International Journal of Hematology-Oncology and Stem Cell Research最新文献_第9页

Parvovirus 4 in Individuals with Severe Hemophilia A and Matched Control Group. 严重A型血友病患者和匹配对照组的细小病毒4

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-07-01 DOI: 10.18502/ijhoscr.v15i3.6849

Sanaz Asiyabi, Seyed Mahdi Marashi, Rouhollah Vahabpour, Ahmad Nejati, Alireza Azizi-Saraji, Aliyeh Sadat Mustafa, Asgar Baghernejad, Zabiholla Shoja, Hassan Mansouritorghabeh

{"title":"Parvovirus 4 in Individuals with Severe Hemophilia A and Matched Control Group.","authors":"Sanaz Asiyabi, Seyed Mahdi Marashi, Rouhollah Vahabpour, Ahmad Nejati, Alireza Azizi-Saraji, Aliyeh Sadat Mustafa, Asgar Baghernejad, Zabiholla Shoja, Hassan Mansouritorghabeh","doi":"10.18502/ijhoscr.v15i3.6849","DOIUrl":"https://doi.org/10.18502/ijhoscr.v15i3.6849","url":null,"abstract":"Background: Hemophilia is a well-known bleeding disorder with worldwide distribution. Replacement therapy, using plasma-derived or recombinant coagulation factors, comprises a gold standard regimen for the treatment. Regardless of the advancements made in viral inactivation methods in the production of plasma-derived coagulation factors, the possibility of transmission of new viral infections remained as a noticeable concern yet. The aim of the current study was to investigate the status of parvovirus 4 (PARV4) in severe hemophilia A, von Willebrand disease (vWD), and healthy control. Materials and Methods: In the current case-control study, 76 patients with hemophilia and vWD and 60 individuals from their family members entered the study. Nested PCR used to determine the presence of PARV4 in study subjects (76 cases). To characterize the PARV4 genotype, positive samples subjected to sequencing and phylogenetic analysis. Results: PARV4 genome detected in 11 (14.47%) patients with bleeding disorders. Among whom, nine patients (14.75%) were with severe hemophilia A and two (13.33%) patients with vWD. Only five healthy controls (8.33%) were positive for PARV4. All PARV4 sequences were found to be genotype 1. Conclusion: PARV4 infection in patients with hemophilia and vWD was higher than the control group. While detection of PARV4 DNA in patients with bleeding disorders may not necessarily reflect a clinical urgency, future investigations are needed to define the clinical significance of PARV4. It seems the detection of the virus immune signature of PARV4 infection, particularly in the context of acute and persistent infections, needs to focus on cellular and tissue targets.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"15 3","pages":"192-198"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/08/IJHOSCR-15-192.PMC8748245.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p53 p.Pro72Arg (rs1042522) and Mouse Double Minute 2 (MDM2) Single-Nucleotide Polymorphism (SNP) 309 Variants and Their Interaction in Chronic Lymphocytic Leukemia(CLL): A Survey in CLL Patients from Western Iran. p53 p.Pro72Arg (rs1042522)和小鼠双分钟2 (MDM2)单核苷酸多态性(SNP) 309变异及其在慢性淋巴细胞白血病(CLL)中的相互作用:伊朗西部CLL患者的调查

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-07-01 DOI: 10.18502/ijhoscr.v15i3.6846

Nazanin Jalilian, Yosra Maleki, Ebrahim Shakiba, Mozafar Aznab, Ziba Rahimi, Mehdi Salimi, Zohreh Rhimi

