Korean Journal of Veterinary Research最新文献

{"title":"Anatomical classification of animal bone relics excavated from the well area of Gasan-ri in Jinju","authors":"Jong-Hyuk Choi, Si-Joon Lee, Chong-Sup Kim, Chungkil Won","doi":"10.14405/kjvr.2021.61.e39","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e39","url":null,"abstract":"곰은 중국의 저우커우덴(周口店)에서 중기홍적세(中期洪積世)에 해당하는 Mindel II기 The classification of the bone pieces excavated from Gasan-ri archaeological site I in Jinju, presumed to be relics was investigated macroscopically. The remains of the animal bone were 3 classes (Mammalia, Aves, Amphibia), 5 orders (Carnivora, Artiodactyla, Galliformer, Rodentia, Salientia), and 6 species (Sus scrofa, Cervidae sp., Nyctereutes procyonides, Phasianidae, Rattus norvegicus caraco, Rana nigromaculata). The total weight of the animal bone remains was 1,002.80 g, with the identified bones comprising 975.30 g and an identification rate of 97.26%. A total of 447 animal bone fragments were identified, including 204 bone pieces of S. scrofa (468.00 g, 47.99%), 102 bone pieces of Cervidae sp. (453.79 g, 46.53%), 68 bone pieces of R. nigromaculata (4.69 g, 0.48%), 59 bone pieces of N. procyonides (47.14 g, 4.83%), 9 bone pieces of Phasianidae (0.98 g, 0.10%), and 5 bone pieces of Rattus norvegicus caraco (0.70 g, 0.07%). The bone pieces of the animal relics consisted of 81 skull (18.12%), 161 axial skeleton (36.02%), 64 forelimb (14.32%), and 141 hindlimb (31.54%) fragments. The archaeological significance of the animal bones excavated in this investigation was that wild boars and deer were presumed to have been mainly used animals in the Gasan-ri area of Jinju during the Three Kingdoms period.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46559741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clear cell hepatocellular carcinoma in an obese dog with hyperlipidemia: a case report","authors":"Jae-Ha Jung, MaRo Lee, Yeseul Yang, Dansong Seo, S. Hwang, Wan-Hee Kim, Yongbaek Kim","doi":"10.14405/kjvr.2021.61.e34","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e34","url":null,"abstract":"This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial license (http://creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Clear cell hepatocellular carcinoma (CCHCC) is a rare subtype of hepatic tumors that occur in less than 10% of dogs and is extremely rare in cats [1]. Histologically, the CCHCC comprises well-differentiated hepatocytes with vacuolated cytoplasm in hematoxylin and eosin (H&E) stained section. Generally, the vacuoles represent intracytoplasmic accumulation of glycogen and/or lipids [2,3]. In human medicine, CCHCC is considered as a low-grade malignancy with a favorable prognosis, which is unique when compared to other subtypes of hepatocellular carcinoma (HCC) [4,5]. However, in veterinary medicine, the incidence of CCHCC is rare, and thus clinical features of CCHCC have not been fully characterized. Here we describe the cytological, histological, and clinical aspects of CCHCC in a dog with obesity and hyperlipidemia. An 11-year-old spayed female mixed-breed dog weighing 7.5 kg presented to a local hospital with elevated liver enzymes and increased total cholesterol levels (450 mg/dL; RI, 112 to 312 mg/dL). There was no evidence of other underlying diseases based on the exam. The patient received liver supplements for 1 month, but the liver enzyme levels remained high. After 2 months, the patient was referred to Seoul National University Veterinary Medical Teaching Hospital (SNUVMTH) for further evaluation. At the time of admission to SNU-VMTH, the patient had no observable clinical signs. On physical examination, no remarkable findings were detected except that the body condition score (BCS) was 8/9. The complete blood count (ADVIA2120i; Siemens Healthcare GmbH, Germany) showed mild thrombocytosis (70.4 × 10/μL; RI, 14.3 to 40.0 × 10/μL) and An 11-year-old obese dog was referred for a liver mass. Cytologic examination revealed vacuolated hepatocytes with mild pleomorphism. A partial liver lobectomy was performed. On histopathologic examination, the mass was diagnosed as hepatocellular carcinoma composed of hepatocytes with clear vacuoles. These findings were consistent with clear cell hepatocellular carcinoma (CCHCC). The CCHCC is a rare subtype of hepatocellular carcinoma in dogs, and clinical features are poorly defined. This is the first report on the cytological, histological and clinical aspects of CCHCC, suggesting that obesity and hyperlipidemia are potential risk factors for CCHCC in dogs.