Iranian Journal of Psychiatry最新文献

{"title":"Impact of Spiritual End-of-Life Support on the Quality of Life for Leukemia Patients","authors":"Narges Yaghoobi Beglar, Fateme Rezaei, Ehsan Izadipour, Seyyed Mahmood TabaTabaei","doi":"10.18502/ijps.v19i1.14346","DOIUrl":"https://doi.org/10.18502/ijps.v19i1.14346","url":null,"abstract":"Objective: Patients with leukemia suffer from significant psychological, spiritual, and social symptoms. Therefore, the current research aimed to study the impact of spiritual end-of-life support on the quality of life for leukemia patients. \u0000Method: To this end, the present quasi-experimental research with a pre-test and post-test design was performed. The sample included 60 cancer patients randomly assigned to intervention and control groups through the method of permutation block. The experimental group received spiritual support intervention for eight sessions of 60 minutes, while the control group received no intervention. Patients filled out the questionnaire of World Health Organization Quality of Life. The World Health Organization conducts a three-phase assessment to measure the quality of life. These phases include a pre-test, which is conducted before any intervention takes place. Then comes the post-test, which occurs after the intervention. Finally, there is a follow-up assessment conducted two months after the post-test. The obtained results were analyzed by repeated-measures analysis and independent samples t-test using SPSS software. \u0000Results: The findings from the repeated measures analysis revealed that there was a statistically significant interaction between time and group (P = 0.01). In other words, being compared to the control group, the spiritual support significantly increased the life quality of the patients in the experimental group. The experimental group witnessed a sustained enhancement in the quality of life for a period of two months following the intervention (follow-up, P = 0.01). \u0000Conclusion: Ultimately, the provision of spiritual support has the potential to enhance the overall well-being of individuals approaching the end of their lives, offering solace and aiding them in comprehending the true essence and purpose of their existence.","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"112 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Brain Activation According to fMRI Data in Patient with Depression (After Acute Coronary Syndrome and Somatically Healthy) and Healthy Volunteers","authors":"Beliaevskaia Alena Antonovna, Petelin Dmitry Sergeevich, Akhapkin Roman Vitalievich, Volel Beatrice Albertovna, Ternovoy Sergey Konstantinovich","doi":"10.18502/ijps.v19i1.14335","DOIUrl":"https://doi.org/10.18502/ijps.v19i1.14335","url":null,"abstract":"Objective: The present study is devoted to the study of brain activation using fMRI in patients with depression (after acute coronary syndrome and somatically healthy) and in healthy volunteers. \u0000Method: The study enrolled a total of 51 patients: 11 with depression after acute coronary syndrome, 16 with primary depressive episode and recurrent depression without prior coronary event, and 24 with ACS without depression. The groups were matched by sex and age. The emotional information processing was evaluated with the Pennsylvania Test of Emotion Recognition. All patients underwent fMRI at the time of this test. The data processing was performed with SPM12 and xjView applications. \u0000Results: During the processing of emotional information in the depressed patients after ACS, specific activation zones in the frontal cortex (P < 0.001), right fusiform gyrus (P < 0.001), and right insular lobe were identified (P = 0.017). In the patients with primary depressive episode and recurrent depression without ACS, certain zones of activation were identified in frontal cortex (P < 0.001; 0.001), left fusiform gyrus (P < 0.001), occipital cortex (P < 0.001). In the patients who had ACS, without depression, some zones of activation were specified in the right middle occipital gyrus (P < 0.001), the right superior frontal gyrus (P = 0.088), and the putamen projection on the right (P < 0.001) and on the left (P = 0.009), as well as the left insular lobe (P = 0.015). \u0000Conclusion: The pathogenesis of depression is significantly associated with the peculiarities of processing emotionally significant information, regardless of the conditions under which it develops. \u0000 ","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"31 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Effects of Marital Empathy, Body Image, and Perceived Social Support on Quality of Life of Married Women with Breast Cancer and the Mediating Role of Perceived Marital Quality","authors":"Zabihollah KavehFarsani, Everett L. Worthington, Jr.","doi":"10.18502/ijps.v19i1.14340","DOIUrl":"https://doi.org/10.18502/ijps.v19i1.14340","url":null,"abstract":"Objective: