Medicinski Casopis最新文献_第5页

The prevalence of low anterior resection syndrome in rectal cancer patients who underwent surgical treatment in Isfahan City Hospital during 2012-2018 2012-2018年在伊斯法罕市医院接受手术治疗的直肠癌患者中低位前切除术综合征的患病率

Medicinski Casopis Pub Date : 2020-09-23 DOI: 10.5937/MCKG54-24636

B. Sanei, Mohammad Ghasemi Fard, M. Kolahduzan

{"title":"The prevalence of low anterior resection syndrome in rectal cancer patients who underwent surgical treatment in Isfahan City Hospital during 2012-2018","authors":"B. Sanei, Mohammad Ghasemi Fard, M. Kolahduzan","doi":"10.5937/MCKG54-24636","DOIUrl":"https://doi.org/10.5937/MCKG54-24636","url":null,"abstract":"Objective. We aimed to determine the relative frequency of low anterior resection syndrome (LARS) in patients with rectal cancers who underwent surgical treatment in Isfahan. Methods. We evaluated all patients who were referred to the surgery clinic of Saint Al-Zahra hospital in Isfahan within six years. If LARS was identified, according to the LARS score tool, the frequency of resection complications, factors affecting the LARS, morbidity, and mortality, the frequency distribution of defecation, stool consistency, and rate of significant improvement was evaluated. Results. Fifty-two patients were evaluated. The prevalence of LARS was 78.8%. Postoperative fecal and gas incontinence, clustering, fecal frequency, and fecal urgency in LARS patients were significantly higher than in patients without LARS (P<0.05). There was no significant difference between the two groups in terms of factors affecting the LARS (p<0.05). In most of the patients with LARS, the defecation frequency was more than seven times a week (82.1%), and they mostly had liquid stool (61.5%). 95.5% of the patients with LARS showed significant improvement, which was mostly after 7-11 months (38.5). There was a significant difference between the frequency distribution of defecation, stool consistency, and significant improvement status in patients with and without LARS. Conclusion. LARS occurs commonly among patients undergoing LAR with TME and it is associated with more resection complications. Patients with LARS have significantly higher frequency of defecation per week and liquid stools and mostly achieve significant improvements. Other factors might not be significantly different between patients with or without LARS.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48851826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the influence of expanded hemodialysis on the rate of removal of middle molecular weight uremic toxins 扩大血液透析对中分子量尿毒症毒素脱除率影响的评价

Medicinski Casopis Pub Date : 2020-01-01 DOI: 10.5937/MCKG54-30496

M. Nenadović, A. Nikolic, M. Kostović, Branislava Drašković, M. Jovanovic, T. Nikolić, D. Petrovic

{"title":"Assessment of the influence of expanded hemodialysis on the rate of removal of middle molecular weight uremic toxins","authors":"M. Nenadović, A. Nikolic, M. Kostović, Branislava Drašković, M. Jovanovic, T. Nikolić, D. Petrovic","doi":"10.5937/MCKG54-30496","DOIUrl":"https://doi.org/10.5937/MCKG54-30496","url":null,"abstract":"Objective. The aim of this study was to examine the effect of expanded hemodialysis on the degree of b2-microglobulin removal. Methods. Sixteen patients treated with extended MCO hemodialysis were examined. The main parameter for assessing the efficiency of removal of uremic toxins of middle molecular weight is the concentration of b2-microglobulin in the serum before and after a single session of extended MCO hemodialysis. The following were used for statistical analysis: Kolmogorov-Smirnov test, Student's T test for bound samples and Wilcoxon test. Results. Extended MCO hemodialysis effectively removes uremic toxins of middle molecular weight. The reduction index of b2-microglobulin during a single session of extended MCO hemodialysis is 70.60 ± 5.88%. The average loss of albumin during a single session of extended MCO hemodialysis is 1.88 ± 1.02 g/4h, and the index of albumin reduction is 4.94 ± 2.49%. Conclusion. Extended MCO hemodialysis effectively removes b2-microglobulin. The b2-microglobulin reduction index is ~ 71% and the albumin loss is less than 4.0 g/4h. This dialysis modality prevents the development of amyloidosis, atherosclerosis and atherosclerotic cardiovascular diseases in the population of patients treated with regular hemodialysis.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Profile of linguistic and cognitive deficits in persons with a semantic variant of a primary progressive aphasia 原发性进行性失语症语义变体患者的语言和认知缺陷概况

