Open Hypertension Journal最新文献_第8页

LETTER TO THE EDITOR: Do we Need Functional Foods for the Treatment of Hypertension? 致编辑:我们需要功能性食品来治疗高血压吗?

Open Hypertension Journal Pub Date : 2013-11-14 DOI: 10.2174/1876526201305010029

Evdoxia Mitsiou

引用次数: 0

EDITORIAL: Is the Beneficial Effect of Mediterranean Diet on Cardiovascular Risk Partly Mediated through Better Blood Pressure Control? 社论:地中海饮食对心血管风险的有益影响是否部分通过更好的血压控制介导?

Open Hypertension Journal Pub Date : 2013-11-14 DOI: 10.2174/1876526201305010036

P. Anagnostis, G. Sfikas, Efthimios Gotsis, S. Karras, V. Athyros

引用次数: 2

LETTER TO THE EDITOR: Functional Foods are a Useful Adjunction to Antihypertensive Drug Treatment 致编辑:功能性食品是抗高血压药物治疗的有效补充

Open Hypertension Journal Pub Date : 2013-11-14 DOI: 10.2174/1876526201305010030

K. Tziomalos, M. Doumas, V. Athyros

引用次数: 0

Effect of a Lipid-Lowering Nutraceutical on Pulse-Wave-Velocity in Hypercholesterolemic Patients with or without Chronic Kidney Disease 降脂营养品对伴或不伴慢性肾病的高胆固醇血症患者脉搏波速度的影响

Open Hypertension Journal Pub Date : 2013-10-18 DOI: 10.2174/1876526201305010018

A. Cicero, A. Parini, M. Rosticci, Barbara Brancaleoni, G. Derosa, E. Grandi, C. Borghi

{"title":"Effect of a Lipid-Lowering Nutraceutical on Pulse-Wave-Velocity in Hypercholesterolemic Patients with or without Chronic Kidney Disease","authors":"A. Cicero, A. Parini, M. Rosticci, Barbara Brancaleoni, G. Derosa, E. Grandi, C. Borghi","doi":"10.2174/1876526201305010018","DOIUrl":"https://doi.org/10.2174/1876526201305010018","url":null,"abstract":"The recent literature has put a large interest on nutraceuticals with lipid lowering activity for the management of moderate cholesterolemia in subjects with mildly increased cardiovascular disease risk. The aim of our study was to evaluate the middle-term effect of a combined lipid-lowering nutraceutical on lipid parameters and aortic stiffness. For this study we consecutively enrolled 40 moderately hypercholesterolemic outpatients with mild-to-moderate chronic kidney disease (CKD) and 40 cross-matched hypercholesterolemic subjects without CKD. All the patient were treated daily with a combined nutraceutical containing red yeast rice (3 mg monacolin K) and berberine (500 mg). At the baseline and after 6 months of treatment we measured blood pressure, pulse wave velocity (PWV) and ematochemistry parameters. No significant change has been observed during the study in both groups regarding body mass index, blood pressure, liver transaminases, creatinin-phosfokinase and eGFR. In non CKD patients TC improved by (-21,6%), LDL-Cholesterol by (-24,2%), non HDL-Cholesterol (-24,0%) and TG (- 20,8%). In CKD patients TC improved by (-21,1%), LDL-Cholesterol by (-23,7%), non HDL-Cholesterol (-23,9%) and TG (- 20,4%). No difference among groups has been observed regarding the effects on lipid metabolism. The PWV has significantly improved in both groups (p<0.01) without differences between groups. In summary, a combined lipid-lowering nutraceutical improved lipid pattern and PWV in both non CKD and mild-to-","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"85 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2013-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68145500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Endothelin Receptor Antagonists (ERA) in Hypertension and ChronicKidney Disease: a Rose with Many Thorns 内皮素受体拮抗剂(ERA)在高血压和慢性肾脏病中的作用:多刺玫瑰