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48429350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomographic features of third eyelid gland adenocarcinoma in a dog: a case report","authors":"Hyun Cho, W. Yoon, K. Cho, Yeong-Bin Baek, Jihye Choi","doi":"10.14405/kjvr.2021.61.e31","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e31","url":null,"abstract":"","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45460816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical case of bovine anemia due to Theileria orientalis group in a non-grazed dairy cow in the upper part of South Korea","authors":"Hector M. Espiritu, Hee-Woon Lee, Sang-Suk Lee, Yong-il Cho","doi":"10.14405/kjvr.2021.61.e33","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e33","url":null,"abstract":"This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial license (http://creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Bovine anemia due to Theileria orientalis group (BATOG) is a tick-borne disease (TBD) affecting cattle, with Haemaphysalis spp. as the major tick involved in disease transmission [1]. Unlike the lymphoproliferative Theileria species, BATOG mainly affects the erythrocytes (RBC) and RBC-associated parameters [2]. Clinical signs include weakness, abortion, fever, pallor, and elevated respiratory and heart rates [2]. However, few clinical cases of T. orientalis infection in cattle have been reported. Consequently, T. orientalis was historically considered to cause benign infection only [2]. Despite the minimal pathogenic effects of BATOG to the cattle, significant losses have been associated due to increased treatment costs, and reduced body weight, production, and reproductive performance, and ultimately, poor welfare and death [2]. BATOG is also known as ‘oriental theileriosis’ because the main vector, Asian long-horned tick, was previously thought to be endemic in East-Asian countries only. But in the past decade, outbreaks of BATOG have been reported in many countries, including several Asian and Asia-Pacific countries [2], and recently the United States [3]. T. orientalis is categorized onto 11 genotypes, with Chitose and Ikeda as genotypes that could lead to reduced health status in cattle [4]. In South Korea, above 95% of cattle farm are operating under non-grazed management. It is favorable for the dairy farmers as it can control outdoor conditions, reduce tick exposure, and enhance the milk yield volume and composition. In South Korea, the most studied bovine TBD was BATOG, as previous reports revealed that it has the highest prevalence compared to anaplasmosis, rickettsiosis, This study reports the detection and genotyping of the first clinical case of bovine anemia due to Theileria orientalis group (BATOG) in non-grazed dairy cow in upper South Korea. Blood and serum tests revealed anemia and hyperbilirubinemia from animal showing clinical symptoms, and later confirmed as piroplasmosis-positive. Follow-up surveillance on the herd revealed 2 asymptomatic cows with anemia. The three animals were confirmed theileriosis-positive and genotyping revealed the clinical and one of the asymptomatic cases have Chitose, while the other has Ikeda genotype. Clinical BATOG cases were rarely reported worldwide, and asymptomatic animals left untreated could serve as parasite reservoir.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47231530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance impairment caused by diazepam in 2 dogs with vestibular disease: case reports","authors":"Hyunseok Kim, W. Son, Inhyung Lee, M. Jang","doi":"10.14405/kjvr.2021.61.e35","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e35","url":null,"abstract":"This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial license (http://creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The vestibular system generates neurological signals containing information about the forces of gravity and movement [1]. Based on these signals, the brain maintains balance and coordinates movements [1]. Vestibular system disease induces signs including nystagmus, head tilt, leaning, falling, and rolling [2]. Magnetic resonance imaging (MRI) is considered a valuable diagnostic tool for vestibular disease [2]. In veterinary medicine, general anesthesia is required for MRI scan, and diazepam is one of the options of premedication for anesthesia in sick patients to reduce the dose of general anesthetics and minimize hemodynamic changes [3]. It is suggested that benzodiazepine may impair postural control in humans medicine [4], however only balance impairment cases after midazolam injection were reported in veterinary medicine [5,6]. Here, the authors present 2 canine cases of sudden onset of leaning, falling, and rolling after diazepam premedication. Case 1. An 11-year-old 3.1 kg castrated male Maltese suffering from acute left head tilt was referred to the diagnostic imaging center for MRI (Magnetom Essenza; Siemens Healthcare, Germany) scan of the brain. The owner noticed that the symptom had begun 2 days earlier. There were no abnormalities on complete blood count, serum chemistry, and thoracic radiography. The dog was bright, alert, and responsive. The neurological examination revealed a left-sided head tilt and horizontal nystagmus (fast phase to the right), and there were no detectable proprioceptive deficits and paresis. The heart rate (HR) of the patient was 102 bpm, and the respiratory rate (RR) was 30 rpm. The systolic blood pressure (BP) measured by Doppler (811-B; Parks Medical Electronics, USA) ultrasonic method was 136 mmHg. The dog was premedicated with intravenous (IV) 0.2 mg/kg diazepam (Diazepam; Samjin Pharm, South Korea). Immediately following the injection, an abrupt balance impairment characterized by leaning, falling, and rolling Following intravenous (IV) administration of diazepam as a preanesthetic agent, sudden balance impairment, such as falling, leaning, and rolling, was identified in 2 canine cases. The 2 dogs were anesthetized for brain magnetic resonance scan to diagnose about a history of head tilt. After end of the diagnostic procedures, during the anesthetic recovery period, balance impairment was also observed. However, the symptoms gradually ceased by IV administration of flumazenil. These 2 canine cases indicated that diazepam premedication was responsible for the acute balance impairment.