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[Ictal arterial spin labeling MRI findings in two cases of acute confusional migraine]. [2例急性迷惑性偏头痛的急性动脉自旋标记MRI表现]。

No To Hattatsu Pub Date : 2017-03-01

Yoshiaki Watanabe, Tasuku Kitajima, Nanako Nishiguchi, Kiyoko Watanabe, Tatsuharu Sato, Sumito Dateki, Reiko Ideguchi, Hiroyuki Moriuchi

{"title":"[Ictal arterial spin labeling MRI findings in two cases of acute confusional migraine].","authors":"Yoshiaki Watanabe, Tasuku Kitajima, Nanako Nishiguchi, Kiyoko Watanabe, Tatsuharu Sato, Sumito Dateki, Reiko Ideguchi, Hiroyuki Moriuchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique that enables visualizing of cerebral blood flow without need of a contrast medium. In recent years, there have been reports from outside Japan related to ASL use in migraine attacks. We report two cases of acute confusional migraine (ACM) in children. At time of confusion, ASL imaging showed reduced blood flow: for the first patient, in both cerebral hemispheres from the occipital lobe through the parietal lobe to the temporal lobe; for the second patient, throughout the left cerebral hemisphere. T1-, T2-, diffusion-weighted images, and fluid attenuation inversion recovery (FLAIR) images indicated normal results. Subsequent ASL re-examinations for both cases showed recovery from reduced blood flow. In our view, ACM can be characterized by a reduction in blood flow not limited to the occipital lobe but across wide regions of the cerebral hemisphere. We consider ASL to be helpful in the difficult differentiation of ACM from other disturbances of consciousness, in addition to enabling repeated examinations without the risks associated with single-photon emission computed tomography (SPECT) concerning radiation exposure or with contrast MRI concerning contrast media use.</p>","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"49 2","pages":"136-40"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36400517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[To promote clinical trials for muscular dystrophy]. [促进肌肉萎缩症的临床试验]。

No To Hattatsu Pub Date : 2017-03-01

Eri Takeshita

引用次数: 0

Diagnostic value of single photon emission computed tomography (SPECT) for patients with non-herpetic acute limbic encephalitis. 单光子发射计算机断层扫描(SPECT)对非疱疹性急性边缘脑炎的诊断价值。

No To Hattatsu Pub Date : 2017-01-01

Nanako Nishiguchi, Tatsuharu Sato, Kouhei Haraguchi, Daishi Inoue, Yukitoshi Takahashi, Hiroyuki Moriuchi

引用次数: 0

A clinical course of patient with Aicardi-Goutieres syndrome due to SAMHD1 gene abnormality. SAMHD1基因异常致阿卡第-古氏综合征患者的临床病程分析。

No To Hattatsu Pub Date : 2017-01-01

Eri Watanabe, Kaori Onozawa, Takako Fujita, Yuko Tomonoh, Yukiko Ihara, Sawa Yasumoto, Ryuta Nishikomori, Toshio Heike, Shinichi Hirose

引用次数: 0

Anti-epileptics alter hypothyroidism of patients with severe motor and intellectual disabilities. 抗癫痫药可改变严重运动和智力障碍患者的甲状腺功能减退。

No To Hattatsu Pub Date : 2017-01-01

Tsunenori Hirayama, Harumi Saijo, Toshihiko Kohji, Takanori Ezoe, Sui Sone, Katsuhito Araki, Hiroshi Hamaguchi, Hisaharu Suzuki, Kiyoko KKurata

{"title":"Anti-epileptics alter hypothyroidism of patients with severe motor and intellectual disabilities.","authors":"Tsunenori Hirayama, Harumi Saijo, Toshihiko Kohji, Takanori Ezoe, Sui Sone, Katsuhito Araki, Hiroshi Hamaguchi, Hisaharu Suzuki, Kiyoko KKurata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective: Anti-epileptic drugs, such as carbamazepine (CBZ) or phenytoin, may induce hypothyroidism in epilepsy patients. We assessed thyroid function of chronic patients with severe motor and intellectual disabilities (SMID) in our hospital. Methods: We examined thyroid-stimulating hormone (TSH), free thyroxine (fT4), and free thyronine (fT3) in 73 patients with SMID (47 men and 26 women, average age 48.4 years, range 30-68 years) without thyroid hormone supplement therapy. We determined the relationship between the thyroid function of patients taking the anti-epileptic drugs CBZ, valproate (VPA), and phenobarbital, other medications including anti-psychotic drugs, and treatments without anti-epileptic or anti-psychotic drugs. Results: TSH levels were not significantly different between the groups taking CBZ (CBZ+med), other anti-epileptic drugs or anti-psychotic drugs (CBZ-med), and only medications without anti-epileptic or anti-psychotic drugs (Non-med). The CBZ+med group had significantly lower fT4 levels than the CBZ-med or Non-med groups. There was a negative correlation between thyroid function level and the phenobarbital groups. TSH levels of the VPA+med group were significantly higher than VPA-med and Non-med group; fT3 and fT4 levels were not significantly different. Conclusions: Our results indicate that hypothyroidism may be present in patients with SMID taking anti-epileptic drugs. This suggests it is important to regularly measure thyroid function in patients with SMID taking anti-epileptic drugs, especially CBZ.</p>","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"49 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36315749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal herpes simplex encephalitis with bilateral temporal mega cystic lesion. 新生儿单纯性脑炎伴双侧颞叶巨大囊性病变。