Medicinski Casopis Pub Date : 2020-01-01 DOI: 10.5937/MCKG54-27796

Lana Jerkić, Dusko Pavlovic, M. Vuković, J. Todorović, Mirna Zelić

{"title":"Profile of linguistic and cognitive deficits in persons with a semantic variant of a primary progressive aphasia","authors":"Lana Jerkić, Dusko Pavlovic, M. Vuković, J. Todorović, Mirna Zelić","doi":"10.5937/MCKG54-27796","DOIUrl":"https://doi.org/10.5937/MCKG54-27796","url":null,"abstract":"Primary progressive aphasia (PPA) includes a group of neurodegenerative disorders that are characterized by progressive deterioration of language functions, while other cognitive functions, at least at the onset of the disease, are relatively spared. There are three basic subtypes of PPA: the nonfluent progressive aphasia (nvPPA), the semantic variant of a primary progressive aphasia (svPPA), and the logopenic progressive aphasia (lvPPA). The semantic variant of a PPA can also be found in the literature under the term of semantic dementia. It is clinically manifested by progressive deterioration of semantic knowledge, fluent aphasia, impaired naming and comprehension, prosopagnosia and surface dyslexia and dysgraphia (in languages with irregular orthography). As the disease progresses, other cognitive changes can be observed. The main cause of the disorder is progressive bilateral atrophy of the anterior temporal lobes, which is more manifested in the left hemisphere. The literature is modest in terms of the use of specific treatment methods in the rehabilitation of these patients. Since speech and language disorders are the most conspicuous symptom, at least at the beginning of the disease, the role of speech therapists in the assessment and restitution of speechlanguage and communication skills is also indisputable.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of nutrition and lifestyles on bone health in patients with schizophrenia and depression 营养和生活方式对精神分裂症合并抑郁症患者骨骼健康的影响

Medicinski Casopis Pub Date : 2020-01-01 DOI: 10.5937/mckg54-28437

B. Bajić, S. Ristić, Marija Palibrk, A. Arnaut, S. Curcic, K. Taušanović

{"title":"The influence of nutrition and lifestyles on bone health in patients with schizophrenia and depression","authors":"B. Bajić, S. Ristić, Marija Palibrk, A. Arnaut, S. Curcic, K. Taušanović","doi":"10.5937/mckg54-28437","DOIUrl":"https://doi.org/10.5937/mckg54-28437","url":null,"abstract":"Objective. The aim of this paper is to investigate the influence of nutrition and pattern behaviors on bone health in people with mental health disorders. Methods. A cross-sectional study has been conducted at the Clinic for Psychiatry of the Clinical Center of Kragujevac and at the Department of Neuropsychiatry of the Specialist-Consultative Service of Health Care Center Kragujevac. The survey included 46 patients from the age of 22 to 81, both genders, with schizophrenia as a diagnosis for mental disorders and depression determined by a psychiatrist. Quantitative testing of calcium, magnesium, phosphorus, sodium and potassium has been performed by standard biochemical methods. Vitamin D has been determined by high performance/pressure liquid chromatography i.e. by a liquid chromatography under high pressure. Results. In the whole group of patients tested, 58.7% of patients were physically active and the patients with schizophrenia (p = 0.026) were less physically active. Out of the total number, 67% of patients eat irregularly and this habit is more present in patients with schizophrenia (p = 0.003). In terms of the presence of certain nutrients, fish is more represented in the nutrition of people suffering from depression. Three patients (6.5%) reported osteoporosis in their medical history, one of whom had a spontaneous fracture. In the anamneses (6.5%) of the patients stated that their parents had had spontaneous bone fractures. Low values of 25 (OH) D in the serum were present in both study groups. Conclusion. Unhealthy lifestyles, low level of Vitamin D found in people who have mental health disorders represent risk factors for the reduced bone mass. The results of our research indicate the need for timely identification of potential risk factors and improvement of prevention in order to raise awareness of the importance of healthy lifestyles and behavior modification.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety in healthcare workers during the COVID-19 pandemic COVID-19大流行期间医护人员的焦虑

