Journal of insurance medicine (New York, N.Y.)最新文献

An Outline of a Simple, Interpretable Epigenetic Composite Score for Mortality Prediction for Accelerated Underwriting. 用于加速核保的死亡率预测的简单、可解释的表观遗传综合评分概要。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00027.1

James A Mills, Jeffrey D Long, Robert A Philibert

{"title":"An Outline of a Simple, Interpretable Epigenetic Composite Score for Mortality Prediction for Accelerated Underwriting.","authors":"James A Mills, Jeffrey D Long, Robert A Philibert","doi":"10.1029/AAIMEDICINE-D-24-00027.1","DOIUrl":"https://doi.org/10.1029/AAIMEDICINE-D-24-00027.1","url":null,"abstract":"Background.—: In principle, it is generally accepted that DNA methylation measures can be used to predict mortality. However, as of yet, no epigenetic metric has been successfully incorporated into underwriting procedures. In part, this failure results from the relative incompatibility of many DNA methylation measures with conventional underwriting practices.Objective.—: To test the ability of previously established epigenetic markers of smoking, drinking and diabetes to standard lipid-based approaches for predicting mortality.Method.—: We constructed a series of Cox proportional hazards models for mortality using clinical data and DNA methylation data from 4 previously described loci from the Framingham Heart Study.Results.—: The incorporation of vital signs, standard lipid and diabetes laboratory assessments to a base model consisting of age and sex only modestly increased prediction of mortality from 0.732 to 0.741 area under the curve (AUC). However, the addition of epigenetic marker information for smoking and drinking to the base model markedly increased prediction (AUC=0.787) while the addition of epigenetic marker for diabetes increased prediction even further (AUC=0.792).Conclusion.—: These results demonstrate the potential of simple interpretable, epigenetic models to predict mortality in a manner compatible with standard underwriting procedures. Potentially, this epigenetic approach using rapid methylation sensitive digital PCR procedures that can utilize saliva or whole blood DNA would increase prediction power even further while facilitating more accurate accelerated underwriting assessments of mortality.","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":"51 3","pages":"175-183"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Future of the Journal of Insurance Medicine and AAIM. 保险医学杂志》和 AAIM 的未来。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00036.1

John R Iacovino

引用次数: 0

Varicose Veins as Model for Apportionment among Risk Factors for Compensation Purposes. 静脉曲张作为赔偿风险因素的分摊模型。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.17849/insm-51-3-1-9.2

Marc J Weber, Mark I Taragin

{"title":"Varicose Veins as Model for Apportionment among Risk Factors for Compensation Purposes.","authors":"Marc J Weber, Mark I Taragin","doi":"10.17849/insm-51-3-1-9.2","DOIUrl":"10.17849/insm-51-3-1-9.2","url":null,"abstract":"Objective.—: To demonstrate a method which is being used to apportion between risk factors for occupationally related disease and compensate individuals with multiple risk factors. The application to individuals will be demonstrated for varicose veins.Background.—: The National Insurance Institute (NII) is tasked with compensating work related injuries and illness in Israel. Population attributable fraction (PAF) has been utilized in order to estimate the amount of disease that can potentially be eliminated in a population through the elimination of individual risk factors. PAF is based on relative risks and the prevalence of these risks.Methods.—: A review of the medical literature consisting of epidemiological studies of varicose veins and its multiple risk factors was conducted, with special attention to prolonged occupational standing. Summary, weighted, relative risks were calculated for eight different risk factors. The proposed formula then allowed for apportioning among those risk factors in the individual.Results.—: The findings of the current study indicate that prolonged standing may be associated with the presence of varicose veins, however in light of the multiple other risk factors associated, its overall contribution is generally minor.Conclusion.—: Apportionment among multiple risk factors for varicose veins can be accomplished mathematically in individuals. This application is being applied successfully for other diseases as well.","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":" ","pages":"129-137"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beware the Black Widow at Claim Time: A Report of Three Cases. 当心索赔时的黑寡妇：三个案例的报告。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.17849/insm-51-3-1-6.2

Vera F Dolan

引用次数: 0

Chronic Fatigue Syndrome: Challenges for Evaluation. 慢性疲劳综合征：评估的挑战。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00033.1

Heinrich H Gerhartz

引用次数: 0

The Survival Benefit of Pancreas Transplantation: Considerations for Insurance Coverage. 胰腺移植的生存益处：保险承保的考虑因素。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00031.1

Angelika C Gruessner, Rainer W G Gruessner

引用次数: 0

Non-Physiologic Doses of Androgenic Anabolic Steroids: Mortality and Underwriting Assessment. 非生理性剂量的雄性同化类固醇：死亡率和承保评估。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00028.1

John R Iacovino

引用次数: 0

Innovative Strategies and Insurance Consequences for Implementing Universal Health Insurance in the United States. 在美国实施全民健康保险的创新战略和保险后果。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00014.1

Rainer W G Gruessner

{"title":"Innovative Strategies and Insurance Consequences for Implementing Universal Health Insurance in the United States.","authors":"Rainer W G Gruessner","doi":"10.1029/AAIMEDICINE-D-24-00014.1","DOIUrl":"https://doi.org/10.1029/AAIMEDICINE-D-24-00014.1","url":null,"abstract":"Universal Health Insurance does not exist in the United States for two reasons: (1) there is a general unwillingness to dismantle the historically grown framework of the world's most complex mix of public and private sector health coverage and (2) mere cost considerations. The first concern can be abated by establishing a Universal Health Insurance system which retains many or most of the historically grown infrastructure. Cost containment of such a reform is addressed herein in that the two proposed pathways comprise either (1) a leveled solution through Medicare-expansion for the uninsured only or (2) a more complex solution through a national, 2-tier healthcare system for all Americans. Both pathways are based on solid financing without major tax increases by using existing and/or yet untapped funding sources. The insurance consequences for both options are assessable. They are minor for the Medicare-expansion and more wide-ranging, yet also achievable, for a national, 2-tier healthcare system. Universal Health Insurance must no longer be an illusion that continues to haunt our society in the 21st century.","PeriodicalId":39345,"journal":{"name":"Journal of insurance medicine (New York, N.Y.)","volume":"51 3","pages":"138-142"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune Diseases following COVID-19 Infection: How Solid is the Evidence? 感染 COVID-19 后的自身免疫性疾病：证据有多充分？

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.1029/AAIMEDICINE-D-24-00026.1

Timothy Meagher

引用次数: 0

Assessing the Pathophysiology, Morbidity, and Mortality of Obstructive Sleep Apnea. 评估阻塞性睡眠呼吸暂停的病理生理学、发病率和死亡率。

Journal of insurance medicine (New York, N.Y.) Pub Date : 2024-11-01 DOI: 10.17849/insm-51-3-1-20.2

R C Richie

引用次数: 0