No To Hattatsu Pub Date : 2017-01-01

Yuri Nagao, Kazue Kimura, Kei Hachimori, Hiroshi Oba, Kyoko Hoshino

引用次数: 0

Angular acceleration and angular jerk of elbow extension-flexion movement as parameters for discriminating a sequential transform of spontaneous movements in early infants. 角加速度和角抽搐肘关节伸屈运动的参数，以区分自发运动的顺序变换在早期婴儿。

No To Hattatsu Pub Date : 2017-01-01

Mamoru Igarashi, Hideki Oyama, Shin-ichi Izumi

{"title":"Angular acceleration and angular jerk of elbow extension-flexion movement as parameters for discriminating a sequential transform of spontaneous movements in early infants.","authors":"Mamoru Igarashi, Hideki Oyama, Shin-ichi Izumi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Objective: We assessed the root mean square (RMS) of angular acceleration and the RMS of an angular jerk as expressions of the transformation of spontaneous movements in early infancy. Methods: During 36-56 weeks post-menstrual age (PMA), 15 premature infants (6 male, 9 female; 36 weeks PMA>) were measured every 4 weeks. A three-dimensional motion analyzer (Fastrak system; Polhemus Inc.) was used to measure spontaneous movements of the upper right limb in the supine infants. Upper limb position data were used to calculate the RMS of angular acceleration and the RMS of angular jerk at the elbow. The calculated data were classified into three terms: 36th and 40th week PMA (termⅠ), the 44th and 48th week PMA (termⅡ), and the 52nd and 56th week PMA (termⅢ). The typical value was the mean value for each term. Results: The RMS of angular acceleration in termⅡ was significantly less than that of termⅠ (p<0.05). The RMS values of angular jerk in termⅡ and termⅢ were significantly less than that of termⅠ (p<0.05). Conclusion: The RMS of angular acceleration and the RMS of the angular jerk are useful for expressing changes in the strength of spontaneous movements of elbow extension-flexion movements.</p>","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"49 1","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36315750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroradiologists and magnetic resonance imaging. 神经放射学家和磁共振成像。

No To Hattatsu Pub Date : 2017-01-01

Keiko Toyoda

引用次数: 0

A case of Dravet syndrome complicated by human herpesvirus-6 infection-associated acute encephalopathy and choreoathetosis. Dravet综合征并发6型人疱疹病毒感染相关急性脑病和舞蹈病1例

No To Hattatsu Pub Date : 2017-01-01

Yasuko Nakamura, Hiroshi Matsumoto, Kiyotaka Zaha

{"title":"A case of Dravet syndrome complicated by human herpesvirus-6 infection-associated acute encephalopathy and choreoathetosis.","authors":"Yasuko Nakamura, Hiroshi Matsumoto, Kiyotaka Zaha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the case of a 14-month-old girl with Dravet syndrome carrying a splice-site mutation of c. 1170+1G>A on neuronal sodium channel alpha 1 subunit (SCN1A). She had a history of recurrent febrile or afebrile seizures since 4 months of age and developed acute encephalopathy due to infection with human herpesvirus-6, which presented with high grade fever, severe consciousness disturbances, and prolonged and clustered seizures. Electroencephalography showed a generalized slow activity. Intensive treatments, including mechanical ventilation, continuous thiopental infusion, and high-dose steroid therapy were initiated, and she gradually recovered. During the recovery phase, choreoathetosis-like involuntary movements appeared on the face and limbs, which were treated successfully with haloperidol. MRI findings during the acute phase were normal; however, diffuse cerebral atrophy became evident during the recovery phase. Single photon emission computed tomography (SPECT) of the brain revealed decreased cerebral perfusion over bilateral frontal and temporal lobes; however, perfusion of the occipital lobes, basal ganglia, and cerebellum remained normal. The patient showed serious developmental regression at discharge, with the loss of head control and meaningful words. Patient’s clinical course and the findings of SPECT resembled those of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), with the exception of lack of reduced diffusion of the subcortical white matter on the acute phase MRI and the prolonged and severe clinical symptoms. It has been reported that patients with Dravet syndrome are prone to complications, including various types of acute encephalopathies. Therefore, clinicians should carefully manage prolonged febrile seizures in patients with Dravet syndrome.</p>","PeriodicalId":39367,"journal":{"name":"No To Hattatsu","volume":"49 1","pages":"32-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36315752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of mitochondrial respiratory chain disorder in the neonatal period for which home mechanical ventilation was introduced. 新生儿线粒体呼吸链障碍1例，采用家用机械通气治疗。

No To Hattatsu Pub Date : 2017-01-01

Mari Sugimoto, Takao Togawa, Kaori Aiba, Norihisa Koyama, Kenji Yokochi, Kei Murayama, Akira Ohtake

引用次数: 0

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