epidemiology, sources of infection, and transmission patterns in non-endemic countries that have reported new cases, such as Indonesia. Until now, no specific treatment has been proven to treat Monkeypox infection. Currently, the therapy used is symptomatic support. The antiviral tecovirimat, or TPOXX, developed by the European Medicines Agency (EMA) as a Monkeypox therapy in 2022 based on research, has not been marketed freely. In addition, antivirals such as cidofovir and brincidofovir have been shown to be effective against orthopox virus in vitro and in animal studies. However, the effectiveness of this drug against monkeypox in humans is not yet known. However, this disease can be prevented by vaccination. In Indonesia, the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine is recommended to prevent Monkeypox disease. The existence of the outbreak report is important to discuss, explore, and understand more about the disease and its management and prevention.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131051256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect of Jump Rope Training on Mood Among Senior High School Students 跳绳训练对高中生情绪的影响

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-09-29 DOI: 10.14710/dmj.v11i5.35479

Nazilla Jufril, H. Hardian, Darmawati Ayu Indraswari, Endang Kumaidah

{"title":"The Effect of Jump Rope Training on Mood Among Senior High School Students","authors":"Nazilla Jufril, H. Hardian, Darmawati Ayu Indraswari, Endang Kumaidah","doi":"10.14710/dmj.v11i5.35479","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35479","url":null,"abstract":"Background: Physical activity has protective effects against the development of depression symptoms for all age groups. Cognitive training and aerobic training are lifestyle interventions that have been shown to have a positive impact on health, reducing cognitive impairment, and delaying the onset of dementia. Jump rope training is one type of aerobic training. Aerobic training is effective in improving mood. Objective: This study aims to prove the effect of jump rope training on adolescent’s mood as measured by the POMS score. Methods: This is an experimental study with 2 parallel groups pre-test and post-test design. The research subjects were 32 students of senior-high school 1 of Gunung Talang, Solok Regency, West Sumatra that were selected by purposive sampling and grouped into 2 groups. The control group without treatment (n=16), and the treatment group (n=16) were given jump rope training for 6 weeks. Mood scores were measured before and after the intervention using a profile of mood state (POMS) questionnaire and expressed as total mood disturbance (TMD) scores. Results: The research shown the significant decreases of TMD scores (p<0.001) on the treatment group rather than the control group. In addition, there was a significant difference between the post-test TMD scores of the control group and the treatment group (p=0.005). Conclusion: Jump rope training for 6 weeks can improve the mood of the adolescent.Keywords: aerobic training, jump rope training, mood, profile of mood state, total mood disturbance","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132100630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baricitinib as Treatment Option for Corona Virus Disease-19: a Literature Review 巴西替尼作为冠状病毒病的治疗选择19:文献综述

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-09-14 DOI: 10.14710/dmj.v11i5.35628

T. Handoyo, Nurain Farhanah, Gianina Dinda Pamungkas

{"title":"Baricitinib as Treatment Option for Corona Virus Disease-19: a Literature Review","authors":"T. Handoyo, Nurain Farhanah, Gianina Dinda Pamungkas","doi":"10.14710/dmj.v11i5.35628","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35628","url":null,"abstract":"Background : Treatment of COVID-19 using IL-6 inhibitors, including Sarilumab or Tocilizumab, significantly decreased mortality risk. Though, Remdesivir therapy gave benefits, morbidity and mortality remained high. Baricitinib, a JAK inhibitor, can inhibit IL-6 activation pathway and has a potential effect of inhibiting disease progression to become severe. \u0000Objective : This study aimed to evaluate the use of Baricitinib for COVID-19 patients. \u0000Methods : This study was conducted by searching for observational and randomized controlled trial studies through online databases, “PubMed” and “Google Scholar”. Studies included must evaluate Baricitinib effectivity as therapy for hospitalized COVID-19 patients. This study included 11 studies (9 observational and 2 randomized controlled trial). Patients included had moderate-to-severe symptoms of COVID-19. \u0000Results : Standard dose of Baricitinib was administered at 4 mg daily dose. Length of therapy was varied between 5-14 days, or up to patients’ discharge. Baricitinib therapy among included studies was administered with intravenous Remdesivir, Steroid, Tocilizumab, or other complement therapies. Mortality rate within 7-day of hospitalization with Baricitinib was 4.4%. Requirement of invasive mechanic ventilation rate after Baricitinib administration was approximately 4%. Laboratory parameters were significantly getting better after Baricitinib administration: IL-6; CRP; ferritin; and D-dimer. Serious adverse events in a randomized controlled trial, occurred more often in placebo treated compared to Baricitinib treated group. \u0000Conclusion : Baricitinib as therapy for COVID-19 patients can decrease progression, morbidity, and mortality of the disease. Further studies are needed to evaluate the benefit of Baricitinib as main therapy for COVID-19.","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129211522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF ANTIBACTERIAL EFFECTIVENESS OF HERBAL TOOTHPASTE AND FLUORIDE ON THE GROWTH OF Streptococcus mutans 中药牙膏与氟化物对变形链球菌生长的抑菌效果比较