Open Hypertension Journal Pub Date : 2013-08-15 DOI: 10.2174/1876526201305010012

M. Doumas, V. Athyros, N. Katsiki, Andromachi Reklou, A. Lazaridis, A. Karagiannis

引用次数: 2

Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure andRenal Function in Lewis Rats 围产期蛋白- nacl日粮对Lewis大鼠子代血压和肾功能的影响

Open Hypertension Journal Pub Date : 2013-04-19 DOI: 10.2174/1876526201305010001

Jong Y. Lee, S. Azar

{"title":"Effects of Perinatal Protein-Nacl Diets on Offspring's Blood Pressure andRenal Function in Lewis Rats","authors":"Jong Y. Lee, S. Azar","doi":"10.2174/1876526201305010001","DOIUrl":"https://doi.org/10.2174/1876526201305010001","url":null,"abstract":"Perinatal diets may affect the cardiovascular-renal functions of offspring. To understand effects of maternal diet on the renal function and blood pressure (BP) of offspring, protein (10% low, LP; 23% normal, NP) and/or NaCl (4% high salt, HS; 0.6% normal, NS) diets were started at pre-pregnancy through pups' weaning to either a 4% high NaCl (hs) or 0.6% NaCl (ns) diet. Telemetered BP data was analyzed by methods of linear least square rhythmometry. Systolic BPs (circadian mean ±SE mm Hg) were: NPNSns, 131±2; NPNShs, 137±2; NPHSns, 137±0.2; NPHShs, 134±3; LPNSns, 138±1; LPNShs, 138±0.6; LPHSns, 135±2; LPHShs, 142±2. Offspring in NPNShs and NPHSns had significantly in- creased SBPs versus NPNSns (both P<0.05). Most LP-offspring had increased SBP (P<0.01 to <0.05) and lower body weight (BW) with smaller glomerular filtration rate changes (renal reserve, RR-GFR) following overnight acute high- protein loads: RR-GFRs (inulin, ml/min/g kidney) for groups stated above were, respectively: 0.935; 0.927; 0.537; -0.064; -0.229; 0.057; -0.515; -0.404. The kidney weight/BW ratio of offspring was higher on hs- than on ns-diets (all P<0.001). Rats on a low caloric diet had reduced sclerotic glomerular numbers compared to those on normal diets (11.2±1 vs. 15.7±2, P<0.001), though glomerular numbers were similar in both groups. In summary, perinatal LP-HS diets significantly affected the BW, BP, renal injuries and kidney function of offspring. RR was seriously reduced, especially among offspring in hs- and perinatal LP groups. The most interesting result was the glomerular maturation staging in the pups, which suggests delayed nephrogenesis by a maternal LP diet.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"80 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2013-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68145653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Application of a Complex of Blood Pressure Profile, Arterial Stiffness and Albuminuria for Cardiorenal Risk Assessment in Diabetic Patients 血压、动脉僵硬度和蛋白尿复合指标在糖尿病患者心肾风险评估中的临床应用