Breast cancer is the most commonly diagnosed cancer in women worldwide, and its incidence has increased recently. Diagnosing cancer can create many challenges, especially for married women. The aim of the present study was thus to evaluate the effect of the relationships among marital empathy, body image, and perceived social support on quality of life (QoL) and the mediating role of perceived marital quality. \u0000Method: Married women with breast cancer (N = 160) were selected through purposive accessible sampling. Measures included body image scale, Batson empathy adjectives, multidimensional scale of perceived social support, perceived marital quality, and QoL. The research method was descriptive-correlational and using structural equation modeling. \u0000Results: The best model obtained showed that all predictors directly predicted QoL: marital empathy, body image, and perceived social support (P < 0.001). Predictors (except for perceived social support by family, friends, and others) also worked indirectly through perceived marital quality to predict QoL (P < 0.001). \u0000Conclusion: Several variables predicted QoL for women with breast cancer, including body image and marital empathy. Most of such variables had both a direct effect and an indirect effect, working through perceived marital quality to affect QoL. Social support, however, had only a direct effect on QoL.","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"528 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139011101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Effects of Acupressure and Clonazepam Tablets on Sleep Quality of Hemodialysis Patients: A Randomized Controlled Trial.","authors":"Mansooreh Ezzati,&nbsp;Masoumeh Bagheri-Nesami,&nbsp;Javad Setareh,&nbsp;Mahmood Moosazadeh,&nbsp;Fatemeh Espahbodi,&nbsp;Nadali Esmaeili Ahangarkelai","doi":"10.18502/ijps.v18i4.13632","DOIUrl":"10.18502/ijps.v18i4.13632","url":null,"abstract":"<p><p><b>Objective:</b> The current study aimed to compare the impact of acupressure and clonazepam tablets on the quality of sleep in hemodialysis patients in light of the rising prevalence of chronic kidney disease (CKD), the high prevalence of sleep disturbance in these patients, and the side effects of hypnotic drugs. <b>Method</b> <b>:</b> A total of 60 patients were selected for this randomized, controlled clinical trial and randomly assigned to two groups. For two weeks during the researcher's evening shift, one group received acupressure (six spots bilaterally for three minutes each day). The opposing group was administered clonazepam tablets (0.5 mg) for two weeks. The Pittsburgh Sleep Quality Index (PSQI), which measures sleep quality, was used to compare sleep in the two groups before and after the intervention. <b>Results:</b> There was no statistically significant difference between the two groups prior to the intervention (P = 0.75) in terms of the mean pre-intervention PSQI scores for the acupressure and clonazepam groups, which were 15.83 ± 1.51 and 16.17 ± 0.91, respectively. However, the average PSQI scores after the intervention in the clonazepam and acupressure groups were 13.25 ± 2.88 and 8.97 ± 4.29, respectively, indicating a statistically significant difference (P < 0.0001). Both the acupressure and the clonazepam groups showed improvements in their post-intervention sleep quality among the patients. However, when the percentage changed in the mean scores of the total score and all of the PSQI components were calculated for each group, it became clear that acupressure was more effective at enhancing sleep than clonazepam tablets. <b>Conclusion:</b> The findings of the present investigation demonstrate that acupressure has a greater impact on patients' sleep quality compared to clonazepam tablets. Depending on the circumstances, acupressure can be used as a simple, safe, and non-drug way to enhance hemodialysis patients' quality of sleep.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"18 4","pages":"455-465"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5b/cd/IJPS-18-455.PMC10593989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Deviation from Time Perspective in Patients with Major Depressive Disorder, Obsessive Compulsive Disorder, and Generalized Anxiety Disorder: A Comparative Analysis in the Clinical Context.","authors":"Hamed Rezaei Golezani,&nbsp;Abbas Bakhshipour,&nbsp;Mahmonir Haghighi,&nbsp;Issa Hekmati,&nbsp;Hamed Abdollahpour Ranjbar","doi":"10.18502/ijps.v18i4.13625","DOIUrl":"10.18502/ijps.v18i4.13625","url":null,"abstract":"<p><p><b>Objective:</b> A growing body of research stresses the effect of time perspective (TP) on the genesis and maintenance of psychological disorders. However, the variations in the TP configuration of individuals with different disorders have not yet been completely investigated. We aimed to compare the