Arhiv za Farmaciju最新文献_第7页

Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection? 人乳腺组织中的镉水平和血清雌二醇水平:有联系吗?

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-34280

Aleksandra Buha-Đorđević, Milena Anđelković, Elena Kačavenda, D. Javorac, Evica Antonijević-Miljaković, Đ. Marić, K. Baralić, Danijela Đukić-Ćosić, M. Ćurčić, B. Antonijević, Z. Bulat

{"title":"Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?","authors":"Aleksandra Buha-Đorđević, Milena Anđelković, Elena Kačavenda, D. Javorac, Evica Antonijević-Miljaković, Đ. Marić, K. Baralić, Danijela Đukić-Ćosić, M. Ćurčić, B. Antonijević, Z. Bulat","doi":"10.5937/arhfarm71-34280","DOIUrl":"https://doi.org/10.5937/arhfarm71-34280","url":null,"abstract":"Cadmium (Cd), one of the most abundant environmental pollutants, is considered to have endocrine disrupting properties. However, data on the dose-response relationship between Cd dose and levels of hormones have been insufficiently studied, especially in human data sets. Thus, the aim of this study was to determine the possibility of analyzing data obtained from a case-control study in female patients with benign/malignant breast tumors, using the Benchmark dose (BMD) concept. The collected data on Cd levels in breast tissue and estrogen serum levels were processed in PROAST software using different variables. The dose-response relationship between the internal dose of Cd and estradiol levels in the serum was investigated and BMD intervals were calculated. The dose-response relationship between the Cd concentration in breast tissue and the estradiol serum level was shown, indicating lower estradiol serum levels as a consequence of higher Cd concentrations in breast tissue. As one of the few studies analyzing human data using the BMD approach, these findings could have a pivotal role in dose response analysis of data collected from human studies.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71199063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Testicular dysgenesis syndrome and phthalate exposure: A review of literature 睾丸发育不良综合征与邻苯二甲酸盐暴露:文献综述

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-34438

P. Erkekoğlu, A. Özyurt, Anıl Yırün, D. Çakır

{"title":"Testicular dysgenesis syndrome and phthalate exposure: A review of literature","authors":"P. Erkekoğlu, A. Özyurt, Anıl Yırün, D. Çakır","doi":"10.5937/arhfarm71-34438","DOIUrl":"https://doi.org/10.5937/arhfarm71-34438","url":null,"abstract":"Endocrine disruptors are chemicals that interfere with the body's endocrine system and cause adverse effects in biological systems. Phthalates are a group of man-made chemicals which are mainly used as plasticizers and classified as endocrine disruptors. They are also used in cosmetic and personal care products as color or smell fixators. Moreover, phthalates are present in inks, adhesives, sealants, automobile parts, tools, toys, carpets, medical tubing and blood storage bags, and food packages. Pathological condition known as \"testicular dysgenesis syndrome\" (TDS) or \"phthalate syndrome\" is usually linked to phthalate exposure and is coined to describe the rise in alterations in reproductive health in men, such as reduced semen quality (decrease in sperm counts, sperm motility and increase in abnormal sperms), hypospadias, cryptorchidism, reduced anogenital distance and early-life testicular cancer. Phthalates are suggested to cause direct effect on gonadal and non-gonadal tissues, impair the differentiation and morphogenesis of seminiferous tubules and accessory sex organs and testicular cells (both Sertoli and Leydig cells), alter estradiol and/or testosterone levels, decrease insulin-like 3 (INSL3) peptide production, impair spermatogenesis and lead to epigenetic alterations, all of which may lead to TDS. This review will mainly focus on phthalates as causes of TDS and their mechanisms of action.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71199206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Can probiotics win the battle against environmental endocrine disruptors? 益生菌能战胜环境内分泌干扰物吗?

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-34237

Çiğdem Sevİm, M. Kara

{"title":"Can probiotics win the battle against environmental endocrine disruptors?","authors":"Çiğdem Sevİm, M. Kara","doi":"10.5937/arhfarm71-34237","DOIUrl":"https://doi.org/10.5937/arhfarm71-34237","url":null,"abstract":"Compounds that have negative effects on the endocrine system are called endocrine disrupting compounds (EDCs). There are several different types of compounds, with several different usage areas in the environment, which can be classified as EDCs. These chemicals have a wide range of negative health effects in organisms, depending on their target hormone system. EDCs are among the most popular topics of scientific research, as they are widely used and organisms are frequently exposed to these chemicals. There are various exposure routes for EDCs, such as oral, inhalation and dermal exposure. Parabens, phenolic compounds, phthalates, and pesticides are the most common EDCs. Nowadays, intestinal microorganism distribution, probiotics, and food supplements that regulate these microorganisms and their protective effects against various harmful chemicals attract attention. For this reason, many studies have been carried out in this field and certain diet schemes have been created according to the results of these studies. In fact, probiotics are preferred in order to reduce and eliminate the negative effects of harmful chemicals and to ensure that the organism reacts strongly in these conditions. In this review, we will focus on EDCs, their health effects and positive effects of probiotics on EDCs exposure conditions.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71199008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endocrine-disrupting activity of mancozeb. 代森锰锌的内分泌干扰作用。