{"title":"p53 p.Pro72Arg (rs1042522) and Mouse Double Minute 2 (MDM2) Single-Nucleotide Polymorphism (SNP) 309 Variants and Their Interaction in Chronic Lymphocytic Leukemia(CLL): A Survey in CLL Patients from Western Iran.","authors":"Nazanin Jalilian, Yosra Maleki, Ebrahim Shakiba, Mozafar Aznab, Ziba Rahimi, Mehdi Salimi, Zohreh Rhimi","doi":"10.18502/ijhoscr.v15i3.6846","DOIUrl":"https://doi.org/10.18502/ijhoscr.v15i3.6846","url":null,"abstract":"Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. The MDM2 and p53 are interacting proteins that play crucial roles in cell biology. Genetic variations of p53 and MDM2 have been identified in many cancers including CLL; among which are SNP309 in the promoter of MDM2 and SNP codon72 in p53. Materials and Methods: In this study, we sought to find the impact of two SNPs of p53 and MDM2 in the pathogenesis of CLL. A total of 100 CLL patients and 102 healthy controls were recruited. Genomic DNA was extracted, and genotyping was performed using the PCR-RFLP method. The allele and genotype associations were analyzed using the χ2 test. The gene-gene interaction analysis was studied using GMDR v0.9. Results: Our study found the absence of a signiﬁcant difference between CLL patients and controls related to the allelic frequencies or genotypic distributions for both MDM2 SNP309 and p53 codon72. A significantly higher frequency of p53 C allele was found in patients with disease duration of more than 36 compared to those less than 36 months. However, GMDR analysis suggests genetic interaction between the genes under study. Conclusion: Our findings indicated each polymorphism of p53 codon72 and MDM2 (SNP309) was not a risk factor for CLL but the p53 C allele could be associated with the disease duration. Besides, the interaction between p53/MDM2 genotypes may confer susceptibility to CLL. Our study could be useful in genetic association studies of CLL and the role of gene-gene interactions in the susceptibility to the disease.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"15 3","pages":"160-169"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/c2/IJHOSCR-15-160.PMC8748241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of Correlation between Serum Free Light-Chain Assay and Bone Marrow Study in Multiple Myeloma Patients. 多发性骨髓瘤患者血清游离轻链试验与骨髓研究的相关性评价。

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-07-01 DOI: 10.18502/ijhoscr.v15i3.6845

Fatemeh Zamani, Mansoureh Shokripour, Maral Mokhtari

{"title":"Evaluation of Correlation between Serum Free Light-Chain Assay and Bone Marrow Study in Multiple Myeloma Patients.","authors":"Fatemeh Zamani, Mansoureh Shokripour, Maral Mokhtari","doi":"10.18502/ijhoscr.v15i3.6845","DOIUrl":"https://doi.org/10.18502/ijhoscr.v15i3.6845","url":null,"abstract":"Background: Multiple myeloma is a hematologic malignancy manifested by the secretion of abnormal immunoglobulin. Different methods have been described for diagnosis and patient response to management. Serum free light-chain assay is recently approved in the diagnosis of multiple myeloma patients. This study aimed to evaluate the diagnostic accuracy of serum free light-chain assay and its agreement to bone marrow findings. Materials and Methods: Forty-six patients with the diagnosis of multiple myeloma were enrolled in the study. The patients were grouped into newly diagnosed cases (22 patients,47.8%) and known cases who were under treatment (24 patients,52.2%). Bone marrow study was done and percentage and clonal status of plasma cells were evaluated by a combination of immunohistochemistry and flow cytometry. Free light-chain assay was done in all patients and sensitivity, specificity, positive predictive value, and negative predictive value were analyzed. Results: Thirty of 46 patients showed monoclonal plasma cell infiltration and 16 patients showed polyclonal plasma cell infiltration based on bone marrow findings. An abnormal κ/λ ratio was seen in 15(68.18%) of new cases and 16(66.6%) of known cases. Sensitivity, specificity, PPV and NPV for κ⁄λ ratio were 72.73%, 46.15%, 71%, and 50%, respectively. Conclusion: In conclusion, due to high false positive and false negative results, the presence of an abnormal serum FLC ratio was not equal to the presence of monoclonal gammopathy, and observation of a normal ratio does not exclude the presence of monoclonal gammopathy.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"15 3","pages":"152-159"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/32/78/IJHOSCR-15-152.PMC8748244.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Peripheral Mononuclear Cells and CD34 Levels as a Predictive Marker for Initiating Apheresis in Autologous Stem Cell Transplant. 外周血单个核细胞和CD34水平作为自体干细胞移植启动单采的预测指标的研究。

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-07-01 DOI: 10.18502/ijhoscr.v15i3.6847

Kiran Pura Krishnamurthy, Vinu Sarathy, Sriniivas Belagutty Jayappa, Girish V Badarkhe, Rajesh Kumar Ks, S Thianeshwaran, Nitin Byas, Suhail Sayeed Mufti, Hrishi Varayathu, Radheshyam Naik

