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Metabolism and Translational Medicine最新文献

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Correlation between renal metabolism and cardiovascular disease 肾脏代谢与心血管疾病的相关性
Metabolism and Translational Medicine Pub Date : 2023-08-31 DOI: 10.54844/mtm.2023.0351
Siying Deng, Wei Huang
{"title":"Correlation between renal metabolism and cardiovascular disease","authors":"Siying Deng, Wei Huang","doi":"10.54844/mtm.2023.0351","DOIUrl":"https://doi.org/10.54844/mtm.2023.0351","url":null,"abstract":"Cardiovascular disease is the main medical burden in the world, and coronary heart disease and heart failure are the main reasons for the increase of all-cause mortality and cardiovascular mortality year by year. There is a synergistic effect between cardiovascular and kidney diseases. Under pathological conditions, there is a significant correlation between various cardiovascular diseases and kidney diseases. In this review, we discussed the effects of metabolite accumulation caused by kidney disease on multiple mechanisms of atherosclerosis from the whole process of the formation and development of atherosclerosis. These metabolites can be mainly divided into uremic toxins, intestinal metabolites, fibroblast growth factor 23, and advanced glycosylation end products. Then we summarized the effects of metabolites related to renal metabolism on heart failure according to the biological changes of patients with heart failure at three different levels.","PeriodicalId":387610,"journal":{"name":"Metabolism and Translational Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130935384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic medicine: The mechanism of metabolic influence on diseases of various systems 代谢医学:研究代谢对各系统疾病的影响机制
Metabolism and Translational Medicine Pub Date : 2023-07-31 DOI: 10.54844/mtm.2023.0345
Shusi Ding, Qiutong Wu, Cong Lu, Zhaomeng Wang, Yue Lan, Lu Fang, Lemin Zheng
{"title":"Metabolic medicine: The mechanism of metabolic influence on diseases of various systems","authors":"Shusi Ding, Qiutong Wu, Cong Lu, Zhaomeng Wang, Yue Lan, Lu Fang, Lemin Zheng","doi":"10.54844/mtm.2023.0345","DOIUrl":"https://doi.org/10.54844/mtm.2023.0345","url":null,"abstract":"Metabolism affects or is influenced by almost every other biological activity. With the deepening of medical research, understanding the nature of natural metabolism is the primary means to solve complicated diseases. Therefore, starting from metabolism, starting from the root, starting from the pathophysiological basis, and realizing the transformation from the underlying mechanism to clinical medicine will be the way that the scientific research community must go for a long time in the future. This review mainly discusses that metabolites produced by some major metabolic pathways, such as glucose metabolism, lipid metabolism, and amino acid metabolism, are important signal transmitters and regulators of activity. It expounds on the role of metabolism in various system diseases, including cardiovascular system diseases, nervous system diseases, endocrine system diseases, and intestinal microbial system diseases, from the levels of metabolites, proteins, organelles, tissues, and systemic physiology.","PeriodicalId":387610,"journal":{"name":"Metabolism and Translational Medicine","volume":"37 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132820507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of gut microbiota in the 5-hydroxytryptamine signal transduction mechanism 肠道菌群在5-羟色胺信号转导机制中的作用
Metabolism and Translational Medicine Pub Date : 2023-06-30 DOI: 10.54844/mtm.2023.0344
Gaofei Hu, Yujie Zhu, Shusi Ding, Lemin Zheng
{"title":"Role of gut microbiota in the 5-hydroxytryptamine signal transduction mechanism","authors":"Gaofei Hu, Yujie Zhu, Shusi Ding, Lemin Zheng","doi":"10.54844/mtm.2023.0344","DOIUrl":"https://doi.org/10.54844/mtm.2023.0344","url":null,"abstract":"As a neurotransmitter, 5-hydroxytryptamine (5-HT) plays a variety of regulatory roles in the brain, including affecting mood, memory, circadian rhythm, and other aspects. However, the brain contains only approximately 10% of the 5-HT in humans. Ninety percent of the 5-HT is produced and stored in the gut. 5-HT in the gut is involved in the regulation of irritable bowel syndrome (IBS), colitis, obesity, and other diseases. Therefore, a comprehensive understanding of the bioactivity of 5-HT is necessary. The gut microbiota has been reported to affect 5-HT synthesis and function, but the exact mechanism remains unclear. This review focuses on the production of 5-HT, its relationship with gut microbiota, its mechanism of action in different disease progression processes, and the biological effects of its derivative 5-hydroxyindoleacetic acid.","PeriodicalId":387610,"journal":{"name":"Metabolism and Translational Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131709766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Metabolism: A rising star in translational medicine 代谢:转化医学中一颗冉冉升起的新星
Metabolism and Translational Medicine Pub Date : 2023-05-28 DOI: 10.54844/mtm.2023.0357
Lemin Zheng
{"title":"Metabolism: A rising star in translational medicine","authors":"Lemin Zheng","doi":"10.54844/mtm.2023.0357","DOIUrl":"https://doi.org/10.54844/mtm.2023.0357","url":null,"abstract":"","PeriodicalId":387610,"journal":{"name":"Metabolism and Translational Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131028002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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