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-34359

Anatoly Skalny, Michael Aschner, Monica Paoliello, Abel Santamaria, Natalia Nikitina, Vladimir Rejniuk, Yueming Jiang, João Rocha, Alexey Tinkov

{"title":"Endocrine-disrupting activity of mancozeb.","authors":"Anatoly Skalny, Michael Aschner, Monica Paoliello, Abel Santamaria, Natalia Nikitina, Vladimir Rejniuk, Yueming Jiang, João Rocha, Alexey Tinkov","doi":"10.5937/arhfarm71-34359","DOIUrl":"https://doi.org/10.5937/arhfarm71-34359","url":null,"abstract":"<p><p>The objective of the present study was to review the existing data on the mechanisms involved in the endocrine disrupting activity of mancozeb (MCZ) in its main targets, including thyroid and gonads, as well as other endocrine tissues that may be potentially affected by MCZ. MCZ exposure was shown to interfere with thyroid functioning through impairment of thyroid hormone synthesis due to inhibition of sodium-iodine symporter (NIS) and thyroid peroxidase (TPO) activity, as well as thyroglobulin expression. Direct thyrotoxic effect may also contribute to thyroid pathology upon MCZ exposure. Gonadal effects of MCZ involve inhibition of sex steroid synthesis due to inhibition of P450scc (CYP11A1), as well as 3β-HSD and 17β-HSD. In parallel with altered hormone synthesis, MCZ was shown to down-regulate androgen and estrogen receptor signaling. Taken together, these gonad-specific effects result in development of both male and female reproductive dysfunction. In parallel with clearly estimated targets for MCZ endocrine disturbing activity, namely thyroid and gonads, other endocrine tissues may be also involved. Specifically, the fungicide was shown to affect cortisol synthesis that may be mediated by modulation of CYP11B1 activity. Moreover, MCZ exposure was shown to interfere with PPARγ signaling, being a key regulator of adipogenesis. The existing data also propose that endocrine-disrupting effects of MCZ exposure may be mediated by modulation of hypothalamus-pituitary-target axis. It is proposed that MCZ neurotoxicity may at least partially affect central mechanisms of endocrine system functioning. However, further studies are required to unravel the mechanisms of MCZ endocrine disrupting activity and overall toxicity.</p>","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390121/pdf/nihms-1828778.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40413632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Concept and utility of population pharmacokinetic and pharmacokinetic/pharmacodynamic models in drug development and clinical practice 群体药代动力学和药代动力学/药效学模型在药物开发和临床实践中的概念和应用

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-32901

M. Roganović, A. Homšek, Marija Jovanović, Valentina Topić-Vučenović, M. Ćulafić, B. Miljković, K. Vučićević

引用次数: 1

Concentrations of persistent organic pollutants in blood of the Spanish population: Temporal trend 西班牙人口血液中持久性有机污染物的浓度:时间趋势

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-33765

Neus González, J. Domingo

引用次数: 1

Validation of a quick and simple chromatographic method for simultaneous quantification of sertraline, escitalopram, risperidone and paliperidone levels in the human plasma 同时定量人血浆中舍曲林、艾司西酞普兰、利培酮和帕利培酮含量的快速简便色谱方法的验证

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-31163

A. Jeremić, F. Milosavljević, S. Vladimirov, B. Batinić, B. Marković, M. Jukic

{"title":"Validation of a quick and simple chromatographic method for simultaneous quantification of sertraline, escitalopram, risperidone and paliperidone levels in the human plasma","authors":"A. Jeremić, F. Milosavljević, S. Vladimirov, B. Batinić, B. Marković, M. Jukic","doi":"10.5937/arhfarm71-31163","DOIUrl":"https://doi.org/10.5937/arhfarm71-31163","url":null,"abstract":"Simultaneous quantification of multiple psychiatric drugs is important for the therapeutic drug monitoring of psychiatric patients. In addition, it would be highly advantageous if the method could be simple, straightforward, and not time-consuming. A 200 µl plasma sample was deproteinized, drugs were separated by a ZORBAX Eclipse XDB-Phenyl column with the mobile phase composed of acetonitrile and 0.1 % formic acid in water (60:40, v/v), and recorded in the MRM mode by using a positive electrospray source with tandem mass spectrometry detection. The dynamic range was 2-256 ng/ml for all the analyzed drugs, except escitalopram (8-256 ng/ml). Quality control samples were prepared in quintuplicates in three relevant concentrations for each drug. Coefficients of determination (R2 ) were higher than 0.99, while the relative difference between nominal and measured concentrations (RE) and CV were lower than 15% for all targets. High performance liquid chromatography coupled with the mass detector (HPLC-MS/MS) method for simultaneous determination of sertraline, escitalopram, risperidone and paliperidone in human plasma was validated with respect to selectivity, linearity, accuracy, precision, matrix effect and stability. This method has significant advantages in terms of low sample volume (200 µl), short preparation time (3 hours) and short runtime per sample (4 minutes).","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development 基于生理的药代动力学/生物药剂学建模在制剂开发中的新兴作用

