P and T最新文献

{"title":"Beyond Medical Cannabis: Considerations for Updates to Hospital Policies and Procedures.","authors":"James O'Donnell,&nbsp;F Randy Vogenberg,&nbsp;F Randy Vogenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As marijuana legalization and use expands across the U.S., health care systems are struggling to keep abreast of the changes and trends in regulations. Considering marijuana's federal illegality and other restrictions on its use, the limited evidence for its clinical efficacy, and the myriad psychological adverse events, caution is recommended when establishing policies and procedures regarding coverage of marijuana and CBD products.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 7","pages":"410-433"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590920/pdf/ptj4407410.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis Treatment-What We Don't Know.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 7","pages":"430-435"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590922/pdf/ptj4407430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-Based Policy in Practice: Management of Carcinoid Syndrome Diarrhea.","authors":"Richard Cook,&nbsp;Andrew E Hendifar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Carcinoid syndrome causes substantial morbidity and reduces quality of life and survival. In a recent clinical trial, 97% of patients reported bowel movement-related issues, abdominal pain, flushing, and low energy. Combining somatostatin analogs with elotristat ethyl provides a new option for managing refractory CS symptoms. Health care providers should consider strategies that take advantage of approved dosing for patients with CS-related diarrhea.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 7","pages":"424-427"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590927/pdf/ptj4407424.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amiodarone-Induced Syndrome of Inappropriate Antidiuretic Hormone: A Case Report and Review of the Literature.","authors":"Gretchen P Marcelino,&nbsp;Cyril Manuel C Collantes,&nbsp;Jomi K Oommen,&nbsp;Shan Wang,&nbsp;Heather Baldassari,&nbsp;Rajanandini Muralidharan,&nbsp;Adel Hanna","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Amiodarone (Cordarone^®, Pfizer Inc) is an antiarrhythmic medication with a well-known toxicity profile, including rare cases of hyponatremia as a result of syndrome of inappropriate antidiuretic hormone (SIADH). We report on such a case in which a patient was found to be hyponatremic after evaluation. An 88-year-old male who presented to the emergency department was found to be hyponatremic secondary to amiodarone-induced SIADH following a fall, with possible seizure and traumatic brain injury. He had a history of hypertension, paroxysmal atrial fibrillation, emphysema, myocardial infarction, benign prostatic hyperplasia, chronic kidney disease, Meniere's disease, anemia, and gastroesophageal reflux. Upon admission, his urine sodium level was elevated, and his serum sodium, urine osmolality, and anion gap were below normal. In the setting of hyponatremia, the patient's amiodarone was held: he had been taking amiodarone 200 mg once daily for nine months prior to admission. He was treated with intravenous (IV) normal saline over four days. He was fluid-restricted and his sodium levels were closely monitored every two hours. Within 19 hours, his serum sodium levels had improved. Amiodarone was restarted approximately three days later. Upon follow-up after discharge, the patient remained on amiodarone for the next two months. His serum sodium level ranged from 126 mEq/L to 131 mEq/L over a two-week period. He was supplemented with sodium chloride tablets and has been otherwise stable. Amiodarone may cause acute or chronic SIADH, with a wide range of symptoms. Seizures have not been reported in the literature but our patient had a witnessed seizure, although his electroencephalogram (EEG) was negative. Syndrome of inappropriate antidiuretic hormone can occur with any formulation of amiodarone in a dose-dependent fashion. Our patient's sodium levels stabilized within two weeks after amiodarone was resumed. The mechanism of amiodarone-induced SIADH remains unclear.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 7","pages":"416-423"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590929/pdf/ptj4407416.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shingrix: A New Herpes Zoster Vaccine.","authors":"Fraidy Maltz,&nbsp;Brooke Fidler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Shingrix, a new vaccine for herpes zoster.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 7","pages":"406-433"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590925/pdf/ptj4407406.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-1 Antitrypsin Replacement in Patients With COPD.","authors":"Adam D Wells, Anna Woods, Daniel E Hilleman, Mark A Malesker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease can be attributed to genetic conditions and predispositions, among other factors. Alpha-1 antitrypsin deficiency (AATD) is a significant risk factor for COPD development and progression, and aggressive screening for all patients with COPD or adult-onset asthma is encouraged.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 7","pages":"412-415"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590928/pdf/ptj4407412.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37377961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin K May Be A-OK, in Kids and Cholestatic Patients.","authors":"Giulia Jannone,&nbsp;Marie-Astrid van Dievoet,&nbsp;Louise Coppin,&nbsp;Etienne Sokal,&nbsp;Xavier Stephenne","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 6","pages":"318-319"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534168/pdf/ptj4406318.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37299039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HHS Proposes Steps Toward Health Data Interoperability CMS and ONC Proposals Would Implement Cures Act.","authors":"Stephen Barlas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since the introduction of the 2009 HITECH Act, how has system-wide data sharing fared among hospitals and physician offices? Not that well, according to the CMS. But will the new proposed rules improve things for providers, system developers, and patients?</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 6","pages":"347-349"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534171/pdf/ptj4406347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37299462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Human Over-Reliance On Technology.","authors":"Matthew Grissinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Implementing IT in medication-use systems reduces adverse drug events by decreasing human error. But over-reliance on technology can lead to automation bias and complacency.</p>","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 6","pages":"320-375"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534180/pdf/ptj4406320.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37299044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Briefs.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":38773,"journal":{"name":"P and T","volume":"44 6","pages":"372-374"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534176/pdf/ptj4406372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37299467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}