Sri Lanka Journal of Child Health最新文献

{"title":"Argininaemia presenting as acute encephalitis in a child","authors":"K. J. Kumar, H. R. Nandish, Devesh Bhaskar Yerrapagada, V. G. Manjunath","doi":"10.4038/sljch.v52i3.10459","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10459","url":null,"abstract":"No abstract available","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47228856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apert syndrome in a Sri Lankan boy with normal head growth and without clinical features of raised intracranial pressure during infancy","authors":"M. Manamperi, Nadunika Amarasinghe, Thilini Harshani, Paba Atapattu, T. Somaratne","doi":"10.4038/sljch.v52i3.10418","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10418","url":null,"abstract":"No abstract available","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44680521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of bilateral humeral fractures associated with Erb’s palsy in a newborn","authors":"M. Lakra, Sagar A. Karotkar, B. Lakhkar","doi":"10.4038/sljch.v52i3.10445","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10445","url":null,"abstract":"No abstract available","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42735297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PRISM IV and PIM III prognostic scores as mortality indicators among paediatric intensive care unit patients\u0000 ","authors":"Mukund Vaja, Shashank Jain, Pradhyumn Pamecha, Ashutosh Singh Rathore, Anushka Aggarwal, Kiran Kumar Jain, Manan Arora","doi":"10.4038/sljch.v52i3.10527","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10527","url":null,"abstract":"Introduction: Identifying prognosis of patients admitted in the paediatric intensive care unit (PICU) is of paramount importance to better allocate medical resources, reduce patient-doctor conflict and for overall better patient care. Many scoring systems have been formulated to accomplish this task including paediatric risk of mortality (PRISM) IV and paediatric index of mortality (PIM) III.Objectives: To compare PRISM IV and PIM III as prognostic scoring tools in the PICU of a tertiary healthcare centreMethod: This prospective observational study was conducted in the PICU, Dhiraj hospital, SBKS MI&RC, Gujarat, India, from March 2021 to September 2022. It included all patients from age 1 month to 18 years who were admitted in the PICU for >24 hours and gave consent for this study. They were thoroughly examined and investigations were done within the first hour of admission as per standard guidelines and their PRISM IV and PIM III scores were calculated and data were analysed.Results: A total of 74 patients was enrolled in this study. Whilst 43 (58.1%) patients were discharged, 18 (24.3%)] were discharged against medical advice(DAMA) moribund, 4 were DAMA (non-moribund) and 9 (12.2%) died. Receiver Operating Characteristic (ROC) curves were made for both PRISM IV and PIM III scores. Discriminatory powers of PIM III (AUC 0.725; 95% CI: 0.609 to 0.823) and PRISM IV (AUC 0.8; 95% CI: 0.691 to 0.884) were acceptable. Whilst PRISM IV was the better predictor of mortality at cut off point of >4 with area under curve of 0.8 for correctly predicting mortality, this difference was not statistically significant (p value=0.354). Multivariate logistic regression analysis showed that the duration of stay(days) and PRISM IV value >4 were significant independent risk factors of mortality after adjusting for confounding factors.Conclusions: Both PRISM IV and PIM III were good prognostic scoring tools in the PICU of the tertiary healthcare centre. Multivariate logistic regression analysis showed that the duration of stay(days) and PRISM IV value >4 were significant independent risk factors of mortality after adjusting for confounding factors.","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46205949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-acetylcysteine vs placebo as adjunctive treatment in paediatric leukaemia: A single blind, randomized controlled trial","authors":"Teny Tjitra Sari, Indah Dina Maritha, Isyanaditta Agung Putri","doi":"10.4038/sljch.v52i3.10541","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10541","url":null,"abstract":"Background: Acute lymphoblastic leukaemia (ALL) accounts for about 25% of all cancer types in children. Many chemotherapeutic agents have been shown to be related to increased oxidative stress and hepatotoxicity which affect the survival rate. N-acetylcysteine (NAC) has been used as adjunctive treatment in malignancy. Objectives: To analyse the effect of NAC administration towards blood oxidant, transaminase enzyme, and bilirubin level in ALL children undergoing induction phase of chemotherapy. Method: This is a single-blind placebo-controlled randomized clinical trial carried out from August to December 2020 in Cipto Mangunkusumo National Hospital, Jakarta, Indonesia. Subjects were randomized consecutively into 2 groups treated with NAC or placebo. Inclusion criteria were newly diagnosed ALL-standard risk (SR) children undergoing chemotherapy induction. Exclusion criteria were subjects contraindicated to NAC, already diagnosed with liver dysfunction, and already taken antioxidants. Data were analysed using SPSS 21. Normality test was conducted followed by data analysis with unpaired t-test. Results: A total of 18 subjects were included in study and 2 of them were excluded. Malondialdehyde levels showed an increase of 0.17nmoL in the NAC group and a decrease of 0.19nmoL in the placebo group. Aspartate transaminase (AST) level increased in mean of 11.40 U/L in the NAC group compared to placebo group 5.67 U/L. Alanine transaminase (ALT) level in the NAC group showed an increase in mean of 23.24 U/L compared to placebo group which showed a decrease in mean of 3.5 U/L. Bilirubin level in the NAC group showed an increase of 0.7 mg/dL compared to placebo group 0.17 mg/dL. There was no significant difference in MDA levels, AST, ALT, and bilirubin levels in the 2 groups (p=0. 