Open Rheumatology Journal最新文献_第7页

Lack of Association of the CD247 SNP rs2056626 with Systemic Sclerosis in Han Chinese. CD247 SNP rs2056626与汉族系统性硬化症缺乏相关性

Open Rheumatology Journal Pub Date : 2014-10-02 eCollection Date: 2014-01-01 DOI: 10.2174/1874312901408010043

Jiucun Wang, Lin Yi, Xinjian Guo, Dongyi He, Hongyi Li, Gang Guo, Yi Wang, Hejian Zou, Yuanhui Gu, Wenzhen Tu, Wenyu Wu, Li Yang, Rong Xiao, Syeling Lai, Shervin Assassi, Maureen D Mayes, Xiaodong Zhou

{"title":"Lack of Association of the CD247 SNP rs2056626 with Systemic Sclerosis in Han Chinese.","authors":"Jiucun Wang, Lin Yi, Xinjian Guo, Dongyi He, Hongyi Li, Gang Guo, Yi Wang, Hejian Zou, Yuanhui Gu, Wenzhen Tu, Wenyu Wu, Li Yang, Rong Xiao, Syeling Lai, Shervin Assassi, Maureen D Mayes, Xiaodong Zhou","doi":"10.2174/1874312901408010043","DOIUrl":"https://doi.org/10.2174/1874312901408010043","url":null,"abstract":"Systemic sclerosis (SSc) is a complex disease involving multiple genetic factors. A recent genome-wide association study (GWAS) indicated that CD247 was strongly associated with SSc, which was subsequently confirmed in a SSc cohort of European population. However, genetic heterogeneity in different ethnic populations may significantly impact the complex trait of SSc. The studies herein aimed to examine whether the SSc-associated SNP rs2056626 of CD247 identified in Caucasian is also associated with Han Chinese SSc. A Han Chinese cohort consisting of 387 SSc patients and 523 healthy controls were examined in the studies. TaqMan assays were performed to examine the SNP. Exact p-values were obtained (Fisher's test) from 2x2 tables of allele counts and disease status. The results showed that there was no association between rs2056626 of CD247 and SSc or any SSc subtypes of Han Chinese. The negative results are important in understanding genetics of SSc in different ethnic populations, which further suggest complex nature of genetics of SSc. ","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"8 ","pages":"43-5"},"PeriodicalIF":0.0,"publicationDate":"2014-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/0f/TORJ-8-43.PMC4192828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32748277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes. 系统性硬化症是一种主要与免疫调节和炎症基因相关的复杂疾病。

Open Rheumatology Journal Pub Date : 2014-09-29 eCollection Date: 2014-01-01 DOI: 10.2174/1874312901408010029

Jingxiao Jin, Chou Chou, Maria Lima, Danielle Zhou, Xiaodong Zhou

{"title":"Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.","authors":"Jingxiao Jin, Chou Chou, Maria Lima, Danielle Zhou, Xiaodong Zhou","doi":"10.2174/1874312901408010029","DOIUrl":"https://doi.org/10.2174/1874312901408010029","url":null,"abstract":"Systemic sclerosis (SSc) is a fibrotic and autoimmune disease characterized clinically by skin and internal organ fibrosis and vascular damage, and serologically by the presence of circulating autoantibodies. Although etiopathogenesis is not yet well understood, the results of numerous genetic association studies support genetic contributions as an important factor to SSc. In this paper, the major genes of SSc are reviewed. The most recent genome-wide association studies (GWAS) are taken into account along with robust candidate gene studies. The literature search was performed on genetic association studies of SSc in PubMed between January 2000 and March 2014 while eligible studies generally had over 600 total participants with replication. A few genetic association studies with related functional changes in SSc patients were also included. A total of forty seven genes or specific genetic regions were reported to be associated with SSc, although some are controversial. These genes include HLA genes, STAT4, CD247, TBX21, PTPN22, TNFSF4, IL23R, IL2RA, IL-21, SCHIP1/IL12A, CD226, BANK1, C8orf13-BLK, PLD4, TLR-2, NLRP1, ATG5, IRF5, IRF8, TNFAIP3, IRAK1, NFKB1, TNIP1, FAS, MIF, HGF, OPN, IL-6, CXCL8, CCR6, CTGF, ITGAM, CAV1, MECP2, SOX5, JAZF1, DNASEIL3, XRCC1, XRCC4, PXK, CSK, GRB10, NOTCH4, RHOB, KIAA0319, PSD3 and PSOR1C1. These genes encode proteins mainly involved in immune regulation and inflammation, and some of them function in transcription, kinase activity, DNA cleavage and repair. The discovery of various SSc-associated genes is important in understanding the genetics of SSc and potential pathogenesis that contribute to the development of this disease. ","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"8 ","pages":"29-42"},"PeriodicalIF":0.0,"publicationDate":"2014-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874312901408010029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32759304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Serum Adenosine Deaminase Level is High But Not Related with Disease Activity Parameters in Patients with Rheumatoid Arthritis. 类风湿关节炎患者血清腺苷脱氨酶水平高但与疾病活动参数无关