differences in TP among patients with three common psychiatric disorders. <b>Method</b> <b>:</b> We recruited 30 patients with major depressive disorder (MDD), 30 with generalized anxiety disorder (GAD), and 30 with obsessive-compulsive disorder (OCD). Participants completed Zimbardo's Time Perspective Inventory, Beck Depression Inventory, Generalized Anxiety Disorder Scale, Maudsley Obsessive Compulsive Inventory, and Structured Clinical Interview for DSM-5 (SCID-5). The one-way MANOVA was utilized for the comparison of TP dimensions among the three disordered groups. <b>Results:</b> The results showed that TP was significantly affected in all three clinical groups. The effect of the disorder on time perspective was significant for Past Negative (PN) (F (2, 84) = 11.86, P < 0.01), Past Positive (PP) (F (2, 84) = 6.66, P < 0.01), Present Fatalistic (PF) (F (2, 84) = 7.08, P < 0.01) and Future (F) (F (2, 84) = 26.40, P < 0.01), but not for Present Hedonistic (PH). The findings revealed that the MDD group scored the highest on PN, with the GAD group scoring higher than the OCD group. The GAD and OCD groups reported higher PP than the MDD group. In addition, the MDD group scored higher than both the GAD and OCD groups on PF. Finally, the GAD patients reported higher scores than both the MDD and OCD patients on the F dimension, while the OCD patients scored higher than the MDD patients. <b>Conclusion:</b> Individuals with MDD tend to obtain higher scores in PN and PF time perspective, whereas those with GAD and OCD showed higher PP and F scores. These findings demonstrate the significance of examining TP in clinical patients and prompt further research into the association between TP and the disorders being studied. Perspectives on therapy are also explored.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"18 4","pages":"380-387"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/f9/IJPS-18-380.PMC10593992.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Neurocognitive Deficits, Quality of Life, and Functional Performance in Ultra-High-Risk Individuals Compared to Familial High-Risk Individuals for Schizophrenia.","authors":"Mohammad Ali Fallah Zadeh,&nbsp;Homayoun Amini,&nbsp;Vandad Sharifi,&nbsp;Mehdi Tehranidoost,&nbsp;Maryam Noroozian","doi":"10.18502/ijps.v18i4.13629","DOIUrl":"10.18502/ijps.v18i4.13629","url":null,"abstract":"<p><p><b>Objective:</b> This study aimed to investigate neurocognitive functioning, quality of life, and global functional performance in Ultra-High Risk (UHR) individuals compared to Familial High-Risk (FHR) individuals for developing schizophrenia. <b>Method</b> <b>:</b> An observational cross-sectional study was conducted using a convenient sampling method at Roozbeh Hospital in Tehran, Iran, from June 2017 to January 2020. The study included 40 UHR individuals based on the Structured Interview for Psychosis Syndrome (SIPS) interview, as well as 34 FHR individuals due to genetic risk. Neurocognitive functioning, quality of life, and global functional performance were assessed by using the Cambridge Automated Neuropsychological Test Battery (CANTAB) and Controlled Oral Word Association Test (COWAT), Quality of Life Scale (QLS), and Global Assessment of Functioning (GAF). <b>Results:</b> UHR individuals for schizophrenia demonstrated significant lower scores in phonemic and semantic verbal fluency (t = 6.218, P < 0.001; t = 4.184, P < 0.001, respectively), more total errors for spatial working memory (t = -5.874, P < 0.001), and fewer problems solved in minimum moves in Stocking of Cambridge (SOC) (t = -2.706, P < 0.01) compared to FHR individuals. Intra-Extra Dimension (IED) did not differ significantly between the two groups. Moreover, the study indicated significant GAF decline (F = 79.257, P < 0.001) and lower total score on the QLS (t = -10.655, P < 0.001) in UHR compared to FHR individuals. <b>Conclusion:</b> It is possible to differentiate UHR individuals from FHR individuals through neurocognitive, quality of life, and global functioning assessment.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"18 4","pages":"420-428"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/f2/IJPS-18-420.PMC10593999.