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Evaluation of the efficacy of different adjuvants in producing murine monoclonal antibodies to the receptor-binding domain of the S-protein of SARS-CoV-2 不同佐剂对产生SARS-CoV-2蛋白受体结合域小鼠单克隆抗体的效果评价
Immunologiya Pub Date : 2023-01-01 DOI: 10.33029/1816-2134-2023-44-4-481-490
T.A. Ivashchenko, Ya.O. Romanenko, M.A. Marin, A.S. Kartseva, M.V. Silkina, N.A. Zeninskaya, I.G. Shemyakin, V.V. Firstova
{"title":"Evaluation of the efficacy of different adjuvants in producing murine monoclonal antibodies to the receptor-binding domain of the S-protein of SARS-CoV-2","authors":"T.A. Ivashchenko, Ya.O. Romanenko, M.A. Marin, A.S. Kartseva, M.V. Silkina, N.A. Zeninskaya, I.G. Shemyakin, V.V. Firstova","doi":"10.33029/1816-2134-2023-44-4-481-490","DOIUrl":"https://doi.org/10.33029/1816-2134-2023-44-4-481-490","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"278 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135699833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentiation of immunomodulatory effects of arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine and glucosaminylmuramyldipeptide on effector functions and phenotype of functionally signifi cant subpopulations of neutrophilic granulocytes in an experimental model of viral-bacterial coinfection 在病毒-细菌共感染的实验模型中，精氨酸- α -天冬氨酸-赖氨酸-谷氨酸-酪氨酸-精氨酸和葡萄糖氨基-鼠胺基二肽对中性粒细胞的效应功能和表型的免疫调节作用的分化
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-1-89-102
I. Nesterova, G. Chudilova, V. N. Chapurina, S. Kovaleva, V. Tarakanov, Yu. V. Teterin, L. Lomtatidze, A.I. Pirogova
{"title":"Differentiation of immunomodulatory effects of arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine and glucosaminylmuramyldipeptide on effector functions and phenotype of functionally signifi cant subpopulations of neutrophilic granulocytes in an experimental model of viral-bacterial coinfection","authors":"I. Nesterova, G. Chudilova, V. N. Chapurina, S. Kovaleva, V. Tarakanov, Yu. V. Teterin, L. Lomtatidze, A.I. Pirogova","doi":"10.33029/0206-4952-2022-43-1-89-102","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-89-102","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indicators of human cellular immunity in conditions of artificial gravity creation using a short-arm centrifuge 短臂离心机人工重力条件下人体细胞免疫指标
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-2-149-156
V. A. Shmarov, M. Rykova, E. Antropova, O. Kutko, S. Shulgina, K. Orlova, E.A. Zhirova, A. Sadova, D. D. Vlasova, E. A. Lysenko, D. Kudlay, S. Ponomarev
{"title":"Indicators of human cellular immunity in conditions of artificial gravity creation using a short-arm centrifuge","authors":"V. A. Shmarov, M. Rykova, E. Antropova, O. Kutko, S. Shulgina, K. Orlova, E.A. Zhirova, A. Sadova, D. D. Vlasova, E. A. Lysenko, D. Kudlay, S. Ponomarev","doi":"10.33029/0206-4952-2022-43-2-149-156","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-2-149-156","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mouse model of respiratory syncytial virus infection mimicking acute human pathology 模拟急性人类病理的呼吸道合胞病毒感染小鼠模型
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-4-423-439
I. Shilovskiy, E. Barvinskaia, A. A. Nikolskii, A. Nikonova, V. Smirnov, V. Kovchina, L. Vishniakova, K. Yumashev, M.M. Kaganova, T.E. Rusak, A. Mitin, V. Komogorova, M. Litvina, N. Sharova, D. Kudlay, M. Khaitov
{"title":"Mouse model of respiratory syncytial virus infection mimicking acute human pathology","authors":"I. Shilovskiy, E. Barvinskaia, A. A. Nikolskii, A. Nikonova, V. Smirnov, V. Kovchina, L. Vishniakova, K. Yumashev, M.M. Kaganova, T.E. Rusak, A. Mitin, V. Komogorova, M. Litvina, N. Sharova, D. Kudlay, M. Khaitov","doi":"10.33029/0206-4952-2022-43-4-423-439","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-423-439","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
«Storm» of soluble differentiation molecules in COVID-19 COVID-19可溶性分化分子的“风暴
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-4-458-467
V. Novikov, A. Karaulov
{"title":"«Storm» of soluble differentiation molecules in COVID-19","authors":"V. Novikov, A. Karaulov","doi":"10.33029/0206-4952-2022-43-4-458-467","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-458-467","url":null,"abstract":"The review presents data on changes in the content, on the prognostic and monitoring significance of soluble differentiation molecules of immune system cells in COVID-19. Among them are soluble differentiation molecules mediating innate immune responses, soluble differentiation molecules that are activation markers of lymphocytes, soluble markers of endothelial dysfunction, soluble forms of adhesion molecules, soluble differentiation molecules related to immune response checkpoints. At development of COVID-19 in blood of patients the