{"title":"Study of Peripheral Mononuclear Cells and CD34 Levels as a Predictive Marker for Initiating Apheresis in Autologous Stem Cell Transplant.","authors":"Kiran Pura Krishnamurthy, Vinu Sarathy, Sriniivas Belagutty Jayappa, Girish V Badarkhe, Rajesh Kumar Ks, S Thianeshwaran, Nitin Byas, Suhail Sayeed Mufti, Hrishi Varayathu, Radheshyam Naik","doi":"10.18502/ijhoscr.v15i3.6847","DOIUrl":"https://doi.org/10.18502/ijhoscr.v15i3.6847","url":null,"abstract":"Background: Autologous HCT in multiple myeloma is done as upfront treatment in newly diagnosed transplant eligible patients after induction chemotherapy. In addition, it is standard for relapsed, aggressive non-Hodgkin lymphoma (NHL) and classical Hodgkin lymphoma (HL), and is curative in ~40% to 45% of patients. Over a decade, many efforts were made to find helpful parameters to predict an optimal time for initiating an efficient peripheral blood stem cell collection so that adequate stem cells are collected. It has been well accepted that CD34+ cell count in peripheral blood before leukapheresis is the best parameter to predict CD34 cell yield. However, white blood cell count, mononuclear cell count, and other easily obtained parameters are still used to guide the clinical practice of peripheral blood stem cell mobilization and collection. Materials and Methods: In the present study, we analyzed the correlation between peripheral blood MNC and Apheresis CD34 levels and also between peripheral blood CD34 by flow cytometry and apheresis CD34 levels. Results: We found that there was a statistically insignificant weak correlation between peripheral MNC and apheresis CD34. There was a statistically significant strong correlation between peripheral CD34 and apheresis CD34. Conclusion: The results show that peripheral blood MNC was analogous indicating that no reliable prediction can be done for CD34 cells collected in apheresis while peripheral CD34 by flow cytometry is the strongest predictor for initiating stem cell collection.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"15 3","pages":"170-177"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/ef/IJHOSCR-15-170.PMC8748243.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperdiploid Multiple Myeloma with Novel Complex Structural Chromosome Abnormalities Associated with Poor Prognosis : A Rare Case Report. 高二倍体多发性骨髓瘤伴新型复杂结构染色体异常伴不良预后:一罕见病例报告。

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-07-01 DOI: 10.18502/ijhoscr.v15i3.6852

Ravindran Ankathil, Eva Foong, Ismail Siti-Mariam, Ramli Norhidayah, Mohd Yunus Nazihah, Vijay Sangeetha, Sreedharan Hariharan, Husin Azlan

{"title":"Hyperdiploid Multiple Myeloma with Novel Complex Structural Chromosome Abnormalities Associated with Poor Prognosis : A Rare Case Report.","authors":"Ravindran Ankathil, Eva Foong, Ismail Siti-Mariam, Ramli Norhidayah, Mohd Yunus Nazihah, Vijay Sangeetha, Sreedharan Hariharan, Husin Azlan","doi":"10.18502/ijhoscr.v15i3.6852","DOIUrl":"https://doi.org/10.18502/ijhoscr.v15i3.6852","url":null,"abstract":"Hyperdiploid multiple myeloma (MM) is associated with better prognosis and non-hyperdiploid subtype is associated with variable to adverse prognosis based on the nature of karyotype abnormality. Rarely exceptions to this hyperdiploid and non-hyperdiploid divisions do exist in a minority. We report an adult male MM patient who showed hyperdiploid karyotype with few novel complex abnormalities and who showed poor clinical outcome. Conventional cytogenetic analysis carried out in 22 GTG banded metaphases showed 53,Y,der(X)t(X;22)(q27;q11.2),+3,+5,+6,+9,+11,+15,der(17)ins(17;1;3)(q11.2;?;?),der(17)ins(17;1;3)(q11.2;?;?),+19,-22,+mar karyotype pattern in 15 metaphases whereas 7 metaphases showed 46,XY karyotype pattern. Interphase FISH revealed biallelic del(13q14) and del(17p13) but no translocations involving the 14q32 region. Through Spectral karyotyping FISH, the origin of complex abnormalities involving der(17) chromosome, translocation t(X;22), and marker chromosome could be clearly delineated. Although the present case showed hyperdiploid karyotype, he showed an adverse prognosis probably due to the co-existence of high risk and complex abnormalities and expired 5 months after initial diagnosis despite standard treatment given.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"15 3","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/39/IJHOSCR-15-199.PMC8748240.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP). 急性免疫性血小板减少性紫癜(ITP)患者巨细胞病毒(CMV)和eb病毒(EBV)亚临床感染的流行

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-07-01 DOI: 10.18502/ijhoscr.v15i3.6843

