The Pathophysiology of Primary Hip Osteoarthritis may Originate from Bone Alterations.

Q4 Medicine

Open Rheumatology Journal Pub Date : 2013-11-29 eCollection Date: 2013-01-01 DOI:10.2174/1874312920130930003

Mikio Kamimura, Yukio Nakamura, Shota Ikegami, Keijiro Mukaiyama, Shigeharu Uchiyama, Hiroyuki Kato

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引用次数: 11

Abstract

Objectives: The aim of this study was to investigate whether bone alterations detected by hip magnetic resonance imaging (MRI) were associated with subsequent primary hip OA.

Methods: We enrolled 7 patients with hip joint pain from their first visit, at which hip joints were classified as grade 0 or I on the Kellgren-Lawrence grading scale. Plain radiographs and magnetic resonance imaging (MRI) were performed on all cases, and pain was assessed with the Denis pain scale. Average age, height, weight, body mass index, bone mineral density (L1-4), central edge angle, Sharp's angle, and acetabular hip index were calculated.

Results: Within two months of the onset of pain, 4 of the 7 cases showed broad bone signal changes, while 3 cases showed local signal changes in the proximal femur on hip MRI. Three to 6 months after the onset of pain, in all patients whose pain was much improved, plain radiographs showed progression to further-stage OA.

Conclusion: Our findings suggest that bone abnormalities in the proximal femur might be involved in the pathogenesis of primary hip OA.

Abstract Image

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原发性髋关节骨关节炎的病理生理可能起源于骨改变。

目的:本研究的目的是探讨髋关节磁共振成像(MRI)检测到的骨改变是否与随后的原发性髋关节骨关节炎有关。方法:我们招募了7例首次就诊时髋关节疼痛的患者，这些患者的髋关节在kelgren - lawrence评分量表中被划分为0级或I级。所有病例均行x线平片和磁共振成像(MRI)检查，并用Denis疼痛量表评估疼痛。计算平均年龄、身高、体重、体质指数、骨密度(L1-4)、中心边缘角、夏普角、髋臼髋指数。结果:疼痛发生后2个月内，7例患者中4例髋关节MRI表现为广泛性骨信号改变，3例患者表现为股骨近端局部信号改变。疼痛发作3 ~ 6个月后，所有疼痛明显改善的患者，x线平片显示进展为进一步期OA。结论:我们的研究结果提示股骨近端骨异常可能参与了原发性髋关节骨关节炎的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Rheumatology Journal Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

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