Canadian Journal of Respiratory Therapy最新文献

筛选
英文 中文
Common infant product materials negatively impact breathing. 常见的婴儿产品材料对呼吸有负面影响。
Canadian Journal of Respiratory Therapy Pub Date : 2025-07-11 eCollection Date: 2025-01-01 DOI: 10.29390/001c.141257
Holly L Olvera, Andrew Bossert, Megan Koster, Camille Stover, Erin M Mannen
{"title":"Common infant product materials negatively impact breathing.","authors":"Holly L Olvera, Andrew Bossert, Megan Koster, Camille Stover, Erin M Mannen","doi":"10.29390/001c.141257","DOIUrl":"10.29390/001c.141257","url":null,"abstract":"<p><strong>Background: </strong>Approximately 3,500 infants die of a sleep-related incident a year in the United States. Although safe sleep guidelines have been implemented, infants are still at risk from many commercial products. Breathing-related injuries or suffocation are of serious concern for younger infants exposed to soft product materials, yet respiration-related measures of these common materials are unknown.</p><p><strong>Methods: </strong>Nine healthy young adults' respiratory patterns were evaluated while breathing into materials commonly used in infant products. Breathing rate, end-tidal carbon dioxide (EtCO2), heart rate, and oxygen saturation (SpO2) were collected using a Capnostream 35. Participants lay prone with their faces in contact with each material for ten-minute trials. Three baseline trials, where participants could breathe freely with no obstruction, were collected for comparison (ANOVA (p < 0.05), Tukey post-hoc comparisons).</p><p><strong>Results: </strong>The 100% cotton and 50/50 (cotton/polyester) materials both resulted in significant changes in EtCO2 and SpO2, while the 10/90 (spandex/polyester) resulted in only a significant change in SpO2, and no significant changes were detected for the 100% polyester material. Mean respiratory rate decreased and mean heart rate increased significantly for all materials.</p><p><strong>Discussion: </strong>EtCO2 and SpO2 are important considerations for suffocation risk when breathing into the selected materials. Even during this short time period, infants with more vulnerable respiratory systems and less robust arousal responses than the adults in this study will be at higher risk.</p><p><strong>Conclusion: </strong>Conscious efforts should be made to prevent infants from interacting with soft goods microenvironments that inhibit normal breathing while using infant products.</p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"157-165"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of respiratory physiotherapeutic interventions on pulmonary mechanics, vital parameters and pain in newborns: A systematic review. 呼吸物理治疗干预对新生儿肺力学、生命参数和疼痛的影响:系统综述。
Canadian Journal of Respiratory Therapy Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI: 10.29390/001c.140878
Adriele de Morais Nunes, Ana Tereza Nascimento Sales Figueiredo Fernandes, Adyna Tévina de Castro Silva, Ingrid Guerra Azevedo, Karolinne Souza Monteiro, Silvana Alves Pereira
{"title":"Effects of respiratory physiotherapeutic interventions on pulmonary mechanics, vital parameters and pain in newborns: A systematic review.","authors":"Adriele de Morais Nunes, Ana Tereza Nascimento Sales Figueiredo Fernandes, Adyna Tévina de Castro Silva, Ingrid Guerra Azevedo, Karolinne Souza Monteiro, Silvana Alves Pereira","doi":"10.29390/001c.140878","DOIUrl":"10.29390/001c.140878","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of conventional and non-conventional respiratory physiotherapy on pulmonary mechanics, vital parameters, and pain in newborns admitted to a neonatal intensive care unit.</p><p><strong>Methods and analyses: </strong>Databases including PubMed, LILACS, SciELO, Science Direct, Cochrane Library, and Web of Science were searched. Randomized clinical trials comparing conventional and non-conventional respiratory physiotherapy in newborns (1 hour to 28 days) in neonatal intensive care units were included. Two reviewers independently screened titles and abstracts and assessed bias using the PEDro scale. Data were presented as mean, standard deviation, median, and quartiles. Meta-analysis was not feasible due to incomplete post-intervention data.</p><p><strong>Results: </strong>Out of 5,653 articles found, four were included. Two studies reported major increases in peripheral oxygen saturation after both respiratory physiotherapy techniques, a third showed decreased respiratory rate, and a fourth showed increased heart rate. Neither conventional nor non-conventional respiratory physiotherapy was suggested to cause pain in participants. No study evaluated lung mechanics parameters. The methodological quality of the included studies was predominantly moderate. Only one study exhibited low methodological quality.</p><p><strong>Conclusion: </strong>Both conventional and non-conventional respiratory physiotherapy techniques showed no adverse effects on vital signs or pain in NICU newborns. Further clinical trials are encouraged to assess lung function more comprehensively. Future studies should include short- and long-term evaluations of lung mechanics, respiratory distress, and pain.</p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"145-156"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of conical-PEP breathing on exercise performance in patients with chronic obstructive pulmonary disease: A single-blind randomized crossover trial. 锥形pep呼吸对慢性阻塞性肺疾病患者运动表现的影响:一项单盲随机交叉试验