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Persian Version of Interpersonal Mindfulness in Parenting Scale.","authors":"Hamid Khanipour,&nbsp;Elham Fathi,&nbsp;Abolfazl Hatami Varzaneh,&nbsp;Masoud Geramipour,&nbsp;Mobina Radfar","doi":"10.18502/ijps.v18i4.13633","DOIUrl":"10.18502/ijps.v18i4.13633","url":null,"abstract":"<p><p><b>Objective:</b> This study was designed to explore the psychometric properties of the Persian version of the Interpersonal Mindfulness in Parenting Scale (IMP-S). <b>Method</b> <b>:</b> This cross-sectional and psychometric study was performed on a sample of 491 parents in Iran who had at least one child in their home and were selected using the convenient sampling method. The Interpersonal Mindfulness in Parenting Scale (IMP-S), Mindful Attention Awareness Scale, Parental Authority Questionnaire, and the Forms of Self-Criticizing/Attacking & Self-Reassuring Scale were ‎conducted on the sample. The validity of the IMP-S was assessed by factor analysis and Pearson correlation coefficients, while reliability was calculated by Cronbach's alpha. <b>Results:</b> At first, the whole data was analyzed using confirmatory factor analysis based on the original English version of the IMP-S. The proposed hypothesized factor solution was not good enough (CMIN / DF = 7.06. RSMEA = 0.081, CFI = 0.732, SRMR = 0.0860). Exploratory factor analysis and parallel analysis led to a three-factor structure for the 28 items, which included mindfulness toward the child, mindfulness about oneself and emotional awareness of parenting. The results of confirmatory factor analysis showed that the data was more fitted with this new three-factor solution (CMIN / DF = 2.06, CFI = 0.82, NFI = 0.715, RMSEA = 0.065, SRMR = 0.0795). The IMP-S was found to have a positive correlation with trait mindfulness, reassured self, and authoritative parenting style, whereas this association for the IMP-S and hatred self, inadequate self, and authoritarian parenting style was negative. The reliability of the whole scale was 0.84 and it was 0.77, 0.83, and 0.68 for the first, second, and third subscales, respectively. <b>Conclusion:</b> It seems that the Persian version of the IMP-S with three factors can better evaluate mindful parenting among the Iranian population. In contrast to people from other countries, Iranian people perceive mindfulness toward themselves and their children during parenting practice as two distinct issues.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"18 4","pages":"466-475"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/1e/IJPS-18-466.PMC10593998.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties of the Persian Version of Social Anxiety Scale for Social Media Users (SAS-SMU).","authors":"Nasrin Faghani,&nbsp;Maryam Moghadasin","doi":"10.18502/ijps.v18i4.13628","DOIUrl":"10.18502/ijps.v18i4.13628","url":null,"abstract":"<p><p><b>Objective:</b> Social anxiety refers to an excessive concern or fear about social situations. It seems that social media, which has become one of the most popular and effective tools for communication today, can be one of the contexts of social anxiety. Due to the lack of a Persian instrument to assess social anxiety in the context of social networks, the current study was undertaken to analyze the psychometric criteria of the Iranian version of the Social Anxiety Scale for Social Media Users (SAS-SMU). The SAS-SMU is a 21-item questionnaire designed by Alkis and colleagues (2017) to measure social anxiety emerging from the social media platforms. <b>Method</b> <b>:</b> In this study, a total of 842 participants within the age range of 11 to 82 years old (mean age 33.11 ± 12.134), 59% female) answered the questions in an online survey. The original version of the scale was translated into Persian using the back translation procedure. All participants completed a Demographic Questionnaire, the SAS-SMU, and the Beck Anxiety Inventory. In order to analyze the collected data, internal and external consistency, factor analysis, construct validity, and confirmatory factor analysis (CFA) were examined. A significance level of less than 0.05 was considered to determine statistical significance. <b>Results:</b> Four subscales were obtained from the exploratory factor analysis (SCA, PCA, IA, and SEA), which were confirmed by the confirmatory factor analysis. Cronbach's alpha for internal consistency was found to be 0.931 for the total scale and 0.920, 0.846, 0.901, 0.828 for SCA, PCA, IA, and SEA, respectively. In addition, the test-retest scores of 30 participants (interval: between 2 to 3 weeks) for all four subscales (SCA = 0.641, PCA = 0.773, IA = 0.688, SEA = 0.727) indicated acceptable stability of the questionnaire over time. <b>Conclusion:</b> This study validates the Persian version of the SAS-SMU for use in studies in the field of psychological problems related to social media and online communications.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"18 4","pages":"406-419"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/28/IJPS-18-406.PMC10593990.