Open Rheumatology Journal Pub Date : 2014-09-12 eCollection Date: 2014-01-01 DOI: 10.2174/1874312901408010024

Gülseren Demir, Pınar Borman, Figen Ayhan, Tuba Ozgün, Ferda Kaygısız, Gulsen Yilmez

{"title":"Serum Adenosine Deaminase Level is High But Not Related with Disease Activity Parameters in Patients with Rheumatoid Arthritis.","authors":"Gülseren Demir, Pınar Borman, Figen Ayhan, Tuba Ozgün, Ferda Kaygısız, Gulsen Yilmez","doi":"10.2174/1874312901408010024","DOIUrl":"https://doi.org/10.2174/1874312901408010024","url":null,"abstract":"Serum adenosine deaminase (ADA) has been previously proposed to predict disease activity in patients with rheumatoid arthritis (RA). The aim of this study was to investigate the level of serum ADA, and the relationship between ADA and disease activity markers, in a group of patients with RA. A hundred and 10 patients with a diagnosis of RA were recruited from outpatient clinic of Rheumatology Unit. Demographic properties comprising age, gender, disease duration and drugs were recorded. Disease activity based on disease activity score (DAS)28-erythrocyte sedimentation rate (ESR) and DAS28- C reactive protein (CRP,) ESR, CRP levels, as well as pain by visual analog scale and rheumatoid factor (RF) were recorded. Serum ADA levels (IU/L) were determined in all RA patients and in 55 age and sex similar healthy control subjects. Ninety-six female and 14 male RA patients with a mean age of 54.32±11.51, and with a mean disease duration of 11.5±9.13 years were included to the study. The control group comprised of 48 female and 7 male healthy subjects. 35.5% of the patients were on methotrexate (MTX) and 64.5% of patients were on combined DMARDs or combined MTX and anti-TNF therapies. The mean serum ADA level was statistically higher in RA patients than in control subjects (27.01±10.6 IU/L vs 21.8 ±9.9 IU/L). The mean values of ESR (23.2±14.8 mm/h), CRP (1.71±1.11mg/dL), pain by VAS (37.2±27.1), DAS28-ESR (2.72±0.77), DAS28 CRP (1.37±0.5) were not correlated with ADA levels (p>0.05). Our results have shown that serum ADA levels are higher in RA patients than in controls but were not related with any of the disease activity markers. We conclude that ADA in the serum may not be a reliable biochemical marker to predict disease activity in patients with RA. ","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"8 ","pages":"24-8"},"PeriodicalIF":0.0,"publicationDate":"2014-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/92/TORJ-8-24.PMC4166793.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32715489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

A case with atypical clinical course diagnosed as osteoarthritis, osteonecrosis, subchondral insufficiency fracture, or rapidly destructive coxopathy. 临床表现不典型，诊断为骨关节炎、骨坏死、软骨下不全性骨折或快速破坏性尾椎病1例。

Open Rheumatology Journal Pub Date : 2014-09-12 eCollection Date: 2014-01-01 DOI: 10.2174/1874312901408010020

Yukio Nakamura, Mikio Kamimura, Keijiro Mukaiyama, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato

引用次数: 5

LETTER TO THE EDITOR Subcutaneous (SC) Methotrexate (MTX) is Better and Well-Tolerable than Oral MTX in Rheumatoid Arthritis Patients, Switched from Oral to SC Administration Due to Gastrointestinal Side Effects. 在类风湿性关节炎患者中，皮下(SC)甲氨蝶呤(MTX)比口服MTX更好，耐受性好，由于胃肠道副作用，从口服改为皮下给药。

Open Rheumatology Journal Pub Date : 2014-09-03 eCollection Date: 2014-01-01 DOI: 10.2174/1874312901408010018

Pinar Borman, Gülseren Demir, Ferda Kaygısız, Muyesser Okumuş

引用次数: 9

Adult-Onset Still's Disease Associated with Thyroid Dysfunction: Case Report and Review of the Literature. 成人发病的Still病伴甲状腺功能障碍:病例报告及文献回顾

Open Rheumatology Journal Pub Date : 2014-07-11 eCollection Date: 2014-01-01 DOI: 10.2174/1874312901408010009

Yingchun Hu, Han Wang, Juelin Deng

引用次数: 6

Adult Onset Still's Disease Presenting with Acute Respiratory Distress Syndrome: Case Report and Review of the Literature. 以急性呼吸窘迫综合征为表现的成人起病斯蒂尔氏病:病例报告及文献回顾

Open Rheumatology Journal Pub Date : 2013-12-30 DOI: 10.2174/1874312901307010125

Anisha B Dua, Augustine M Manadan, John P Case

引用次数: 12

Effect of Aqueous Extract of Giant Horsetail (Equisetum giganteum L.) in Antigen-Induced Arthritis. 巨马尾水提物对抗原性关节炎的作用。

