Immunologiya最新文献

{"title":"Congenital T- and NK-cell immunodeficiency with impaired expression of β-integrin on neutrophils in a patient with a mutation in the KMT2D gene: a description of a clinical case","authors":"I. Dolgopolov, E. Kochegurova, L. Grivtsova, O. K. Ustinova, M. Rykov","doi":"10.33029/0206-4952-2022-43-2-137-148","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-2-137-148","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental model of antigen-collagen induced arthritis in mice","authors":"M. Fisher, V. Kurilin, V. Tereshchenko, A. Bulygin, M. Kuznetsova, E. Ivleva, S. Sennikov","doi":"10.33029/0206-4952-2022-43-2-157-165","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-2-157-165","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoregulatory role of nucleated erythroid cells","authors":"R. Zavodskii, Y. Shevchenko, O.Yu. Koneva, K. Nazarov, M. Kuznetsova, S. Sennikov","doi":"10.33029/0206-4952-2022-43-1-103-111","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-103-111","url":null,"abstract":"Nucleated erythroid cells (NEC) are the precursors of the most massive population of human cells – erythrocytes, for which functions of hemo- and immunoregulation have been shown at various stages of ontogenesis and in various organs and tissues of the human body. NEC perform this function by secreting cytokine proteins, growth factors, enzymes such as arginase-2, ROS, and by surface molecules PD-L1 and PD-L2. Their important regulatory role has been shown for the formation of fetoplacental immunosuppression, immunosuppression during pregnancy, suppression of the response against commensals in the gastrointestinal tract, in the pathogenesis of bacterial and viral infections in adults, in the pathogenesis of tumor growth and autoimmune diseases, as well as participation in the recognition of pathogen-associated molecular patterns using Toll-like receptors in fish and birds. Such qualities, together with their number and width of distribution, represent NEC as active participants in hemo- and immunoregulation, which makes it important to study their regulatory role in health and disease.","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome","authors":"I. Osmanov, I. M. Khegai, I. Trunina, T. A. Chebotareva, A. Cheburkin, P. Shumilov","doi":"10.33029/0206-4952-2022-43-1-217-223","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-1-217-223","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69481905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supercationic peptide dendrimers as vectors for nucleic acids delivery to mammalian cells","authors":"K. Kozhikhova, S. M. Andreev, D.V. Uspenskaya, A.V. Shatilova, E. Turetskiy, A. Shatilov, A. Lushnikova, L. Vishniakova, I. Shilovskiy, V. Smirnov, D. Kudlay, M. Khaitov","doi":"10.33029/0206-4952-2022-43-3-320-332","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-3-320-332","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty: a controversial role of inflammaging","authors":"O. Artemyeva, V. Grechenko, T. V. Gromova, L. Gankovskaya","doi":"10.33029/0206-4952-2022-43-6-746-756","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-6-746-756","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Сorrelation between age and the intensity of the post-vaccination humoral immune response in individuals passed COVID-19","authors":"A. I. Andreev, I. V. Andreev, K.O. Nechay, D. R. Esaulova, O. S. Baklakova, V.I. Vecherko, I. Shilovskiy, I. Kofiadi, G. Gudima, А. Martynov, V. Smirnov, D. Kudlay, M. Khaitov","doi":"10.33029/0206-4952-2022-43-5-583-592","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-583-592","url":null,"abstract":"Introduction. Despite widespread vaccination against COVID-19 worldwide, the epidemiological situation remains insufficient. The appearance of mutant forms of SARS-CoV-2 with increased virulence causes new waves of COVID-19 morbidity. The virus variability can cause the reduction of the vaccination effectiveness. In this regard, it is important to study the dynamics of post-vaccination immunity, its features in various population groups, as well as the relationship between post-infectious and post-vaccination immunity. The study continues a series of researches of the features of SARS-CoV-2-specific immunity in COVID-19 convalescents and recipients of the <<Sputnik V>> vaccine. The aim of the study - assessment of the intensity of the SARS-CoV-2-specific immune response in different age groups of people passed COVID-19 and subsequently vaccinated with <<Sputnik V>>. Material and methods. With the help of EIA, the level of IgG antibodies to S-antigen and N-antigen of SARS-CoV-2 was studied in 155 samples of blood sera of individuals (men and women) aged 18 to 70 years who passed COVID-19 and after 6 month of recovery underwent a full course of vaccination with <<Sputnik V>>. Samples from individuals of the following age groups were examined: from 18 to 35, from 35 to 45, from 45 to 55, from 55 to 65, from 65 to 70 years. Results. In all the examined age groups of individuals passed COVID-19 and then vaccinated with <<Sputnik V>>, there was a high level of IgG antibodies to SARS-CoV-2 S-protein (positivity coefficient 8.1 and higher). The level of IgG antibodies to the N-protein in more than half of the cases was lower than positive values among all the subjects. Conclusion. The study showed that individuals passed COVID-19 and then vaccinated with <<Sputnik V>>, regardless of age, have intense post-vaccination humoral immunity. Copyright © 2022 Meditsina Publishers. All rights reserved.","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprogramming of myeloid cells of the tumor microenvironment – a new approach in the immunotherapy of malignant neoplasms","authors":"R. Ataullakhanov, E. Ushakova, S.A. Al Khudhur, A. Pichugin, E. Lebedeva","doi":"10.33029/0206-4952-2022-43-4-375-388","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-375-388","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity of a multi-antigen vaccine made from a lysate of tumor malignant cells or from primary solid tumor tissue","authors":"E. Ushakova, A. Fedorova, E. Lebedeva, A. Pichugin, R. Ataullakhanov","doi":"10.33029/0206-4952-2022-43-4-389-400","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-4-389-400","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid metabolism in experimental autoimmune atherosclerosis","authors":"I. Menshikov, Abdulkadhim Zerjawi, L. Beduleva, K. Fomina, A. Terentiev, N. Abisheva, I. Cherepanov","doi":"10.33029/0206-4952-2022-43-5-593-605","DOIUrl":"https://doi.org/10.33029/0206-4952-2022-43-5-593-605","url":null,"abstract":"","PeriodicalId":38750,"journal":{"name":"Immunologiya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69482590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}