Farshad Abbasi, Gholam Abbas Kaydani, Zari Tahannezhad, Mohsen Nakhaie, Ali Amin Asnafi, Maryam Moradi

{"title":"Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP).","authors":"Farshad Abbasi, Gholam Abbas Kaydani, Zari Tahannezhad, Mohsen Nakhaie, Ali Amin Asnafi, Maryam Moradi","doi":"10.18502/ijhoscr.v15i3.6843","DOIUrl":"https://doi.org/10.18502/ijhoscr.v15i3.6843","url":null,"abstract":"Background: Immune thrombocytopenic purpura (ITP) defined as a bleeding disorder in which the number and production of platelets reduced by the immune system; however, the destruction of peripheral blood platelets also occurs. Although its exact etiology and pathogenesis not already know, several studies have shown that Epstein-Barr virus (EBV) and cytomegalovirus (CMV) known as possible causative agents of ITP. This investigation aims to evaluate the presence of CMV and EBV in two groups of case and control by polymerase chain reaction (PCR). Materials and Methods: we considered the presence of CMV and EBV in 48 acute ITP patients and 48 healthy people. Study participants were recruited from Ahvaz Shafa Hospital between 2017 and 2018 and the presence of two viruses was investigated by (PCR). Results: Out of 48 acute ITP patients, the CMV DNA was detected from the blood of 12 (25%) patients and the EBV DNA from the blood of 2 (4.2%) other patients. In addition, only one patient was (2.1%) co-infected with CMV and EBV. In contrast, in 48 healthy subjects, 3 (6.6%) had CMV and none of the control group was infected with EBV. Conclusion: Due to the presence of both EBV and CMV in the acute ITP patients in Ahvaz, they can be considered as factors in the progression of this disease. Therefore, consideration of the methods of elimination and treatment of these two viruses in these patients may be used as a treatment strategy in ITP patients in the future.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"15 3","pages":"139-144"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/70/IJHOSCR-15-139.PMC8748239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39861931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Role of Ultrasonography forDiagnosing Wilms Tumor in Developing Country. 超声检查在发展中国家诊断肾母细胞瘤中的作用。

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-07-01 DOI: 10.18502/ijhoscr.v15i3.6844

Aulia Rahmani, Nur Melani Sari, Vita Indriasari

{"title":"The Role of Ultrasonography forDiagnosing Wilms Tumor in Developing Country.","authors":"Aulia Rahmani, Nur Melani Sari, Vita Indriasari","doi":"10.18502/ijhoscr.v15i3.6844","DOIUrl":"https://doi.org/10.18502/ijhoscr.v15i3.6844","url":null,"abstract":"Background: Overall five-year survival rate of Wilm's Tumor (WT) in developing countries is still poor. Delayed diagnosis is one of the contributing factors, whereas early diagnosis is an important thing for the outcome. It is caused by the WT burden in developing countries that was not comparable with the number of facilities for diagnosis and treatment. Ultrasonography (USG) is the mandatory first-line imaging modality in children with a suspected abdominal mass and an overall sensitivity of 76%. Additionally, it can be found in many health facilities at a lower cost, quick, non-invasive, and carries no risk of radiation. Therefore, the relationship between USG and histopathology should be measured. Materials and Methods: A cross-sectional study with an analytical approach was performed in pediatric (0 untill 18 year of age) renal malignancy and neuroblastoma that admitted to Dr. Hasan Sadikin Hospital, Bandung between 2015-2018. Data were collected from medical records. Statistical analyses using Fisher exact test were done to determine the significance of the relationship between USG and histopathology. Results: Forty-three samples were obtained based on inclusion criteria, such as WT (n=33), neuroblastoma (n=6), renal clear cell carcinoma (n=2) and no specific type of renal malignancy (n=2). Fisher exact test revealed no-significant relationship between USG and histopathology with p-value > 0.05 Conclusion: There is no significant relationship between USG and histopathology. Therefore, centralized unity for USG interpretation is recommended.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"15 3","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/e2/IJHOSCR-15-145.PMC8748242.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39861932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clinical, Laboratory and Radiologic Course and Prognosis of COVID-19 in Cancer Patients and Comparison with General Population: A Single-Center Experience 癌症患者中COVID-19的临床、实验室和放射学病程和预后以及与普通人群的比较:单中心经验

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-06-30 DOI: 10.4999/uhod.214718

