Tokai Journal of Experimental and Clinical Medicine最新文献_第9页

A Boy Presenting with a Fever and Pancytopenia Diagnosed with Systemic Lupus Erythematosus without a Positive Anti-ds-DNA Antibody Result or Hypocomplementemia: A Case Report. 一个男孩表现为发烧和全血细胞减少诊断为系统性红斑狼疮没有阳性抗-ds- dna抗体结果或补体不足:1例报告。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-12-20

Yuichi Kama, Kenta Kuruma, Tomofumi Otomo, Takashi Sakama, Kosuke Akiyama, Hiromitsu Takakura, Daisuke Toyama, Kota Hirai, Hiroyuki Mochizuki, Masahiko Kato

{"title":"A Boy Presenting with a Fever and Pancytopenia Diagnosed with Systemic Lupus Erythematosus without a Positive Anti-ds-DNA Antibody Result or Hypocomplementemia: A Case Report.","authors":"Yuichi Kama, Kenta Kuruma, Tomofumi Otomo, Takashi Sakama, Kosuke Akiyama, Hiromitsu Takakura, Daisuke Toyama, Kota Hirai, Hiroyuki Mochizuki, Masahiko Kato","doi":"","DOIUrl":"","url":null,"abstract":"Background: Hematological involvement, including anemia, leukopenia, lymphopenia, and thrombocytopenia, is one of the most common manifestations of childhood-onset systemic lupus erythematosus (cSLE). Specifically, relatively severe forms of hematological involvement, such as macrophage activation syndrome (MAS) and thrombotic microangiopathy, occur in the course of the disease. Positivity for anti-double stranded-DNA (ds-DNA) antibody and hypocomplementemia are important as not only criteria of diagnosing cSLE but also in the determination of the disease activity.Case report: A 13-year-old boy without pre-existing disease was referred to our hospital chiefly complaining of a fever for > 7 days, long-lasting malaise, nausea, and non-malar face rash. His blood examination showed pancytopenia and hyperferritinemia, but positive results for anti-ds-DNA antibody and hypocomplementemia were not recognized. Bone marrow aspiration revealed no evidence of malignant diseases, hemophagocytic lymphohistiocytosis, or MAS. A renal biopsy for the differential diagnosis of proteinuria and hematuria revealed class IIIa +V lupus nephritis, leading to the diagnosis of cSLE.Conclusions: It is important for cSLE to be considered in patients with pancytopenia, even those without positive anti-ds-DNA antibody findings or hypocomplementemia, and for aggressive approaches to be adopted for the differential diagnosis, including a renal biopsy.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"47 4","pages":"177-181"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Study of Transdermal Application of Diphenhydramine to the Nasal Ala in Patients with Allergic Rhinitis and Asthma. 苯海拉明经皮应用于变应性鼻炎及哮喘患者鼻甲的初步研究。

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-12-20

Mitsuhiro Kamimura, Toshiya Inui, Atsuto Mouri, Hiroaki Todo, Kenji Sugibayashi, Koichiro Asano

{"title":"A Pilot Study of Transdermal Application of Diphenhydramine to the Nasal Ala in Patients with Allergic Rhinitis and Asthma.","authors":"Mitsuhiro Kamimura, Toshiya Inui, Atsuto Mouri, Hiroaki Todo, Kenji Sugibayashi, Koichiro Asano","doi":"","DOIUrl":"","url":null,"abstract":"Background: To date, topical allergic rhinitis drugs must be applied intranasally. We studied the efficacy, safety, and impact on co-existing asthma symptoms of transdermal delivery of diphenhydramine through the nasal ala.Methods: We enrolled outpatients with symptomatic allergic rhinitis and asthma who were on stable medication for at least 4 weeks. Patients applied diphenhydramine ointment, 0.07 g measured with weighing spoon (0.7 mg diphenhydramine), to the nasal ala twice a day for 2 weeks, followed by 2 weeks' washout. Effects were assessed with the Japanese Allergic Rhinitis Standard Quality of Life Questionnaire (JRQLQ) and Self-assessment of Allergic Rhinitis and Asthma (SACRA) and Asthma Control Test (ACT) questionnaires.Results: Ten patients participated in the study. Two patients experienced acute exacerbation of asthma during the intervention phase, but no other adverse effects occurred. Self-assessments indicated efficacy in treating nasal symptoms in 5 patients. No significant changes in scores were seen, although mean total JRQLQ score showed a numerical improvement (from 34.3 [21.0] to 14.4 [8.8]; P = 0.0547). Asthma symptoms improved subjectively in 2 patients.Conclusions: The efficacy of transdermal application of diphenhydramine on the nasal ala for treating allergic rhinitis was not conclusive, but appears to be effective in certain patients.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"47 4","pages":"170-176"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Miscarriage in a patient with Glanzmann Thrombasthenia and low ovarian reserve: A case report 格兰兹曼血栓性贫血合并卵巢储备不足患者流产1例

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.62

I. E. Uluisik, M. Sonkaya, N. Dokuzeylul Gungor

引用次数: 0

The effects of sperm parameters and sperm DNA damage on pregnancy outcomes of women undergoing intrauterine insemination 精子参数和精子DNA损伤对宫内授精妇女妊娠结局的影响

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.12

Murat Önal, M. Kavrut, N. Dokuzeylül Güngör, T. Gürbüz

引用次数: 0

An evaluation of IGF-1 and IGFBP-3 levels in patients receiving growth hormone therapy and these parameters therapeutic efficacy 接受生长激素治疗的患者IGF-1和IGFBP-3水平的评估及这些参数的治疗效果