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45276271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive lymphangiosarcoma in a dog: a case report","authors":"M. Seo, Yeon-Woo Choi, D. Jung, Hee-Chun Lee, I. Hong","doi":"10.14405/kjvr.2021.61.e32","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e32","url":null,"abstract":"This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial license (http://creativecommons. org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Lymphangiosarcoma is a rare tumor arising from lymphatic endothelial cells in both humans and animals [1]. Dogs in the literature with lymphangiosarcoma range from 8 weeks to 13 years of age, and most reported cases occurred in medium to large breeds with no sexual predisposition [2-4]. Lymphangiosarcoma in dogs typically presents as a poorly demarcated subcutaneous mass or focal swelling with edema tissues. Lesions have been commonly reported to originate in the subcutaneous tissue in the inguinal and axillary regions; thoracic cavity; mediastinum; limbs; ventral cervical and midline areas [2,3,5]. However, information regarding the treatment of lymphangiosarcoma is limited, and the prognosis is considered to be poor in both humans and animals because of its aggressive and infiltrative characteristics [6]. Although it has been described in dogs, cats, and horses, the number of reported cases of lymphangiosarcoma is limited in veterinary medicine [1,2,7,8]. This case report describes the clinical history and histopathological features of a progressive and metastatic lymphangiosarcoma in the submandibular region of a dog. A 12-year-old neutered male Golden Retriever was presented to the animal hospital with a history of a progressively enlarging mass in the submandibular region, which had rapidly grown for approximately 1 month. Complete blood count and serum biochemistry analyses were within the normal ranges for the species but revealed anemia. Radiographic and computed tomographic (CT) analyses were performed for the examination of other organs and detection of metastasis. The mass was biopsied for histopathological diagnosis. The biopsied tissue was fixed in 10% neutral buffered formalin, processed routinely, and embedded in paraffin wax. The samples were sectioned 4-μm thick, stained with hematoxylin and eosin A 12-year-old neutered male Golden Retriever presented with a progressively enlarging mass in the submandibular region. Histopathological diagnosis confirmed lymphangiosarcoma with metastasis to the liver and spleen. The pleomorphic neoplastic endothelial cells of the tumor grow directly on bundles of dermal collagen, forming numerous clefts and interconnecting channels that are devoid of conspicuous hematic elements. As lymphangiosarcoma is an uncommon malignant neoplasm, the number of previously reported cases and information of the tumor is limited. The present report describes the clinical history and histopathological diagnosis of a progressive lymphangiosarcoma in the submandibular region with metastases in a dog.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44866526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and pathologic study of porcine epidemic diarrhea in Jeju","authors":"Hyeon-Ju Kim, Hyoung-Seok Yang, Sang-Chul Kang, Jae-Hoon Kim","doi":"10.14405/kjvr.2021.61.e30","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e30","url":null,"abstract":"TGE와 매우 유사한 증상을 나타내었다[2]. 이후 다른 유럽 국가들로 전파되어 이 질병 From April 2014 to September 2015, 153 piglets from 52 farms in Jeju were diagnosed with porcine epidemic diarrhea (PED). The major PED cases were focused on suckling piglets (144 piglets, 94.1%), particularly in 1-7-day-old piglets. Histopathologically, severe villous atrophy was observed in the small intestine, especially in the jejunum and ileum. The mean villous height to crypt depth ratios of the jejunum and ileum were 1.4:1 and 1.5:1, respectively. The major histopathologic findings of the small intestine were cytoplasmic vacuolation, cuboidalization, squamation, and exfoliation of the mucosal enterocytes in the villi. The cytoplasmic vacuolations in the enterocytes were the most prevalent lesions in the small intestine and were more severe in the ileum than in the jejunum. According to immunohistochemistry methods, the PED virus (PEDV) antigens were presented in the cytoplasms of the enterocytes, and were distributed more prevalently in the ileum than in the jejunum. PEDV antigens were also detected in the colon of 26 piglets (19.5%). Sequence comparison and phylogenetic analysis indicated that 12 PEDV had more than a 98.9% homology with each other. These PEDV strains were highly homologous with the genogroup 2 North American group.