Open Hypertension Journal最新文献_第6页

Mobile Device for Monitoring of Cardiovascular System State Based on Assessment of Synchronization of its Low-Frequency Rhythms 基于低频节律同步评估的心血管系统状态监测移动装置

Open Hypertension Journal Pub Date : 2018-11-23 DOI: 10.2174/1876526201810010046

Prokhorov, D. Kulminskiy, E. Borovkova, A. Karavaev, V. Ponomarenko, A. Kiselev, B. Bezruchko

引用次数: 3

Regulation of Biogenesis and Fusion/Fission Processes of Vascular Mitochondria In Aldosterone-Induced Hypertension 醛固酮诱导的高血压中血管线粒体的生物发生和融合/分裂过程的调控

Open Hypertension Journal Pub Date : 2018-11-15 DOI: 10.2174/1876526201810010076

Elena Olivares-Álvaro, M. B. Ruiz-Roso, M. Klett-Mingo, S. Ballesteros, R. Gredilla, Adrian Galiana-Simal, N. Heras, V. Lahera, B. Martín-Fernández

{"title":"Regulation of Biogenesis and Fusion/Fission Processes of Vascular Mitochondria In Aldosterone-Induced Hypertension","authors":"Elena Olivares-Álvaro, M. B. Ruiz-Roso, M. Klett-Mingo, S. Ballesteros, R. Gredilla, Adrian Galiana-Simal, N. Heras, V. Lahera, B. Martín-Fernández","doi":"10.2174/1876526201810010076","DOIUrl":"https://doi.org/10.2174/1876526201810010076","url":null,"abstract":"Aldosterone plays a key role in the development of endothelial dysfunction and hypertension. The regulation of biogenesis and fusion/fission processes of vascular mitochondria has not been examined in aldosterone-induced hypertension. Thereby, we sought to explore in greater depth the role of aldosterone in mitochondrial biogenesis and fusion/fission processes in hypertension and the associated increases in oxidative stress.Male Wistar rats received aldosterone (1mg/Kg/day) + 1% NaCl as drinking water for 3 weeks.Systolic blood pressure was elevated (p<0.05) in aldosterone-treated rats. eNOS and p-eNOSSer1177protein expression was down regulated (p<0.05) and NADPH oxidase subunit p22phox expression was increased (p<0.05) in aldosterone-treated rats. Expression of mitochondrial biogenesis proteins SIRT1, PGC1α, PPARγ, and TFAM decreased (p<0.05) in aldosterone-treated rats. Protein expression of vascular DRP1, OMA1 and S-OPA1 up regulated (p<0.05) in aldosterone-treated rats. MFN1 and L-OPA1 (p<0.05) decreased in aldosterone-treated animals.The results showed that, in aldosterone-treated rats, hypertension is likely associated with increased oxidative stress in the aorta and with changes in the regulation of two key mitochondrial processes such as biogenesis and fusion/fission processes. The overall mitochondrial alterations observed in the study may play a role in aldosterone-derived vascular oxidative stress and hypertension.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41751241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suboptimal Adherence to Antihypertensive Treatment: Causes and Management 对降压治疗的次优依从性：原因和处理

Open Hypertension Journal Pub Date : 2018-10-23 DOI: 10.2174/1876526201810010041

Stelina Alkagiet, K. Tziomalos

引用次数: 0

Nocturnal Blood Pressure Decrease in Hypertensive Patients and Normotensives- Association with Obstructive Sleep Apnoea and Renal Function 高血压患者和正常人夜间血压下降与阻塞性睡眠呼吸暂停和肾功能的关系

Open Hypertension Journal Pub Date : 2018-10-17 DOI: 10.2174/1876526201810010028

B. Hornstrup, Jeppe B. Rosenbaek, N. Hoffmann-petersen, Pia H. Gjoerup, J. Wessels, T. G. Lauridsen, Erling B. Pedersen, J. Bech