E. Erdur

{"title":"Clinical, Laboratory and Radiologic Course and Prognosis of COVID-19 in Cancer Patients and Comparison with General Population: A Single-Center Experience","authors":"E. Erdur","doi":"10.4999/uhod.214718","DOIUrl":"https://doi.org/10.4999/uhod.214718","url":null,"abstract":"In this study, we aimed to investigate the clinical findings and follow-up data of patients with COVID-19 and had a history of cancer, and compare these data with other COVID-19 patients We included 2349 COVID-19 inpatients between March 2020 and July 2020 82 of these patients were found to have a cancer diagnosis (Group 1) Patients undergoing chemotherapy were assigned to group 1A, patients receiving non-chemotherapy treatment were assigned to group 1B, cancer patients without any treatment to group 1C and non-cancer patients to group 2 These groups were compared in terms of basic demographic characteristics, symptoms, comorbidities, laboratory and imaging findings, intensive care unit (ICU) admission rate and death The median age of the patients in group 1 was statistically higher than group 2 (61 and 52, p< 0 001) The most common cancer diagnosis was breast cancer (n= 16, 19 5%) Inflammatory parameters such as CRP and D-dimer were found to be higher in patients in group 1 than group 2 (p= 0 005 and p= 0 003, respectively) The mortality rate of the patients in group 1 was 15 8%, while the mortality rate in group 2 was 5 1% and this was statistically significantly higher (p< 0 001) Being in group 1 and group 1A were determined as the predictive parameters for death (r= 0 087, p< 0 001 and r: 0 254, p= 0 021 respectively) Our data suggests that history of cancer and active chemotherapy treatment are independent prognostic factors for severe disease and mortality in COVID-19","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85173210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Radiotherapy on the Excretion and Concentration Functions of the Salivary Glands 放射治疗对唾液腺排泄和浓缩功能的影响

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-04-30 DOI: 10.4999/uhod.214141

Sedef GOKHAN ACIKGOZ

引用次数: 0

Lennert Lymphoma (lymphoepithelioid lymphoma) with Extensive Necrosis: A Case Report Lennert淋巴瘤(淋巴上皮样淋巴瘤)伴广泛坏死1例报告

International Journal of Hematology-Oncology and Stem Cell Research Pub Date : 2021-04-28 DOI: 10.14302/issn.2372-6601.jhor-21-3801

JiaJie Lu, Pete Pow, Anpongkul, Jennifer Cai, Changjun Yue, Xin Qing

{"title":"Lennert Lymphoma (lymphoepithelioid lymphoma) with Extensive Necrosis: A Case Report","authors":"JiaJie Lu, Pete Pow, Anpongkul, Jennifer Cai, Changjun Yue, Xin Qing","doi":"10.14302/issn.2372-6601.jhor-21-3801","DOIUrl":"https://doi.org/10.14302/issn.2372-6601.jhor-21-3801","url":null,"abstract":"Lennert lymphoma (lymphoepitheloid lymphoma) is an extremely rare variant of peripheral T-cell lymphoma, not otherwise specified. Here we report a case of Lennert lymphoma diagnosed in a 57-year-old woman. She had a three-year history of waxing and waning lymphadenopathy with a rapid increase in size in the past four months before presentation. A needle biopsy and a fine needle aspiration were non-diagnostic due to extensive necrosis. The patient underwent a right neck lymph node excisional biopsy which showed the lymph node architecture was effaced by numerous and sometimes confluent clusters of epithelioid histiocytes and infiltration of small lymphocytes. Extensive necrosis was present. Immunohistochemical stains revealed a mixed population of B- and T-cells with the T-cells showing diminished T-cell markers CD3, CD5, and CD7. Flow cytometric analysis detected a small population (7% of total lymphocytes) of CD4-positive T-lymphocytes with loss of CD3, CD5, and CD7 expressions. PCR-based T-cell receptor gene rearrangement studies showed positive results (clonal peaks) in both gamma and beta genes. Stains for microorganisms were negative. The overall findings indicate Lennert lymphoma. To our knowledge, this is the first reported case of Lennert lymphoma with extensive necrosis. The patient is undergoing chemotherapy. The diagnosis of Lennert lymphoma can be challenging, particularly in cases with extensive necrosis. Our case highlights that adequate sampling is important in the investigation of patients with suspected Lennert lymphoma. A careful pathologic examination with ancillary studies including flow cytometry, immunohistochmistry, and cytogenetic and molecular studies leads to the accurate diagnosis.","PeriodicalId":38991,"journal":{"name":"International Journal of Hematology-Oncology and Stem Cell Research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90278280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0