Canadian Journal of Respiratory Therapy Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI: 10.29390/001c.138738
Nimit Kosura, Aung Aung Nwe, Chatchai Phimphasak, Worawat Chumpangern, Kongrit Sriya, Chulee Ubolsakka-Jones
{"title":"Influence of conical-PEP breathing on exercise performance in patients with chronic obstructive pulmonary disease: A single-blind randomized crossover trial.","authors":"Nimit Kosura, Aung Aung Nwe, Chatchai Phimphasak, Worawat Chumpangern, Kongrit Sriya, Chulee Ubolsakka-Jones","doi":"10.29390/001c.138738","DOIUrl":"10.29390/001c.138738","url":null,"abstract":"<p><strong>Background: </strong>Conical-positive expiratory pressure (conical-PEP) has been applied during exercise to improve exercise capacity, dynamic hyperinflation (DH), and dyspnea in COPD. However, evidence remains limited regarding the individualized selection of its resistor (orifice size) and its effects on exercise duration, DH development, and dyspnea.</p><p><strong>Method: </strong>A randomized crossover trial was conducted to evaluate the effects of conical-PEP. Participants performed spot marching exercise while breathing through a conical-PEP device with a mask, compared to a sham-PEP condition in which a similar mask was worn without the conical-PEP component. The conical-PEP resistor was selected to achieve the minimum required PEP level, calculated by the proposed formula, while ensuring that pressure did not exceed 35 cmH₂O. Exercise endurance time, end-exercise inspiratory capacity (IC) to assess DH, and dyspnea using the modified Borg scale were recorded.</p><p><strong>Results: </strong>Twenty moderate to severe COPD subjects (19 male, 1 female, age 67.40 ± 8.22 years, FEV1% predicted 56.05 ± 16.90) participated. Conical-PEP resulted in longer exercise time (4.98 ± 2.97 minutes) than sham-PEP (3.99 ± 2.19 minutes, p = 0.004). End-exercise IC was significantly better in conical-PEP (1.51 [1.24, 1.85] L) than sham-PEP (1.42 [1.16, 1.84] L, <i>p</i> = 0.020). Dyspnea was significantly lower in conical-PEP at iso-time (4 [4, 5]) compared to sham-PEP (5 [5, 6], <i>p</i> = 0.005), though no significant difference was found at end exercise.</p><p><strong>Conclusion: </strong>Conical-PEP with minimum required PEP level improves exercise capacity, delays DH development, and delays dyspnea onset in COPD patients.</p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"132-144"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Code blues: The role of anesthesia assistants in anesthesia care teams. 蓝色代码:麻醉助理在麻醉护理团队中的作用。
Canadian Journal of Respiratory Therapy Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI: 10.29390/001c.138402
Homer Yang
{"title":"Code blues: The role of anesthesia assistants in anesthesia care teams.","authors":"Homer Yang","doi":"10.29390/001c.138402","DOIUrl":"10.29390/001c.138402","url":null,"abstract":"","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"128-131"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individualized parameters for mechanical ventilation during thoracic operations: Optimizing respiratory support. 胸外科手术中机械通气的个性化参数:优化呼吸支持。
Canadian Journal of Respiratory Therapy Pub Date : 2025-05-13 eCollection Date: 2025-01-01 DOI: 10.29390/001c.137289
Mukhtar Batyrkhanov, Dilyara Mukhtarkhanova
{"title":"Individualized parameters for mechanical ventilation during thoracic operations: Optimizing respiratory support.","authors":"Mukhtar Batyrkhanov, Dilyara Mukhtarkhanova","doi":"10.29390/001c.137289","DOIUrl":"10.29390/001c.137289","url":null,"abstract":"<p><strong>Introduction: </strong>Adequate respiratory support with mechanical lung ventilation (MLV) is crucial for maintaining gas exchange and pulmonary circulation hemodynamics in patients with severe lung diseases in the perioperative period. However, the selection of optimal parameters for ventilation is often a serious problem, which can lead to the development of complications and worsening of treatment outcomes.</p><p><strong>Purpose: </strong>This study aimed to evaluate the effectiveness of the developed method of individual calculation of ventilator parameters to optimize respiratory support in patients with various lung diseases undergoing surgical intervention.</p><p><strong>Methods: </strong>This study used a prospective clinical approach to optimize mechanical lung ventilation by calculating individualized ventilatory parameters based on each patient's lung function during surgery.