Medicinski Casopis Pub Date : 2020-01-01 DOI: 10.5937/mckg54-27871

M. Lazarević

{"title":"Anxiety in healthcare workers during the COVID-19 pandemic","authors":"M. Lazarević","doi":"10.5937/mckg54-27871","DOIUrl":"https://doi.org/10.5937/mckg54-27871","url":null,"abstract":"Objective. At the time of a pandemic, anxiety is a common occurrence in those persons who are exposed to direct contact with the patients or the possibility of the same. The aim of the study was to determine the degree of anxiety among medical workers employed in the city of Loznica and suburban municipalities, at the time of the COVID-19 pandemic. Methods. Anxiety in 120 adult health workers (36 males, 84 females, 25-65 years old) at the time of the pandemic was assessed based on the value of Beck Anxiety Inventory for determining the degree of anxiety, which was sent electronically to all respondents in the days of the epidemic increase and peak in the number of patients infected with COVID-19 virus. The results. The analysis of the results yielded a mean value of the Beck Anxiety Inventory for the assessment of fear and anxiety of 6.82 (standard deviation, 7.49, range 0-39), which is a state of anxiety without clinical significance. There were no statistically significant differences of the mean Beck Anxiety Inventory values between study subgroups based on subjects' gender (p=0.32), age (p=0.96) and education (p=0.06) categories. Conclusion. The paper presents the emotional reaction of health workers in the city of Loznica and suburban municipalities during the COVID-19 pandemic. It was determined that the anxiety reaction is not present in a significant form, and the most common psychosomatic reactions that occur at the peak of a pandemic are presented.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Local guidelines for drug treatment of patients with COVID-19 当地COVID-19患者药物治疗指南

Medicinski Casopis Pub Date : 2020-01-01 DOI: 10.5937/mckg54-29760

S. Janković, K. Pavlović, V. Vukićević, J. Gavrilović, M. Folic, Predrag Čanović, R. Marjanovic, S. Mojsilović, Nebojša Stevanović, N. Rošić

{"title":"Local guidelines for drug treatment of patients with COVID-19","authors":"S. Janković, K. Pavlović, V. Vukićević, J. Gavrilović, M. Folic, Predrag Čanović, R. Marjanovic, S. Mojsilović, Nebojša Stevanović, N. Rošić","doi":"10.5937/mckg54-29760","DOIUrl":"https://doi.org/10.5937/mckg54-29760","url":null,"abstract":"Objective. Until now, there have been no guidelines for the use of drugs in patients with COVID 19 in the Republic of Serbia that have been authorized and published in the professional or scientific literature, or on the official websites of the Ministry of Health or healthcare institutions. The aim of this paper is to present a local guideline for the use of drugs in patients with COVID 19 and the process of its development and adoption. Methods. The guideline proposal was prepared by a working group based on the results of a systematic research of the medical literature, and quality control of found publications from the category \"clinical practice guidelines\". The proposal of the working group was considered and adopted at the sessions of the Drug / Therapeutics Committee and the Quality Assurance Committee of the University Clinical Centre Kragujevac. Results. The guideline's recommendations are based on the type of patient, and all have the same degree of recommendation and the same quality of evidence on which they are based. Patient types are formed according to the severity of the disease and the need for respiratory support, as well as according to the risk of secondary bacterial infection. Conclusion. The local guideline to the use of drugs in patients with COVID 19 was developed and adopted in a short period of time, primarily due to the need for its urgent use. A revision of this guide is planned after 6 months from the moment of adoption.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis of tiazofurin-induced DNA damage in human whole blood cells using an in vitro comet assay 用体外彗星试验分析噻唑呋喃诱导的人全血细胞DNA损伤

Medicinski Casopis Pub Date : 2020-01-01 DOI: 10.5937/MCKG54-28798

Dijana Topalović, L. Živković, Ninoslav Đelić, V. Bajic, B. Spremo-Potparević

{"title":"Analysis of tiazofurin-induced DNA damage in human whole blood cells using an in vitro comet assay","authors":"Dijana Topalović, L. Živković, Ninoslav Đelić, V. Bajic, B. Spremo-Potparević","doi":"10.5937/MCKG54-28798","DOIUrl":"https://doi.org/10.5937/MCKG54-28798","url":null,"abstract":"Objective. Inosine 5'-monophosphate dehydrogenase (IMPDH) activity in cancer cells is increased. Tiazofurin selectively inhibits the activity of IMPDH, and it has been granted for the treatment of different cancers and new viral diseases. Its widespread use was limited because exposure to tiazofurin under certain circumstances was found to have a higher frequency of severe non-hematologic toxicity. Therefore, the objective of this study was to examine genotoxic action and inducement of DNA damage of tiazofurin using the comet assay. Methods. The ability of tiazofurin to induce DNA damage was evaluated using single-cell gel electrophoresis (SCGE) technique/comet assay. Human whole blood cells were exposed to three final concentrations of tiazofurin (1µM/mL, 2 µM/mL, and 5 µM/mL) for 30 min in vitro. Results. Our results indicate that tiazofurin produced a significant level of DNA damage on whole blood cells after 30 min of exposure vs. control. All tested concentrations were significantly comet-forming, in a concentration-dependent manner. Conclusion. Our investigation on the tiazofurin-treated cells and their relationship to the formation of DNA damage demonstrated that the genotoxic effect was induced after exposure to tiazofurin under described conditions.","PeriodicalId":39117,"journal":{"name":"Medicinski Casopis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70985700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0