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43224017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation of cryoprotective extender with resveratrol decreases apoptosis index and reactive oxygen species levels in post-thaw dog sperm","authors":"S. Bang, B. Tanga, A. Qamar, Xun Fang, Gyeong-Ah Seong, Abdelbagi Hamad Talha Nabeel, I. Yu, Jongki Cho","doi":"10.14405/kjvr.2021.61.e29","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e29","url":null,"abstract":"The use of artificial insemination (AI) has expanded widely in livestock and canine reproduction. This technique reduces the use of breeding dogs, which requires transportation of animals, is relatively costly, is time-consuming, and poses risks of disease transmission [1-3]. AI also facilitates breeding of the required, usually genetically superior dogs, both within and among countries [4,5]. Cryopreservation of genetic materials in livestock has various limitations that negatively affect fertility quality [6-9]. Cryo-induced damage causes alteration of sperm cell homoeostasis and leads to failure of the antioxidant system, which plays a major role in controlling the level of oxidative stress (OS) and is responsible for controlling excessive free radicals [10]. Various reports have shown that supplementation of antioxidants in cryopreserResveratrol (RSV, 3,5,4′-trihydroxytrans-stilbene) protects sperm from cryo-induced damage in various animal and human species. In this study, we aimed to assess the effect of dog sperm cryoprotective extender containing RSV on the quality of postthaw dog sperm. Sperm were collected from 4 Beagles and supplemented with different concentrations of RSV (0, 100, 200, and 400 μM). After thawing, apoptosis index, and reactive oxygen species (ROS) levels were assessed to determine post-thaw sperm quality. Dog sperm cryopreserved with 400 μM RSV showed significant improvement in post-thaw sperm quality with lower apoptosis index and ROS levels (p < 0.05). Our results showed that the supplementation of dog sperm cryoprotective extender with RSV at a concentration of 400 μM improved the post-thaw dog sperm quality in the term of sperm ROS production and apoptosis. In addition, we emphasize the necessity of testing the ROS levels and apoptosis index using flow cytometry to determine the quality of post-thaw semen.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43752999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal chondrosarcoma in the maxillary gingiva of a Maltese dog: a case report","authors":"S. Yim, Jinyong Lee, Jae-Hoon Kim, Ji-Youl Jung","doi":"10.14405/kjvr.2021.61.e27","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e27","url":null,"abstract":"A 13-year-old castrated male Maltese dog was presented to a local animal hospital with an oral hemorrhage. An intraoral examination revealed an irregular proliferated lobular mass at the right side of the maxillary gingiva and hard palate. A surgically excised mass was requested for a histopathology examination. Histopathologically, the neoplastic foci were composed of biphasic morphologic patterns, such as primitive mesenchymal tissue and mature or immature cartilage tissue. Immunohistochemically, most of the neoplastic cells forming cartilaginous islands tested positive for S-100; the surrounding mesenchymal cells tested positive for vimentin. This paper describes a rare case of mesenchymal chondrosarcoma in the maxillary gingiva of a Maltese dog.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42675587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effects of fenbendazole, an anthelmintics, on lipopolysaccharide-activated mouse bone marrow cells","authors":"Seonmi Park, H. Joo","doi":"10.14405/kjvr.2021.61.e22","DOIUrl":"https://doi.org/10.14405/kjvr.2021.61.e22","url":null,"abstract":"Fenbendazole (FBZ) is a commonly used anthelmintic in veterinary medicine that has recently been found to have anticancer effects in humans. On the other hand, few studies have examined the anti-inflammatory effects of FBZ, and its mechanism is unknown. In this study, mouse bone marrow cells (BMs) were treated with lipopolysaccharide (LPS), a representative inflammation-inducing substance, to generate a situation similar to osteomyelitis in vitro. The effect of FBZ on inflammatory BMs was examined by measuring the metabolic activity, surface marker expression, cell nuclear morphology, and mitochondrial membrane potential (MMP) of BMs. FBZ decreased the metabolic activity and MMP of LPS-treated BMs. Annexin Ⅴ-fluorescein isothiocyanate/propidium iodide staining and Hoechst 33342 staining showed that FBZ reduced the number of viable cells and induced the cell death of inflammatory BMs. In addition, FBZ reduced the proportion of granulocytes more than B lymphocytes in LPS-treated BMs. Overall, FBZ induces cell death by destabilizing the MMP of LPS-induced inflammatory BMs. FBZ can play a role as an anthelmintic and anticancer agent and an anti-inflammatory agent.","PeriodicalId":38891,"journal":{"name":"Korean Journal of Veterinary Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48726967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}