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.51

A. Asik, S. Bolu

引用次数: 0

Values of intensive care scores in predicting morbidity and mortality in patients treated for COVID-19 pneumonia 重症监护评分在预测COVID-19肺炎患者发病率和死亡率中的价值

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.43

Hale Kefeli Çelik, Z. Doğanay, Ramazan BURAK FERLİ

{"title":"Values of intensive care scores in predicting morbidity and mortality in patients treated for COVID-19 pneumonia","authors":"Hale Kefeli Çelik, Z. Doğanay, Ramazan BURAK FERLİ","doi":"10.52142/omujecm.39.4.43","DOIUrl":"https://doi.org/10.52142/omujecm.39.4.43","url":null,"abstract":"Some of the patients with COVID-19 pneumonia are followed up in intensive care units (ICU). This study aimed to determine the success of intensive care scores used in patients followed up in the ICU with the diagnosis of COVID-19 pneumonia in predicting morbidity and mortality. This retrospective study included patients treated for COVID-19 pneumonia in the ICUs of Samsun Training and Research Hospital. We used the patients' demographic characteristics, vital signs, arterial blood gas values, radiological imaging, and laboratory data by using the hospital database and patient files. Group I was composed of alive patients, while Group II was of dead ones. A total of 75 patients were included in the study, of which 34 (45.3%) were female and 41 (54.7%) were male. The median length of intensive care stay was 8 (5-15) days in Group I patients and 5 (2-8) days in Group II patients, which was higher in alive patients (p=0.004). Radiological involvement was present in 93.3% (n=70) of the patients, and involvement was observed in both lungs in 77.3% (n=58). We observed complications in 54.7% (n=41) of the patients, whereas the incidence of complications was 20% in Group I and 72% in Group II, which was statistically significant (p<0.001). APACHE II, PSI, SOFA, qSOFA, SMART-COP, CURB65, A-DROP and NEWS2 scores were statistically significantly higher in patients who died, whereas APACHE II, SOFA, qSOFA, and SMART-COP scores were more successful in predicting morbidity. It is vital to predict the mortality risk early in patients with COVID-19 pneumonia followed up in intensive care units. Among the scoring systems, APACHE II, PSI, SOFA, qSOFA, SMART-COP, CURB65, A-DROP, and NEWS2 can be used safely to predict mortality. Copyright © 2022 Ondokuz Mayis Universitesi. All rights reserved.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"130 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82124897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between demographic indicators and mortality rate of COVID-19 disease comparatively and retrospectively in different waves of COVID-19 disease in Iran 伊朗不同流行阶段人口统计学指标与COVID-19死亡率的对比与回顾性分析

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.22

K. Aghakhani, S. Soltani, A. Memarian, S. Mehrpisheh

{"title":"The relationship between demographic indicators and mortality rate of COVID-19 disease comparatively and retrospectively in different waves of COVID-19 disease in Iran","authors":"K. Aghakhani, S. Soltani, A. Memarian, S. Mehrpisheh","doi":"10.52142/omujecm.39.4.22","DOIUrl":"https://doi.org/10.52142/omujecm.39.4.22","url":null,"abstract":"Coronavirus disease-19 (COVID-19) is a novel emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2). In this study, we aimed to examine the relationship between demographic indicators and mortality rates in Covid-19 disease in different Covid-19 waves in Iran. In this retrospective cross-sectional study, the study population consisted of 9874 patients of Covid-19 admitted to Hazrat Rasoul Akram Hospital of Tehran, from the beginning of the disease to the end of the fifth wave. Demographic variables such as age and sex as well as clinical variables such as hospitalization date and mortality rate were collected and evaluated. The analysis was performed using SPSS software version 26. The mean age of 9874 participants was 58.9 +/- 17.0 years. In this study 5510 (55.8%) of patients were male. 1762 (17.8%) patients died. The fifth wave had the highest number of patients (31.1%) and the trend in the number of patients was increasing from wave second to fifth. However, the percentage of death was lower in waves fourth (14.5%) and fifth (15.3%). The mean age of deceased patients was significantly greater than alive patients (69.25 +/- 14.60 vs. 56.76 +/- 16.75, P=0.0001). The frequency of male deaths was significantly higher than female deaths (P=0.0001). The results of the present study indicate that the frequency of mortality in recent waves, despite a significant increase in hospitalization, has been decreased. It can also be said that mortality increases with age as well as male gender, and males are more prone to death due to covid-19 disease with age. Copyright © 2022 Ondokuz Mayis Universitesi. All rights reserved.","PeriodicalId":38819,"journal":{"name":"Tokai Journal of Experimental and Clinical Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86463604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Change in GFR in relation to pulse rate, dipping blood pressure, anti-hypertensives, NLR and PLR in patients with chronic kidney disease 慢性肾病患者GFR与脉率、低血压、抗高血压、NLR和PLR相关的变化

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.3

Hüseyin Duru

引用次数: 0

Significance of tissue oxygenation in patients connected to a mechanical ventilator 连接机械呼吸机患者组织氧合的意义

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.44

Fulya Köse, Bülent Güngörer, H. Arslan, A. S. Girişgin, Z. D. Dündar, Merve Güven

引用次数: 0

Management of subcutaneous emphysema due to penetrating oropharyngeal trauma 穿透性口咽外伤所致皮下肺气肿的处理

Tokai Journal of Experimental and Clinical Medicine Pub Date : 2022-10-29 DOI: 10.52142/omujecm.39.4.64

Emre Demirel, E. Tahir, H. Albayrak, N. Yener, S. Atmaca

引用次数: 0