{"title":"Nocturnal Blood Pressure Decrease in Hypertensive Patients and Normotensives- Association with Obstructive Sleep Apnoea and Renal Function","authors":"B. Hornstrup, Jeppe B. Rosenbaek, N. Hoffmann-petersen, Pia H. Gjoerup, J. Wessels, T. G. Lauridsen, Erling B. Pedersen, J. Bech","doi":"10.2174/1876526201810010028","DOIUrl":"https://doi.org/10.2174/1876526201810010028","url":null,"abstract":"Blunted nocturnal Blood Pressure (BP) decrease is seen in patients with hypertension and obstructive sleep apnoea (OSA). The influence of OSA and renal function on nocturnal BP decrease is not fully clarified.In this case control study of hypertensive patients and healthy controls, we aimed to analyse the relationship between nocturnal BP decrease on one hand and presence of OSA, renal function, plasma levels of syndecan and vasoactive hormones, and urinary sodium excretion on the other.In 75 hypertensive patients and 56 controls, we performed brachial and central 24h ambulatory BP measurement and cardio respiratory monitoring. We measured syndecan, renin, angiotensinII, aldosterone, vasopressin, and brain natriuretic peptide in plasma and 24h urinary excretion of sodium, aquaporin2, and a component of the epithelial sodium channel (u-ENaCγ).Nocturnal BP decrease was lower in patients than controls, brachial (13% versus 17%,p=0.001) and central (8% versus 10%,p=0.019). Moderate-to-severe OSA was present in 13% of patients, 2% of controls (p<0.005). Neither brachial nor central nocturnal BP decrease was associated with OSA, renal function, plasma levels of vasoactive hormones, syndecan-1, or urinary sodium excretion. P-syndecan and u-ENaCɣ were higher in patients than controls.Both brachial and central nocturnal BP decrease was lower in patients than in controls. Neither brachial nor central nocturnal BP decrease was associated with the presence of OSA, renal function, or plasma levels of vasoactive hormones. Increased syndecan in plasma in hypertensive patients suggested damage to the endothelial glycocalyx.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49327429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Determinants of Blood Pressure Control and Prevalence of Hypertension in Adults in 2017: A Population-Based Study in West Jakarta 2017年成人血压控制和高血压患病率的决定因素:雅加达西部一项基于人群的研究

Open Hypertension Journal Pub Date : 2018-09-28 DOI: 10.2174/1876526201810010015

L. Bawazir, W. Sianipar

{"title":"Determinants of Blood Pressure Control and Prevalence of Hypertension in Adults in 2017: A Population-Based Study in West Jakarta","authors":"L. Bawazir, W. Sianipar","doi":"10.2174/1876526201810010015","DOIUrl":"https://doi.org/10.2174/1876526201810010015","url":null,"abstract":"The high prevalence of hypertension in developing countries underlines the need for accurate data on the prevalence of adult hypertension, as well as patient characteristics and determinants of blood pressure control. As this information is currently not available, our aim was to collect such data from a population of patients in the Tegal Alur Administrative Village, West Jakarta Indonesia.We conducted a case-control study (n = 152) to identify determinants of hypertension and a cross-sectional study (n = 3842) to determine hypertension prevalence and investigate determinants of blood pressure control in hypertensive adults (≥18 years old).The cross-sectional design involved the diagnosis of hypertension via home visits (active detection) and routine clinical examinations at the Tegal Alur II Community Health Center (passive detection). In the case-control design, the groups were sex-matched.In 2017, the prevalence of hypertension in adults in Tegal Alur was 16.8% (n = 646), and the rate of uncontrolled hypertension was 89% (n = 572). A multivariate analysis showed that the adjusted prevalence ratio for comorbidities was 2.1 (95% confidence interval [CI]: 1.48–3.12;p= 0.005). A body mass index indicative of being overweight (≥23 kg/m2) had an odds ratio of 2.25 (95% CI: 1.14–4.44;p= 0.016).Comorbidities were the strongest predictor of uncontrolled blood pressure in hypertensive adults of Tegal Alur. Being overweight (BMI ≥23 kg/m2) was significantly associated with hypertension.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43126837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Features of the Lipid Profile in Patients with Arterial Hypertension and Cardiovascular Diseases According to Smoking Status 从吸烟状态看动脉高压和心血管疾病患者的血脂特征