level of the soluble molecules CD14, CD25, CD163, TREM-1, CD177, ST-2, RAGE, ICAM-1, P- and E-selectin, 14 soluble control points of the immune response including HLA-G dramatically increases. The level of soluble CD26 molecules, on the contrary, decreases. Changing the level of soluble differentiation molecules has monitoring and prognostic significance. The ideas about the <<storm>> of soluble differentiation molecules in the severe course of COVID-19 were formulated, complementing the ideas about the <<cytokine storm>>. Copyright © 2022 Meditsina Publishers. All rights reserved.","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Studying of protein-DNA interactions in the cells of immune system using chromatin immunoprecipitation and chromatin immunocleavage 利用染色质免疫沉淀和染色质免疫切割技术研究免疫系统细胞中蛋白质- dna相互作用
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-6-722-736
A. Masyutina, N. Murugina, M. Pashenkov
{"title":"Studying of protein-DNA interactions in the cells of immune system using chromatin immunoprecipitation and chromatin immunocleavage","authors":"A. Masyutina, N. Murugina, M. Pashenkov","doi":"10.33029/0206-4952-2022-43-6-722-736","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-6-722-736","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interferon system for COVID-19 COVID-19干扰素系统
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-3-245-254
A. N. Narovlyansky, F. Ershov, A. Sanin, A. Pronin
{"title":"Interferon system for COVID-19","authors":"A. N. Narovlyansky, F. Ershov, A. Sanin, A. Pronin","doi":"10.33029/0206-4952-2022-43-3-245-254","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-3-245-254","url":null,"abstract":"SARS-CoV-2 is the causative agent of COVID-19 and infects the respiratory tract, blood cells, gastrointestinal tract, kidneys, liver, heart, brain and other organs. The ability of SARS-CoV-2 to escape from immune surveillance leads to deregulation of the immune response, cytokine storm and extensive tissue damage to infected organs. It is assumed that the pathogenesis of the deterioration of the course of COVID-19 is much more complicated and one of the mechanisms for the escape of SARS-Cov-2 from the influence of innate immunity is the inhibition of signaling pathways for the production and action of interferon (IFN). This review summarizes the role of the IFN system in SARS-CoV-2 infection and discusses the sophisticated mechanisms that coronaviruses have developed over the course of evolution to evade immune surveillance and suppress IFN responses. The IFN-related issues of counteraction to SARS-Cov-2 infection and the IFN-dependent adverse course of COVID-19 is also discussed.","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Genome-wide DNA methylation profi le and expression of TLR2, TLR9, IL4, IL13 genes in pediatric patients with atopic dermatitis 儿童特应性皮炎患者全基因组DNA甲基化谱及TLR2、TLR9、IL4、IL13基因的表达
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-3-255-265
E. Bystritskaya, N. Murashkin, A. I. Materikin, E. Naumova, O. Svitich
{"title":"Genome-wide DNA methylation profi le and expression of TLR2, TLR9, IL4, IL13 genes in pediatric patients with atopic dermatitis","authors":"E. Bystritskaya, N. Murashkin, A. I. Materikin, E. Naumova, O. Svitich","doi":"10.33029/0206-4952-2022-43-3-255-265","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-3-255-265","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New mutations in the BTK gene in Russian patients with X-linked agammaglobulinemia 俄罗斯x连锁无球蛋白血症患者BTK基因的新突变
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-1-33-43
S. Ivanova, I. Bulusheva, E. Latysheva, I. A. Manto, A. I. Nikiforova, A. A. Kazakova, T. Latysheva, M. Khaitov, I. Kofiadi
{"title":"New mutations in the BTK gene in Russian patients with X-linked agammaglobulinemia","authors":"S. Ivanova, I. Bulusheva, E. Latysheva, I. A. Manto, A. I. Nikiforova, A. A. Kazakova, T. Latysheva, M. Khaitov, I. Kofiadi","doi":"10.33029/0206-4952-2022-43-1-33-43","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-33-43","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of MAGE-A4 specific TCR-like CAR-T lymphocytes in vitro MAGE-A4特异性tcr样CAR-T淋巴细胞的体外研究
Immunologiya Pub Date : 2022-01-01 DOI: 10.33029/0206-4952-2022-43-4-401-411
V. Tereshchenko, M. Kuznetsova, Y. Shevchenko, M. Fisher, V. Kurilin, A. Alsalloum, Y. Akahori, H. Shiku, S. Sennikov
{"title":"Study of MAGE-A4 specific TCR-like CAR-T lymphocytes in vitro","authors":"V. Tereshchenko, M. Kuznetsova, Y. Shevchenko, M. Fisher, V. Kurilin, A. Alsalloum, Y. Akahori, H. Shiku, S. Sennikov","doi":"10.33029/0206-4952-2022-43-4-401-411","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-401-411","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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