186; p=0.638; p=0.164; p=0.352, respectively). Conclusions: Higher malondialdehyde level was shown as a trend in subjects in both groups before chemotherapy was done. N-acetyl cysteine administration showed no significant difference in reducing MDA levels, transaminase enzymes, and bilirubin levels in ALL-SR patients compared to placebo.","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46525038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and demographic characteristics of organic acidaemias in children in a tertiary care hospital in Sri Lanka: A 4-year experience in a single centre","authors":"D. M. Vidanapathirana, P. M. S. Fernando, K. L. S. P. K. M. Jayasena, N. D. P. D. Chandrasiri, A. V. Gunaratne, D. Samaranayake, P. M. Jones, E. A. Jasinge","doi":"10.4038/sljch.v52i3.10542","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10542","url":null,"abstract":"Background: Organic acidaemias (OAs) are a biochemically heterogeneous group of inborn errors of metabolism. They are rare and infrequently reported worldwide. Most OAs are clinically apparent in the neonatal period or early infancy while some can present as a chronic progressive form or even an asymptomatic form. Objectives: To describe the clinical presentation, demographic characteristics and the incidence of OAs in Sri Lankan children. Method: A retrospective descriptive cross-sectional study was conducted over a 4-year period by reviewing records of children suspected of having OAs referred to the Department of Chemical Pathology, Lady Ridgeway Hospital. Demographic information, clinical manifestations, biochemical investigations and mutational results were recorded and analysed using descriptive statistics. Definitive diagnosis was established by gas chromatography and mass spectroscopy (GC-MS) of urine for organic acids. Results: Among the 458 patients suspected, 20 (4.3%) were confirmed to have an OA resulting in an incidence of 13/319,000 live births per year. The mean ages at onset of symptoms and diagnosis were 11.8 months (range; day 1 to 5 years) and 27.1 months (range; day 10 to 12 years) respectively. Among the 20 patients were 5 (25%) with propionic acidaemia and 4 (20%) with beta-ketothiolase deficiency. Nineteen (95%) presented acutely. Common manifestations were respiratory distress in 12 (60%) and persistent or recurrent vomiting in 10 (50%). Learning difficulty, dyskinesia and macrocephaly were some chronic manifestations. Biochemically, 15 (75%) had acidosis and 9 (45%) had ketosis. There were 13 (65%) deaths of which 6 were neonates with acute presentation. Conclusions: Propionic acidaemia and beta-ketothiolase deficiency were the common OAs identified. Common clinical presentations were respiratory distress and persistent or recurrent vomiting. Acidosis was a common biochemical finding.","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135320313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing excessive screen time in children and adolescents","authors":"Yasodha Maheshi Rohanachandra","doi":"10.4038/sljch.v52i3.10661","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10661","url":null,"abstract":"No abstract available","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135364599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of neonatal I-cell disease with multiple intrauterine fractures ","authors":"Santoshi Subhadarsini, R. Prashanth, A. Mujeeb, A. Haribalakrishna","doi":"10.4038/sljch.v52i3.10444","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10444","url":null,"abstract":"No abstract available","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46603100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do children need humans or screen? Institutional-based cross-sectional study","authors":"M. Rajalakshmi, Reena Mohan, T. Kanimozhi, Karthika Devi","doi":"10.4038/sljch.v52i3.10501","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10501","url":null,"abstract":"Introduction: Screen exposure is on the rise and has been virtually unavoidable in the post-Covid era. Screen exposure during the critical period of brain development results in delayed language, learning and behaviour problems and subsequent sedentary lifestyle results in non-communicable disease later in life.Objectives: To assess the burden of digital screen exposure and parental perceptions of its effects in children.Method: This institution-based cross-sectional study was conducted among children aged 1-13 years in a tertiary healthcare centre in Puducherry, India, from April 2022 to June 2022. Data were collected using the Digital Screen Exposure Questionnaire (DSEQ), administered by trained Compulsory Rotatory Residential Internship (CRRI) after pilot testing.Results: Our study shows that the prevalence of excessive screen exposure (>1 hour) was 25% during weekdays and 44.9% during weekends. The most common media used was television (TV) in 92.8%, closely followed by smart phones in 90%. Most frequently watched content (>5 times/ week) was random things for enjoyment in 57.8% followed by rhymes in 25.7%; 57.1% had no outside play during weekdays. Mother’s education was the main predictor which influenced the duration of screen exposure in study participants.Conclusions: Our study shows that the prevalence of excessive screen exposure (>1 hour) was 25% during weekdays and 44.9% during weekends. Common media used were TV in 92.8% and smart phones in 90%. Except for mother’s education, no other socio-demographic factor influenced the duration of screen exposure in study participants. There was excessive screen exposure in children despite parental perception of its harmful effects","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47376684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varied presentation of rickettsial meningoencephalitis in children: A case series","authors":"S. Gaikwad, Punam Uke, Ashwini Kundalwal, Lavanya Ramakrishnan, Sai Samhita Chundi","doi":"10.4038/sljch.v52i3.10415","DOIUrl":"https://doi.org/10.4038/sljch.v52i3.10415","url":null,"abstract":"No abstract available","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46502399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}