Open Hypertension Journal Pub Date : 2011-12-30 DOI: 10.2174/1876526201104010037

A. Khoshdel, K. Bowen, S. Carney, G. Eather, J. Fowler, A. Gillies, K. James

{"title":"Clinical Application of a Complex of Blood Pressure Profile, Arterial Stiffness and Albuminuria for Cardiorenal Risk Assessment in Diabetic Patients","authors":"A. Khoshdel, K. Bowen, S. Carney, G. Eather, J. Fowler, A. Gillies, K. James","doi":"10.2174/1876526201104010037","DOIUrl":"https://doi.org/10.2174/1876526201104010037","url":null,"abstract":"Background: In modern epidemiology, risk assessment is a crucial step in diabetes care. Clinic blood pressure reading though is not a good measurement for this purpose since both uncontrolled hypertension and white coat hypertension (WCH) are frequent among patients with diabetes mellitus (DM). Given the problems with clinical application of ambulatory blood pressure monitoring (ABPM), in this study we evaluated clinical utility of home self measurement (HSM) with a wrist-cuff device in DM patients with hypertension to make a BP profile. Also, the clinical application of a complex of arterial study, albuminuria and blood pressure profile, in DM risk assessment was investigated. Methods and Materials: Seventy-eight adult DM patients with labile or uncontrolled hypertension were randomly assigned to 24 hour ABPM or HSM for 4 consecutive days and their BP profiles were evaluated in conjunction with an assessment of arterial stiffness and renal function as well as lipid profile. Results: The two groups were of comparable age, gender, BP, DM duration and control, smoking, lipids, renal function, arterial compliance and antihypertensive medication use. ABPM detected 33% WCH and 17.6% evening/night-time dipping, compared to 32% and 16% respectively for HSM, with overlapping 95% confidence intervals for day versus night BP regression coefficients. WCH patients had more compliant arteries as well as less albuminuria compared to the sustained hypertensive group. Conclusion: A complex of BP profile (by either ABPM or HSM), arterial compliance and albuminuria is a reliable and economical alternative to current methods for risk assessment in hypertensive diabetic patients.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"4 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2011-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68145523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overestimation of Mean Heart Rate by the Arithmetic Average of Beat-By-Beat Sampled Heart Rate Values 用逐拍采样心率值的算术平均值高估平均心率

Open Hypertension Journal Pub Date : 2011-11-25 DOI: 10.2174/1876526201104010033

H. Stauss, K. Rarick

{"title":"Overestimation of Mean Heart Rate by the Arithmetic Average of Beat-By-Beat Sampled Heart Rate Values","authors":"H. Stauss, K. Rarick","doi":"10.2174/1876526201104010033","DOIUrl":"https://doi.org/10.2174/1876526201104010033","url":null,"abstract":"The arithmetic average of beat-by-beat sampled heart rate (HR) values overestimates true HR defined as number of heart beats per time unit. The aims of this study were to (1) estimate the magnitude of overestimation; (2) illustrate the significance of this issue using data from patients with congestive heart failure (CHF) and control subjects; and (3) outline approaches to correctly calculate mean HR. Linear regression analysis of computer-generated time series, representing beat-by-beat HR values in humans, rats, and mice, revealed that the difference between the arithmetic average of beat-by-beat sampled HR values and the true mean HR (error e) can be approximated by the variance (σ 2 ) divided by the arithmetic average (µ) of the beat-by-beat HR values (e = σ 2 /µ). True mean HR was higher in patients with CHF (92.9±4.3 bpm) than in control subjects (82.6±2.1 bpm, P=0.045). However, if mean HR was calculated as arithmetic average of the beat-by-beat HR values the difference in mean HR was no longer significant (93.4±4.4 bpm in CHF vs. 83.8±2.1 bpm in controls, P=0.059). In conclusion, the arithmetic average of beat-by-beat sampled HR values overestimates true HR by approximately the ratio of σ 2 to µ of the beat-by-beat HR values. Thus, the error (e) is largest in subjects with high HR variability and low average HR and may affect interpretation of mean HR values in studies investigating populations of subjects with differing HR variability, such as CHF patients vs. healthy subject or old vs. young subjects.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"4 1","pages":"33-36"},"PeriodicalIF":0.0,"publicationDate":"2011-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68145485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambulatory Cardiovascular Activities in L-NAME-Treated Mice l - name治疗小鼠的动态心血管活动