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison between Single and Double-Dose Intravenous Ketamine Administration in Bipolar Mood Disorder: A Double-Blind Controlled Clinical Trial.","authors":"Ali Talaei,&nbsp;Farhad Farid Hoseini,&nbsp;Meisam Mahdavi,&nbsp;Maryam Salehi,&nbsp;Asieh Karimani,&nbsp;Fahimeh Afzaljavan","doi":"10.18502/ijps.v18i4.13627","DOIUrl":"10.18502/ijps.v18i4.13627","url":null,"abstract":"<p><p><b>Objective:</b> As glutamatergic system dysfunction is involved in bipolar depression pathophysiology, the glutamate receptor modulators such as Ketamine have been applied as complementary medication for mood stabilizers. While the treatment is currently just the intravenous injection of a single dose, and there is no robust conclusion on Ketamine effectiveness or its side effects in bipolar patients, this study aimed to consider single- and double-dose intravenous injections of Ketamine in bipolar patients compared to the placebo. <b>Method</b> <b>:</b> In a randomized, double-blind controlled clinical trial, 30 patients diagnosed with bipolar I and II disorders according to DSM-IV-TR (SCID-I) were randomly divided into three groups: the first group received an intravenous injection of Ketamine (0.5 mg/kg) and placebo with a three-day interval, the second group received two doses of Ketamine (0.5 mg/kg) in the same interval, and the third group received two placebo injections. Patients were assessed for depression, anxiety, and mania at various time points, including before the injection, 60 minutes after the injection, on the first, third, fifth, seventh, and 14th day, as well as at the end of the first month using the Hamilton Depression Rating Scale, Beck Anxiety Inventory, and Young Mania Scale, respectively. Data were analyzed using ANOVA and Repeated measure tests. <b>Results:</b> The mean age of patients was 36.8 ± 7.9 years, with 18 females (60%) and 12 (40%) males. Depression and anxiety showed significant differences in both the single- and double-dose Ketamine groups over time (P < 0.01). Moreover, mania displayed significant changes during the study time in the single- and double-dose Ketamine groups, as well as the in the control group. However, during the study time, there were no significant differences observed in depression, anxiety, and mania among the three groups (P = 0.198, P = 0.416, and P = 0.540, respectively). Patients did not indicate any side effects during the study. <b>Conclusion:</b> Intravenous Ketamine administration may relieve depressive manifestations in bipolar patients. The findings suggest that a double dose of Ketamine does not lead to greater improvement than a single dose.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"18 4","pages":"396-405"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/ba/IJPS-18-396.PMC10593997.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey.","authors":"Mahan Shafie,&nbsp;Jaber Darijani,&nbsp;Zahra Mirsepassi,&nbsp;Alireza Razavi,&nbsp;Mahsa Mayeli,&nbsp;Mohammad Arbabi,&nbsp;Vajiheh Aghamollaii","doi":"10.18502/ijps.v18i4.13634","DOIUrl":"10.18502/ijps.v18i4.13634","url":null,"abstract":"<p><p><b>Objective:</b> Psychoses of epilepsy usually have an acute onset, accompanied by brief symptom duration and a risk of recurrence. Managing these conditions can be challenging due to the potential for seizures associated with certain antipsychotic medications, as well as exacerbating psychosis resulting from some antiepileptic medications. Our objective in this study was to assess the occurrence of psychosis among patients with epilepsy, as well as identify the factors linked to the presence and severity of psychosis in this population. <b>Method</b> <b>:</b> In this study, we included a total of 514 subjects diagnosed with epilepsy referring to our neuropsychiatry clinic affiliated with Tehran University of Medical Sciences from April 2011 to December 2021, among whom 57 patients showed psychotic presentations. We compared baseline and clinical characteristics between patients with psychosis of epilepsy and non-psychosis patients who also had epilepsy. <b>Results:</b> Marital status was the sole demographic factor that displayed a statistically significant difference between the psychosis and non-psychosis groups (P = 0.019). There was no significant difference observed between the two groups regarding family history of epilepsy and age at the onset of the epilepsy. Patients with psychosis experienced significantly more frequent seizures and generalized type (P < 0.001). Participants were matched for demographics and other clinical factors between the refractory and controlled psychosis groups, except for the psychosis frequency (P = 0.007). The type of epilepsy was significantly associated with psychosis when adjusted for the covariates (P < 0.001). <b>Conclusion:</b> Patients with psychosis of epilepsy experienced more episodes of epilepsy than non-psychotics. We identified generalized epilepsy as an independent risk factor for the development of psychosis. Additional cohorts are warranted to explore the factors associated with epilepsy-related psychosis across diverse populations.</p>","PeriodicalId":38866,"journal":{"name":"Iranian Journal of Psychiatry","volume":"18 4","pages":"476-483"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/2d/IJPS-18-476.PMC10593996.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}