</p><p><strong>Results: </strong>The results showed that in patients with unilateral lesions, the application of the developed method achieved PaO2 94.1±6.7 mmHg and PaCO2 36.2±4.5 mmHg, mean pulmonary artery pressure 25.8±3.6 mmHg, as well as cardiac output 4.8±0.8 l/min and oxygen transport 489±77 ml/min at the final post-operative stage. Even in bilateral diffuse lesions, individualized ventilatory parameters provided PaO2 79.6±11.3 mmHg and reduced bronchial resistance to 11.4±3.6 cmH2O/l/sec after surgery. Despite gross respiratory dysfunction, the personalized approach maintained PaO2 79.2±9.7 mmHg and PaCO2 46.1±6.3 mmHg postoperatively in patients with congenital pulmonary malformations such as cystic hypoplasia.</p><p><strong>Conclusion: </strong>This study demonstrates the high efficacy of personalized approaches to respiratory support management to improve patient outcomes and reduce the risk of complications in patients with lung disease in the perioperative period.</p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"117-127"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings from the Canadian Society of Respiratory Therapists Annual Conference May 8-10, 2025. 加拿大呼吸治疗师协会年会论文集,2025年5月8-10日。
Canadian Journal of Respiratory Therapy Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.29390/001c.137201
{"title":"Proceedings from the Canadian Society of Respiratory Therapists Annual Conference May 8-10, 2025.","authors":"","doi":"10.29390/001c.137201","DOIUrl":"https://doi.org/10.29390/001c.137201","url":null,"abstract":"<p><p><i>We are pleased to present a select number of abstracts from the proceedings of the CSRT Annual Conference. Held in Ottawa, Ontario, from May 8 to 10, 2025, this conference included topics delivered by individuals with expertise in various areas of respiratory therapy practice.</i>  <i>As evidenced by the following abstracts, the work of our colleagues in 2025 highlighted current research and practice innovations led by RTs. We have made every effort to include all abstracts accepted by the Program Committee before the publication deadline; however, please note that this collection does not represent the entire program (available at www.csrt.com).</i>  <i>The editorial board looks forward to receiving manuscripts from this conference for consideration for publication in the Canadian Journal of Respiratory Therapy in order to continue building the body of knowledge specific to our profession.</i>  <i>Please note these abstracts have not been peer-reviewed.</i></p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"94-116"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Sealing the deal': An innovative use of the endotracheal cuff manometer. “成交”:气管内袖带压力计的创新应用。
Canadian Journal of Respiratory Therapy Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.29390/001c.137018
Chandini Kukanti, Sumit R Chowdhury, Rajendra S Chouhan
{"title":"'Sealing the deal': An innovative use of the endotracheal cuff manometer.","authors":"Chandini Kukanti, Sumit R Chowdhury, Rajendra S Chouhan","doi":"10.29390/001c.137018","DOIUrl":"https://doi.org/10.29390/001c.137018","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Intraoperative air leakage from the endotracheal tube (ETT) cuff can lead to significant complications, including compromised tidal volume delivery, ineffective ventilation, and an increased risk of pulmonary aspiration. These issues, if unrecognized and unmanaged, contribute to heightened perioperative morbidity and mortality. While structural defects in the ETT cuff or pilot balloon system are common causes of leakage, additional factors such as cuff malposition, excessive airway pressure, and material degradation can also contribute. Early identification of the underlying etiology is critical for implementing appropriate interventions, mitigating airway-related complications, and ensuring surgical continuity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Case report: &lt;/strong&gt;This report presents a case of intraoperative ETT cuff leakage identified after surgical positioning in the prone position. To address this challenge, an innovative approach utilizing an ETT cuff manometer was employed, allowing for continuous monitoring of cuff pressure. This strategy enabled real-time detection of pressure deviations and facilitated prompt reinflation whenever the cuff pressure dropped below 20 cm H₂O or a fresh gas flow leak was observed. This technique effectively maintained adequate cuff inflation, preventing intraoperative airway compromise.