Role of gut microbiota in the 5-hydroxytryptamine signal transduction mechanism

Gaofei Hu, Yujie Zhu, Shusi Ding, Lemin Zheng
{"title":"Role of gut microbiota in the 5-hydroxytryptamine signal transduction mechanism","authors":"Gaofei Hu, Yujie Zhu, Shusi Ding, Lemin Zheng","doi":"10.54844/mtm.2023.0344","DOIUrl":null,"url":null,"abstract":"As a neurotransmitter, 5-hydroxytryptamine (5-HT) plays a variety of regulatory roles in the brain, including affecting mood, memory, circadian rhythm, and other aspects. However, the brain contains only approximately 10% of the 5-HT in humans. Ninety percent of the 5-HT is produced and stored in the gut. 5-HT in the gut is involved in the regulation of irritable bowel syndrome (IBS), colitis, obesity, and other diseases. Therefore, a comprehensive understanding of the bioactivity of 5-HT is necessary. The gut microbiota has been reported to affect 5-HT synthesis and function, but the exact mechanism remains unclear. This review focuses on the production of 5-HT, its relationship with gut microbiota, its mechanism of action in different disease progression processes, and the biological effects of its derivative 5-hydroxyindoleacetic acid.","PeriodicalId":387610,"journal":{"name":"Metabolism and Translational Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metabolism and Translational Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54844/mtm.2023.0344","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

As a neurotransmitter, 5-hydroxytryptamine (5-HT) plays a variety of regulatory roles in the brain, including affecting mood, memory, circadian rhythm, and other aspects. However, the brain contains only approximately 10% of the 5-HT in humans. Ninety percent of the 5-HT is produced and stored in the gut. 5-HT in the gut is involved in the regulation of irritable bowel syndrome (IBS), colitis, obesity, and other diseases. Therefore, a comprehensive understanding of the bioactivity of 5-HT is necessary. The gut microbiota has been reported to affect 5-HT synthesis and function, but the exact mechanism remains unclear. This review focuses on the production of 5-HT, its relationship with gut microbiota, its mechanism of action in different disease progression processes, and the biological effects of its derivative 5-hydroxyindoleacetic acid.
肠道菌群在5-羟色胺信号转导机制中的作用
5-羟色胺(5-羟色胺,5-HT)作为一种神经递质,在大脑中起着多种调节作用,包括影响情绪、记忆、昼夜节律等方面。然而,人类大脑中只含有大约10%的5-羟色胺。90%的5-羟色胺是在肠道中产生和储存的。肠道中的5-羟色胺参与肠易激综合征(IBS)、结肠炎、肥胖和其他疾病的调节。因此,全面了解5-HT的生物活性是必要的。据报道,肠道微生物群影响5-羟色胺的合成和功能,但确切的机制尚不清楚。本文就5-羟色胺的产生、与肠道菌群的关系、在不同疾病进展过程中的作用机制及其衍生物5-羟基吲哚乙酸的生物学效应进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信