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-09-14 DOI: 10.14710/dmj.v11i5.35640

Rosalia Indri Dewanti, V. R. Ciptaningtyas, Ryan Halleyantoro, Gustantyo Wahyu Wibobo

{"title":"COMPARISON OF ANTIBACTERIAL EFFECTIVENESS OF HERBAL TOOTHPASTE AND FLUORIDE ON THE GROWTH OF Streptococcus mutans","authors":"Rosalia Indri Dewanti, V. R. Ciptaningtyas, Ryan Halleyantoro, Gustantyo Wahyu Wibobo","doi":"10.14710/dmj.v11i5.35640","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35640","url":null,"abstract":"Background: Streptococcus mutans was the most dominant bacteria in caused caries. Caries could be prevented by chemical plaque control methods used toothpaste. Toothpaste had antibacterial properties by helped to prevent bacteria from colonized. There were two antibacterial ingredients in toothpaste, fluoride and herbal ingredients. \u0000Aim: Determined the antibacterial effect of toothpaste with herbal and fluoride content on the growth of Streptococcus mutans. \u0000Methods: This study was an experimental study with a post-test only control group design. This research method was a diffusion method by means of wells. The sample used was the Streptococcus mutans colony. The study was divided into four groups, namely herbal toothpaste, fluoride toothpaste, positive control (chlorhexidine), and negative control (aquadest sterile) which were replicated 16 times in each group. The results of this study was the diameter of the resistance zone. \u0000Results: The average diameter of the zone of inhibition results obtained 12.49 mm (herbal toothpaste), 14.66 mm (fluoride toothpaste), 21.70 mm (chlorhexidine) and aquadest sterile there were no inhibition zones. There was a significant difference with the p value","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123464137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE EFFECTIVENESS OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON PLASMA MALONDIALDEHYDE LEVEL IN DEMENTIA MICE 青柠皮提取物对痴呆小鼠血浆丙二醛水平的影响

DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Pub Date : 2022-09-14 DOI: 10.14710/dmj.v11i5.35304

M. Ilham, Endang Mahati, M. Muniroh, Y. Nindita

{"title":"THE EFFECTIVENESS OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON PLASMA MALONDIALDEHYDE LEVEL IN DEMENTIA MICE","authors":"M. Ilham, Endang Mahati, M. Muniroh, Y. Nindita","doi":"10.14710/dmj.v11i5.35304","DOIUrl":"https://doi.org/10.14710/dmj.v11i5.35304","url":null,"abstract":"ABSTRACTBackground: Antioxidant is a substance that can catch and neutralize free radicals so that the process of oxidative stress can be stopped and cell damage can be avoided. Kaffir lime peel contains antioxidant compounds that have the potential to be the neuroprotective agent and can protect neurons from free radical-induced damage.Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the plasma malondialdehyde (MDA) level of mice induced by Scopolamine (SCM).Method: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups consisting of a healthy control (K+), Negative Control (K-), extract 5 mg/20gBW group (P1), 10 mg/20gBW group (P2), 20 mg/20gBW group (P3). SCM was injected intraperitoneally on days 1-7 and kaffir lime peel extract was given orally on days 2-7, the MDA levels testing of mice using TBARS method on day 8. Data analysis used One-Way ANOVA test and continued with Post Hoc LSD test.Results: The mean MDA levels of K+, K-, P1, P2, P3 were 4,212; 4,644; 3,481; 4,555; 4,733 nmol/mL, respectively. MDA levels of P1 were lower than K-, even though there were no statistically significant differences.Conclusion: There was no effect of administration kaffir lime peel extract (Citrus hystrix) on MDA levels in mice with scopolamine-induced dementia.Keywords: Citrus hystrix, malondialdehyde, dementia, mice","PeriodicalId":394284,"journal":{"name":"DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122824862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1