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;ETT cuff leaks can be categorized into two primary mechanisms: (1) those resulting from structural failure of the cuff or inflation system and (2) those occurring due to inadequate sealing despite an intact cuff. Intraoperative air leaks pose risks to the patient-through impaired ventilation and aspiration risk-and to operating room personnel by potentially exposing them to unfiltered anesthetic gases. Various strategies for managing ETT leaks have been described, including conservative approaches such as pharyngeal packing, application of lubricating agents like lidocaine jelly, and continuous inflation via an oxygen flowmeter. In cases where these measures fail, ETT replacement remains the definitive intervention. However, exchanging the ETT presents a significant challenge in prone-positioned patients, necessitating a thorough risk-benefit assessment before attempting tube replacement or repositioning the patient. While previous studies have explored methods for addressing intraoperative ETT leaks, continuous quantitative monitoring of cuff pressure using a manometer has not been widely reported. This technique provides a dynamic assessment of cuff integrity and allows for proactive management of intraoperative air leaks.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In this case, the application of an ETT cuff manometer enabled continuous, quantitative assessment of cuff pressure, facilitating early leak detection and effective management. This approach represents a valuable adjunct in the intraoperative setting, enhancing patient safety and reducing the likelihood of airway-related","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of anesthesia assistants within the code blue team at in-hospital cardiopulmonary arrests: A retrospective analysis. 院内心肺骤停中蓝色代码小组麻醉助理的作用:回顾性分析。
Canadian Journal of Respiratory Therapy Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI: 10.29390/001c.136463
Claire A Ward, Melissa Berry, Maria Bou-Habib, Julia Law, Andrew D Milne
{"title":"Roles of anesthesia assistants within the code blue team at in-hospital cardiopulmonary arrests: A retrospective analysis.","authors":"Claire A Ward, Melissa Berry, Maria Bou-Habib, Julia Law, Andrew D Milne","doi":"10.29390/001c.136463","DOIUrl":"https://doi.org/10.29390/001c.136463","url":null,"abstract":"<p><strong>Introduction: </strong>Anesthesia assistants (AAs) are respiratory therapists or nurses who have additional sub-specialty training in the provision and maintenance of anesthesia. Their skill set includes advanced airway management, vascular access, and knowledge of vasoactive medications and resuscitative protocols. AAs function as non-physician members of the anesthesia team and can act as physician extenders to help offset the current shortage of anesthesiologists.</p><p><strong>Methods: </strong>This study was a retrospective analysis of AA roles at code blue events at an adult academic teaching centre. Data was extracted from administrative data collection forms completed by AAs at adult code blue events between 2017 and 2022. The data elements that each form captured included time and location of event, presumed cause of the code, airway management details, vascular access provision, medication preparation or administration, human factors and cognitive supports provided to the team by the AAs.</p><p><strong>Results: </strong>Administrative data collection forms from 320 code blue events were analyzed in this study. The most common primary causes of the code blue events were \"arrest\" (39%) and \"respiratory failure\" (26%). Regular floor beds (47%) and the intermediate care units (18%) were the most common locations of code blue events. Airway support was required in 77% of the codes, and in 50% of the cases requiring intubation, it was performed by the AAs. The first pass success rate for AA intubations was 83%, and overall success rate was 96%. In addition to airway management at codes, the AAs also reported providing numerous other valuable contributions to the team. The most reported supports provided to the team included cognitive support regarding resuscitation (49% of cases), intravenous access (19% of cases), and medication preparation or administration (9% of cases). Other roles included placement of arterial lines and drawing blood gases, obtaining interosseous vascular access, and assisting with patient transport to critical care units after resuscitation.</p><p><strong>Conclusions: </strong>Our study characterizes the supporting roles that AAs can provide as members of the code blue team and demonstrates their contributions to management of critically ill patients. The AAs' airway management, vascular access skillsets, and knowledge of vasoactive and resuscitative medications and protocols make them well-suited to the code blue team. In addition to assisting within the operating room team, AAs can also provide valuable support in non-operating room environments such as cardiopulmonary arrests.</p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"78-86"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of normal, obstructive, and restrictive breathing patterns on aerosol drug delivery with jet and mesh nebulizers in simulated spontaneously breathing adults. 正常、阻塞性和限制性呼吸模式对模拟自主呼吸成人喷射和网状雾化器雾化给药的影响。
Canadian Journal of Respiratory Therapy Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.29390/001c.134080
Arzu Ari, Jordan A Hoops, Zari Williams, James B Fink