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-32479

S. Cvijić, Jelisaveta Ignjatović, J. Parojčić, S. Ibrić

{"title":"The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development","authors":"S. Cvijić, Jelisaveta Ignjatović, J. Parojčić, S. Ibrić","doi":"10.5937/arhfarm71-32479","DOIUrl":"https://doi.org/10.5937/arhfarm71-32479","url":null,"abstract":"Computer-based (in silico) modeling & simulation tools have been embraced in different fields of pharmaceutics for a variety of applications. Among these, physiologically-based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) emerged as a particularly useful tool in formulation development. PBPK/PBBM facilitated strategies have been increasingly evaluated over the past few years, as demonstrated by several reports from the pharmaceutical industry, and a number of research and review papers on this subject. Also, the leading regulatory authorities have recently issued guidance on the use of PBPK modeling in formulation design. In silico PBPK models can comprise different dosing routes (oral, intraoral, parenteral, inhalation, ocular, dermal etc.), although the majority of published examples refer to modeling of oral drugs performance. In order to facilitate the use of PBPK modeling tools, a couple of companies have launched commercially available software such as GastroPlus™, Simcyp™ PBPK Simulator and PK-Sim®. This paper highlights various application fields of PBPK/PBBM modeling, along with the basic principles, advantages and limitations of this approach, and provides relevant examples to demonstrate the practical utility of modeling & simulation tools in different stages of formulation development.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

'In silico' toxicology methods in drug safety assessment 药物安全评价中的“计算机”毒理学方法

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-32966

Danijela Đukić-Ćosić, K. Baralić, D. Jorgovanović, K. Živančević, D. Javorac, N. Stojilković, B. Radović, Đ. Marić, M. Ćurčić, Aleksandra Buha-Đorđević, Z. Bulat, Evica Antonijević-Miljaković, B. Antonijević

{"title":"'In silico' toxicology methods in drug safety assessment","authors":"Danijela Đukić-Ćosić, K. Baralić, D. Jorgovanović, K. Živančević, D. Javorac, N. Stojilković, B. Radović, Đ. Marić, M. Ćurčić, Aleksandra Buha-Đorđević, Z. Bulat, Evica Antonijević-Miljaković, B. Antonijević","doi":"10.5937/arhfarm71-32966","DOIUrl":"https://doi.org/10.5937/arhfarm71-32966","url":null,"abstract":"While experimental animal investigation has historically been the most conventional approach conducted to assess drug safety and is currently considered the main method for determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over the last 20 years, there have been significant advances in computational sciences and computer data processing, while knowledge of alternative techniques and their application has developed into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety assessment is constantly increasing. They are very complex and are grounded on accumulated knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as molecular biology. This review will summarize current state-of-the-art scientific data on the use of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting the strategies that should deliver consistent results, while covering the applications of in silico methods in preclinical trials and drug impurities toxicity testing.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine disruption by PFAS: A major concern associated with legacy and replacement substances PFAS对内分泌的干扰:与遗留和替代物质相关的主要问题

Arhiv za Farmaciju Pub Date : 2021-01-01 DOI: 10.5937/arhfarm71-34197

E. Panieri, Aleksandra Buha-Đorđević, L. Saso

{"title":"Endocrine disruption by PFAS: A major concern associated with legacy and replacement substances","authors":"E. Panieri, Aleksandra Buha-Đorđević, L. Saso","doi":"10.5937/arhfarm71-34197","DOIUrl":"https://doi.org/10.5937/arhfarm71-34197","url":null,"abstract":"Perand poly-fluorinated alkyl substances (PFAS) have been used for decades in a great variety of processes and products by virtue of their exceptional properties, versatility and chemical stability. Nevertheless, it is increasingly recognized that these substances can represent a serious hazard to human health and living organisms due to their persistence, long-range transport potential and tendency to accumulate in biota. For this reason, some efforts have been made across the EU to identify alternative molecules, with a shorter carbon chain and theoretically safer profile, that might replace the previous generation of legacy PFAS. Unfortunately, this strategy has not been entirely successful and serious concerns are still posed by PFAS in different human populations. Among others, an emerging aspect is represented by the adverse effects that both legacy and alternative PFAS can exert on the human endocrine system, with respect to vulnerable target subpopulations. In this review we will briefly summarize PFAS properties, uses and environmental fate, focusing on their effects on human reproductive capacity and fertility, body weight control and obesity as well as thyroid function.","PeriodicalId":39173,"journal":{"name":"Arhiv za Farmaciju","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71198949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2