Open Hypertension Journal Pub Date : 2018-03-30 DOI: 10.2174/1876526201810010008

O. Gaisenok, S. Martsevich, M. Leonova

引用次数: 1

Perceptions, Attitudes and Self-care Practices on Management of Hypertension Among Hypertensive Patients at Teaching Hospital, Batticaloa District, Sri Lanka 斯里兰卡Batticaloa区教学医院高血压患者高血压管理的认知、态度和自我保健实践

Open Hypertension Journal Pub Date : 2018-01-25 DOI: 10.2174/1876526201810010001

G. Kisokanth, Ilankoon Imps, K. Arulanandem, Sundaresan Kt, Goonewardena Cse, J. Joseph

引用次数: 3

Estimation of Delay Times in Coupling Between Autonomic Regulatory Loops of Human Heart Rate and Blood Flow Using Phase Dynamics Analysis 用相动力学分析估计人体心率和血流自主调节回路耦合的延迟时间

Open Hypertension Journal Pub Date : 2017-12-29 DOI: 10.2174/1876526201709010016

V. Khorev, A. Karavaev, E. Lapsheva, T. A. Galushko, M. Prokhorov, A. Kiselev

引用次数: 2

Clinical Factors Affecting the Goal Blood Pressure in Hypertensive Patients of a Rural Polyclinic in Russia 影响俄罗斯农村综合医院高血压患者目标血压的临床因素

Open Hypertension Journal Pub Date : 2017-12-19 DOI: 10.2174/1876526201709010006

O. Posnenkova, S. N. Gerasimov, Y. V. Popova, I. Popov, G. N. Shemetova, V. Gridnev, A. Kiselev

{"title":"Clinical Factors Affecting the Goal Blood Pressure in Hypertensive Patients of a Rural Polyclinic in Russia","authors":"O. Posnenkova, S. N. Gerasimov, Y. V. Popova, I. Popov, G. N. Shemetova, V. Gridnev, A. Kiselev","doi":"10.2174/1876526201709010006","DOIUrl":"https://doi.org/10.2174/1876526201709010006","url":null,"abstract":"We analyzed the data on 182 patients with essential hypertension (64.6 ± 11.3 yo; 48.5% men), who were treated in polyclinic settings of a rural settlement in the Saratov Region of the Russian Federation. Outpatient medical records were used as a source of clinical data. Repeat patients with hypertension diagnosis specified in their medical records, visiting a therapeutist or cardiologist on two randomly selected workdays, were enrolled in our study. The first appointment took place during 1-31 July, 2015 (n = 88), while the second visit occurred on 131 July, 2016 (n = 94). Eleven district therapeutists, two general practitioners and the only cardiologist of the polyclinic participated in the study. Discriminant function analysis was used to identify factors affecting the achievement of the goal blood pressure in the patients. Basic demographic and anamnesis data, risk factors, medical treatment type and lifestyle modification measures, if any, which exhibited statistical significance in univariate analysis (p<0.05), were selected for multi-factor discriminant analysis.","PeriodicalId":38918,"journal":{"name":"Open Hypertension Journal","volume":"9 1","pages":"6-15"},"PeriodicalIF":0.0,"publicationDate":"2017-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45066206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Arterial Stiffness and Nonalcoholic Fatty Liver Disease: Which is the Chicken and Which is the Egg? 动脉硬化与非酒精性脂肪性肝病:哪个是鸡哪个是蛋?

Open Hypertension Journal Pub Date : 2017-04-28 DOI: 10.2174/1876526201709010001

T. Griva, C. Boutari, K. Tziomalos, M. Doumas, A. Karagiannis, V. Athyros

引用次数: 0