{"title":"Impact of normal, obstructive, and restrictive breathing patterns on aerosol drug delivery with jet and mesh nebulizers in simulated spontaneously breathing adults.","authors":"Arzu Ari, Jordan A Hoops, Zari Williams, James B Fink","doi":"10.29390/001c.134080","DOIUrl":"https://doi.org/10.29390/001c.134080","url":null,"abstract":"<p><strong>Background: </strong>Aerosol drug delivery is widely used in treating respiratory conditions, but the patient's breathing pattern can significantly influence its effectiveness. This study investigates the impact of normal, obstructive, and restrictive breathing patterns on aerosol drug delivery with jet and mesh nebulizers in a simulated model of spontaneously breathing adults.</p><p><strong>Methods: </strong>A spontaneously breathing adult was simulated using a teaching manikin (Nasco Healthcare) connected to a breathing simulator (QuickLung Breather; IngMar Medical Inc). A collecting filter (CareFusion) was placed distal to the bifurcation of the mainstem bronchi and connected to the breathing simulator. Albuterol sulfate (2.5 mg/3 mL) was delivered with jet (MistyMax 10) and mesh nebulizers (Aerogen Ultra). Each experiment was conducted in triplicate (n = 3), comparing drug delivery across six breathing patterns: (1) normal, (2) moderate obstruction, (3) severe obstruction, (4) moderate restriction, (5) severe restriction, and (6) combined obstruction and restriction. Data analysis included the Friedman ANOVA, uncorrected Dunn's test, and paired t-tests with Holm-Sidak's multiple comparison test (GraphPad Prism 10.3), with statistical significance set at <i>p</i> < 0.05.</p><p><strong>Results: </strong>Our findings indicate that obstructive, restrictive, and combined breathing patterns significantly reduce aerosol deposition with jet and mesh nebulizers compared to normal breathing (<i>p</i> < 0.05). Aerosol delivery with the mesh nebulizer was up to 3-fold more than the jet nebulizer regardless of the breathing pattern tested in this study (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>This study highlights the necessity for tailored aerosol therapy strategies to optimize drug delivery in patients with different respiratory conditions..</p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thoracic mobility in school-aged asthmatic children. 学龄期哮喘儿童的胸廓活动度。
Canadian Journal of Respiratory Therapy Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.29390/001c.131921
Stefanie Tonguino-Rosero, Nelsy-Liliana Holguín-Ordoñez, Juan Esteban Ossa Tabares, Isis Yinela Correa Mejía, Carolina Ramírez Paz, Luis-David García-Basto
{"title":"Thoracic mobility in school-aged asthmatic children.","authors":"Stefanie Tonguino-Rosero, Nelsy-Liliana Holguín-Ordoñez, Juan Esteban Ossa Tabares, Isis Yinela Correa Mejía, Carolina Ramírez Paz, Luis-David García-Basto","doi":"10.29390/001c.131921","DOIUrl":"https://doi.org/10.29390/001c.131921","url":null,"abstract":"<p><strong>Introduction: </strong>Asthma is a chronic respiratory condition frequently observed in childhood, which can have detrimental effects on breathing and thoracic mobility.</p><p><strong>Objective: </strong>To describe the thoracic mobility of 6- to 11-year-old children diagnosed with asthma and compare it with that of non-asthmatic children in schools in Cali, Colombia.</p><p><strong>Materials and methods: </strong>This cross-sectional analytical study used a non-probabilistic convenience sampling technique to assess thoracic mobility. Data were analyzed using STATA 14® statistical software. Measurement of thoracic mobility was performed using cirtometry at the axillary (CAx) and xiphoid (CX) levels according to the protocol established by Bockenhauer et al. Asthma prevalence, history, symptoms, and associated risk factors were assessed using the self-administered International Asthma and Allergies in Childhood (ISAAC) questionnaire. In addition, anthropometric measurements were collected to account for potential confounding variables.</p><p><strong>Results: </strong>Of the 282 children enrolled, 193 met the inclusion criteria, and 11.9% were diagnosed with asthma. The asthmatic group exhibited several identified risk factors, including exposure to dust (47.8%), environmental fumes (30.4%), tobacco smoke (13%), and colds (47.8%). There were no statistically significant differences in anthropometric variables between the two groups. However, the asthmatic group showed significantly reduced thoracic mobility compared to the non-asthmatic group, especially in the CAx measurement (5.82 cm ± 2 for the non-asthmatic group vs. 5.18 cm ± 1.2 for the asthmatic group; <i>p =</i> 0.047).</p><p><strong>Conclusions: </strong>Individuals diagnosed with asthma have reduced thoracic mobility compared to those without the condition.</p>","PeriodicalId":39373,"journal":{"name":"Canadian Journal of Respiratory Therapy","volume":"61 ","pages":"60-70"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信