Open Hypertension Journal Pub Date : 2011-11-04 DOI: 10.2174/1876526201104010023

Jong Y. Lee, S. Azar

{"title":"Ambulatory Cardiovascular Activities in L-NAME-Treated Mice","authors":"Jong Y. Lee, S. Azar","doi":"10.2174/1876526201104010023","DOIUrl":"https://doi.org/10.2174/1876526201104010023","url":null,"abstract":"Objective: High blood pressure (BP) is a dominant risk factor in cardiovascular diseases. An experimental model of nitric oxide synthase (NOS) inhibitor induced hypertension was developed to study some etiologic mechanisms in cardiovascular parameters. Methods: Cardiovascular rhythm characteristics were documented in mice following the N-omega-nitro-L-arginine- methyl-ester (L-NAME)-treatment (Rx). Radio-telemetered BP, heart rate (HR), and locomotor activity (LA) were measured every 4 min for 5 days before and for 14 days after Rx. Data was converted into an hourly average and analyzed by the linear least square rhythmometry. Results: L-NAME-Rx increased systolic BP (SBP) significantly without significant changes in diastolic BP and markedly reduced HR: SBP (mm Hg) 143.4 ± 0.6 versus 148.9 ± 0.4, P <0.0001; HR (beat/min): 552.13 ± 2.7 vs. 481 ± 1.8, P <0.0001, with markedly depleted amplitude. SBP variations were mainly during the night time, while HR variations were almost every time-point comparison throughout the 24-h span. Although the overall LA was not significantly changed with L-NAME-Rx, time-point depleted LA was noted, especially when the light was off at 18:00 hour through midnight (P <0.0001), while an opposite result was observed at noon with significantly increased LA in this nocturnal animal (P <0.005), with markedly decreased amplitude (P <0.01). Interestingly, we observe reduced HR with L-NAME-Rx contradicted to other reports. Conclusion: The results suggest that the NOS blockade may impair cardiovascular autonomic adaptations and arterial baroreflex integration, resulting in an increased vascular tone during the systole, but not an end diastole in the relaxed cardiac autonomic tonus.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"4 1","pages":"23-32"},"PeriodicalIF":0.0,"publicationDate":"2011-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Appropriate Cardiovascular Prevention is Not Implemented in Diabetic Hypertensive Patients Treated in General Practice 适当的心血管预防没有在普通治疗的糖尿病高血压患者中实施

Open Hypertension Journal Pub Date : 2011-06-02 DOI: 10.2174/1876526201104010018

J. Varis, Heljä Savola, R. Vesalainen, I. Kantola

{"title":"Appropriate Cardiovascular Prevention is Not Implemented in Diabetic Hypertensive Patients Treated in General Practice","authors":"J. Varis, Heljä Savola, R. Vesalainen, I. Kantola","doi":"10.2174/1876526201104010018","DOIUrl":"https://doi.org/10.2174/1876526201104010018","url":null,"abstract":"Introduction of guidelines and more effective cardiovascular prevention have taken place in Finland. This study clarified whether treatment of the Finnish diabetics reflects these changes. Antihypertensive, lipemic and diabetic care of diabetics in Finnish general practice was analyzed nationwide by using a questionnaire. Subjects that participated in the study were consecutive hypertensive patients that had met their general practitioners during a given week in 2006. Only 9.4 % of the diabetics reached the blood pressure target below 130/80 mmHg. Fifty-six % of the patients reached the target of glycocylated haemoglobin (GHbA1c) below 7.0 %. The low density lipoprotein (LDL) cholesterol was below 2.5 mmol/l (96.7 mg/dl) in 43.9 % of the patients. In multivariate model, young age and high GHbA1c associated with high diastolic blood pressure. Fewer patients with GHbA1c > 7 % reached the target pressure below 140/90 mmHg than those with GHbA1c ≤7.0 % (p<0.05), but no difference was found if the target was below 130/80 mmHg. Neither the number of antihypertensive agents nor home blood pressure monitoring did affect the blood pressure. Blood pressure control of the treated Finnish diabetics was poor. Metabolic targets were more commonly reached than the blood pressure target but still too seldom. The cardiovascular prevention is not implemented in Finnish diabetic patients treated in general practice.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"4 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2011-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0