Open Rheumatology Journal Pub Date : 2013-12-30 eCollection Date: 2013-01-01 DOI: 10.2174/1874312901307010129

Mirian Farinon, Priscila Schmidt Lora, Leandro Nicolodi Francescato, Valquiria Linck Bassani, Amélia Teresinha Henriques, Ricardo Machado Xavier, Patricia Gnieslaw de Oliveira

引用次数: 15

Risk factors for infection following total joint arthroplasty in rheumatoid arthritis. 类风湿性关节炎全关节置换术后感染的危险因素。

Open Rheumatology Journal Pub Date : 2013-11-29 DOI: 10.2174/1874312920131210005

Ranjani Somayaji, Cheryl Barnabe, Liam Martin

{"title":"Risk factors for infection following total joint arthroplasty in rheumatoid arthritis.","authors":"Ranjani Somayaji, Cheryl Barnabe, Liam Martin","doi":"10.2174/1874312920131210005","DOIUrl":"https://doi.org/10.2174/1874312920131210005","url":null,"abstract":"Objectives: Determine risk factors for infection following hip or knee total joint arthroplasty in patients with rheumatoid arthritis.Methods: All rheumatoid arthritis patients with a hip or knee arthroplasty between years 2000 and 2010 were identified from population-based administrative data from the Calgary Zone of Alberta Health Services. Clinical data from patient charts during the hospital admission and during a one year follow-up period were extracted to identify incident infections.Results: We identified 381 eligible procedures performed in 259 patients (72.2% female, mean age 63.3 years, mean body mass index 27.6 kg/m2). Patient comorbidities were hypertension (43.2%), diabetes (10.4%), coronary artery disease (13.9%), smoking (10.8%) and obesity (32%). Few infectious complications occurred: surgical site infections occurred within the first year after 5 procedures (2 joint space infections, 3 deep incisional infections). Infections of non-surgical sites (urinary tract, skin or respiratory, n=4) complicated the hospital admission. The odds ratio for any post-arthroplasty infection was increased in patients using prednisone doses exceeding 15 mg/day (OR 21.0, 95%CI 3.5-127.2, p=<0.001), underweight patients (OR 6.0, 95%CI 1.2-30.9, p=0.033) and those with known coronary artery disease (OR 5.1, 95%CI 1.3-19.8, p=0.017). Types of disease-modifying therapy, age, sex, and other comorbidities were not associated with an increased risk for infection.Conclusion: Steroid doses over 15 mg/day, being underweight and having coronary artery disease were associated with significant increases in the risk of post-arthroplasty infection in rheumatoid arthritis. Maximal tapering of prednisone and comorbidity risk reduction must be addressed in the peri-operative management strategy.","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"7 ","pages":"119-24"},"PeriodicalIF":0.0,"publicationDate":"2013-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/43/TORJ-7-119.PMC3893721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32055043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 94

The Pathophysiology of Primary Hip Osteoarthritis may Originate from Bone Alterations. 原发性髋关节骨关节炎的病理生理可能起源于骨改变。

Open Rheumatology Journal Pub Date : 2013-11-29 eCollection Date: 2013-01-01 DOI: 10.2174/1874312920130930003

Mikio Kamimura, Yukio Nakamura, Shota Ikegami, Keijiro Mukaiyama, Shigeharu Uchiyama, Hiroyuki Kato

{"title":"The Pathophysiology of Primary Hip Osteoarthritis may Originate from Bone Alterations.","authors":"Mikio Kamimura, Yukio Nakamura, Shota Ikegami, Keijiro Mukaiyama, Shigeharu Uchiyama, Hiroyuki Kato","doi":"10.2174/1874312920130930003","DOIUrl":"https://doi.org/10.2174/1874312920130930003","url":null,"abstract":"Objectives: The aim of this study was to investigate whether bone alterations detected by hip magnetic resonance imaging (MRI) were associated with subsequent primary hip OA.Methods: We enrolled 7 patients with hip joint pain from their first visit, at which hip joints were classified as grade 0 or I on the Kellgren-Lawrence grading scale. Plain radiographs and magnetic resonance imaging (MRI) were performed on all cases, and pain was assessed with the Denis pain scale. Average age, height, weight, body mass index, bone mineral density (L1-4), central edge angle, Sharp's angle, and acetabular hip index were calculated.Results: Within two months of the onset of pain, 4 of the 7 cases showed broad bone signal changes, while 3 cases showed local signal changes in the proximal femur on hip MRI. Three to 6 months after the onset of pain, in all patients whose pain was much improved, plain radiographs showed progression to further-stage OA.Conclusion: Our findings suggest that bone abnormalities in the proximal femur might be involved in the pathogenesis of primary hip OA.","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":"7 ","pages":"112-8"},"PeriodicalIF":0.0,"publicationDate":"2013-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/91/TORJ-7-112.PMC3866704.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31973830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11